Exposure to 7,12-dimethylbenz[a]anthracene impacts ovarian DNA damage sensing and repair proteins differently in lean and obese female mice and weight loss may mitigate obesity-induced ovarian dysfunction
Toxicol Appl Pharmacol. 2024 Apr 14:116930. doi: 10.1016/j.taap.2024.116930. Online ahead of print.ABSTRACTObesity impairs oocyte quality, fertility, pregnancy maintenance, and is associated with offspring birth defects. The model ovotoxicant, 7,12-dimethylbenz[a]anthracene (DMBA), causes ovarian DNA damage and follicle loss. Both DMBA-induced chemical biotransformation and the DNA damage response are partially attenuated in obese relative to lean female mice but whether weight loss could improve the DNA damage response to DMBA exposure has not been explored. Thus, at six weeks of age, C57BL/6 J female mice were divided in...
Source: Toxicology and Applied Pharmacology - April 16, 2024 Category: Toxicology Authors: M Estefan ía González-Alvarez Imaobong Inyang Aileen F Keating Source Type: research
Roxithromycin exposure induces motoneuron malformation and behavioral deficits of zebrafish by interfering with the differentiation of motor neuron progenitor cells
In this study, we used the zebrafish as a vertebrate model to explore the potential developmental toxicity of early ROX exposure, particularly focusing on its effects on locomotor functionality and CaP motoneuron development. Early exposure to ROX induces marked developmental toxicity in zebrafish embryos, significantly reducing hatching rates (n=100), body lengths (n=100), and increased malformation rates (n=100). The zebrafish embryos treated with a corresponding volume of DMSO (0.1%, v/v) served as vehicle controls (veh). Moreover, ROX exposure adversely affected the locomotive capacity of zebrafish embryos, and observa...
Source: Ecotoxicology and Environmental Safety - April 16, 2024 Category: Environmental Health Authors: Wenjie Xie Juntao Chen Xiaoqian Cao Jiannan Zhang Juanjuan Luo Yajun Wang Source Type: research
Developmental toxicity of short-chain chlorinated paraffins on early-stage chicken embryos in a shell-less (ex-ovo) incubation system
In conclusion, SCCPs induce developmental toxicity by disrupting thyroid functions at the early-life stage of chicken embryos.PMID:38626606 | DOI:10.1016/j.ecoenv.2024.116304 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 16, 2024 Category: Environmental Health Authors: Hao Chen Kaori Chigusa Kazuki Kanda Rumi Tanoue Mari Ochiai Hisato Iwata Source Type: research
Aflatoxin B1 inhibited the development of primary myoblasts of grass carp (Ctenopharyngodon idella) by degrading extracellular matrix
Ecotoxicol Environ Saf. 2024 Apr 15;276:116332. doi: 10.1016/j.ecoenv.2024.116332. Online ahead of print.ABSTRACTAccording to the International Agency for Research on Cancer (IARC), aflatoxin B1 (AFB1) has been recognized as a major contaminant in food and animal feed and which is a common mycotoxin with high toxicity. Previous research has found that AFB1 inhibited zebrafish muscle development. However, the potential mechanism of AFB1 on fish muscle development is unknown, so it is necessary to conduct further investigation. In the present research, the primary myoblast of grass carp was used as a model, we treated myobla...
Source: Ecotoxicology and Environmental Safety - April 16, 2024 Category: Environmental Health Authors: Xiang-Ning He Wei-Dan Jiang Pei Wu Yang Liu Hong-Mei Ren Xiao-Wan Jin Sheng-Yao Kuang Ling Tang Shu-Wei Li Lin Feng Xiao-Qiu Zhou Source Type: research
Effects of Streptomyces sp. HU2014 inoculation on wheat growth and rhizosphere microbial diversity under hexavalent chromium stress
Ecotoxicol Environ Saf. 2024 Apr 15;276:116313. doi: 10.1016/j.ecoenv.2024.116313. Online ahead of print.ABSTRACTWheat (Triticum aestivum L.) is a major foodstuff for over 40% of the world's population. However, hexavalent chromium [Cr(VI)] in contaminated soil significantly affects wheat production and its ecological environment. Streptomyces sp. HU2014 was first used to investigate the effects of Cr (VI) stress on wheat growth. We analyzed the Cr(VI) concentration, physicochemical properties of wheat and soil, total Cr content, and microbial community structures during their interactions. HU2014 reduced the toxicity of C...
Source: Ecotoxicology and Environmental Safety - April 16, 2024 Category: Environmental Health Authors: Hongxia Zhu Linfeng Hu Yunlong Wang Peipei Mei Feng Zhou Tetiana Rozhkova Chengwei Li Source Type: research
Unique Advantages of Dendrimers-Structured Mesoporous Silica Nanoparticles over Traditional Hollow ones in Delivering Bcl2-Functional Converting Peptide for Multidrug Resistant Cancer Treatment
This article is protected by copyright. All rights reserved.PMID:38626918 | DOI:10.1002/adhm.202400888 (Source: Adv Data)
Source: Adv Data - April 16, 2024 Category: Epidemiology Authors: Yuehuang Wu Fangmei Ma Lixue Yu Ruimiao Lin Sijin Lin Zhihan Guo Min Zhou Mingyu Li Yi Zhang Jingjing Xie Source Type: research
The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods
Arch Toxicol. 2024 Apr 16. doi: 10.1007/s00204-024-03739-w. Online ahead of print.ABSTRACTAll areas of the modern society are affected by fluorine chemistry. In particular, fluorine plays an important role in medical, pharmaceutical and agrochemical sciences. Amongst various fluoro-organic compounds, trifluoromethyl (CF3) group is valuable in applications such as pharmaceuticals, agrochemicals and industrial chemicals. In the present study, following the strict OECD modelling principles, a quantitative structure-toxicity relationship (QSTR) modelling for the rat acute oral toxicity of trifluoromethyl compounds (TFMs) was e...
Source: Archives of Toxicology - April 16, 2024 Category: Toxicology Authors: Xinyi Lu Xin Wang Shuo Chen Tengjiao Fan Lijiao Zhao Rugang Zhong Guohui Sun Source Type: research
Uremic toxins and the brain in chronic kidney disease
J Nephrol. 2024 Apr 16. doi: 10.1007/s40620-024-01929-4. Online ahead of print.ABSTRACTChronic kidney disease (CKD) patients have an increased risk for cognitive impairment compared to the general population. The risk is much higher in CKD patients who progress to end-stage kidney disease (ESKD) and require hemodialysis or peritoneal dialysis. Multiple factors may contribute to cognitive impairment in CKD patients and in patients on chronic dialysis. However, the observation that, after kidney transplantation, there is an improvement in several cognitive performance markers and that some structural and functional brain abn...
Source: Journal of Nephrology - April 16, 2024 Category: Urology & Nephrology Authors: Maurizio Bossola Barbara Picconi Source Type: research
Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer
This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer (mHSPC). PubMed, EMBASE, and the Cochrane Library were comprehensively searched for eligible randomized controlled trials (RCTs) published from inception to October 2023. Interventions included abiraterone, apalutamide, enzalutamide, docetaxel, darolutamide, and androgen deprivation therapy (ADT), either as doublet or triplet therapies. The outcomes examined were overall survival (OS), progression-free survival (PFS), castration-resistant prostate cancer (CRPC)-free survival, time to symptomat...
Source: Asian Journal of Andrology - April 16, 2024 Category: Urology & Nephrology Authors: Shan-Shan Wang Xiao-Jie Bian Jun-Long Wu Bei-He Wang Sheng Zhang Ding-Wei Ye Source Type: research
The Accomplishments of KoCVAM in the Development and Implementation of Alternative Methods in Korea
Altern Lab Anim. 2024 Apr 16:2611929241244520. doi: 10.1177/02611929241244520. Online ahead of print.ABSTRACTThe Korean Center for the Validation of Alternative Methods (KoCVAM), which promotes the Three Rs principles and the use of alternative methods in Korea, has been operating within the Toxicological Screening and Testing Division of the Ministry of Food and Drug Safety (MFDS) since 2009. KoCVAM has exchanged opinions and information on the development and validation of non-animal alternative test methods as part of the International Cooperation on Alternative Test Methods (ICATM), and provided input into draft OECD T...
Source: Alternatives to Laboratory Animals : ATLA - April 16, 2024 Category: Research Authors: Nam-Hee Kang JaeHo Oh Source Type: research
Oncological Rehabilitation for Breast Cancer
Rehabilitation (Stuttg). 2024 Apr;63(2):119-130. doi: 10.1055/a-2129-9279. Epub 2024 Apr 16.ABSTRACTAs a result of increasingly individualized and multimodal therapy, prognosis of breast cancer has improved significantly over the last years. However, multimodal treatment and the use of new medications can lead to a variety of somatic, sometimes new, side effects such as fatigue, polyneuropathy or autoimmune toxicities. This and the oncological diagnosis lead to a high level of psychological distress in the women affected and often to subsequent psychological disorders (sleep/anxiety disorders, depression, ...). Both the di...
Source: Die Rehabilitation - April 16, 2024 Category: Rehabilitation Authors: Holger G Hass Source Type: research
Abscisic acid signaling through LANCL2 and PPAR γ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells
Oncol Rep. 2024 Mar;51(3):39. doi: 10.3892/or.2024.8698. Epub 2024 Jan 12.ABSTRACTProstate cancer (PCa) is one the most common malignancies in men. The high incidence of bone metastasis years after primary therapy suggests that disseminated tumor cells must become dormant, but maintain their ability to proliferate in the bone marrow. Abscisic acid (ABA) is a stress response molecule best known for its regulation of seed germination, stomal opening, root shoot growth and other stress responses in plants. ABA is also synthesized by mammalian cells and has been linked to human disease. The aim of the present study was to exam...
Source: Ann Oncol - April 16, 2024 Category: Cancer & Oncology Authors: Keshab Raj Parajuli Younghun Jung Russell S Taichman Source Type: research
Deciphering the prognostic landscape of osteosarcoma: Integrating the roles of hippo pathway genes, programmed cell death, and the tumor immune microenvironment
Environ Toxicol. 2024 Apr 15. doi: 10.1002/tox.24280. Online ahead of print.ABSTRACTOsteosarcoma is a highly aggressive cancer prevalent among adolescents and young adults, notorious for its tendency to metastasize to the lungs. This research delves into the molecular foundations of osteosarcoma by examining the role of the Hippo signaling pathway and its interaction with the tumor immune microenvironment (TME). Through analysis of transcriptomic data from the TARGET-OS dataset and control samples from GTEx, we identified a set of 131 genes that link high expression profiles in osteosarcoma with the Hippo pathway. A focuse...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Huayan Ma Yuxian Zhang Jing Li Tiantian Xie Zhi Zhao Source Type: research
Recent advances in immunotherapies against infectious diseases
Immunother Adv. 2020 Nov 25;1(1):ltaa007. doi: 10.1093/immadv/ltaa007. eCollection 2021 Jan.ABSTRACTImmunotherapies are disease management strategies that target or manipulate components of the immune system. Infectious diseases pose a significant threat to human health as evidenced by countries continuing to grapple with several emerging and re-emerging diseases, the most recent global health threat being the SARS-CoV2 pandemic. As such, various immunotherapeutic approaches are increasingly being investigated as alternative therapies for infectious diseases, resulting in significant advances towards the uncovering of path...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Dharanidharan Ramamurthy Trishana Nundalall Sanele Cingo Neelakshi Mungra Maryam Karaan Krupa Naran Stefan Barth Source Type: research
Phase I/II study of stereotactic body radiotherapy boost in patients with cervical cancer ineligible for intracavitary brachytherapy
CONCLUSION: These findings suggested that a SBRT boost is more effective than the conventional EBRT boost and can be an important treatment option for ICBT-ineligible patients with cervical cancer.STUDY REGISTRATION: This study was registered at the University Hospital Medical Information Network Clinical Trials Registry (UMIN000036845).PMID:38625476 | DOI:10.1007/s11604-024-01566-8 (Source: Cancer Control)
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: Kei Ito Yujiro Nakajima Hiroaki Ogawa Akiko Furusawa Keiko Nemoto Murofushi Satoshi Kito Nao Kino Toshiharu Yasugi Takashi Uno Katsuyuki Karasawa Source Type: research
