A Japanese multi-institutional phase II study of moderate hypofractionated intensity-modulated radiotherapy with image-guided technique for prostate cancer
CONCLUSION: The safety and efficacy of moderately hypofractionated IMRT with prostate-based image-guidance was confirmed among Japanese patients with prostate cancer.PMID:38630382 | DOI:10.1007/s10147-024-02517-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Katsumasa Nakamura Keiji Nihei Yoshihiro Saito Naoto Shikama Shin-Ei Noda Ryusuke Hara Toshiyuki Imagumbai Takashi Mizowaki Takeshi Akiba Etsuo Kunieda Masanori Someya Saiji Ohga Jiro Kawamori Takuyo Kozuka Yosuke Ota Koji Inaba Takeshi Kodaira Yoshiyuki Source Type: research
A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Conclusions: Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration. Further investigation of the optimal treatment schedule for lenvatinib is warranted. Clinical Trial Registration: UMIN000022243.PMID:38629757 | DOI:10.1089/thy.2023.0553 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research
Hematological toxicities post-CAR-T cells: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)
Bull Cancer. 2024 Apr 16:S0007-4551(24)00119-X. doi: 10.1016/j.bulcan.2024.02.013. Online ahead of print.ABSTRACTChimeric antigen receptor T cell (CAR-T cell) therapy has become a standard-of-care for several hematological and a promising treatment for solid malignancies or for selected non-malignant autoimmune disorders. Hematological complications following this treatment are very common with the majority of patients experiencing at least one cytopenia after CAR-T cell injections. The management of these adverse events is not standardized and represents an area of active research and unmet clinical needs. This harmonizat...
Source: Bulletin du Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Tamim Alsuliman Clotilde Aubrun Jacques Olivier Bay Yves Beguin Camille Bigenwald Eolia Brissot Yves Chalandon Patrice Chevallier Simona Pagliuca L éonardo Magro Micha Srour Source Type: research
Levels and Health Risk Assessments of Heavy Metals in Khat and Its Support Soil in Algesachi, Ilu Ababor, Ethiopia
CONCLUSION: The hazard index (HI) of metals in khat from study areas was less than 1 indicating a less likelihood of non-carcinogenic toxicological health effects. However, the presence of these toxic chemicals in soil and khat indicates product contamination and needs extensive further investigation involving other heavy metals.PMID:38628468 | PMC:PMC11020725 | DOI:10.1177/11786302241246455 (Source: Environmental Health Insights)
Source: Environmental Health Insights - April 17, 2024 Category: Environmental Health Authors: Shibiru Damana Abiyot Kelecha Geletu Ibrahim Umer Keru Source Type: research
The impact of nanomaterials on autophagy across health and disease conditions
Cell Mol Life Sci. 2024 Apr 17;81(1):184. doi: 10.1007/s00018-024-05199-y.ABSTRACTAutophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response ...
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Ida Florance Marco Cordani Parya Pashootan Mohammad Amin Moosavi Ali Zarrabi Natarajan Chandrasekaran Source Type: research
BIOACTIVES OF Melipona rufiventris PROPOLIS: EXPLORING ITS ANTIMICROBIAL, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITIES
This study explores the potential of propolis from Melipona rufiventris species. With its composition encompassing resin, wax, pollen, and soil, propolis holds historical significance in traditional medicine within tropical regions. This research is driven by the scarcity of information surrounding M. rufiventris propolis, prompting an investigation into its chemical constituents, in vivo toxicity, and antimicrobial, antioxidant, and anti-inflammatory properties. This exploration could potentially uncover novel applications for this natural product, bolstering both meliponiculture practices and the preservation of native b...
Source: Chemistry and Biodiversity - April 17, 2024 Category: Biochemistry Authors: Amanda Tristao Santini Rayra Annara Otac ílio Pinto Josy Goldoni Lazarini Daniel Vieira de Morais Anna Maria Alves de Piloto Fernandes Marcelo Franchin Patricia Lunardelli Negreiros de Carvalho Carolina Girotto Pressete Pedro Luiz Rosalen Severino Matias Source Type: research
In vitro and in vivo exposure of endothelial cells to dibutyl phthalate promotes monocyte adhesion
Food Chem Toxicol. 2024 Apr 15;188:114663. doi: 10.1016/j.fct.2024.114663. Online ahead of print.ABSTRACTThe effect of endothelial cells' exposure to dibutyl phthalate (DBP) on monocyte adhesion is largely unknown. We evaluated monocyte adhesion to DBP-exposed endothelial cells by combining three approaches: short-term exposure (24 h) of EA.hy926 cells to 10-6, 10-5, and 10-4 M DBP, long-term exposure (12 weeks) of EA.hy926 cells to 10-9, 10-8, and 10-7 M DBP, and exposure of rats (28 and 90 days) to 100, 500, and 5000 mg DBP/kg food. Monocyte adhesion to human EA.hy926 and rat aortic endothelial cells, expression of selec...
Source: Food and Chemical Toxicology - April 17, 2024 Category: Food Science Authors: Dunja Kokai Jelena Markovic Filipovic Marija Opacic Ivana Ivelja Vojislav Banjac Bojana Stanic Nebojsa Andric Source Type: research
RIFM fragrance ingredient safety assessment, N,N-diethyloctamide, CAS Registry Number 996-97-4
Food Chem Toxicol. 2024 Apr 15:114657. doi: 10.1016/j.fct.2024.114657. Online ahead of print.NO ABSTRACTPMID:38631436 | DOI:10.1016/j.fct.2024.114657 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - April 17, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
Investigating aluminum toxicity effects on callose deposition, oxidative stress, and nutrient homeostasis in banana genotypes
This study seeks to explore the differential responses of two banana genotypes with varying Al tolerance (Baodao and Baxi) to Al exposure (100 and 500 µM) for 24 h. Microscopic analysis uncovered distinctive structural modifications in root cells, with Baodao displaying more severe alterations in response to Al stress. There was higher superoxide (O2-.) and hydrogen peroxide (H2O2) production and lipid peroxidation in Baodao indicating enhanced oxidative stress and membrane damage. Al accumulation in root tips was higher in Baxi than Baodao, while the roots of Baodao had a higher accumulation of callose. Nutrient content ...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Yue Hu Shahbaz Khan Liyan Yin Hua Tang Jiaquan Huang Source Type: research
Natural products for biocontrol: review of their fate in the environment and impacts on biodiversity
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33256-3. Online ahead of print.ABSTRACTBiocontrol solutions (macroorganisms, microorganisms, natural substances, semiochemicals) are presented as potential alternatives to conventional plant protection products (PPPs) because they are supposed to have lower impacts on ecosystems and human health. However, to ensure the sustainability of biocontrol solutions, it is necessary to document the unintended effects of their use. Thus, the objectives of this work were to review (1) the available biocontrol solutions and their regulation, (2) the contamination of the ...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Marcel Amichot C édric Bertrand Bruno Chauvel Marie-France Corio-Costet Fabrice Martin-Laurent Sophie Le Perchec Laure Mamy Source Type: research
Co-application of biochar and selenium nanoparticles improves yield and modifies fatty acid profile and essential oil composition of fennel (Foeniculum vulgare Mill.) under cadmium toxicity
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33270-5. Online ahead of print.ABSTRACTFatty acids and essential oils (EOs) are the primary variables that influence the quality of fennel (Foeniculum vulgare Mill.). Soil toxicity to cadmium (Cd) is the main environmental issue facing fennel, and priming methods like soil amendments and nanoparticles (NPs) are commonly utilized to deal with it. The goal of the current study was to examine the effects of biochar (BC) and selenium nanoparticles (Se NPs) on fennel plants in Cd-contaminated soils. The pot experiment was conducted with Cd stress at 0, 10, and 20 ...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Masoumeh Jahantigh Marzieh Ghanbari Jahromi Fatemeh Sefidkon Marjan Diyanat Weria Weisany Source Type: research
Incorporating functional lung imaging (FLI) into radiation therapy planning in patients with lung cancer: A systematic review and meta-analysis
CONCLUSIONS: FLI shows promise as a method to spare FL during thoracic RT, but interventional trials related to FL avoidance planning are sparse. Such trials are critical to understanding the impact of FL avoidance planning on toxicity reduction and patient outcomes.PMID:38631538 | DOI:10.1016/j.ijrobp.2024.04.001 (Source: Health Physics)
Source: Health Physics - April 17, 2024 Category: Physics Authors: Julie Midroni Rohan Salunkhe Zhihui Liu Ronald Chow Gabriel Boldt David Palma Douglas Hoover Yevgeniy Vinogradskiy Srinivas Raman Source Type: research
Toxicity evaluation of dose-escalation in hypofractionated regional nodal irradiation for breast cancer: a retrospective study
CONCLUSIONS: Patients who received dose-escalation in hypofractionated RNI face a higher risk of developing lymphedema and shoulder stiffness compared to those who received standard-dose hypofractionated RNI. Therefore, it is crucial to implement close and frequent monitoring for early detection, along with timely rehabilitation interventions for these patients.PMID:38631540 | DOI:10.1016/j.ijrobp.2024.04.014 (Source: Health Physics)
Source: Health Physics - April 17, 2024 Category: Physics Authors: Euidam Kim Ji Sung Yoo Yeon-Joo Kim Jungnam Joo Eun Sang Oh Yoonsun Chung Seung Hyun Chung Tae Hyun Kim Source Type: research
Influence of the use of remediated soil and agricultural drainage water on the safety of tomato fruits
In conclusion, the employed bioremediation techniques successfully reduced the PTE content and microbial load in both soil and drainage water ecosystems and in harvested tomato fruits. Henceforth, no health risks are expected from the consumption of this product.PMID:38632200 | DOI:10.1007/s11356-024-33187-z (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Salah H Salem Mohamed Saber Samir Gadow Hoda Kabary Alaa Zaghloul Source Type: research
Japanese Planocerid Flatworms: Difference in Composition of Tetrodotoxin and Its Analogs and the Effects of Ingestion by Toxin-Bearing Fishes in the Ryukyu Islands, Japan
Mar Biotechnol (NY). 2024 Apr 17. doi: 10.1007/s10126-024-10312-0. Online ahead of print.ABSTRACTTetrodotoxin (TTX), known as pufferfish toxin, is a potent neurotoxin blocking sodium channels in muscle and nerve tissues. TTX has been detected in various taxa other than pufferfish, including marine polyclad flatworms, suggesting that pufferfish toxin accumulates in fish bodies via food webs. The composition of TTX and its analogs in the flatworm Planocera multitentaculata was identical to those in wild grass puffer Takifugu alboplumbeus. Previously, Planocera sp. from Okinawa Island, Japan, were reported to possess high lev...
Source: Marine Biotechnology - April 17, 2024 Category: Biotechnology Authors: Hiroyuki Ueda Masaaki Ito Ryo Yonezawa Kentaro Hayashi Taiga Tomonou Maho Kashitani Hikaru Oyama Kyoko Shirai Rei Suo Kazutoshi Yoshitake Shigeharu Kinoshita Shuichi Asakawa Shiro Itoi Source Type: research
