Elevated intracellular Ca < sup > 2+ < /sup > functions downstream of mitodysfunction to induce Wallerian-like degeneration and necroptosis in organophosphorus-induced delayed neuropathy
This study was designed to investigate that deregulated cytosolic Ca2+ may function downstream of mitodysfunction in activating Wallerian-like degeneration and necroptosis in OPIDN. Adult hens were administrated a single dosage of 750mg/kg tri-ortho-cresyl phosphate (TOCP), and then sacrificed at 1day, 5day, 10day and 21day post-exposure, respectively. Sciatic nerves and spinal cords were examined for pathological changes and proteins expression related to Wallerian-like degeneration and necroptosis. In vitro experiments using differentiated neuro-2a (N2a) cells were conducted to investigate the relationship among mitochon...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Mingxue Song Kang Kang Shuai Wang Cuiqin Zhang Xiulan Zhao Fuyong Song Source Type: research
Ferroptosis is involved in human chorionic trophoblast cells cytotoxicity induced by black phosphorus nanoparticles
Toxicology. 2024 Apr 21:153810. doi: 10.1016/j.tox.2024.153810. Online ahead of print.ABSTRACTBlack phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta. H&E staining fu...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Ruolan You Yaming Mu Jiaqi Zhou Chunying Wang Zhenya Fang Yu Liu Shiyu Liu Qingfeng Zhai Changqing Zhang Source Type: research
Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
Greenspace and human microbiota: A systematic review
CONCLUSION: The current evidence suggests that greenspace exposure may diversify gut and skin microbiota and alter their composition to healthier profiles. These findings would be helpful in uncovering the potential mechanisms underlying greenspace and human health and in promoting a healthier profile of human microbiota.PMID:38653130 | DOI:10.1016/j.envint.2024.108662 (Source: Environment International)
Source: Environment International - April 23, 2024 Category: Environmental Health Authors: Yi-Dan Zhang Gang-Long Zhou Lu Wang Matthew H E M Browning Iana Markevych Joachim Heinrich Luke D Knibbs Tianyu Zhao Yizhen Ding Shi Chen Kang-Kang Liu Payam Dadvand Guang-Hui Dong Bo-Yi Yang Source Type: research
Genome-wide DNA methylation changes in Oryzias melastigma embryos exposed to the water accommodated fraction of crude oil
Ecotoxicol Environ Saf. 2024 Apr 22;277:116325. doi: 10.1016/j.ecoenv.2024.116325. Online ahead of print.ABSTRACTThe water accommodated fraction (WAF) of crude oil exerts considerable impacts on marine fish during embryonic stage. Clarifying changes in epigenetic modifications is helpful for understanding the molecular mechanism underlying the toxicity of embryonic WAF exposure. The aim of this study was to explore genome-wide DNA methylation changes in Oryzias melastigma embryos after exposure to the nominal total petroleum hydrocarbon concentration of 500 μg/L in WAF for 7 days. Whole-genome bisulfite sequencing reveale...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Chenshi Wang Wei Lei Lichao Du Yiran Xu Yingbin Lou Mo Peng Dongxu Gao Source Type: research
The mitochondria-targeted antioxidant MitoQ ameliorates inorganic arsenic-induced DCs/Th1/Th2/Th17/Treg differentiation partially by activating PINK1-mediated mitophagy in murine liver
This study has provided new insights on the immunotoxicity of inorganic arsenic and established a foundation for exploring preventive and therapeutic strategies targeting PINK1-mediated mitophagy in acute liver injury. Consequently, the application of mitochondrial antioxidant MitoQ may offer a promising treatment for the metalloid-induced acute liver injury.PMID:38653026 | DOI:10.1016/j.ecoenv.2024.116350 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Hui Li Yaning Guo Wei Su Huan Zhang Xiaoxi Wei Xinyu Ma Shuwen Gong Gaoyang Qu Lin Zhang Hong Xu Fuhai Shen Shoufang Jiang Dingjie Xu Jinlong Li Source Type: research
Effect of zeolites on the reduction of the ecotoxicity of carbamazepine in the environment
In this study, the impact of calcination of zeolites on the ecotoxicity of carbamazepine solutions in two matrices, water and synthetic sewage, was assessed. Two types of zeolites were tested: natural zeolite, in the form of a zeolite rock consisting mainly of clinoptilolite, and a synthetic zeolite type 5 A. Additionally, zeolites were calcined at a temperature of 200 °C. The kinetics of carbamazepine adsorption in aqueous solutions and in synthetic sewage matrix was determined. Higher adsorption capacity was obtained for carbamazepine aqueous solutions as well as zeolites after the calcination process. Considering type ...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Aleksandra Bogusz Beata Tomczyk Magdalena Trzci ńska Barbara Miros ław Barbara Gworek Source Type: research
Tracing toxic path of antimony: From bioaccumulation to DNA hypomethylation in zebrafish (Danio rerio)
This study investigated the toxicokinetics, Global DNA Methylation (GDM), biomarker expression, and Integrated Biological Response (IBR) of Sb at different concentrations in zebrafish. The toxic mechanism of Sb exposure was simulated using molecular dynamics (MD). The results showed that significant differences effect existed (BCFk: liver > ovary > gut > brain) and uptake saturation phenomenon of Sb among zebrafish tissues. Over a 54-day exposure period, the liver emerged as the main target site for Sb-induced GDM, and the restoration was slower than in other tissues during the 54-day recovery period. Moreover, th...
Source: Ecotoxicology and Environmental Safety - April 23, 2024 Category: Environmental Health Authors: Jingyun Zhang Aijiang Yang Wen Cui Jian Zhang Apin Niu Xia Hu Qing Li Source Type: research
Contaminants in Dietary Supplements: Toxicity, Doping Risk, and Current Regulation
Int J Sport Nutr Exerc Metab. 2024 Apr 23:1-10. doi: 10.1123/ijsnem.2023-0263. Online ahead of print.ABSTRACTAthletes, both amateur and professional, often resort to the consumption of nutritional supplements without professional supervision and without being aware of the risks they may entail. We conducted an exhaustive literature search to determine the most common substances found as contaminants in dietary supplements. For each substance, we analyzed its mechanism of action, clinical indication, health risk, and putative use as doping agent. In addition, we evaluated the current regulation of these supplements. Contami...
Source: International Journal of Sport Nutrition and Exercise Metabolism - April 23, 2024 Category: Sports Medicine Authors: Jes ús Zapata-Linares Guillermo Gervasini Source Type: research
Durvalumab impacts progression-free survival while high-dose radiation & gt;66 Gy improves local control without excess toxicity in unresectable NSCLC stage III: Real-world data from the Austrian radio-oncological lung cancer study association registry (ALLSTAR)
CONCLUSION: While Durvalumab impacts PFS, LC can be improved by total radiation doses > 66 Gy without excess toxicity.PMID:38653380 | DOI:10.1016/j.radonc.2024.110294 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 23, 2024 Category: Radiology Authors: Franz Zehentmayr Petra Feurstein Elvis Ruznic Brigitte Langer Brane Grambozov Marisa Klebermass Herbert H üpfel Johann Feichtinger Danijela Minasch Martin Heilmann Barbara Breitfelder Claudia Steffal Gisela Gastinger-Grass Karoline Kirchhammer Margit Kaz Source Type: research
Identification of small molecule inhibitors of penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus for the therapeutics of bacterial infection
In conclusion, the results suggest alpha-mangostin as a promising candidate for inhibiting PBP2a. Further, extensive studies are warranted to explore its clinical applications.PMID:38650157 | DOI:10.14715/cmb/2024.70.3.6 (Source: Cellular and Molecular Biology)
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Anwer Razique Source Type: research
A woman in her fifties with a post-operative infection, generalised rash and organ failure
This article presents a case of a middle-aged woman who developed symptoms of toxic shock syndrome five days after elective breast cancer surgery, with high fever, multiorgan failure and a characteristic desquamation of the palms.INTERPRETATION: Toxic shock syndrome is a potentially lethal, toxin-mediated disease. Symptoms develop quickly, within hours. Early recognition and appropriate surgical management, intensive care and antibiotics are therefore important to reduce mortality and sequelae.PMID:38651709 | DOI:10.4045/tidsskr.23.0623 (Source: Tidsskrift for den Norske Laegeforening)
Source: Tidsskrift for den Norske Laegeforening - April 23, 2024 Category: General Medicine Authors: Naima Borg Tahri Berit Gravdehaug Nazli Bahrami Laurens Reitsma Source Type: research
BiliQML: A supervised machine-learning model to quantify biliary forms from digitized whole-slide liver histopathological images
Am J Physiol Gastrointest Liver Physiol. 2024 Apr 23. doi: 10.1152/ajpgi.00058.2024. Online ahead of print.ABSTRACTThe progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed error-prone and lack architectural context; or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quant...
Source: Am J Physiol Gastroi... - April 23, 2024 Category: Gastroenterology Authors: Dominick J Hellen Meredith E Fay David H Lee Caroline Klindt-Morgan Ashley Bennett Kimberly J Pachura Arash Grakoui Stacey S Huppert Paul A Dawson Wilbur A Lam Saul J Karpen Source Type: research
Approach to the patient: Concept and application of targeted radiotherapy in the paraganglioma patient
J Clin Endocrinol Metab. 2024 Apr 23:dgae252. doi: 10.1210/clinem/dgae252. Online ahead of print.ABSTRACTParagangliomas can metastasize, posing potential challenges in both symptomatic management and disease control. Systemic targeted radiotherapies using 131I-MIBG and 177Lu-DOTATATE are a mainstay in the treatment of metastatic paragangliomas. This clinical scenario and discussion aim to enhance physicians' knowledge of the stepwise approach to treat these patients with paraganglioma targeted radiotherapies. It comprehensively discusses current approaches to selecting paraganglioma patients for targeted radiotherapies and...
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Karel Pacak David Taieb Frank I Lin Abhishek Jha Source Type: research
Fulfilling the Role of a Parent While Undergoing Treatment for Cancer: A Review of the Literature and the Potential Impact of Childcare Support on Cancer Outcomes
Am J Clin Oncol. 2024 Apr 23. doi: 10.1097/COC.0000000000001102. Online ahead of print.ABSTRACTBreast cancer is the most prevalent malignancy among adolescents and young adults (AYAs). Despite the efficacy of chemotherapy, AYA patients contend with psychosocial challenges, including psychological distress and financial toxicity, exacerbated further by those with dependent children. Parenting responsibilities intersect with cancer care, impacting both family dynamics and treatment adherence. Despite recognized needs, however, the impact of parenting concerns or even parenting status and the presence of dependents has not be...
Source: Clinical Genitourinary Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Kang Woo Kim Mary Lopresti Stephanie L Graff Sabrina Witherby Don S Dizon Mary Anne Fenton Source Type: research
