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Vascular sclerosing effects of bleomycin on cutaneous veins: a pharmacopathologic study on experimental animals
Conclusions: This study showed that bleomycin-loaded liposomes were able to induce vasculitis and vascular occlusion without any toxicity or complications. It might be useful, hence, to treat patients suffering from Varicose veins and other ectatic vascular diseases with this agent. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - September 21, 2017 Category: Dermatology Source Type: research

Dihydroartemisinin and Curcumin Synergistically Induce Apoptosis in SKOV3 Cells Via Upregulation of MiR-124 Targeting Midkine
Conclusion: Co-treatment with DHA and Cur exhibited a synergistic anti-tumor effect on SKOV3 cells bothin vitro andin vivo.Cell Physiol Biochem 2017;43:589 –601 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - September 21, 2017 Category: Cytology Source Type: research

The direct costs of treating human visceral leishmaniasis in Brazil
CONCLUSIONS: This analysis indicates the economic feasibility of replacing N-methyl glucamine antimoniate with liposomal amphotericin B, which allows a shorter treatment period with less toxicity compared with other treatments, provided that the purchase value used by the WHO and transferred to the MH is maintained. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - September 21, 2017 Category: Tropical Medicine Source Type: research

Rethinking Brain Cancer Therapy: Tumor Enzyme Activatable Theranostic Nanoparticles.
Authors: Daldrup-Link HE Abstract This invited commentary discusses a recent article by Mohanty et al in Molecular Cancer Therapeutics about significant therapeutic efficacies of novel theranostic nanoparticles (TNPs) for the treatment of human brain cancers in mouse models. The TNPs were cleaved by enzymes in the tumor tissue, matrix metalloproteinase (MMP-14), which lead to release of a highly potent therapeutic drug, azademethylcolchicine. Data showed that the TNPs caused selective toxic effects in MMP-14-expressing glioblastoma and not normal brain. In addition, the iron oxide nanoparticle backbone enabled in v...
Source: Molecular Imaging - September 21, 2017 Category: Radiology Tags: Mol Imaging Source Type: research

High-dose interleukin-2 (IL-2) for the treatment of melanoma: Safety considerations and future directions.
Authors: Marabondo S, Kaufman HL Abstract INTRODUCTION: In 1998, high-dose interleukin-2 (IL-2) was the first immunotherapy approved for the treatment of metastatic melanoma based on durable objective responses documented in a subset of patients but widespread utilization was limited by significant toxicity. Advances in targeted therapy and the emergence of T cell checkpoint inhibitors, which can generally be given in the ambulatory setting, have further limited consideration of IL-2 for melanoma patients and the role of IL-2 in the current landscape of melanoma treatment is uncertain. Areas covered: In this review...
Source: Expert Opinion on Drug Safety - September 21, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Post-prostatectomy radiation therapy for locally recurrent prostate cancer.
In this study, we review the evidence for the adjuvant and salvage radiation therapy after radical prostatectomy. Areas covered: A literature review of the Medline and Embase databases was performed. The search strategy included the following terms: prostate cancer, adjuvant radiotherapy, salvage radiotherapy, radical prostatectomy, biochemical recurrence, and prostate cancer recurrence. Prospective randomized trials for the adjuvant radiotherapy and observational studies supporting salvage radiotherapy were included for discussion. Expert commentary: As postoperative radiotherapy is associated with non-trivial risks of ac...
Source: Expert Review of Anticancer Therapy - September 21, 2017 Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research

The challenge of curbing aminoglycoside resistance: can antimicrobial stewardship programs play a critical role?
Authors: Pitiriga V, Dimitroulia E, Saroglou G, Tsakris A Abstract INTRODUCTION: Aminoglycosides are useful antimicrobials, primarily for serious infections involving aerobic gram-negative pathogens. The inevitable increase in aminoglycoside resistance has led to calls for reducing levels of inappropriate aminoglycoside prescribing through the implementation of various antibiotic stewardship programs (ASPs). These programs mainly include restriction policies and aminoglycoside cycling. Although aminoglycoside resistance rates appear essential for measuring effectiveness of these interventions, most studies have foc...
Source: Expert Review of Anti-Infective Therapy - September 21, 2017 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

Hepatotoxicity of the Methanol Extract of Carica papaya. (Paw-Paw) Seeds in Wistar Rats.
Authors: Udoh FV, Udoh PB Abstract Activity of Carica papaya. Linn. (commonly known as paw-paw.) seed extract in liver physiology of albino (Wistar) rats was studied. The MeOH extract of C. papaya. seeds were Soxhlet extracted. Tolerated doses of C. papaya. were estimated in acute toxicity studies and administered orally, single or repeated doses, for 30 days to adult male rats weighing between 190 and 200 g, which were divided into four groups of five rats per group. Group 1 received 10 mg/kg; group 2 received 50 mg/kg; group 3 received 200 mg/kg; group 4 received normal saline (1 ml/rat) as control. Twenty-four h...
Source: Pharmaceutical Biology - September 21, 2017 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Safety and Efficacy of the S-1/Temozolomide Regimen in Patients with Metastatic Neuroendocrine Tumors
Conclusions: The STEM regimen is exceptionally highly active and well tolerated in patients with locally advanced or metastatic NETs. Even in patients who showed disease progression with previous therapies, it is still highly active. In this 20-patient study, the regimen appeared to be similarly active in pancreatic endocrine tumors and nonpancreatic NETs.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 21, 2017 Category: Endocrinology Source Type: research

Combination of cheminformatics and bioinformatics to explore the chemical basis of the rhizomes and aerial parts of Dioscorea nipponica Makino
ConclusionsThese findings indicated that combination of cheminformatics and bioinformatics may facilitate achieving the objectives of this study. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - September 21, 2017 Category: Drugs & Pharmacology Authors: Xu ‐zhao Li, Shuai‐nan Zhang, Xu‐yan Yang Tags: Research Paper Source Type: research

Low-Energy Intraoperative Radiation Therapy and Competing Risks of Local Control and Normal Tissue Toxicity
Geraldine M. Jacobson, Ramon Alfredo Siochi (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - September 21, 2017 Category: Cancer & Oncology Source Type: research

Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.7b00111 (Source: Chemical Research in Toxicology)
Source: Chemical Research in Toxicology - September 21, 2017 Category: Toxicology Authors: Gabriele Sabbioni Source Type: research

Ginsenoside Rb1 inhibits hypoxia-induced epithelial-mesenchymal transition in ovarian cancer cells by regulating microRNA-25.
In conclusion, ginsenoside Rb1 may reverse hypoxia-induced EMT by abrogating the suppression of miR-25 on EP300 and E-cadherin, which suggests that ginsenoside Rb1 may be a potential therapeutic candidate for the treatment of ovarian cancer. PMID: 28928801 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - September 21, 2017 Category: General Medicine Tags: Exp Ther Med Source Type: research

The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal
Xiangyu Wang, Yanli Du, Ying Hua, Muqing Fu, Cong Niu, Bao Zhang, Wei Zhao, Qiwei Zhang, Chengsong Wan (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - September 21, 2017 Category: Microbiology Source Type: research

Belatacept Compared With Tacrolimus for Kidney Transplantation: A Propensity Score Matched Cohort Study
Background: Although tacrolimus is the basis of most maintenance immunosuppression regimens for kidney transplantation, concerns about toxicity have made alternative agents, such as belatacept, attractive to clinicians. However, limited data exist to directly compare outcomes with belatacept-based regimens to tacrolimus. Methods: We performed a propensity score matched cohort study of adult kidney transplant recipients transplanted between May 1, 2001, and December 31, 2015, using national transplant registry data to compare patient and allograft survival in patients discharged from their index hospitalization on belatace...
Source: Transplantation - September 21, 2017 Category: Transplant Surgery Tags: Original Clinical Science-General Source Type: research

Comparison of carboplatin and paclitaxel with or without bevacizumab in chemotherapeutic regimens for unresectable stage III non-small cell lung cancer.
Authors: Ding T, Li ZT, Zhang X, Shi YT Abstract OBJECTIVE: Our study aimed to compare the chemoradiotherapeutic regimens of carboplatin and paclitaxel with or without bevacizumab for stage III non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: From July 2010 to December 2016, 102 patients with inoperable stage III NSCLC were finally included and divided randomly into two groups. Patients in the CP group received the treatment of carboplatin (area under the curve of 6) on day 1 and paclitaxel (80 mg/m2) on days 1, 8, and 15. Patients in the CPB group received the treatment of carboplatin (area under the ...
Source: European Review for Medical and Pharmacological Sciences - September 21, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Rectal/urinary toxicity after hypofractionated vs. conventional radiotherapy in high risk prostate cancer: systematic review and meta analysis.
CONCLUSIONS: Our analysis doesn't want to establish a definitive truth; very few trials assessed only high risk-class patients. Our purpose is to stimulate further randomized prospective trials focusing both on the effectiveness and toxicity profile (toxicity/effectiveness ratio), taking into account the use of different technologies and doses. PMID: 28925488 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - September 21, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Nanomedicine in the diagnosis and treatment of atherosclerosis - A systematic review.
Authors: Vaidyanathan K, Gopalakrishnan S Abstract BACKGROUND: Atherosclerosis is a chronic inflammatory condition causing very high morbidity and mortality. It is characterized by accumulation of plaques within arteries. Nanomedicine is an emerging field of medicine utilizing nanotechnology for advanced imaging and therapy. Nanomedicine has led to significant developments in the field of cardiovascular diseases, including atherosclerosis. Many nanoformulations have been developed with anti-atherosclerotic effects. Nanomedicine tools have been used in the imaging of atherosclerosis. Various nanocarriers have been e...
Source: Cardiovascular and Hematological Disorders Drug Targets - September 21, 2017 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Cytoprotective effects of xanthohumol against methylglyoxal ‐induced cytotoxicity in MC3T3‐E1 osteoblastic cells
Abstract Methylglyoxal (MG) has been suggested to be a major source of intracellular reactive carbonyl compounds, and has been implicated in increasing the levels of advanced glycation end products in age‐related diseases. Xanthohumol is a prenylated flavonoid found in hops (Humulus lupulus) and beer. In the present study, we investigated the effects of xanthohumol on MG‐induced cytotoxicity in osteoblastic MC3T3‐E1 cells. Xanthohumol attenuated MG‐induced cytotoxicity, as evidenced by improved cell viability, and prevented MG‐induced MG‐protein adducts, inflammatory cytokines, reactive oxygen species and mitoc...
Source: Journal of Applied Toxicology - September 21, 2017 Category: Toxicology Authors: Kwang Sik Suh, Suk Chon, Eun Mi Choi Tags: RESEARCH ARTICLE Source Type: research

Novel carbon dots derived from Schizonepetae Herba Carbonisata and investigation of their haemostatic efficacy.
In this study, we developed novel water-soluble carbon dots (CDs) in aqueous extracts of SHC for the first time and a modified pyrolysis method was used to prepare the SHC using Schizonepetae Herba (SH) as the sole precursor. The SHC-CDs were characterized using transmission electron microscopy (TEM), high-resolution TEM (HRTEM), Fourier transform infrared (FT-IR), ultraviolet-visible (UV-Vis) and fluorescence spectroscopy, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD) and high-performance liquid chromatography (HPLC). Furthermore, the CDs with a quantum yield (QY) around 2.26% exhibited no toxicity withi...
Source: Artificial Cells, Nanomedicine and Biotechnology - September 21, 2017 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Enhanced biological nitrate removal by alternating electric current bioelectrical reactor: Selectivity and mechanism
Publication date: November 2017 Source:Journal of Molecular Liquids, Volume 246 Author(s): Edris Hoseinzadeh, Abbas Rezaee, Mahdi Farzadkia This work was aimed at investigating the performance of the biofilm inducing by applying an alternating current (AC) as an innovative bioelectrical reactor (BER) for simultaneous removal of hard biodegradable organic carbon (i.e., ibuprofen) as a model of pharmaceuticals and nitrate in a single chamber reactor. The performance of this system improved with the increase in the applied AC voltage until peak-to-peak voltage (Vp-p) reaches 8Vp-p. The results showed that the highest removal...
Source: Journal of Molecular Liquids - September 21, 2017 Category: Molecular Biology Source Type: research

Safety evaluation for ingredients used in baby care products: Consideration of diaper rash
Publication date: November 2017 Source:Regulatory Toxicology and Pharmacology, Volume 90 Author(s): Susan P. Felter, Andrew N. Carr, Tingting Zhu, Taryn Kirsch, Gloria Niu Diaper rash can adversely impact the barrier properties of skin, with potential implications for increased absorption of chemicals through the skin, and this should be accounted for in any exposure assessment used in the safety evaluation of consumer products used in the diaper (“nappy”) area. In the absence of a quantitative evaluation of the potential impact of diaper rash, a default assumption of 100% dermal penetration is often made for ...
Source: Regulatory Toxicology and Pharmacology - September 21, 2017 Category: Toxicology Source Type: research

Metformin selectively targets redox control of complex I energy transduction
Publication date: April 2018 Source:Redox Biology, Volume 14 Author(s): Amy R. Cameron, Lisa Logie, Kashyap Patel, Stefan Erhardt, Sandra Bacon, Paul Middleton, Jean Harthill, Calum Forteath, Josh T. Coats, Calum Kerr, Heather Curry, Derek Stewart, Kei Sakamoto, Peter Repiščák, Martin J. Paterson, Ilmo Hassinen, Gordon McDougall, Graham Rena Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are likely to accou...
Source: Redox Biology - September 21, 2017 Category: Biology Source Type: research

Comments on: “In vitro and in vivo pharmacokinetics and toxicity evaluation of curcumin incorporated titanium dioxide nanoparticles for biomedical applications”
Publication date: 1 November 2017 Source:Chemico-Biological Interactions, Volume 277 Author(s): Nuggehally R. Srinivas (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - September 21, 2017 Category: Biochemistry Source Type: research

Preparation and characterization of a novel hybrid chelating material for effective adsorption of Cu(II) and Pb(II)
Publication date: Available online 19 September 2017 Source:Journal of Environmental Sciences Author(s): Ya Liu, Peng Qian, Yang Yu, Bo Yu, Yongliang Wang, Shufeng Ye, Yunfa Chen The discharge of heavy metal ions such as Cu2+ and Pb2+ poses a severe threat to public health and the environment owing to their extreme toxicity and bioaccumulation through food chains. Herein, we report a novel organic–inorganic hybrid adsorbent, Al(OH)3-poly(acrylamide-dimethyldiallylammonium chloride)-graft-dithiocarbamate (APD), for rapid and effective removal of Cu2+ and Pb2+. In this adsorbent, the “star-like” structure ...
Source: Journal of Environmental Sciences - September 21, 2017 Category: Environmental Health Source Type: research

Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle
Publication date: April 2018 Source:Redox Biology, Volume 14 Author(s): William Dott, Jayne Wright, Kelvin Cain, Pratibha Mistry, Karl E. Herbert There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel xenobiotics. To this end, an in vitro rat skeletal muscle model (L6) was used to study the translation of transcriptomics data generated from an in vivo rat model. Novel sulfonyl isoxazoline herbicides were associated with skeletal muscle toxicity in an in vivo rat model. Gene expression pathway analysis on skeletal muscle tissues ta...
Source: Redox Biology - September 21, 2017 Category: Biology Source Type: research

Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells
In this study, a systemic phytochemical investigation of the aerial parts of C. chartophyllum led to the isolation of thirty chemical constituents, which were further evaluated for their Nrf2 inducing potential using NAD(P)H: quinone reductase (QR) assay. Among these purified constituents, a sesquiterpenoid bearing α, β-unsaturated ketone group, 3S-(+)-9-oxonerolidol (NLD), and a diphenyl sharing phenolic groups, 3, 3′, 4, 4′-tetrahydroxydiphenyl (THD) significantly activated Nrf2 and its downstream genes, NAD(P)H quinone oxidoreductase 1 (NQO-1), and γ-glutamyl cysteine synthetase (γ-GCS...
Source: Redox Biology - September 21, 2017 Category: Biology Source Type: research

Effects of exposure to multiple heavy metals on biochemical and histopathological alterations in common carp, Cyprinus carpio L.
In conclusion, toxicity of multiple metal mixtures of Cr, Cd and Pb has antioxidant and immunotoxic effects on C. carpio. (Source: Fish and Shellfish Immunology)
Source: Fish and Shellfish Immunology - September 21, 2017 Category: Biology Source Type: research

The biodistribution and pharmacokinetics of the oxime acetylcholinesterase reactivator RS194B in guinea pigs
Publication date: Available online 21 September 2017 Source:Chemico-Biological Interactions Author(s): Michael A. Malfatti, Heather A. Enright, Nicholas A. Be, Edward A. Kuhn, Saphon Hok, M. Windy McNerney, Victoria Lao, Tuan H. Nguyen, Felice C. Lightstone, Timothy S. Carpenter, Brian J. Bennion, Carlos A. Valdez Organophosphorus-based (OP) nerve agents represent some of the most toxic substances known to mankind. The current standard of care for exposure has changed very little in the past decades, and relies on a combination of atropine to block receptor activity and oxime-type acetylcholinesterase (AChE) reactivators ...
Source: Chemico Biological Interactions - September 21, 2017 Category: Biochemistry Source Type: research

Voltammetric determination of thujone by a renewable silver amalgam film electrode in herbal matrices and thuja oil
Publication date: Available online 20 September 2017 Source:Journal of Electroanalytical Chemistry Author(s): Mateusz Kowalcze, Małgorzata Jakubowska Thujone is a ketone and a dicyclic monoterpene which naturally occurs in a variety of common plants, but in large quantities may be toxic for humans. In this work a simple and rapid DPV methodology of thujone determination on renewable silver amalgam film electrode is proposed. It was observed that the reduction of thujone in nitric acid is a quasi-reversible two-electron process, while the reaction was controlled by surface phenomena. Experimental conditions such as compos...
Source: Journal of Electroanalytical Chemistry - September 21, 2017 Category: Chemistry Source Type: research

Enantioselective electrochemical carbon-chloride bond cleavage of hexachlorocyclohexanes (HCHs) catalyzed by Mn(III)Cl-phthalocyanine
Publication date: 15 October 2017 Source:Journal of Electroanalytical Chemistry, Volume 803 Author(s): Junxia Wen, Baoqiu Yu, Tingting Huang, John Mack, Martijn Wildervanck, Tebello Nyokong, Minzhi Li, Weihua Zhu, Xu Liang A lipophilic and electron-rich metallophthalocyanine Mn(III)Cl(α,α′-n-OC5H11)8Pc has been synthesized and characterized. A series of electrochemical experiments demonstrate that the Mn(III)Cl(α,α′-n-OC5H11)8Pc complex can be used as a catalyst for highly efficient carbon-chloride bond cleavage of environmental toxic hexachlorocyclohexanes (HCHs) through electrochemica...
Source: Journal of Electroanalytical Chemistry - September 21, 2017 Category: Chemistry Source Type: research

Hydrogen purification over lanthanum-doped iron oxides by WGSR
Publication date: 1 November 2017 Source:Catalysis Today, Volume 296 Author(s): Maria do Carmo Rangel, Peterson Santos Querino, Sarah Maria Santana Borges, Sergio Gustavo Marchetti, José Mansur Assaf, Doris Polett Ruiz Vásquez, Cristiane Barbieri Rodella, Tatiana de Freitas Silva, Alisson Henrique Marques da Silva, Adriana Paula Ramon Hydrogen technology has been greatly increased in last decades as a promising solution to protect the environment. When carbon-based feedstocks are used, such as natural gas, biomass and biogas, the water gas shift reaction (WGSR) plays an important step in the production of hi...
Source: Catalysis Today - September 21, 2017 Category: Chemistry Source Type: research

2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid ‐Induced Osteoporosis
This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - September 21, 2017 Category: Rheumatology Authors: Lenore Buckley, Gordon Guyatt, Howard Fink, Timothy McAlindon Tags: Reply to Letter to the editor Source Type: research

Safety, Tolerability, and Pharmacodynamics of ABT ‐122, a TNF‐ and IL‐17–Targeted Dual Variable Domain Immunoglobulin, in Patients With RA
ConclusionThese phase 1 results suggest that dual neutralization with ABT‐122 has a profile acceptable for further exploration of therapeutic potential in TNF‐ and IL‐17A–driven immune‐mediated inflammatory diseases.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - September 21, 2017 Category: Rheumatology Authors: Roy M. Fleischmann, Frank Wagner, Alan J. Kivitz, Heikki T. Mansikka, Nasser Khan, Ahmed A. Othman, Amit Khatri, Feng Hong, Ping Jiang, Melanie Ruzek, Robert J. Padley Tags: Full Length Source Type: research

Mn3+-saturated bovine lactoferrin asa new complex with potential prebiotic activities for dysbiosis treatment and prevention – On the synthesis, chemical characterization and origin of biological activity
Publication date: November 2017 Source:Journal of Functional Foods, Volume 38, Part A Author(s): Klaudyna Śpiewak, Grzegorz Majka, Magdalena Pilarczyk- Żurek, Paweł M. Nowak, Michał Woźniakiewicz, Piotr Pietrzyk, Tomasz Korzeniak, Anna Stochel-Gaudyn, Krzysztof Fyderek, Magdalena Strus, Małgorzata Brindell A new bioactive compound, Mn3+-saturated bovine lactoferrin (Mn2-bLf) was obtained. It was stable under physiological conditions (pH≈7.5) although gradually releases Mn2+ ions under the simulated intestinal conditions (pH ≈ 6.5). This feature might be utilized for controlled delivery of Mn2+ ions to bi...
Source: Journal of Functional Foods - September 21, 2017 Category: Nutrition Source Type: research

Multicenter phase II study of trastuzumab plus S-1 alone in elderly patients with HER2-positive advanced gastric cancer (JACCRO GC-06)
ConclusionsTrastuzumab in combination with S-1 alone demonstrated promising antitumor activity and manageable toxic effects as well as promising survival results in elderly patients with HER2-positive AGC.Clinical trials registrationUMIN000007368. (Source: Gastric Cancer)
Source: Gastric Cancer - September 21, 2017 Category: Gastroenterology Source Type: research

Dermal –epidermal separation methods: research implications
AbstractDermal –epidermal separation is an important basic investigation technique for pharmacology, toxicology and biology. To choose the optimal method for a given research need, we reviewed studies on epidermal separation. PubMed, Embase, and Web of Science were utilized. Different separation systems have bee n compared, including chemical, enzyme, heat and mechanical separation; each has advantages and disadvantages. Heat is simple but causes thermal damage. Chemical reagents are effective but disturb cellular electrolyte equilibrium. Enzymes provide complete separation, but destroy important components . Mechani...
Source: Archives of Dermatological Research - September 21, 2017 Category: Dermatology Source Type: research

Methionine and vitamin B ‐complex ameliorate antitubercular drugs‐induced toxicity in exposed patients
Abstract Tuberculosis therapy utilizes drugs that while effective cause treatment‐related toxicity. Modulation of antitubercular drugs‐induced toxicity by methionine and vitamin B‐complex in patients was evaluated. 285 treatment‐naïve tuberculosis patients at the Chest Clinics of Infectious Diseases Hospital, Yaba and General Hospital, Lagos in Lagos, Nigeria was prospectively recruited and allotted into test (antitubercular medicines, methionine and vitamin B‐complex) and control groups (antitubercular medicines). Data on adverse drug reactions and blood samples were collected at initiation, 2 months a...
Source: Pharmacology Research and Perspectives - September 21, 2017 Category: Drugs & Pharmacology Authors: Kennedy I. Amagon, Olufunsho Awodele, Abidemi J. Akindele Tags: Original Article Source Type: research

Toxicological evaluation of an aqueous suspension from leaves and stems of Petiveria alliacea L (Phytolaccaceae)
Conclusions P. alliacea powder from stems and leaves was classed in the hazard category 5 (LD50>2000 mg/kg) according to the acute toxicology study. There were no toxicity signs at 1000mg/kg in the repeated dose study, although higher values of total leukocytes were found in the satellite and males of the experimental group, which were attributed to the immunomodulatory properties of this plant. According to GC-MS, the prevailing compounds identified were phytol, (R)-(-)-(Z)−14-methyl-8-hexadecen-1-ol, 1-(2-hydrohyethyl)−1,2,4-triazole and methyl β-dimethylaminoisobutyrate. In conclusion, the oral a...
Source: Journal of Ethnopharmacology - September 21, 2017 Category: Drugs & Pharmacology Source Type: research

Oxygen transport in hollow fibre membrane bioreactors for hepatic 3D cell culture: A parametric study
Publication date: 15 December 2017 Source:Journal of Membrane Science, Volume 544 Author(s): Shervin Khakpour, Alberto Di Renzo, Efrem Curcio, Francesco Paolo Di Maio, Lidietta Giorno, Loredana De Bartolo Hepatic cell cultures are exploited for different applications in liver disease studies, drug toxicity testing and bioartificial liver (BAL) devices. Despite the development of various 3D cell culture systems, mass transfer properties and limitations, especially oxygen supply, still remain a controversial topic. In this paper, oxygen transport in a convection-enhanced, crossed-configuration hollow fibre membrane bioreact...
Source: Journal of Membrane Science - September 21, 2017 Category: Materials Science Source Type: research

Zr-Al-Co-Cu bulk metallic glasses for biomedical devices applications
Publication date: 30 December 2017 Source:Journal of Alloys and Compounds, Volume 729 Author(s): Kaiming Han, Jianbing Qiang, Yingmin Wang, Peter Häussler Toxic element-free Zr-based bulk metallic glasses (BMGs) with a property combination of high glass-forming ability, ultrahigh strength and large room-temperature plasticity are useful as surgical devices materials. In the present work, the critical glass formation size (d max), thermal glass stability and room-temperature mechanical properties of a series of Zr56.25Al18.75(Co1-xCux)25 (x = 0, 0.125, 0.25, 0.375, 0.5, at.%) alloys have been investigated. T...
Source: Journal of Alloys and Compounds - September 21, 2017 Category: Chemistry Source Type: research

Mechanism insights into the oxidative degradation of decabromodiphenyl ethane by potassium permanganate in acidic conditions
Publication date: 15 January 2018 Source:Chemical Engineering Journal, Volume 332 Author(s): Jing Chen, Xinxin Xu, Xiaoxue Pan, Jiayi Yao, Chenguang Li, Ruijuan Qu, Zunyao Wang The KMnO4 degradation of decabromodiphenyl ethane (DBDPE), an additive in brominated flame retardants (BFRs), was investigated in a sulfuric acid system. The degradation tests showed that DBDPE reacted completely with KMnO4 in sulfuric acid, and a removal rate of 99.71% seems realistic. Many products were detected by liquid chromatography-quadrupole-time-of-flight-mass spectrometry (LC-Q-TOF-MS) analysis and gas chromatography-electron ionization-m...
Source: Chemical Engineering Journal - September 21, 2017 Category: Chemistry Source Type: research

Impact of waterborne and trophic mercury exposures on cardiac function of two ecologically distinct Neotropical freshwater fish Brycon amazonicus and Hoplias malabaricus
Publication date: Available online 20 September 2017 Source:Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology Author(s): Diana A. Monteiro, Edwin W. Taylor, Francisco T. Rantin, Ana L. Kalinin Metal pollutants have been considered one of the main factors underlying the depletion of biodiversity in natural populations unbalancing aquatic environments. The aim of this study was to evaluate the effects of exposure to inorganic Hg on myocardial contractility and the electrocardiogram (ECG) of two ecologically distinct Neotropical fish species, namely: matrinxã (Brycon amazonicus) and tra...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - September 21, 2017 Category: Toxicology Source Type: research

Impact of teflubenzuron on the rockpool shrimp (Palaemon elegans)
In conclusion, this study shows that teflubenzuron can bioaccumulate in shrimps living in the littoral zone and at sublethal concentrations affects molecular mechanisms in non-hepatopancreatic tissue. (Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology)
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - September 21, 2017 Category: Toxicology Source Type: research

Toxicological effects of paracetamol on the clam Ruditapes philippinarum: exposure vs recovery
Publication date: Available online 20 September 2017 Source:Aquatic Toxicology Author(s): Bruno Nunes, Joana Nunes, Amadeu M.V.M. Soares, Etelvina Figueira, Rosa Freitas Exposure of wild organisms to anthropogenic substances never follows a definite time-course and pulsed events can often determine biological responses to such chemicals, confounding the interpretation of toxicological data. This is the case of specific chemicals such as pharmaceutical drugs, which are commonly released by sewage systems into sensitive areas, including estuaries. The presence and amount of these chemicals in the wild can be modulated by ev...
Source: Aquatic Toxicology - September 21, 2017 Category: Toxicology Source Type: research

Sulforaphane mitigates cadmium-induced toxicity pattern in human peripheral blood lymphocytes and monocytes
In this study, we investigated the protective role of sulforaphane on Cd-induced toxicity in human peripheral blood lymphocytes and monocytes. Sulforaphane did not show any major reduction in the viability of lymphocytes and monocytes. However, Cd treatment at a concentration of 50μM induced around 69% cell death. Treatment of IC10-Cd and 100μM sulforaphane combination for 24 and 48h increased viability by 2 and 9% in cells subjected to Cd toxicity, respectively. In addition, IC25 of Cd and 100μM sulforaphane combination recovered 17–20% of cell viability. Cd induced apoptotic and necrotic cell death. Sulfor...
Source: Environmental Toxicology and Pharmacology - September 21, 2017 Category: Environmental Health Source Type: research

Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids
Publication date: Available online 20 September 2017 Source:Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology Author(s): Pablo Ricardo Bertelli, Renata Biegelmeyer, Eduardo Pacheco Rico, Luiz Carlos Klein-Junior, Natally S.B. Toson, Luciane Minetto, Sergio A.L. Bordignon, André L. Gasper, Sidnei Moura, Diogo L. de Oliveira, Amélia T. Henriques Palicourea genus is chemically and taxonomically close to Psychotria genus, a well-known source of neuroactive alkaloids. It has been previously reported the pharmacological potential of these alkaloids in some targets related to the neu...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - September 21, 2017 Category: Toxicology Source Type: research

Biodiversity change behind wide applications of nanomaterials?
Publication date: Available online 20 September 2017 Source:Nano Today Author(s): Ming Chen, Xiaosheng Qin, Guangming Zeng Nanomaterials, like carbon nanotubes, graphene, metal and metal oxide nanoparticles, are increasingly applied in a wide range of areas with numerous benefits to economy and society. Large-scale production and applications of nanomaterials can increase the possibility of exposure to living organisms, pose risks to human health and ecosystems, and potentially lead to biodiversity losses. Previous environmental impact and safety studies that targeted nanomaterials typically focused on their toxicity, fat...
Source: Nano Today - September 21, 2017 Category: Nanotechnology Source Type: research

Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study
Conclusions: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330 Received: 07 November 2016 Revised: 13 July 2017 Accepted: 21 July 2017 Published: 20 September 2017 Address correspondence to C. B. Manzano-Salgado, ISGlobal–Centre for Research in Environmental Epidemiology (CREAL), Doctor Aiguader, 8808003 Barcelona, Catalonia, Spain. Phone: +34 932 147 314. Email: cyntia.manzano@isglobal.org Supplemental Material is available online (https...
Source: EHP Research - September 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Metabolism of N-Methyl-2-Pyrrolidone in Honey Bee Adults and Larvae: Exploring Age Related Differences in Toxic Effects
Environmental Science& TechnologyDOI: 10.1021/acs.est.7b03291 (Source: Environmental Science and Technology)
Source: Environmental Science and Technology - September 20, 2017 Category: Environmental Health Authors: managing.editor at est.acs.org (American Chemical Society) Source Type: research