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Generation of Advanced Glycation End-Products (AGEs) by glycoxidation mediated by copper and ROS in a human serum albumin (HSA) model peptide: reaction mechanism and damage in motor neuron cells.
Abstract Glucose, in the presence of reactive oxygen species (ROS), acts as an as an oxidative agent and drives deleterious processes in Diabetes Mellitus. We have studied the mechanism and the toxicological effects of glucose-dependent glycoxidation reactions driven by copper and ROS, using a model peptide based on the exposed sequence of Human Serum Albumin (HSA) and containing a lysine residue susceptible to copper complexation. The main products of these reactions are Advanced Glycation End-products (AGEs). Carboxymethyl lysine and pyrraline condensed on the model peptide, generating a Modified Peptide (MP). T...
Source: Cell Research - November 19, 2017 Category: Cytology Authors: Marques CMS, Nunes EA, Lago L, Pedron CN, Manieri TM, Sato RH, Oliveira VX, Cerchiaro G Tags: Mutat Res Source Type: research

DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells.
In this study, we demonstrate that Ag-np treatment trigger the activation of DNA-PKcs and JNK pathway at selected doses, presumably as a physiologic response to DNA damage and repair in normal and malignant cells. Ag-np altered the telomere dynamics by disrupting the shelterin complex located at the telomeres and telomere lengths. The genotoxic effect of Ag-np was not restricted to telomeres but the entire genome as Ag-np induced γ-H2AX foci formation, an indicator of global DNA damage. Inhibition of DNA-PKcs activity sensitised the cancer cells towards the cytotoxicity of Ag-np and substantiated the damaging effect ...
Source: Cell Research - November 19, 2017 Category: Cytology Authors: Lim HK, Gurung RL, Hande MP Tags: Mutat Res Source Type: research

Host target-based approaches against arboviral diseases.
Authors: Rocha RF, Del Sarto JL, Marques RE, Vasconcelos Costa V, Teixeira MM Abstract In the 20th century, socioeconomic and environmental changes facilitated the reintroduction of mosquitoes in developing cities, resulting in the reintroduction of mosquito-borne viral diseases and the dispersal of their causative agents in a worldwide scale. Recurrent outbreaks of arboviral diseases are being reported, even in regions without a previous history of arboviral disease transmission. Of note, arboviral infections represented approximately 30% of all emerging vector-borne diseases of the last decade. Therapeutic strate...
Source: Biological Chemistry - November 19, 2017 Category: Chemistry Tags: Biol Chem Source Type: research

Preparation and evaluation of Curcumin-loaded self-assembled micelles.
Conclusions The prepared SSCMs were characterized by PS, PDI, LE%, EE% data analysis. After the soluplus and solutol ® HS15 were self assembled into micelles, both the solubility and membrane permeability of curcumin were evaluated to have been enhanced, as well as the effect of efflux pump of curcumin was inhibited, hence to promote oral absorption and generate an increased bioavailability. PMID: 29148846 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - November 19, 2017 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

IJERPH, Vol. 14, Pages 1414: Acute Toxicity and Ecological Risk Assessment of Benzophenone-3 (BP-3) and Benzophenone-4 (BP-4) in Ultraviolet (UV)-Filters
Li-Wei Sun Ultraviolet (UV)-absorbing chemicals (UV filters) are used in personal care products for the protection of human skin and hair from damage by UV radiation. Although these substances are released into the environment in the production and consumption processes, little is known about their ecotoxicology effects. The acute toxicity and potential ecological risk of UV filters benzophenone-3 (BP-3) and benzophenone-4 (BP-4) on Chlorella vulgaris, Daphnia magna, and Brachydanio rerio were analyzed in the present study. The EC50 values (96 h) of BP-3 and BP-4 on C. vulgaris were 2.98 and 201.00 mg/L, respectivel...
Source: International Journal of Environmental Research and Public Health - November 19, 2017 Category: Environmental Health Authors: Yang Du Wen-Qian Wang Zhou-Tao Pei Fahmi Ahmad Rou-Rou Xu Yi-Min Zhang Li-Wei Sun Tags: Article Source Type: research

A Phase II Trial of Rituximab in Combination with Pegfilgrastim in Patients with Indolent B-Cell Non-Hodgkin ’s Lymphoma
Conclusion Pegfilgrastim-rituximab combination was well tolerated with favorable outcomes when compared to historical controls. A shorter time to peak oxidative burst was associated with higher CR rates and longer PFS. Our results support further evaluation of strategies that enhance the innate immune system to improve rituximab activity in B-NHL. Teaser This phase 2 study demonstrates that augmenting neutrophil function by addition of pegfilgrastim can potentiate the clinical activity of rituximab in indolent B-cell non-Hodgkin’s lymphomas (B-NHL) while retaining its excellent safety profile. Strategies to boost the...
Source: Clinical Lymphoma Myeloma and Leukemia - November 19, 2017 Category: Cancer & Oncology Source Type: research

PARKIN overexpression in human mesenchymal stromal cells from Wharton's jelly suppresses 6-hydroxydopamine –induced apoptosis: Potential therapeutic strategy in Parkinson's disease
Discussion 6-OHDA induced apoptosis in MSCs via generation of H2O2, activation of c-JUN and PUMA, mitochondrial depolarization and nuclei fragmentation. Our findings suggest that PARKIN protects MSCs against 6-OHDA toxicity by partly interacting with H2O2, reducing the expression of c-JUN, PUMA, AIF and caspase-3, and maintaining the mitochondrial ΔΨm. (Source: Cytotherapy)
Source: Cytotherapy - November 19, 2017 Category: Cytology Source Type: research

Sorption of Pb(II), Cu(II), Fe(II) and Cr(VI) metal ions onto cross-linked graft copolymers of chitosan with binary vinyl monomer mixtures
Publication date: December 2017 Source:Reactive and Functional Polymers, Volume 121 Author(s): Rajeev Kr. Sharma, Lalita, Anirudh P. Singh Novel adsorbents for sorption of Pb(II), Cu(II), Fe(II) and Cr(VI) metal ions from waste water were synthesized by simultaneous cross-linking and graft copolymerization of chitosan (Ch) with N-isopropyl acrylamide (NIPAM) and its binary comonomers acrylic acid, acrylamide and acrylonitrile in presence of azo-bis(isobutyronitrile) (AIBN) as free radical initiator and N,N′-methylene bisacrylamide (MBA) cross-linker. FTIR, XRD, SEM and TGA/DTA techniques were used to describe the st...
Source: Reactive and Functional Polymers - November 19, 2017 Category: Chemistry Source Type: research

Ferrofluid mediated chitosan@mesoporous carbon nanohybrid for green adsorption/preconcentration of toxic Cd(II): Modeling, kinetic and isotherm study
Publication date: Available online 10 November 2017 Source:Reactive and Functional Polymers Author(s): Hassan Yadaei, Mostafa Hossein Beyki, Farzaneh Shemirani, Siavash Nouroozi In this research an efficient ionic liquid based ferrofluid system was developed for efficient adsorption/preconcentration of cadmium using magnetic mesoporous carbon – chitosan nanohybrid. Mesoporous CMK - 3 was synthesized using MCM – 48 as ordered template. Then magnetic CMK was combined with chitosan through reaction with epichlorohydrin. The nanohybrid was characterized with FESEM, TEM, XRD, SEM mapping, FTIR, BET and VSM techniqu...
Source: Reactive and Functional Polymers - November 19, 2017 Category: Chemistry Source Type: research

Septic systems contribute to nutrient pollution and harmful algal blooms in the St. Lucie Estuary, Southeast Florida, USA
Publication date: December 2017 Source:Harmful Algae, Volume 70 Author(s): Brian E. Lapointe, Laura W. Herren, Armelle L. Paule Nutrient enrichment is a significant global-scale driver of change in coastal waters, contributing to an array of problems in coastal ecosystems. The St. Lucie Estuary (SLE) in southeast Florida has received national attention as a result of its poor water quality (elevated nutrient concentrations and fecal bacteria counts), recurring toxic Microcystis aeruginosa blooms, and its proximity to the northern boundary of tropical coral species in the United States. The SLE has an artificially large wa...
Source: Harmful Algae - November 19, 2017 Category: Environmental Health Source Type: research

The influence of salinity in the domoic acid effect on estuarine phytoplankton communities
In this study, the environmental factors driving the growth of Pseudo-nitzschia and the production of dissolved DA (dDA) in North Inlet estuary were examined. The effect of salinity on the growth inhibition of phytoplankton induced by the initial presence as well as by an addition of dDA was also assessed. Initially, the diatom abundance was negatively correlated with the abundance of Pseudo-nitzschia and with the concentration of dDA. With the addition of a concentrated solution of dDA, the percent inhibition of cryptophytes and diatoms was significantly correlated with salinity and suggested a higher sensitivity to dDA a...
Source: Harmful Algae - November 19, 2017 Category: Environmental Health Source Type: research

Morphology and phylogeny of Prorocentrum caipirignum sp. nov. (Dinophyceae), a new tropical toxic benthic dinoflagellate
Publication date: December 2017 Source:Harmful Algae, Volume 70 Author(s): Silvia M. Nascimento, M. Cristina Q. Mendes, Mariângela Menezes, Francisco Rodríguez, Catharina Alves-de-Souza, Suema Branco, Pilar Riobó, José Franco, José Marcos C. Nunes, Mariusz Huk, Steven Morris, Santiago Fraga A new species of toxic benthic dinoflagellate is described based on laboratory cultures isolated from two locations from Brazil, Rio de Janeiro and Bahia. The morphology was studied with SEM and LM. Cells are elliptical in right thecal view and flat. They are 37–44μm long and 29–36μm ...
Source: Harmful Algae - November 19, 2017 Category: Environmental Health Source Type: research

Life-history stages of natural bloom populations and the bloom dynamics of a tropical Asian ribotype of Alexandrium minutum
This study provides the first continuous record of in situ life-cycle stages of a natural bloom population of A. minutum through a complete bloom cycle. The event has provided a fundamental understanding of the pelagic life-cycle stages of this tropical dinoflagellate, and demonstrated a unique bloom development characteristic shared among toxic Alexandrium species in coastal embayments. (Source: Harmful Algae)
Source: Harmful Algae - November 19, 2017 Category: Environmental Health Source Type: research

A multilevel trait-based approach to the ecological performance of Microcystis aeruginosa complex from headwaters to the ocean
Publication date: December 2017 Source:Harmful Algae, Volume 70 Author(s): Carla Kruk, Angel M. Segura, Lucía Nogueira, Ignacio Alcántara, Danilo Calliari, Gabriela Martínez de la Escalera, Carmela Carballo, Carolina Cabrera, Florencia Sarthou, Paola Scavone, Claudia Piccini The Microcystis aeruginosa complex (MAC) clusters cosmopolitan and conspicuous harmful bloom-forming cyanobacteria able to produce cyanotoxins. It is hypothesized that low temperatures and brackish salinities are the main barriers to MAC proliferation. Here, patterns at multiple levels of organization irrespective of taxonomic ide...
Source: Harmful Algae - November 19, 2017 Category: Environmental Health Source Type: research

Use of erlotinib and thalidomide in advanced NSCLC patients with acquired resistance to erlotinib: A pilot study
In this study, we firstly confirmed that thalidomide can reversion of erlotinib-acquired resistance with a 7 weeks median progression-free survival (PFS); besides, this combination therapy shows acceptable drug tolerance; the most common drug related adverse events were astriction, numbness and sleeve-like feeling in the limbs, no thrombosis occurred in any patient. Those evidences indicate that thalidomide may be a useful candidate for reversion of erlotinib-acquired resistance. (Source: Pathology Research and Practice)
Source: Pathology Research and Practice - November 19, 2017 Category: Pathology Source Type: research

Water-related-ocular-diseases: A review
Publication date: Available online 4 November 2017 Source:Saudi Journal of Ophthalmology Author(s): Syed Shoeb Ahmad A number of ocular diseases can be attributed to contaminated water and we have coined a term “Water-related ocular diseases (WRODs)” to denote this wide-spectrum of conditions. WRODs are directly related to human contact with water and can occur through toxic, allergic, inflammatory or infective mechanisms. The non-infective causes can include chemicals used to clean swimming pools, oil spills and water-sport related injuries. Similarly, a number of infective organisms causing ocular diseases a...
Source: Saudi Journal of Ophthalmology - November 19, 2017 Category: Opthalmology Source Type: research

The natural compound magnolol affects growth, biofilm formation, and ultrastructure of oral Candida isolates
In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp. (four standard and 60 oral isolates) through minimum inhibitory concentration (MIC) and growth curve assays. Insight into the mechanisms of the antifungal action has been gained through ultrastructural studies using confocal scanning laser microscopy (CSLM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Molecular docking was done for predicting the interactions of magnolol with ergosterol at supramolecular level. The toxicity of magnolol on human erythrocytes was measured by in vitro hemolyt...
Source: Microbial Pathogenesis - November 19, 2017 Category: Infectious Diseases Source Type: research

Bio-prospecting of coral (Porites lutea) mucus associated bacteria, Palk Bay reefs, Southeast coast of India
Publication date: December 2017 Source:Microbial Pathogenesis, Volume 113 Author(s): N.K. Ahila, S. Prakash, B. Manikandan, J. Ravindran, N.M. Prabhu, E. Kannapiran Coral mucus is one of the key localization in the coral holobiont, as this serves as an energy rich substrate for a wide range of abundant, diverse and multifunctional microbiota. However, very little is known about the functional role of bacterial communities in their associations with corals. In the present study, a total of 48 isolates were obtained from Porites lutea wherein the genus of Bacillus sp. and Vibrio sp. were predominant. Bio-prospecting the cor...
Source: Microbial Pathogenesis - November 19, 2017 Category: Infectious Diseases Source Type: research

Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: An effective way to alter the barrier integrity
Publication date: December 2017 Source:Microbial Pathogenesis, Volume 113 Author(s): J. Daniel Dubreuil Enterotoxigenic Escherichia coli are responsible for causing secretory diarrhea in animal(s), including human(s). This group of microorganisms is classified on the basis of production of toxins acting on the intestinal epithelium of the small intestine. Various enterotoxins, heat-labile and heat-resistant, are produced by distinct strains of ETEC. Although the mechanisms of action of ETEC enterotoxins were shown to involve diverse ion channels recent data suggest that these molecules could also be involved in disruption...
Source: Microbial Pathogenesis - November 19, 2017 Category: Infectious Diseases Source Type: research

Whole-brain radiotherapy or autologous stem-cell transplantation as consolidation strategies after high-dose methotrexate-based chemoimmunotherapy in patients with primary CNS lymphoma: results of the second randomisation of the International Extranodal Lymphoma Study Group-32 phase 2 trial
This study is registered with ClinicalTrials.gov, number NCT01011920. Findings Between Feb 19, 2010, and Aug 27, 2014, 227 patients were recruited from 53 centres in five countries. 219 of 227 enrolled patients were assessable. Of the 122 patients eligible for the second randomisation, 118 patients were randomly assigned to WBRT or ASCT (59 patients per group) and constitute the study population. WBRT and ASCT were both effective, and achieved the predetermined efficacy threshold of at least 40 progression-free survivors at 2 years among the first 52 patients in both groups D and E. There were no significant differences in...
Source: The Lancet Haematology - November 19, 2017 Category: Hematology Source Type: research

Lipid Emulsion, More Than Reversing Bupivacaine Cardiotoxicity: Potential Organ Protection.
This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page. PMID: 29145932 [PubMed - in process] (Source: Journal of Pharmacy and Pharmaceutical Sciences)
Source: Journal of Pharmacy and Pharmaceutical Sciences - November 18, 2017 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research

Personalised medicine for nonsmall cell lung cancer.
Abstract After years of standard care prescribed to cancer patients without any selection except the primary site and histology of the tumour, the era of precision medicine has revolutionised cancer care. Personalised medicine refers to the selection of patients for specific treatment based on the presence of specific biomarkers which indicate sensitivity to corresponding targeted therapies and/or lower toxicity risk, such that patients will have the greatest chance of deriving benefit from the treatments. Here, we review personalised medicine for nonsmall cell lung cancer. PMID: 29141962 [PubMed - in process...
Source: Respiratory Care - November 18, 2017 Category: Respiratory Medicine Authors: Mascaux C, Tomasini P, Greillier L, Barlesi F Tags: Eur Respir Rev Source Type: research

Financial Toxicity: Management as an Adverse Effect of Cancer Treatment 
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Financial Toxicity: Management as an Adverse Effect of Cancer Treatment
. Clin J Oncol Nurs. 2017 Dec 01;21(6):762-764 Authors: Fessele KL Abstract Along with many physical and emotional adverse effects associated with cancer therapy, attention has been directed to defining and identifying interventions to manage financial strain that can occur because of high medical payments and reduced income from employment interruption. Nurses can support patients and families by encouraging open communication during shared treatment decision making and throughout the cancer experience.
. PMID: 29149134 ...
Source: Clinical Journal of Oncology Nursing - November 18, 2017 Category: Nursing Authors: Fessele KL Tags: Clin J Oncol Nurs Source Type: research

MAPK Pathway-Targeted Therapies: Care and Management of Unique Toxicities in Patients With Advanced Melanoma 
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This article aims to provide nurses with an overview of the key toxicities and associated management strategies of the characteristic adverse event (AE) profile associated with agents targeting the MAPK pathway.
. METHODS: Data from clinical trials evaluating vemurafenib, dabrafenib, trametinib, and cobimetinib were reviewed and summarized along with research on management of AEs identified in clinical trials.
. FINDINGS: The key AEs associated with these agents included pyrexia and cutaneous toxicities. Other notable AEs included arthralgias, ocular toxicities, and cardiac events. Because these agents are ad...
Source: Clinical Journal of Oncology Nursing - November 18, 2017 Category: Nursing Authors: Rubin KM Tags: Clin J Oncol Nurs Source Type: research

Toxicological characterization of ZnO nanoparticles in malignant and non ‐malignant cells
This study was designed to systematically investigate cytotoxicity, apoptosis, cell cycle alterations, and genotoxicity induced by ZnO‐NP. Moreover, it was an aim of the investigations to specify the diverse effects of nanoparticle exposure in malignant in comparison with non‐malignant cells. Therefore, human head and neck squamous cell carcinoma‐derived FaDu cells were incubated with 4–20 µg/ml of ZnO‐NPs for 1–48 hr and tested for cell viability, cell cycle alterations, apoptosis and caspase‐3 gene expression as a sensitive marker of molecular apoptotic processes with regard to time...
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Authors: Helena Moratin, Agmal Scherzad, Thomas Gehrke, Pascal Ickrath, Katrin Radeloff, Norbert Kleinsasser, Stephan Hackenberg Tags: Research Article Source Type: research

Use of a trigger tool to detect adverse drug reactions in an emergency department.
CONCLUSIONS: The use of the trigger tool to identify adverse reactions in the emergency department was possible to identify a prevalence of 2.3%. It showed to be a viable method that can provide a better understanding of adverse drug reactions in this patient population. PMID: 29141696 [PubMed - in process] (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - November 18, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Methylxanthines induce structural and functional alterations of the cardiac system in zebrafish embryos.
Authors: Basnet RM, Zizioli D, Guarienti M, Finazzi D, Memo M Abstract BACKGROUND: Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline, doxofylline, etophylline, 3-isobutyl-1-methylxanthine (IBMX), pentoxifylline and theophylline. METHODS: Microinjections of the eight methylxanthines were performed in 1-2 cell stage zebrafish embryos and the general toxicity and cardiovascular effects were analyzed at different time points. Embry...
Source: BMC Pharmacology and Toxicology - November 18, 2017 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research

Targeted Nanoparticles in Pregnancy: A New Frontier in Perinatal Therapeutics
(Am J Obstet Gynecol. 2017;216(3):204–205) This editorial advocates for the continued collective effort in perinatal medicine to employ principles of nanomedicine to improve maternal and fetal care. Nanomedicine may be able to increase the safety and efficacy of a drug by manipulating physical and chemical properties of the particles (such as size and surface chemistry) to vector it preferentially to the affected tissue, minimizing fetal exposure and combating risks associated with systemic drug toxicities to the mother and the developing fetus. Such targeted delivery of drugs to the maternal organs could revolution...
Source: Obstetric Anesthesia Digest - November 18, 2017 Category: Anesthesiology Tags: Epidemiologic Reports Surveys Source Type: research

The Effect of Immunosuppression on Airway Integrity
Conclusions Our findings suggest that MMF is present in the airways of lung transplant patients and might affect the structural integrity of the airway, which needs further investigation and validation in the clinical setting. (Source: Transplantation)
Source: Transplantation - November 18, 2017 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Spatially resolved quantification of gadolinium deposited in the brain of a patient treated with gadolinium-based contrast agents
Publication date: January 2018 Source:Journal of Trace Elements in Medicine and Biology, Volume 45 Author(s): Stefanie Fingerhut, Ann-Christin Niehoff, Michael Sperling, Astrid Jeibmann, Werner Paulus, Thomas Niederstadt, Thomas Allkemper, Walter Heindel, Markus Holling, Uwe Karst Due to its paramagnetic properties resulting from seven unpaired f-electrons, Gd is frequently applied in magnetic resonance imaging examinations. Due to the acute toxicity of free Gd3+, ligand ions based on polyaminocarboxylic acids are used to create thermodynamically stable linear or macrocyclic complexes. The highly water soluble Gd-based co...
Source: Journal of Trace Elements in Medicine and Biology - November 18, 2017 Category: Biochemistry Source Type: research

The importance of boron in biological systems
Publication date: January 2018 Source:Journal of Trace Elements in Medicine and Biology, Volume 45 Author(s): Irem Uluisik, Huseyin Caglar Karakaya, Ahmet Koc Boron is an essential element for plants and probably essential for human and animal health. Boron has a broad range of physiological effects on biological systems at low concentrations, whereas it is toxic to at high concentrations. Eventhough there are many studies on boron’s biological effects and toxicity, more information is needed to understand the mechanisms of its action. The aim of the current work is to review boron’s function, transport and to...
Source: Journal of Trace Elements in Medicine and Biology - November 18, 2017 Category: Biochemistry Source Type: research

Effect of long-term aerobic, anaerobic and aerobic-anaerobic physical training in seric toxic minerals concentrations
Conclusions In some cases physical exercise induces favorable adaptations to avoid environmental pollution damage. Endurance training (65–75% VO2max) can be considered the most effective exercise to prevent toxicity effects. However, integral-matrixes analysis are required in further research to overcome some controversial behaviors of some elements. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 18, 2017 Category: Biochemistry Source Type: research

Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population
In conclusion, the results confirmed maternal smoking-related increases in Cd and Pb levels in the maternal-placental-foetal unit. They also provided additional data on concomitant metal concentrations in representative samples of maternal blood, placenta, and cord blood, as well as increased cord blood Fe and Cu, placental Zn, and maternal serum MT2 in smokers. New evidence is that MT2A –5A/G SNP was associated with decreased placental Fe levels in non-smokers. For a final conclusion on the influence of the MT2A –5A/G polymorphism on toxic and essential element levels in mother-newborn pairs, further research ...
Source: Journal of Trace Elements in Medicine and Biology - November 18, 2017 Category: Biochemistry Source Type: research

Status and interrelationship of toenail elements in Pacific children
Conclusions This research contributes to the understanding of the elemental concentrations for Pacific children by using tissue samples from toenails, which improves the completeness of sampling than other tissues and provides a longer exposure time frame. The study also reports several inter-correlations between essential, non-essential and toxic elements in Pacific Island population. (Source: Journal of Trace Elements in Medicine and Biology)
Source: Journal of Trace Elements in Medicine and Biology - November 18, 2017 Category: Biochemistry Source Type: research

The impact of pathological complete response after neoadjuvant chemoradiotherapy in locally advanced squamous cell carcinoma of esophagus
Conclusion Pathological complete response after neoadjuvant chemoradiotherapy is associated with a significant survival benefit in patients with locally advanced squamous cell carcinoma of esophagus. The toxicities related to neoadjuvant chemoradiotherapy were tolerable. (Source: Journal of the Chinese Medical Association)
Source: Journal of the Chinese Medical Association - November 18, 2017 Category: General Medicine Source Type: research

Enzymatic extract from Ecklonia cava: Acute and subchronic oral toxicity and genotoxicity studies
Publication date: February 2018 Source:Regulatory Toxicology and Pharmacology, Volume 92 Author(s): Jun-Won Yun, Seung-Hyun Kim, Yun-Soon Kim, Ji-Ran You, Eun-Young Cho, Jung-Hee Yoon, Euna Kwon, In-Jue Yun, Je-Hun Oh, Ja-June Jang, Jin-Sung Park, Jeong-Hwan Che, Byeong-Cheol Kang Ecklonia cava (EC) is known to have antioxidant, anti-inflammatory, antidiabetic, and anticancer properties. Despite its wide use and beneficial properties, comprehensive toxicological information regarding EC extract is currently limited. Therefore, the purpose of this study was to investigate acute toxicity, subchronic toxicity, and genotoxici...
Source: Regulatory Toxicology and Pharmacology - November 18, 2017 Category: Toxicology Source Type: research

Safety of intrathecal route: focus to methylprednisolone acetate (Depo-Medrol) use
ConclusionsIntrathecal methylprednisolone acetate (Depo-Medrol)  therapy seems not fully safe due to reported adverse events. The use of other forms of corticosteroid therapy free from excipients should be emphasized such as soluble methylprednisolone sodium succinate. (Source: European Spine Journal)
Source: European Spine Journal - November 18, 2017 Category: Orthopaedics Source Type: research

The effect of follicullar fluid pesticides and polychlorinated biphenyls concentrations on intracytoplasmic sperm injection (ICSI) embryological and clinical outcome
Conclusion Higher concentrations of any studied PCBs and pesticides are associated with thinner endometrial thickness. The higher the level of Pretilachlor, β-cyfluthrin, PCB 28 and 180, the lower the retrieval, fertilization, and embryo cleavage rates. High PCB and pesticide concentrations in the FF adversely affected embryological ICSI outcomes. However, more data are needed to evaluate their effect on the clinical outcome. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - November 18, 2017 Category: OBGYN Source Type: research

Potent apoptosis-inducing activity of erypoegin K, an isoflavone isolated from Erythrina poeppigiana , against human leukemia HL-60 cells
AbstractErypoegin K is an isoflavone isolated from the stem bark ofErythrina poeppigiana. It contains a furan group at the A-ring of the core isoflavone structure and can inhibit the activity of glyoxalase I, an enzyme that catalyzes the detoxification of methylglyoxal (MG), a by-product of glycolysis. In the present study, we found that erypoegin K has a potent cytotoxic effect on human leukemia HL-60 cells. Its cytotoxic effect was much stronger than that of a known glyoxalase I inhibitorS-p-bromobenzylglutathione cyclopentyl diester. Conversely, erypoegin K demonstrated weak cytotoxicity toward normal human peripheral l...
Source: Journal of Natural Medicines - November 18, 2017 Category: Drugs & Pharmacology Source Type: research

Genotoxicity of 11 heavy metals detected as food contaminants in two human cell lines
In this study, the genotoxic and cytotoxic properties of 15 different oxidation statuses of 11 different heavy metals were investigated using high‐throughput screening (γH2AX assay) in two human cell lines (HepG2 and LS‐174T) representative of target organs (liver and colon) for food contaminants. Base on their lowest observed adverse effect concentration, the genotoxic potency of each heavy metal in each cell line was ranked in decreasing order, NaAsO2 > CdCl2 > PbCl2 (only in LS‐174T cells) > As2O5 > SbCl3 > K2TeO3 >...
Source: Environmental and Molecular Mutagenesis - November 18, 2017 Category: Molecular Biology Authors: B. Kopp, D. Zalko, M. Audebert Tags: Research Article Source Type: research

Molecules, Vol. 22, Pages 2007: Studies for Improving a Rat Model of Alzheimer ’s Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory
Molecules, Vol. 22, Pages 2007: Studies for Improving a Rat Model of Alzheimer’s Disease: Icv Administration of Well-Characterized β-Amyloid 1-42 Oligomers Induce Dysfunction in Spatial Memory Molecules doi: 10.3390/molecules22112007 Authors: Ágnes Kasza Botond Penke Zsuzsanna Frank Zsolt Bozsó Viktor Szegedi Ákos Hunya Klaudia Németh Gábor Kozma Lívia Fülöp During the past 15 years, several genetically altered mouse models of human Alzheimer’s disease (AD) have been developed. These costly models have greatly facilitated the evalu...
Source: Molecules - November 18, 2017 Category: Chemistry Authors: Ágnes Kasza Botond Penke Zsuzsanna Frank Zsolt Bozs ó Viktor Szegedi Ákos Hunya Klaudia N émeth G ábor Kozma L ívia Fülöp Tags: Article Source Type: research

Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis.
Authors: Bothe MK, Meyer C, Mueller U, Queudot JC, Roger V, Harleman J, Westphal M Abstract Plasma amino acid level changes occur in mild, moderate and severe stages of liver injury in human patients. In animal models, however, data are mainly restricted to severe liver injury models in rats. Here we present the characterization of a rat model of moderate liver dysfunction secondary to alpha-napthylisothiocyanate (ANIT)-induced cholestasis. Rats treated with 30 mg/kg/day ANIT for 3 weeks exhibited a time-dependent increase in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and bilirubin leve...
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Change in redox state and heat shock protein expression in an Indian major carp Cirrhinus cirrhosus exposed to zinc and lead.
Authors: Moniruzzaman M, Midday P, Dhara A, Das D, Ghosal I, Mukherjee D, Chakraborty SB Abstract Fish are exposed to different heavy metals that may induce numerous physiological changes. In the present study, we examined the redox state in response to a severe stress resulting from two heavy metals (Zinc and Lead) contamination in carp Cirrhinus cirrhosus. Fish were exposed to 1/10th of LC50 of the respective metals [zinc chloride (2.72 mg/L) and lead acetate (2.53 mg/L)] for 30 days and allowed to recover for another 30 days without any metal exposure. Concentration of metals, different enzymatic and non-enzymat...
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Evaluation system for arrhythmogenic potential of drugs using human-induced pluripotent stem cell-derived cardiomyocytes and gene expression analysis.
Authors: Higa A, Hoshi H, Yanagisawa Y, Ito E, Morisawa G, Imai JI, Watanabe S, Takagi M Abstract In recent years, human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) have been widely used to develop evaluation systems for drug cardiotoxicity, including the arrhythmia caused by QT prolongation. To accurately assess the arrhythmogenic potential of drugs, associated with QT prolongation, we developed an evaluation system using hiPS-CMs and gene expression analysis. hiPS-CMs were treated with 8 arrhythmogenic and 17 non-arrhythmogenic drugs at several concentrations for 24 hr to comprehensively analy...
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Macrophage differentiation induced by PMA is mediated by activation of RhoA/ROCK signaling.
In conclusion, the activation of RhoA/ROCK signaling is responsible for the macrophage differentiation induced by PMA. PMID: 29142175 [PubMed - in process] (Source: Journal of Toxicological Sciences)
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.
Authors: Okuda Y, Kushida M, Kikumoto H, Nakamura Y, Higuchi H, Kawamura S, Cohen SM, Lake BG, Yamada T Abstract High dietary levels of the non-genotoxic synthetic pyrethroid momfluorothrin increased the incidence of hepatocellular tumors in male and female Wistar rats. Mechanistic studies have demonstrated that the mode of action (MOA) for momfluorothrin-induced hepatocellular tumors is constitutive androstane receptor (CAR)-mediated. In the present study, to evaluate the potential human carcinogenic risk of momfluorothrin, the effects of momfluorothrin (1-1,000 µM) and a major metabolite Z-CMCA (5-1,000 &mi...
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Perinatal exposure to tetrabromobisphenol A (TBBPA), a brominated flame retardant, exacerbated the pneumonia in respiratory syncytial virus (RSV)-infected offspring mice.
Authors: Watanabe W, Hirose A, Takeshita T, Hashiguchi S, Sakata K, Konno K, Miyauchi A, Akashi T, Yoshida H, Sugita C, Kurokawa M Abstract To investigate the effects of perinatal exposure to tetrabromobisphenol A (TBBPA), a brominated flame retardant, on the immune system, a respiratory syncytial virus (RSV) infection mouse model was utilized. Female mice were exposed to TBBPA mixed with the diet from 10 days after conception to weaning on postnatal day 21. Offspring mice were infected intranasally with A2 strain of RSV. Although no general toxicological sign was observed, the pulmonary viral titers of offspring m...
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Actual consumption amount of personal care products reflecting Japanese cosmetic habits.
Authors: Yamaguchi M, Araki D, Kanamori T, Okiyama Y, Seto H, Uda M, Usami M, Yamamoto Y, Masunaga T, Sasa H Abstract Safety assessments of cosmetics are carried out by identifying possible harmful effects of substances in cosmetic products and assessing the exposure to products containing these substances. The present study provided data on the amounts of cosmetic products consumed in Japan to enhance and complement the existing data from Europe and the United States, i.e., the West. The outcomes of this study increase the accuracy of exposure assessments and enable more sophisticated risk assessment as a part of ...
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

The effects of ethylene glycol monomethyl ether on female reproductive system in juvenile rats.
Authors: Taketa Y, Mineshima H, Ohta E, Nakano-Ito K Abstract Ethylene glycol monomethyl ether (EGME), which is widely used in various industrial products, is known for adverse effects on the reproductive system in adult rats. However, the effects of EGME on reproductive development in juvenile rats have not been demonstrated. In order to investigate the effects of EGME on the female reproductive system and pubertal development in juvenile rats, EGME was administered to female Sprague Dawley rats from postnatal day 21 to 41 at a dose level of 0, 50, 100, or 300 mg/kg. The animals were examined for general condition...
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research

Background data on NOD/Shi-scid IL-2R γ(null) mice (NOG mice).
This study provided detailed background data on NOG mice up to 52 weeks-old and provided information on appropriate use of NOG mice in the various research fields. PMID: 29142168 [PubMed - in process] (Source: Journal of Toxicological Sciences)
Source: Journal of Toxicological Sciences - November 17, 2017 Category: Toxicology Tags: J Toxicol Sci Source Type: research