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Biocompatibility of Bespoke 3D-Printed Titanium Alloy Plates for Treating Acetabular Fractures.
In conclusion, both in vivo and in vitro experiments suggested favorable biocompatibility of 3D-printed titanium alloy plates, indicating that it is a promising option for treatment of acetabular fractures. PMID: 29682523 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - April 24, 2018 Category: Research Authors: Lin X, Xiao X, Wang Y, Gu C, Wang C, Chen J, Liu H, Luo J, Li T, Wang D, Fan S Tags: Biomed Res Int Source Type: research

Anti-Inflammatory Effect of Geniposide on Osteoarthritis by Suppressing the Activation of p38 MAPK Signaling Pathway.
In this study, we evaluated the inhibition effect of geniposide on the inflammatory progression of the surgically induced osteoarthritis and whether the protective effect of geniposide on OA is related to the inhibition of the p38 MAPK signaling pathway. In vitro, geniposide attenuated the expression of inflammatory cytokines including interleukin-1 (IL-1), tumor necrosis factor (TNF-α), and nitric oxide (NO) production as well as matrix metalloproteinase- (MMP-) 13 in chondrocytes isolated from surgically induced rabbit osteoarthritis model. Additionally, geniposide markedly suppressed the expression of IL-1, TNF-&a...
Source: Biomed Res - April 24, 2018 Category: Research Authors: Chen Y, Shou K, Gong C, Yang H, Yang Y, Bao T Tags: Biomed Res Int Source Type: research

Toxic Effects of Di-2-ethylhexyl Phthalate: An Overview.
Abstract Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products. DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and pollutes the environment through release from industrial settings and plastic waste disposal sites. DEHP can enter the body through inhalation, ingestion, and dermal contact on a daily basis, which has raised some concerns ...
Source: Biomed Res - April 24, 2018 Category: Research Authors: Rowdhwal SSS, Chen J Tags: Biomed Res Int Source Type: research

Let's Talk About Financial Toxicities.
Abstract I have attended a number of conferences in the past few months that have included excellent sessions about precision medicine, targeted therapies, and personalized medicine. there terms may be confusing, and the generic names of the various drugs, not to mention the trade names, present some unique challenges. PMID: 29683119 [PubMed - in process] (Source: Oncology Nursing Forum)
Source: Oncology Nursing Forum - April 24, 2018 Category: Nursing Authors: Katz A Tags: Oncol Nurs Forum Source Type: research

Sarcoid-like reactions in patients receiving modern melanoma treatment
The development of cancer immunotherapy and targeted therapy has reached an important inflection point in the history of melanoma. Immune checkpoint inhibitors and kinase inhibitors are today’s standard of care treatments in advanced melanoma patients. Treatment-related toxicities can be very intriguing and quite challenging. Sarcoidosis is a multisystemic granulomatous disease characterized by an aberrant immune response to unknown antigens, whereas sarcoid-like reactions (SLRs) refer to localized clinical features. We carried out a single-center observational study in patients with stage IIB–IV melanoma treat...
Source: Melanoma Research - April 24, 2018 Category: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clinical research Source Type: research

Combination immunotherapies implementing adoptive T-cell transfer for advanced-stage melanoma
Immunotherapy is a promising method of treatment for a number of cancers. Many of the curative results have been seen specifically in advanced-stage melanoma. Despite this, single-agent therapies are only successful in a small percentage of patients, and relapse is very common. As chemotherapy is becoming a thing of the past for treatment of melanoma, the combination of cellular therapies with immunotherapies appears to be on the rise in in-vivo models and in clinical trials. These forms of therapies include tumor-infiltrating lymphocytes, T-cell receptor, or chimeric antigen receptor-modified T cells, cytokines [interleuk...
Source: Melanoma Research - April 24, 2018 Category: Cancer & Oncology Tags: Review Article Source Type: research

Prospective observational study of 177 Lu-DOTA-octreotate therapy in 200 patients with advanced metastasized neuroendocrine tumours (NETs): feasibility and impact of a dosimetry-guided study protocol on outcome and toxicity
ConclusionsDosimetry-based therapy with177Lu-DOTA-octreotate is feasible. Patients in whom the absorbed dose to the kidneys reached 23  Gy had a longer OS than those in whom it did not. Patients with CR/PR had a longer OS than those with SD. Bone marrow dosimetry did not predict toxicity. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2018 Category: Nuclear Medicine Source Type: research

Toxicity of Food-Grade TiO2 to Commensal Intestinal and Transient Food-Borne Bacteria: New Insights Using Nano-SIMS and Synchrotron UV Fluorescence Imaging
Joanna M. Radziwill-Bienkowska, Pauline Talbot, Jasper B. J. Kamphuis, V éronique Robert, Christel Cartier, Isabelle Fourquaux, Esther Lentzen, Jean-Nicolas Audinot, Frédéric Jamme, Matthieu Réfrégiers, Jacek K. Bardowski, Philippe Langella, Magdalena Kowalczyk, Eric Houdeau, Muriel Thomas, Muriel Mercier-Bonin (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - April 24, 2018 Category: Microbiology Source Type: research

Comprehensive Insights into Interaction Mechanism between Perfluorodecanoic Acid and Human Serum Albumin.
New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8NJ00124C, PaperSichen Gao, Rutao Liu This investigation explored toxic mechanism of perfluorodecanoic acid (PFDA) on human serum albumin (HSA), established interaction mode of PFDA with HSA and provided a new strategy for the toxicity evaluation... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 24, 2018 Category: Chemistry Authors: Sichen Gao Source Type: research

[ASAP] The Toxicogenome of < italic toggle="yes" > Hyalella azteca < /italic > : A Model for Sediment Ecotoxicology and Evolutionary Toxicology
Environmental Science& TechnologyDOI: 10.1021/acs.est.8b00837 (Source: Environmental Science and Technology)
Source: Environmental Science and Technology - April 24, 2018 Category: Environmental Health Authors: managing.editor at est.acs.org (American Chemical Society) Source Type: research

Vulvar Recurrences After Intensity-modulated Radiation Therapy for Squamous Cell Carcinoma of the Anus
Conclusions: In a cohort of patients treated with IMRT-based chemoradiation, 2 vulvar recurrences were identified within the avoided external genitalia despite limited recurrence rates within the cohort overall. This experience suggests that for patients with a locally advanced primary tumor and bulky bilateral inguinal or pelvic disease, the in-transit vulvar dermal lymphatics may be at risk for subclinical involvement and subsequent recurrence. If substantiated by a similar pattern of recurrence at other institutions, the external genitalia may need to be reclassified from an avoidance structure to a clinical treatment...
Source: American Journal of Clinical Oncology - April 24, 2018 Category: Cancer & Oncology Tags: Original Articles: Gastrointestinal Source Type: research

Retrospective Analysis of Cisplatin Nephrotoxicity in Patients With Head and Neck Cancer Receiving Outpatient Treatment With Concurrent High-dose Cisplatin and Radiotherapy
Objectives: Cisplatin remains the pivotal chemotherapy in squamous cell carcinoma of the head and neck (SCCHN), with nephrotoxicity considered the dose-limiting toxicity. The purpose of our study was to propose an outpatient high-dose cisplatin protocol aimed at preventing nephrotoxicity and to analyze the results of its utilization in patients with SCCHN treated with concurrent radiotherapy. Materials and Methods: We retrospectively evaluated 82 SCCHN patients treated with outpatient high-dose cisplatin concurrent with radiotherapy at our institution. Acute kidney injury (AKI) and chronic kidney disease were defined ...
Source: American Journal of Clinical Oncology - April 24, 2018 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Malignant Peripheral Nerve Sheath Tumors: A Single Institution’s Experience Using Combined Surgery and Radiation Therapy
Conclusions: Combination therapy with surgery and RT provides favorable LC. Distant recurrences, however, continue to be challenging with limited salvage success at the time of relapse. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 24, 2018 Category: Cancer & Oncology Tags: Original Articles: Soft Tissue Source Type: research

Locally Advanced Cervical Cancer: Outcomes With Variable Adherence to Treatment
Conclusions: Adherence to both optimal treatment time and radiation dose is significantly associated with improved survival. Total radiation dose is an independent predictor of survival among patients with locally advanced cervical cancer. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 24, 2018 Category: Cancer & Oncology Tags: Original Articles: Gynecologic Source Type: research

Phase I Trial Using Induction Ciplatin, Docetaxel, 5-FU and Erlotinib Followed by Cisplatin, Bevacizumab and Erlotinib With Concurrent Radiotherapy for Advanced Head and Neck Cancer
Conclusions: Erlotinib in combination with induction TPF followed by erlotinib, cisplatin, and bevacizumab with XRT is active but toxic. Gastrointestinal toxicities partly caused high rates of study withdrawal. All doses studied in this protocol caused unexpected toxicities and we do not recommend advancement to phase II. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - April 24, 2018 Category: Cancer & Oncology Tags: Original Articles: Head and Neck Source Type: research

Adenosine deaminase deficiency: a review
Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine degradation by-products, most potently affecting lymphocytes, leading to adenosine deaminase-deficient severe combined immunodefici... (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - April 24, 2018 Category: Internal Medicine Authors: Aisling M. Flinn and Andrew R. Gennery Tags: Review Source Type: research

Application of INAA technique for analysis of essential trace and toxic elements in medicinal seeds of Carum carvi L. & amp; Foeniculum vul-gare Mill. used in Algeria
The objective of this work is to contribute by using nuclear analytical techniques, for studying a large number of natural food samples consumed in Algeria related to nutrition and human health. The present study focuses on the analysis of the seeds of caraway and fennel used in our country by using instrumental neutron activation analysis (INAA) technique. Twenty-seven elements were assessed (As, Ce, Co, Cr, Cs, Eu, Hf, La, Mo, Lu, Nd, Sb, Sc, Se, Sm, Tb, Yb, Th, Ba, Br, Rb, Sr, Zn, Ca, K, Na and Fe) and the accuracy of the method was evaluated by analyzing the Certified Reference Materials (CRMs). The daily intake of ess...
Source: Journal of Applied Research on Medicinal and Aromatic Plants - April 24, 2018 Category: Complementary Medicine Source Type: research

Feasibility of 3D UV-C treatment to reduce fungal growth and mycotoxin loads on maize and wheat kernels
This study has shown that 3D UV-C treatment is a feasible option for reducingFusarium andPenicillium growth on maize kernels and, at higher doses, decreasing ZEN by ~  50%. (Source: Mycotoxin Research)
Source: Mycotoxin Research - April 24, 2018 Category: Toxicology Source Type: research

Lead hazard evaluation for cathode ray tube monitors in Brazil
Abstract Cathode ray tube (CRT) monitors are electronic equipment mainly made of glass, polymers and metals. These devices became obsolete because of emerging technologies such as LCD, LED and plasma; thus generating a huge stockpile of e-waste worldwide. In this CRT study, a natural leaching simulation (NBR10005) was performed to determine the toxicity of this e-waste. The standard NBR 10005 procedure was performed for 7 different monitors. The results show all samples are hazardous according to local environmental law (NBR 10004) due to lead leaching. The CRT panel is lead free, while the CRT funnel and neck have about 2...
Source: Brazilian Journal of Chemical Engineering - April 23, 2018 Category: Chemistry Source Type: research

Understanding the hydrogen transfer mechanism for the biodegradation of 2,4,6-trinitrotoluene catalyzed by pentaerythritol tetranitrate reductase: molecular dynamics simulations
Phys. Chem. Chem. Phys., 2018, Advance Article DOI: 10.1039/C8CP00345A, PaperZhilin Yang, Junxian Chen, Yang Zhou, Hui Huang, Dingguo Xu, Chaoyang Zhang The explosive 2,4,6-trinitrotoluene (TNT) is a highly toxic pollutant. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 23, 2018 Category: Chemistry Authors: Zhilin Yang Source Type: research

Suicide attempts: epidemiologic trends towards geoprocessing
Abstract In order to study data about suicide attempts and do the mapping of occurrence areas, it was developed an ecologic and exploring study, making use of techniques of geoprocessing, based on confirmed cases of suicide attempts. Cases of self-poisoning were included in the urban area of Campina Grande county, in the period of 2010-2013. A total of 446 suicide attempts were geo-referred, pointing up an incidence of 120 cases out of each 100,000 inhabitants. The sample was mostly feminine (66.4%), and 62.3% being up to 30 years old. Kernel's map remarked hot spot areas. Compared to surrounding areas the suicide risk of ...
Source: Ciencia e Saude Coletiva - April 23, 2018 Category: Occupational Health Source Type: research

[Variability of chloroquine and hydroxychloroquine retinopathy among various ethnicities].
CONCLUSION: The pathophysiology of these ethnic differences is unknown and may be due to distinct genetic predisposition to CQ and HCQ toxicity. Screening strategies should be adjusted to the ethnicity and performed in Asian subjects with larger visual fields (30°C), along with SD-OCT, looking for ellipsoid disruption≥8°C from the fovea. The recognition of this pericentral topography and an adjusted screening protocol should avoid late diagnosis in Asians treated with CQ and HCQ. PMID: 29678344 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - April 23, 2018 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research

Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells
David Gr ünig, Urs Duthaler, Stephan Krähenbühl (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - April 23, 2018 Category: Drugs & Pharmacology Source Type: research

[ASAP] Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2
Chemical Research in ToxicologyDOI: 10.1021/acs.chemrestox.8b00062 (Source: Chemical Research in Toxicology)
Source: Chemical Research in Toxicology - April 23, 2018 Category: Toxicology Authors: Ji Jiang, Lok Ming Tam, Pengcheng Wang, Yinsheng Wang Source Type: research

Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage [Basic Sciences]
Conclusions—LTF delivered to the ICH-affected brain by infiltrating PMNs may assist in hematoma detoxification and represent a powerful potential target for the treatment of ICH. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Xiurong Zhao, Shun–Ming Ting, Guanghua Sun, Meaghan Roy–O’Reilly, Alexis S. Mobley, Jesus Bautista Garrido, Xueping Zheng, Lidiya Obertas, Joo Eun Jung, Marian Kruzel, Jaroslaw Aronowski Tags: Translational Studies Original Contributions Source Type: research

Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model [Basic Sciences]
Conclusions—Thalidomide and lenalidomide improve mural cell coverage of bAVM vessels and reduce bAVM hemorrhage, which is likely through upregulation of Pdgfb expression. (Source: Stroke)
Source: Stroke - April 23, 2018 Category: Neurology Authors: Wan Zhu, Wanqiu Chen, Dingquan Zou, Liang Wang, Chen Bao, Lei Zhan, Daniel Saw, Sen Wang, Ethan Winkler, Zhengxi Li, Meng Zhang, Fanxia Shen, Sonali Shaligram, Michael Lawton, Hua Su Tags: Angiogenesis, Animal Models of Human Disease, Cerebrovascular Malformations, Intracranial Hemorrhage Original Contributions Source Type: research

Antibiotics with Interleukin-15 Inhibition Reduce Joint Inflammation and Bone Erosions but Not Cartilage Destruction in Staphylococcus aureus-Induced Arthritis [Bacterial Infections]
Staphylococcus aureus-induced arthritis causes rapid joint destruction, often leading to disabling joint damage despite antibiotics. We have previously shown that interleukin-15 (IL-15) inhibition without antibiotics is beneficial in S. aureus-induced arthritis. We therefore hypothesized that the inhibition of IL-15, in combination with antibiotics, might represent a useful therapy that would reduce inflammation and joint destruction but preserve the host's ability to clear the infection. Female wild-type C57BL/6 mice were intravenously inoculated with the toxic shock syndrome toxin 1 (TSST-1)-producing LS-1 strain of S. a...
Source: Infection and Immunity - April 23, 2018 Category: Infectious Diseases Authors: Bergmann, B., Jirholt, P., Henning, P., Lindholm, C., Ohlsson, C., McInnes, I. B., Lerner, U. H., Gjertsson, I. Tags: Bacterial Infections Source Type: research

FXR Deletion in Hepatocytes does not Affect the Severity of Alcoholic Liver Disease in Mice
Emerging evidence has shown that FXR activation ameliorates the development of alcoholic liver diseases (ALD) while whole-body deficiency of FXR in mice leads to more severe ALD. However, it ’s unknown whether the enhanced susceptibility to ALD development in FXR−/− mice is due to deficiency of hepatic FXR or increased toxicity secondary to increased bile acid (BA) levels. Hepatocyte-specific FXR knockout mice (FXRhep−/−) present similar BA levels compared to wild-type mice, a nd are therefore a useful model to study a direct role of hepatic FXR in ALD development. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - April 23, 2018 Category: Gastroenterology Authors: Min Zhang, Bo Kong, Mingxing Huang, Ruixuan Wan, Laura E. Armstrong, Justin D. Schumacher, Daniel Rizzolo, Monica D. Chow, Yi-Horng Lee, Grace L Guo Tags: Liver, Pancreas and Biliary Tract Source Type: research

Extrahepatic cytochrome P450s play an insignificant role in triptolide-induced toxicity
Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. How... (Source: Chinese Medicine)
Source: Chinese Medicine - April 23, 2018 Category: Complementary Medicine Authors: Yuan Wei, Dujun Wang, Meng Chen, Zhen Ouyang, Shuo Wang and Jun Gu Tags: Research Source Type: research

Myrtle berries seeds aqueous extract abrogates chronic alcohol consumption-induced erythrocytes osmotic stability disturbance, haematological and biochemical toxicity
This study examined the effects of chronic alcohol consumption in the rat erythrocytes membrane as well as the involvement of reactive oxygen species and proinflammatory cytokines in its pathogenicity in rats ... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 23, 2018 Category: Lipidology Authors: Mohamed-Amine Jabri, Lamjed Marzouki and Hichem Sebai Tags: Research Source Type: research

Multigenerational Effects of Maternal Cigarette Smoke Exposure during Pregnancy on Sperm Counts of F1 and F2 Male Offspring
This study used a mouse model to investigate the effects of maternal exposure to cigarette smoke on reproductive systems in F1 and F2 male offspring. Female ICR mice were exposed either to clean air or to cigarette smoke during pregnancy at the post-implantation stage. Epididymal sperm counts were decreased in a cigarette smoke dose–dependent manner in F1 (by 40–60%) and F2 males (by 23–40%) at postnatal day 56. In F1, the seminiferous epithelium heights were lower in the cigarette smoke–exposed groups than in the control group, and these effects were sustained in F2 males. Results suggest that mate...
Source: Reproductive Toxicology - April 23, 2018 Category: Toxicology Source Type: research

Reproductive and Developmental Toxicity of Potassium Perfluorohexanesulfonate in CD-1 Mice
Publication date: Available online 22 April 2018 Source:Reproductive Toxicology Author(s): Sue Chang, John L. Butenhoff, George A. Parker, Prägati S. Coder, Jeremiah D. Zitzow, Ryan M. Krisko, James A. Bjork, Kendall B. Wallace, Jennifer G. Seed Potassium perfluorohexanesulfoante (K+PFHxS) was evaluated for reproductive/developmental toxicity in CD-1 mice. Up to 3 mg/kg-d K+PFHxS was administered (n = 30/sex/group) before mating, for at least 42 days in F0 males, and for F0 females, through gestation and lactation. F1 pups were directly dosed with K+PFHxS for 14 days after weaning. There was an equivocal ...
Source: Reproductive Toxicology - April 23, 2018 Category: Toxicology Source Type: research

Tricarbonylrhenium(I) complexes with the N-methylpyridine-2-carbothioamide ligand – Synthesis, characterization and cytotoxicity studies
Publication date: 1 July 2018 Source:Journal of Organometallic Chemistry, Volume 866 Author(s): Krzysztof Lyczko, Monika Lyczko, Sylwia Meczynska-Wielgosz, Marcin Kruszewski, Józef Mieczkowski A new series of tricarbonyl complexes of rhenium(I) in the ‘2 + 1’ system with the bidentate ligand N-methylpyridine-2-carbothioamide (NC5H4-CS-NH-CH3, LH(Me) NS) and a monodentate ligand, being either an anion (Cl, Br, I or SCN) or a neutral molecule (3,5-dimethylpyrazole (Hdmpz) or imidazole (Him)), was synthesized. The use of mixed ligands leads to the formation of neutral or cationic (in the form of ...
Source: Journal of Organometallic Chemistry - April 23, 2018 Category: Chemistry Source Type: research

Long-term effects of environmentally relevant concentrations of silver nanoparticles on microbial biomass, enzyme activity, and functional genes involved in the nitrogen cycle of loamy soil
Publication date: Available online 22 April 2018 Source:Journal of Environmental Sciences Author(s): Anna-Lena Grün, Susanne Straskraba, Stefanie Schulz, Michael Schloter, Christoph Emmerling The increasing production and use of engineered silver nanoparticles (AgNPs) in industry and private households are leading to increased concentrations of AgNP in the environment. An ecological risk assessment of AgNP is needed, but it requires understanding the long term effects of environmentally relevant concentrations of AgNP on the soil microbiome. Hence, the aim of this study was to reveal the long-term effects of AgNP on ...
Source: Journal of Environmental Sciences - April 23, 2018 Category: Environmental Health Source Type: research

Economic optimization of in situ extraction of inhibitors in acetone-ethanol-butanol (ABE) fermentation from lignocellulose
Publication date: Available online 22 April 2018 Source:Process Biochemistry Author(s): Víctor Hugo Grisales Díaz, Gerard Olivar Tost The inhibitors produced in the pretreatment (phenolics, furans, and organic acids) as well as in the fermentation (butanol and organic acids) limit acetone, butanol, and ethanol (ABE) production from lignocellulose. To reduce their negative impact on the fermentation, a process involving simultaneous saccharification, ABE fermentation, and detoxification by liquid-liquid extraction was proposed and economically optimized. Although several extractants may be used to reduce buta...
Source: Process Biochemistry - April 23, 2018 Category: Biochemistry Source Type: research

Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors
The regulatory management of chemicals and toxicants in the EU addresses hundreds of different chemicals and health hazards individually, one by one. An issue is that, so far, the possible interactions among c... (Source: Environmental Health)
Source: Environmental Health - April 23, 2018 Category: Environmental Health Authors: Jean-Pierre Bourguignon, Anne-Simone Parent, Jos C. S. Kleinjans, Tim S. Nawrot, Greet Schoeters and Nicolas Van Larebeke Tags: Hypothesis Source Type: research

A novel method for the detection of silver ions with carbon dots: Excellent selectivity, fast response, low detection limit and good applicability
Publication date: 15 August 2018 Source:Sensors and Actuators B: Chemical, Volume 267 Author(s): Jian-Cheng Jin, Bei-Bei Wang, Zi-Qiang Xu, Xiao-Hang He, Han-Feng Zou, Qi-Qi Yang, Feng-Lei Jiang, Yi Liu With the extensive application of silver containing materials in industry, the issue of release of silver ions has attracted increasing attention due to toxic effect of silver ions on the human health and environment. Traditionally, silver ions can be detected by atomic absorption spectroscopy, atomic emission spectrometry etc., which needed expensive and elaborate instruments and were high energy consumption. Therefore, e...
Source: Sensors and Actuators B: Chemical - April 23, 2018 Category: Chemistry Source Type: research

Tyrosine Kinase Inhibitors in the Treatment of Chronic-Phase CML: Strategies for Frontline Decision-making
AbstractPurpose of ReviewOver the past two decades, the introduction of tyrosine kinase inhibitors (TKIs) has transformed the treatment of chronic myeloid leukemia (CML). With four agents currently approved for frontline use in chronic-phase (CP) disease, it follows that treatment decision-making has been rendered more challenging. Here we will review recent advances that help inform the selection of a first-line TKI.Recent FindingsExtended follow-up of the seminal CML trials has demonstrated the long-term efficacy of TKIs, while also highlighting significant differences in their respective toxicity profiles and potency. D...
Source: Current Hematologic Malignancy Reports - April 23, 2018 Category: Hematology Source Type: research

Diffusible, highly bioactive oligomers represent a critical minority of soluble A β in Alzheimer’s disease brain
AbstractSignificant data suggest that soluble A β oligomers play an important role in Alzheimer’s disease (AD), but there is great confusion over what exactly constitutes an Aβ oligomer and which oligomers are toxic. Most studies have utilized synthetic Aβ peptides, but the relevance of these test tube experiments to the conditions that prev ail in AD is uncertain. A few groups have studied Aβ extracted from human brain, but they employed vigorous tissue homogenization which is likely to release insoluble Aβ that was sequestered in plaques during life. Several studies have found such extracts...
Source: Acta Neuropathologica - April 23, 2018 Category: Neurology Source Type: research

Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis
In conclusion, CTZ promoted an overall amelioration of endometriosis in a rat model due to the anti-angiogenic properties of the drug. Therefore, our results support the proposal of a clinical trial using CTZ for the treatment of endometriosis. Graphical abstract (Source: Molecular and Cellular Endocrinology)
Source: Molecular and Cellular Endocrinology - April 23, 2018 Category: Endocrinology Source Type: research

Short-term oral gavage administration of adenine induces a model of fibrotic kidney disease in rats
Discussion Short-term delivery of adenine via precise gavage delivery induced a robust model with hallmarks of fibrotic kidney disease, had limited variance between animals, and no animal morbidity within the 20 days studied. This model represents a methodical alternative to long-term dietary dosing of adenine. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 23, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of relative dose intensity during the early phase of first-line sunitinib treatment using a 2-week-on/1-week-off regimen for metastatic renal cell carcinoma
AbstractSunitinib treatment with a 2-week-on/1-week-off schedule (Schedule 2/1) is a common alternative regimen with high relative dose intensity (RDI) and superior tolerability for patients with metastatic renal cell carcinoma (mRCC). The prognostic impact of RDI is reported only in 4-week-on/2-week-off or mixed regimens. Herein, we evaluated the prognostic impact of RDI during early-phase sunitinib treatment using Schedule 2/1. Seventy-four patients who received first-line sunitinib treatment using Schedule 2/1 were evaluated. Endpoints were progression-free survival (PFS) and overall survival (OS). We assessed RDI withi...
Source: Medical Oncology - April 23, 2018 Category: Cancer & Oncology Source Type: research

Protective Effect of Apigenin on Acrylonitrile-Induced Inflammation and Apoptosis in Testicular Cells via the NF- κB Pathway in Rats
AbstractApigenin (AP) as a plant flavonoid is found to attenuate acrylonitrile (ACN) toxicity by reducing ROS production and inhibiting apoptosis. Therefore, the present study aimed to evaluate the role of AP on ACN-induced inflammation and apoptosis in germ cells and whether it is through the NF- κB signaling pathway. AP increased the concentrations of lactate dehydrogenase isozyme (LDH) and sorbitol dehydrogenase (SDH), while the concentrations of interleukin β (IL-1β), tumor-necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were significantly reduced. AP could downregulate the expre ssion o...
Source: Inflammation - April 23, 2018 Category: Allergy & Immunology Source Type: research

Structural and Lipid Peroxidation Effects of Lead on Rat Hippocampus and Its Attenuation by Hydrogen Rich Water
Publication date: Available online 22 April 2018 Source:Journal of Chemical Neuroanatomy Author(s): Melad G. Paulis, Osama A. Hassan, Mohmed F. Abbass, Mostafa Abo-AL Hamad Mohammad Despite the well-known toxicity and the efforts to control its exposure, lead still has a serious health concern, particularly in young ages. Chelation therapy cannot correct the neurocognitive effects of chronic exposure. So, there is a requirement to test different protective agents for lead intoxication. Hydrogen-rich water (HRW) has gained attraction recently as an antioxidant. Four groups of rats received sodium acetate, HRW, lead acetate...
Source: Journal of Chemical Neuroanatomy - April 23, 2018 Category: Neuroscience Source Type: research

Confocal micrographs: automated segmentation and quantitative shape analysis of neuronal cells treated with ostreolysin A/pleurotolysin B pore-forming complex
This study aimed to develop a procedure for accurate morphological analysis of cell shape and use it as a tool to estimate toxin activity. With the aim of optimizing the method of cell morphology analysis, we determined the influence of ostreolysin A and pleurotolysin B complex (OlyA/PlyB) on the morphology of murine neuronal NG108-15 cells. A computational method was introduced and successfully applied to quantify morphological attributes of the NG108-15 cell line before and after 30 and 60  min exposure to OlyA/PlyB using confocal microscopy. The modified circularity measure\(C_{2}^{n}(S)\) for shape analysis was ap...
Source: Histochemistry and Cell Biology - April 23, 2018 Category: Biomedical Science Source Type: research

Exploring the complex removal behavior of natural organic matter upon N-doped reduced graphene oxide-activated persulfate via excitation-emission matrix combined with parallel factor analysis and size exclusion chromatography
In this study, nitrogen-doped reduced graphene oxide (NrGO) was applied as a catalyst first to investigate the degradation behavior of NOM. A parallel system was also examined without PS for non-oxidative interaction. For three tested NOM, the extent of the removal increased with the addition of NrGO, and the removal rates were consistently higher for the systems with versus without PS (by 25–102%). Specific ultraviolet absorbance (SUVA) exhibited declining trends with NrGO for both oxidative and non-oxidative systems. Up to 86.9%, 59.9%, and 60.3% reduction in SUVA values were found for the oxidative removal of Suwa...
Source: Chemical Engineering Journal - April 23, 2018 Category: Chemistry Source Type: research

Toxicokinetic and toxicodynamic studies of carbaryl alone or in binary mixtures with azinphos methyl in the freshwater gastropod Planorbarius corneus
This study aimed to (1) assess the inhibitory effects of carbaryl on B-esterase activity in soft tissues and hemolymph of Planorbarius corneus; (2) establish whether binary mixtures of carbaryl and azinphos-methyl depart or not from a model of concentration addition on the inhibition of cholinesterase activity; (3) determine the bioconcentration and elimination of the pesticides. The results showed that exposure of gastropods to increasing concentrations of carbaryl (0.1–5 mg L−1) for 48 h inhibited cholinesterase activity in a concentration-dependent manner, with an EC50 of 1.4 ± 0.3 mg L&...
Source: Aquatic Toxicology - April 23, 2018 Category: Toxicology Source Type: research

Pembrolizumab combined with stereotactic body radiotherapy in a patient with human immunodeficiency virus and advanced non-small cell lung cancer: a case report
ConclusionsPembrolizumab combined with SBRT therapy for patients with human immunodeficiency virus infection and non-small cell lung cancer may lead to serious immune-related adverse events and more clinical trials are needed. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 23, 2018 Category: General Medicine Source Type: research

The issue of financial toxicity in the management of chronic myeloid leukemia with blast crisis.
Authors: Eskazan AE PMID: 29673265 [PubMed - as supplied by publisher] (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 22, 2018 Category: Health Management Tags: J Med Econ Source Type: research

Arsenic, cadmium, lead, and chromium in well water, rice, and human urine in Sri Lanka in relation to chronic kidney disease of unknown etiology.
Authors: S Herath HMA, Kawakami T, Nagasawa S, Serikawa Y, Motoyama A, Chaminda GGT, Weragoda SK, Yatigammana SK, Amarasooriya AAGD Abstract Chronic kidney disease of unknown etiology (CKDu) is spreading gradually in Sri Lanka. In the current research, 1,435 well water samples from all 25 districts of Sri Lanka, 91 rice samples, and 84 human urine samples from both CKDu-endemic and non-endemic areas in Sri Lanka were analyzed for arsenic, cadmium, lead, and chromium to detect whether toxic elements could be a cause of CKDu. The liver-type fatty acid binding protein (L-FABP) concentration and arsenic, cadmium, lead,...
Source: Journal of Water and Health - April 22, 2018 Category: Environmental Health Tags: J Water Health Source Type: research