In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters

In conclusion, these results indicate that not all substances contribute equally (or at all) to the systemic exposure to salicylic acid. Therefore, we propose a realistic metabolism correction factor by which the potential contribution of salicylate esters to the aggregate consumer exposure to salicylic acid from cosmetic use can be estimated.PMID:38658404 | DOI:10.1007/s00204-024-03749-8

Source: Archives of Toxicology - April 24, 2024 Category: Toxicology Authors: Abdulkarim Najjar Sebastien Gr égoire Beate Nicol Andreas Natsch Nazanin Golbamaki Fanny Boisleve Amaia Irizar Brian Wall Angus Swinscoe Val érie Masini-Etévé Dan Selechnik Anne Marie Api Peter Griem Nicola Hewitt Estefania Cardamone Source Type: research