Histone deacetylase as emerging pharmacological therapeutic target for neuropathic pain: From epigenetic to selective drugs

CONCLUSIONS: Abnormally elevated HDACs promote neuronal excitability and neuroinflammation by epigenetically modulating pivotal gene expression in neuronal and immune cells, contributing to peripheral and central sensitization in the progression of neuropathic pain, and HDACi showed significant efficacy and great potential for alleviating neuropathic pain.PMID:38715326 | DOI:10.1111/cns.14745

Source: CNS Neuroscience and Therapeutics - May 8, 2024 Category: Neuroscience Authors: Wencui Zhang Bo Jiao Shangchen Yu Caixia Zhang Kaiwen Zhang Baowen Liu Xianwei Zhang Source Type: research