The protective effect of Korean Red Ginseng against rotenone-induced Parkinson's disease in rat model: modulation of nuclear factor- κβ and caspase-3.
CONCLUSION: Ginseng could be a promising treatment in PD. It can suppress the dopaminergic neuron degeneration through variable mechanisms mainly via inhibition of NF-κβ pathway in addition to inhibition oxidative stress and apoptosis. PMID: 31198107 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 11, 2019 Category: Biotechnology Authors: Zaafan MA, Abdelhamid AM, Ibrahim SM Tags: Curr Pharm Biotechnol Source Type: research

The Effect of Dihydroartemisinin on the Malignancy and Epithelial-Mesenchymal Transition of Gastric Cancer Cells.
Abstract OBJECTIVE: To observe the effects of dihydroartemisinin (DHA) on the proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT) of the human gastric cancer cell line SGC7901 cultured in vitro. METHODS: We applied varying concentrations of DHA to SGC7901 cells. Cell proliferation was measured using the cell counting kit-8 (CCK-8). Flow cytometry, Transwell invasion assay, and cell scratch assay were used to investigate the cells' apoptosis, invasion, and migratio. Western blot was used to assess the expression levels of EMT markers E-cadhein and vimentin, protein kinase...
Source: Current Pharmaceutical Biotechnology - June 11, 2019 Category: Biotechnology Authors: Li N, Zhang S, Luo Q, Yuan F, Feng R, Chen X, Yang S Tags: Curr Pharm Biotechnol Source Type: research

Comparison Among Five Eucalyptus Species Based on Their Leaf Contents of Some Primary and Secondary Metabolites.
CONCLUSION: Acetone-water combination has enhanced the phenolics extraction from Eucalyptus tissues. This is the first report aiming to compare between the aforementioned Eucalyptus species highlighting either their nutritional or medicinal importance. PMID: 31187707 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 9, 2019 Category: Biotechnology Authors: Nasr A, Khan TS, Huang SP, Wen B, Shao JW, Zhu GP Tags: Curr Pharm Biotechnol Source Type: research

Opioid Substitution Therapy: Achieving Harm Reduction While Searching for a Prophylactic Solution.
Abstract PMID: 31146660 [PubMed - in process] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 1, 2019 Category: Biotechnology Authors: Blum K, Baron D Tags: Curr Pharm Biotechnol Source Type: research

Trends in the Bioremediation of Pharmaceuticals and Other Organic Contaminants Using Native or Genetically Modified Microbial Strains: A Review.
Abstract Nowadays, numerous synthetic chemicals are extensively produced and consequently used worldwide for many different purposes, such as pharmaceuticals, pesticides, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and other organic species. The presence of the aforementioned xenobiotic substances not only in various environmental matrices (water, air, and soil), but also in biological tissues (organisms) as well as in several compartments of raw or processed food (of fruit, vegetal, and animal origin), has raised global scientific concerns regarding their potential toxicity towards ...
Source: Current Pharmaceutical Biotechnology - May 27, 2019 Category: Biotechnology Authors: A S P, M C V Tags: Curr Pharm Biotechnol Source Type: research

Mitogen-Induced Interferon Gamma Production in Human Whole Blood: The Effect of Heat and Cations.
CONCLUSION: Therefore, PWM is an appropriate mitogen for use as a positive control in IGRAs. It is a potential indicator of cytokine production in the diagnostic as well as research settings, and calcium supplementation improved stimulation. PMID: 31132974 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 27, 2019 Category: Biotechnology Authors: Nam JH, Choi H, Cha B, Kim HD, Park JY, Abekura F, Kim CH, Kim JR Tags: Curr Pharm Biotechnol Source Type: research

Evaluation of the effect of Nanoparticles Zinc Oxide/ Camellia sinensis Complex on the kidney of rats treated with Monosodium Glutamate: Antioxidant and Histological Approaches.
Abstract Zinc oxide nanoparticles (ZnO NPs) are robustly used biomedicine. Moreover, no study had been conducted to explore the consequence of green synthesis of ZnO NPs with Camellia sinensis on kidneys of rats treated with monosodium glutamate (MSG). Therefore, the objective of this research was designed to explore the possible defensive effect of GTE / ZnO NPs against MSG-induced renal stress was investigated at redox and histopathological points. The levels of urea and creatinine increase as the effect of high dose of MSG, in addition, the myeloperoxidase and xanthine oxidase activates elevated significantly w...
Source: Current Pharmaceutical Biotechnology - May 21, 2019 Category: Biotechnology Authors: El-Shenawy NS, Hamza RZ, Al-Salmi FA, Al-Eisa RA Tags: Curr Pharm Biotechnol Source Type: research

"Nutritional Psychiatry: Evidence of the Role of Foods in Mental Health" Part 1.
"Nutritional Psychiatry: Evidence of the Role of Foods in Mental Health" Part 1. Curr Pharm Biotechnol. 2019;20(2):98-99 Authors: Silva AS, Sobarzo-Sánchez E Abstract PMID: 31084589 [PubMed - in process] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - May 17, 2019 Category: Biotechnology Authors: Silva AS, Sobarzo-Sánchez E Tags: Curr Pharm Biotechnol Source Type: research

Does nimodipine, a selective calcium channel blocker, impair chondrocyte proliferation or damage extracellular ma.
Abstract To investigate the effects of the active ingredient nimodipine on chondrocyte proliferation and extracellular matrix (ECM) structures in cartilage tissue cells. Chondrocyte cultures were prepared from tissues resected via surgical operations. Nimodipine was then applied to these cultures. Molecular analysis was performed. The data obtained were statistically calculated. Both the results of the (3-(4,5 dimethylthiazol2-yl)-2,5-diphenyltetrazolium (MTT) assay and the results of the fluorescence microscope analysis (a membrane permeability test carried out with acridine orange/propidium iodide staining (AO/P...
Source: Current Pharmaceutical Biotechnology - May 6, 2019 Category: Biotechnology Authors: Kaplan N, Yilmaz I, Karaarslan N, Kaya YE, Sirin DY, Ozbek H Tags: Curr Pharm Biotechnol Source Type: research

Suicide Gene Therapy: A New Frontier for Cancer Fighting.
PMID: 31002032 [PubMed] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 20, 2019 Category: Biotechnology Authors: Prosperi D, Colombo M Tags: Curr Pharm Biotechnol Source Type: research

Molecular docking of natural phenolic compounds for screening of urease inhibitors.
Abstract Bacterial ureases have been the cause of various human and animal pathogenicity including hepatic encephalopathy, hepatic coma urolithiasis, gastric and peptic ulcers, pyelonephritis, and urinary catheter encrustation by production of ammonia. Hence in view of the side effects of existing drugs, there is a strong need to discover, more safe, effective and potent compounds for treatment of infections caused by urease. For this purpose, several natural phenolic compounds have been screened by molecular modelling techniques. Wherein the phenolic compounds were docked to the active site of Jack bean urease (P...
Source: Current Pharmaceutical Biotechnology - April 9, 2019 Category: Biotechnology Authors: Kataria R, Khatkar A Tags: Curr Pharm Biotechnol Source Type: research

Effect of simultaneous snail slime-aided degradation and yeast fermentation on terpenoid composition of plantain pseudostem waste.
CONCLUSION: The findings of this study indicate the imminent application of simultaneous saccharification and fermentation for the enhancement of bioactivities of terpenoids. PMID: 30961480 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 8, 2019 Category: Biotechnology Authors: Amadi P, Ogunka-Nnoka C, Abbey B Tags: Curr Pharm Biotechnol Source Type: research

The Interaction of Zinc Oxide/Green Tea Extract Complex Nanoparticles and its Effect on Monosodium Glutamate Toxicity in Liver of Rats.
CONCLUSION: In conclusion, MSG at both doses caused oxidative stress and inflammation on liver after 28 days of exposure that supported histological analysis and transmission view of hepatic parenchyma. GTE / ZnO NPs act as partial hepato-protective against MSG. PMID: 30961481 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 8, 2019 Category: Biotechnology Authors: Al-Salmi FA, Hamza RZ, El-Shenawy NS Tags: Curr Pharm Biotechnol Source Type: research

Preterm Birth, Inflammation and Infection: New Alternative Strategies for their Prevention.
Conclusion: This review focuses on the existing literature regarding the use of different drugs, medicinal plants, and microorganisms that show promising benefits for the prevention of preterm birth associated with inflammation and infection. New alternative strategies involving the use of PDE-4 inhibitors, medicinal plants and probiotics could have a great impact for improving prenatal and neonatal outcomes and give babies the best start in life, ensuring lifelong health benefits. Despite promising results from well-documented cases, only a small number of these alternative strategies have been studied in clinical trials....
Source: Current Pharmaceutical Biotechnology - April 8, 2019 Category: Biotechnology Authors: Muñoz-Pérez VM, Ortiz MI, Cariño-Cortés R, Fernández-Martínez E, Rocha-Zavaleta L, Bautista-Ávila M Tags: Curr Pharm Biotechnol Source Type: research

Evaluation of changes in the expression pattern of EDIL3 in different grades of endometrial cancer Subtitle: EDIL3 in endometrial cancer.
Abstract BACKGROUND: EDIL3 is an extracellular matrix protein that plays a key role in angiogenesis. Changes in the pattern of its expression also affect cellular processes and the tumor microenvironment. Elevated level of EDIL3 is considered an unfavorable prognostic marker of survival. OBJECTIVE: The aim of this study was to evaluate the changes in EDIL3 expression in endometrial cancer at various degrees of its differentiation (G1-G3) and to discuss its potential role as a molecular diagnostic marker and therapeutic target. METHOD: The study group consisted of 45 patients with endometrial cancer: G1, ...
Source: Current Pharmaceutical Biotechnology - April 8, 2019 Category: Biotechnology Authors: Oplawski M, Dziobek K, Zmarzły N, Grabarek B, Tomala B, Leśniak E, Adwent I, Januszyk P, Januszyk K, Dąbruś D, Boroń D Tags: Curr Pharm Biotechnol Source Type: research

Phytochemical Analysis and Evaluation of Antimicrobial Activity of Peumus boldus, Psidium guajava, Vernonia polysphaera, Persea Americana, Eucalyptus citriodora leaf extracts and Jatropha multifida raw sap.
CONCLUSION: All extracts, except from Assa-Peixe, showed promising values against Staphylococcus aureus, with halos varying from 13-20 mm. Analysis of the minimum inhibitory concentration (MIC) values of the six medicinal plants revealed inhibitory activity of S. aureus, with concentrations varying from 3.12-12.5 mg/mL, which is a significant result considering that S. aureus is one of the main causes of hospital infections. In the analysis of the phytochemical profile, Goiaba contained the best yield of phenolic compounds and total flavonoids, as well as higher antioxidant activity by DPPH and phosphomolybdenum, demonstra...
Source: Current Pharmaceutical Biotechnology - April 8, 2019 Category: Biotechnology Authors: da Cruz JER, da Costa Guerra JF, de Souza Gomes M, Freitas GROE, Morais ER Tags: Curr Pharm Biotechnol Source Type: research

New rules on patient's safety and professional liability for the Italian Health Service.
Abstract The phenomenon of clinical negligence claims has rapidly spread to United States, Canada and Europe assuming the dimensions and the severity of a pandemia. Consequently, the issues related to medical malpractice need to be studied from a transnational perspective since they raise similar problems in different legal systems. Over the last two decades, medical liability has become a prominent issue in healthcare policy and a major concern for healthcare economics in Italy. The failures of the liability system and the high cost of healthcare have led to considerable legislative activity concerning medical ma...
Source: Current Pharmaceutical Biotechnology - April 7, 2019 Category: Biotechnology Authors: Albolino S, Bellandi T, Cappelletti S, Di Paolo M, Fineschi V, Frati P, Offidani C, Tanzini M, Tartaglia R, Turillazzi E Tags: Curr Pharm Biotechnol Source Type: research

Advanced Loss Eventuality Assessment and Technical Estimates: an Integrated Approach for Management of Healthcare-Associated Infections.
CONCLUSION: The proposed methodological approach allows a productive analysis of the internal processes, providing fundamental data for the refinement of the preventive strategies and for the rationalization of the resources through the expenditure forecasts. PMID: 30961487 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 7, 2019 Category: Biotechnology Authors: Gatto V, Scopetti M, La Russa R, Santurro A, Cipolloni L, Viola RV, Di Sanzo M, Frati P, Fineschi V Tags: Curr Pharm Biotechnol Source Type: research

Medical Records Quality as Prevention Tool for Healthcare-Associated Infections (HAIs) Related Litigation: a Case Series.
Abstract Healthcare-associated infections are one of the most serious Public Health concern, as they prolong length of hospitalization, reduce quality of life, and increase morbidity and mortality. Despite they are not completely avoidable, the number of healthcare-associated infections related negligence claims has risen over the last years, contributing to remarkable economic and reputation losses of Healthcare System. In this regard, several studies suggested a key role of medical records quality in determining medical care process, risk management and preventing liability. Clinical documentation should be able...
Source: Current Pharmaceutical Biotechnology - April 7, 2019 Category: Biotechnology Authors: Albano GD, Bertozzi G, Maglietta F, Montana A, Di Mizio G, Esposito M, Mazzeo P, D'Errico S, Salerno M Tags: Curr Pharm Biotechnol Source Type: research

Healthcare-Associated Infections Due to Multidrug-Resistant Organisms: a Surveillance Study on Extra Hospital Stay and Direct Costs.
CONCLUSIONS: The present study presents an accurate mapping of the clinical and economic impact of infections attributable to alert organisms demonstrating that infections due to multidrug-resistant organisms are associated with higher mortality, longer hospital stays, and increased costs. PMID: 30961489 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 7, 2019 Category: Biotechnology Authors: Giraldi G, Montesano M, Frati P, La Russa R, Santurro A, Scopetti M, Napoli C, Orsi GB Tags: Curr Pharm Biotechnol Source Type: research

Multi-walled carbon nanotubes reinforced into hollow fiber by chitosan sol-gel for solid/ liquid phase microextraction of NSAIDs from urine prior to HPLC-DAD analysis.
Abstract The efficient analytical method for analysis of nonsteroidal anti-inflammatory drugs (NSAIDs) in biological fluid are important for determining the toxicological aspects of such long-term used therapies. In the present work, multi-walled carbon nanotubes reinforced into hollow fiber by chitosan sol-gel assisted-solid/ liquid phase microextraction (MWCNTs-HF-CA-SLPME) method followed by high performance liquid chromatography-diode array detection (HPLC-DAD) was developed for determination of three NSAIDs, ketoprofen, diclofenac, and ibuprofen in human urine samples. MWCNTs with various dimensions were char...
Source: Current Pharmaceutical Biotechnology - April 5, 2019 Category: Biotechnology Authors: Al-Hashimi NN, El-Sheikh AH, Qawariq RF, Shtaiwi MH, AlEjielat R Tags: Curr Pharm Biotechnol Source Type: research

Valorization of fruits by-products to unconventional sources of additives, oil, biomolecules and innovative functional foods.
Abstract Owning to the increase in the world population as well as the consumer's awareness on the health benefits of consumption of fruits, the demand for both fresh and processed fruits has been increased. The by-product and waste streams generated from fruit processing industries are extremely diverse, owning mainly to different fruits varieties and the wide range of the processes employed towards the production of the end fruit-based products. Due to the increasing production and processing of fruits, disposal of waste and by-product streams is a very significant issue, since these materials are prone to micro...
Source: Current Pharmaceutical Biotechnology - April 5, 2019 Category: Biotechnology Authors: Dimou C, Karantonis HC, Skalkos D, Koutelidakis AE Tags: Curr Pharm Biotechnol Source Type: research

Catheter-related bloodstream infections: a root cause analysis in a series of simultaneous Ochrobactrum anthropi infections.
zio G Abstract Catheter-related bloodstream infections (CRBSIs) pathogenesis is complex and multifactorial mostly due to cutaneous microorganisms migration through the catheter insertion site and catheter tip colonization. Ochrobactrum anthropi is a gram-negative bacteria belonging to the Brucellaceae and related infections are especially observed in immunocompromised patients. Therefore, O. anthropi infection prevention and surveillance is a relevant issue for healthcare system and risk management, in order to improve healthcare quality and patient safety. Four cases of anthropi-related CRBSIs occurred in immunod...
Source: Current Pharmaceutical Biotechnology - April 5, 2019 Category: Biotechnology Authors: Caroleo B, Malandrino P, Liberto A, Condorelli D, Patanè F, Maiese A, Casella F, Geraci D, Ricci P, Di Mizio G Tags: Curr Pharm Biotechnol Source Type: research

Feasibility of using adjunctive optogenetic technologies in cardiomyocyte phenotyping - from the single cell to the whole heart .
We describe how these are overcome by optogenetic tools which put electrically excitable cells under the control of light. We discuss how this enables studies in cardiac material from the single cell to the whole heart scale. We review the current commercial platforms that incorporate optogenetic stimulation strategies, and summarize the global literature to date on cardiac applications of optogenetics. We show that the advantages of optogenetic stimulation relevant to iPS-CM based screening include independence from contact, elimination of electrical stimulation artefacts in field potential measuring approaches such as th...
Source: Current Pharmaceutical Biotechnology - April 5, 2019 Category: Biotechnology Authors: Bub G, Daniels MJ Tags: Curr Pharm Biotechnol Source Type: research

Tanshinone IIA promotes macrophage cholesterol efflux and attenuates atherosclerosis of apoE-/- mice by Omentin-1/ABCA1 pathway.
CONCLUSIONS: Our results revealed that Tan IIA promotes cholesterol efflux and ameliorates lipid accumulation in macrophages most likely via the Omentin-1/ABCA1pathway, reducing the development of aortic atherosclerosis. PMID: 30947667 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 4, 2019 Category: Biotechnology Authors: Tan YL, Ou HX, Zhang M, Gong D, Zhao ZW, Chen LY, Xia XD, Mo ZC, Tang CK Tags: Curr Pharm Biotechnol Source Type: research

Detection and Extraction of Heparin from Camel Lungs.
CONCLUSION: Preparation of active heparin from camel lung tissue is a technology applicable in manufacturing. Further method development is needed to increase heparin purity and potency. PMID: 30931857 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - April 1, 2019 Category: Biotechnology Authors: Almeman A, Abdulmajed K, Eid EE Tags: Curr Pharm Biotechnol Source Type: research

Computer-Assisted Drug Virtual Screening Based on Natural Product Databases.
CONCLUSION: We highlight the applications of these databases in many fields of virtual screening, and attempt to forecast the importance of the natural product database in next-generation drug discovery. PMID: 30919773 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 27, 2019 Category: Biotechnology Authors: Yang B, Gao B, Lu X, Mao J Tags: Curr Pharm Biotechnol Source Type: research

In vitro antioxidant, antithrombotic, antiatherogenic and antidiabetic activities of Urtica dioica, Sideritis euboea and Cistus creticus water extracts and investigation of pasta fortification with the most bioactive one.
Abstract BACKGROUND: The present work evaluated the in vitro antioxidant, antithrombotic, antiatherogenic and antidiabetic activities of Urtica dioica, Sideritis euboea and Cistus creticus and investigated pasta fortification with the most bioactive one. The methods employed were total phenolic content (TPC) in mg of gallic acid equivalents per g of dried-herb, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radical scavenging in mg of dried-herb, cupric reducing antioxidant capacity (CUPRAC) in micromol trolox equivalent per g of dried-herb, platelet aggregation inhibition (PAF-PAI); plasma ox...
Source: Current Pharmaceutical Biotechnology - March 27, 2019 Category: Biotechnology Authors: Vasiliki G, Charalampia D, Haralabos KC Tags: Curr Pharm Biotechnol Source Type: research

Vancomycin Therapeutic Regime Adjustment In Newborn And Infant With Bacterial Infection: Case Series.
CONCLUSION: The pharmacokinetic adjustment has been proven to be an useful and necessary tool to increase therapeutic efficacy and treatment benefits. Then the standard dose of vancomycin can be used to initiate therapy in neonates and infants admitted to the ICU, but after reaching the drug steady state, the dosing regimen should be individualized and guided by pharmacokinetic parameters. PMID: 30892160 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 19, 2019 Category: Biotechnology Authors: Bidu NS, Fernandes BJD, Dias EJC, Filho JNC, de Andrade Bastos RE, Godoy ALPC, Azeredo FJ, Pedreira JNR, Couto RD Tags: Curr Pharm Biotechnol Source Type: research

Tamarix Articulata (T. articulata) - an important halophytic medicinal plant with potential pharmacological properties.
CONCLUSION: In this review, the spectrum of phytochemical(s) has been summarized for their pharmacological properties and the mechanisms of action, and the possible potential therapeutic applications of this plant against various diseases discussed. PMID: 30887920 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 18, 2019 Category: Biotechnology Authors: Alnuqaydan AM, Rahb B Tags: Curr Pharm Biotechnol Source Type: research

Amruthapala (Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter): A comprehensive review on Diversity, therapeutic uses, and valorization of bioactive constituents.
CONCLUSIONS: The plant has the potential to generate the investigational new lead (IND) based on its major secondary metabolite i.e.2-Hydroxy-4-methoxy-benzaldehyde. The present mini-review summarizes the current knowledge on Decalepis arayalpathra, covering its phytochemical diversity, biological potentials, strategies for its conservation, and intellectual property rights (IPR) status. PMID: 30887919 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 17, 2019 Category: Biotechnology Authors: Mishra S, Srivastava N, Sundaresan V, Shanker K Tags: Curr Pharm Biotechnol Source Type: research

Microorganisms Isolated from Stored Meat in India, with Potential Antimicrobial Activity against Food Pathogens.
CONCLUSION: Leuconostoc are known to be effective in controlling foodborne pathogens and therefore, these strains have the potential for application in food and human. PMID: 30868947 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 14, 2019 Category: Biotechnology Authors: Thangavel G, Thiruvengadam S Tags: Curr Pharm Biotechnol Source Type: research

Effect of pre-analytical conditions on prothrombin time and partial activated thromboplastin time.
CONCLUSION: Results indicate that PT and aPTT can be stored at -70 ºC for at least 1 month without any significant changes in the assay result. PMID: 30868948 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 14, 2019 Category: Biotechnology Authors: Moutinho B, Pinto B, Cardoso R, Alves H, Botelho MC Tags: Curr Pharm Biotechnol Source Type: research

Corticosteroid Catabolism by Klebsiella pneumoniae as a Possible Mechanism for Increased Pneumonia Risk.
CONCLUSION: The presence of corticosteroid catabolism enzymes in K. pneumoniae enhances the ability to utilize corticosteroid for their own nutrition source. This is the first report to demonstrate the corticosteroid degradation pathway in clinical strains of K. pneumoniae. PMID: 30868949 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 13, 2019 Category: Biotechnology Authors: Chattopadhyay P, Banerjee G Tags: Curr Pharm Biotechnol Source Type: research

Combined Amelioration of Ginsenoside (Rg1, Rb1, and Rg3)-enriched Korean Red Ginseng and Probiotic Lactobacillus on Non-Alcoholic Fatty Liver Disease.
Abstract Red ginseng is a traditional medicine that has been used to treat numerous metabolic and inflammatory diseases. Probiotic administration has been established to have beneficial effects in non-alcoholic fatty liver disease (NAFLD). The purpose of this study was to determine whether a combination of Korean red ginseng (KRG) and probiotics could synergistically reduce NAFLD and liver inflammation compared with the effects reported for each individual product. db/db and C57BL/6 mice were fed a normal chow diet and high-fat diet (HFD), respectively, and were treated with KRG, probiotics, or both. Samples were ...
Source: Current Pharmaceutical Biotechnology - March 11, 2019 Category: Biotechnology Authors: Kim JC, Jeon JY, Yang WS, Kim CH, Eom DW Tags: Curr Pharm Biotechnol Source Type: research

Evaluation of polyphenolic profile and antibacterial activity of pomegranate juice in combination with rifampin (R) against MDR-TB clinical isolates.
CONCLUSION: Minimum inhibitory concentration (MIC) of FPJ for first group ranged from (4%-13%), while for second group and third group were approximately between (10%-15%). Thus, FPJ at 15% inhibited 100% of bacteria for all tested isolates (MIC100% =15%). Phenolic compounds identified in FPJ were gallic acid, benzoic acid, syringic, folic acid, pelargonidin, naringin+ellagic acid, naringenin, chlorogenic acid, caffeic acid, catechin, myricetin, Kaempferol, Quercetin, cyanidin-3-glycoside, p-cummaric acid, ferulic acid, and rutin. Total phenolic (TP), total flavonoid (TF), and total anthocyanin (TA) content were 841.5 mg /...
Source: Current Pharmaceutical Biotechnology - March 8, 2019 Category: Biotechnology Authors: AlMatar M, Var I, Kayar B, Eker E, Kafkas E, Zarifikhosroshahi M, Köksal F Tags: Curr Pharm Biotechnol Source Type: research

Medicinal plant compounds for combating the multi-drug resistant pathogenic bacteria: A review.
CONCLUSION: Hence, this paper aims to confer a current overview of the novel compounds, quorum sensing, quorum quenching, biofilm formation in the development of antibiotic resistance and an update on their importance as a potential target for natural substances. PMID: 30854956 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 8, 2019 Category: Biotechnology Authors: Mulat M, Pandita A, Khan F Tags: Curr Pharm Biotechnol Source Type: research

Osteoarthritis: Prognosis and Emerging Therapeutic Approach for Disease Management.
DISCUSSION: Under this review, we have stepped ahead to fixate on the intermediate goal molecules in the osteoarthritis' development pathway and switched the attention toward discovering the new feasible treatment by considering the disease prognosis cross-talking signaling pathway. PMID: 30827234 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 27, 2019 Category: Biotechnology Authors: Kumar A, Palit P, Choudhury MD Tags: Curr Pharm Biotechnol Source Type: research

Role of Probiotics in Prophylaxis of Helicobacter Pylori Infection.
Abstract Helicobacter pylori, a pathogenic bacterium, has been known to be the root cause of numerous gastrointestinal disorders. In patients showing symptoms of its infection, antibiotic therapy is a likely treatment. However, the high cost of antibiotic therapy, associated antibiotic resistance along with other adverse effects has led to the use of probiotics for Helicobacter pylori treatment. In recent times, probiotics have played an essential role as complementary prophylaxis for gastrointestinal diseases, thus minimizing antibiotics' usage and their side effects. Probiotics are live microbial agents that exu...
Source: Current Pharmaceutical Biotechnology - February 27, 2019 Category: Biotechnology Authors: Chakravarty K, Gaur S Tags: Curr Pharm Biotechnol Source Type: research

Sodium Oleate Increases c in Methylophilus quaylei Biofilms on Teflon and Polypropylene.
Conclusion: The study demonstrates that sodium oleate has a promoting activity against planktonic growth of M. quaylei strains and has a slight inhibitory effect on biofilm. Addition of sodium oleate enhances the bactericidal effect of ampicillin against biofilm cells. Combination of ampicillin 0.1 mg/ml (MIC) and sodium oleate 0.03 mg/ml showed a remarkable destruction effect on established biofilms. Overall, results indicated that sodium oleate in combination with ampicillin enhances the inhibition of M. quaylei biofilms and this combination can be utilized for combating bacterial biofilm resistance. PMID: 30806309 ...
Source: Current Pharmaceutical Biotechnology - February 22, 2019 Category: Biotechnology Authors: Abdelzaher Mohamed AMHA, Vladimirovna SN, Grigorievich ZV, Borisovna PA, Ivanovich SV Tags: Curr Pharm Biotechnol Source Type: research

Comparative evaluation of conventional and novel extracts of stem bark of Terminalia arjuna for antihypertensive activity in BSO induced oxidative stress based rat model.
CONCLUSION: The total percentage yield, the yield of the marker compounds arjunolic and arjunic acid, the IC50 values for antioxidant activity as well as the antihypertensive effect was in order: MAE>USAE>SE>RTE that suggested the role of biomarkers arjunolic acid and arjunic acid in reversing the effect of buthionine sulfoxamine. PMID: 30806310 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 22, 2019 Category: Biotechnology Authors: Khatkar S, Nanda A, Ansari SH Tags: Curr Pharm Biotechnol Source Type: research

Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules.
Abstract BACKGROUND: The modern immunology is targeted to the detailed study of various immunopathological conditions at the molecular and cellular level, development of new methods for prevention, diagnostics and treatment of contagious and non-contagious diseases of humans and animals. METHODS: In the present work we took the rats with model of cyclophosphamide-induced immunodeficiency and studied the features of the gender impact of the complex extract of immunocompetent organs (thymus, spleen and mesenteric lymph nodes) Sus scrofa and its separate fraction with molecular weight less than 30 kDa administer...
Source: Current Pharmaceutical Biotechnology - February 22, 2019 Category: Biotechnology Authors: Fedulova LV, Basov AA, Vasilevskaya ER, Dzhimak SS Tags: Curr Pharm Biotechnol Source Type: research

Expression of NRP-1 and NRP-2 in Endometrial Cancer.
CONCLUSION: NRP1 and NRP2 are candidates for complementary diagnostic molecular markers and promising new targets for molecular, personalized anticancer therapies. PMID: 30806307 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 19, 2019 Category: Biotechnology Authors: Oplawski M, Dziobek K, Grabarek B, Zmarzly N, Dabrus D, Januszyk P, Brus R, Tomala B, Boron D Tags: Curr Pharm Biotechnol Source Type: research

Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic- related Liver Diseases and Hepatocellular Carcinoma.
Conclusion: Plant and food-derived sterols and triterpenoids (TTP) possess antioxidant, metabolic-regulating, immunomodulatory, and anti-inflammatory activities, as well as they are recognized as anticancer agents, suggesting their application strongly as an alternative therapy in some chronic diseases. Thus, it is interesting to review current reports about them as hepatoprotective agents, but also because they structurally resemble cholesterol, sexual hormones, corticosteroids and bile acids due to the presence of the steroid nucleus, so they all can share pharmacological properties through activating nuclear and membran...
Source: Current Pharmaceutical Biotechnology - February 19, 2019 Category: Biotechnology Authors: Isabel SC, Eduardo FM, Raquel CC, Gabriel BC, Rosa BA Tags: Curr Pharm Biotechnol Source Type: research

A Novel Oral Glutarimide Derivative XC8 Suppresses Sephadex-Induced Lung Inflammation in Rats and Acute Asthma in Guinea Pigs.
CONCLUSION: The anti-asthmatic effect of XC8 is comparable to that of budesonide. Moreover, in contrast to budenoside treatment XC8 is capable of reducing of airway resistance and degranulating mast cell numbers in the airway tissue. PMID: 30767739 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 14, 2019 Category: Biotechnology Authors: Ferko B, Romanova J, Rydlovskaya AV, Kromova TA, Proskurina OV, Amelina AN, Schmutz H, Renner A, Nebolsin VE Tags: Curr Pharm Biotechnol Source Type: research

Separation, Characterization and Discriminant Analysis of Subvisible Particles in Biologics Formulations.
Abstract The presence of subvisible particles (SVPs) in parenteral formulations of biologics is a major challenge in the development of therapeutic protein formulations. Distinction between proteinaceous and non-proteinaceous SVPs is vital in monitoring formulation stability. The current compendial method based on light obscuration (LO) has limitations in the analysis of translucent/low refractive index particles. A number of attempts have been made to develop an unambiguous method to characterize SVPs, albeit with limited success. Herein, we describe a robust method that characterizes and distinguishes both poten...
Source: Current Pharmaceutical Biotechnology - February 13, 2019 Category: Biotechnology Authors: Akhunzada ZS, Hubert M, Sahin E, Pratt J Tags: Curr Pharm Biotechnol Source Type: research

Nutritional culturomics and big data: Macroscopic patterns of change in food, nutrition and diet choices.
Abstract Nutritional culturomics (NCs) is a specific focus area of culturomics epistemology developing digital humanities and computational linguistics approaches to search for macro-patterns of public interest in food, nutrition and diet choice as a major component of cultural evolution. Cultural evolution is considered as driver at the interface of environmental and food science, economy and policy. The paper presents an epistemic programme that builds on the use of big data from web-based services such as Google Trends, Google Adwords or Google Ngram Viewer. A comparison of clearly defined NCs in terms of geogr...
Source: Current Pharmaceutical Biotechnology - February 11, 2019 Category: Biotechnology Authors: Troumbis AY, Hatziantoniou M, Vasios GK Tags: Curr Pharm Biotechnol Source Type: research

Valorization of crude glycerol, residue deriving from biodiesel-production process, with the use of wild-type new isolated Yarrowia lipolytica strains: production of metabolites with pharmaceutical and biotechnological interest.
Abstract Crude glycerol (Glol), used as substrate for screening eleven natural Yarrowia lipolytica strains in shake-flask experiments. Aim of this study was to assess the ability of the screened strains to produce biomass (dry cell weight; X), lipid (L), citric acid (Cit), mannitol (Man), arabitol (Ara) and erythritol (Ery), compounds presenting pharmaceutical and biotechnological interest, in glycerol-based nitrogen-limited media, in which initial glycerol concentration had been adjusted to 40 g/L. Citric acid may find use in biomedical engineering (i.e. drug delivery, tissue engineering, bioimaging, orthopedics,...
Source: Current Pharmaceutical Biotechnology - February 11, 2019 Category: Biotechnology Authors: Sarris D, Sampani Z, Rapti A, Papanikolaou S Tags: Curr Pharm Biotechnol Source Type: research

Antitumoral and anticholinesterasic activity of the seven species from Rubiaceae.
CONCLUSION: Herein, the anticholinesterasic and antiproliferative activity of extracts produced from species of Psychotria and Palicourea genus with anticholinesterasic and antiproliferative activity is reported. PMID: 30747062 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 11, 2019 Category: Biotechnology Authors: Volobuff CRF, de Oliveira PC, Dos Santos SM, Pereira ZV, Ferreira DC, Cardoso CAL, Ruiz ALTG, Foglio MA, de Carvalho JE, Formagio ASN Tags: Curr Pharm Biotechnol Source Type: research

Improve Healthcare quality through Mortality Committee: Retrospective analysis of Bambino Ges ù Children Hospital's ten years' experience 2008-2017.
CONCLUSION: Introduction of the mortality review committee has proved to be a valid instrument to improve the quality of the care provided in a hospital, allowing early identification of care gaps that could lead to an increase in mortality rates. PMID: 30747063 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - February 11, 2019 Category: Biotechnology Authors: Offidani C, Lodise M, Gatto V, Frati P, D'Errico S, Degli Atti MLC, Raponi M Tags: Curr Pharm Biotechnol Source Type: research