LC-MS/MS Determination of Apigenin in Rat Plasma and Application to Pharmacokinetic Study.
CONCLUSION: The assay has been successfully applied to the pharmacokinetic study of apigenin in rats. PMID: 32767914 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - August 6, 2020 Category: Biotechnology Authors: Zhu S, Zhang J, Lv Z, Yu M Tags: Curr Pharm Biotechnol Source Type: research

Ginseng Omics for Ginsenoside Biosynthesis.
Abstract Ginseng, also known as the king of herbs, has been regarded as an important traditional medicine for several millennia. Ginsenosides, a group of triterpenoid saponins, have been characterized as bioactive compounds of ginseng. The complexity of ginsenosides hindered ginseng research and development both in cultivation and in clinical research. Therefore, deciphering the ginsenoside biosynthesis pathway has been a focus of interest for researchers worldwide. The new emergence of biological research tools consisting of omics and bioinformatic tools or computational biology tools are the research trend in th...
Source: Current Pharmaceutical Biotechnology - August 6, 2020 Category: Biotechnology Authors: Yin X, Hu H, Shen X, Li X, Pei J, Xu J Tags: Curr Pharm Biotechnol Source Type: research

Scaling up the enzymatic hydrolysis of bovine plasma protein to produce an antioxidant from a biological source.
CONCLUSION: The results showed that while DH depends on So, the antioxidant capacity only depends on the DH. Additionally, the dimensional analysis using Re as a scaling criterion obtain allowed us to obtain the same results in the model (1 L) and the prototype (5 L). PMID: 32767916 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - August 6, 2020 Category: Biotechnology Authors: Grimaldos NAG, Zapata JEM Tags: Curr Pharm Biotechnol Source Type: research

Evaluation of Microbiological Contamination of Dummies used in Cardio-pulmonary Resuscitation in Korea.
CONCLUSION: To minimize the possibility of secondary infections during CPR training, there is a requirement for a standardized protocol for proper microbiological management of dummies. PMID: 32767917 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - August 6, 2020 Category: Biotechnology Authors: Cho SH, Bak YS, Kim CH, Kim JB Tags: Curr Pharm Biotechnol Source Type: research

Comparative Inhibitory Efficacy on the iNOS/NO System of Curcumin- and Tetrahydrocurcumin-Self-Microemulsifying Liquid Formulation in Chronic Gastric Ulcer Model.
CONCLUSION: The SMEDDS used in the study could bring an enhancement of inhibitory efficacy on the iNOS/NO system of antiulcer drug, leading to a reduction of daily dosing and dosing frequency. PMID: 32767918 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - August 6, 2020 Category: Biotechnology Authors: Mahattanadul S, Kongpuckdee S, Wiwattanapatapee R, Tansakul P, Nitiruangjaras A, Hansakul P Tags: Curr Pharm Biotechnol Source Type: research

Three-decade failure to eradication of refractory Helicobacter pylori infec-tion and recent efforts to eradicate the infection.
CONCLUSION: Eradication of H. pylori is crucial for the treatment of important diseases such as gastric cancer. Therefore, it seems that identifying the failure causes of treating this bacterium can be helpful in controlling the infections. Besides, further studies on new therapeutic strategies may help eradicate H. pylori in the future. PMID: 32767919 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - August 6, 2020 Category: Biotechnology Authors: Moghadam MT, Chegini Z, Norouzi A, Dosari AS, Shariati A Tags: Curr Pharm Biotechnol Source Type: research

The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review.
Abstract SARS-CoV 2 is a novel virus strain of Coronavirus, reported in China in late December 2019. Its highly contagious nature in humans has prompted WHO to designate the ongoing pandemic as a Public Health Emergency of International Concern. At this moment, there is no specific treatment and the therapeutic strategies to deal with the infection are only supportive, and prevention aimed at reducing community transmission. A permanent solution for the pandemic, which has brought the world economy to the edge of collapse, is the need of the hour. This situation has brought intense research in traditional systems ...
Source: Current Pharmaceutical Biotechnology - August 6, 2020 Category: Biotechnology Authors: Adithya J, Nair B, Aishwarya S, Nath LR Tags: Curr Pharm Biotechnol Source Type: research

Challenges in oral drug delivery and applications of lipid nanoparticles as potent oral drug carriers for managing cardiovascular risk factors.
Conclusion: In this review, the most current and promising studies involving Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as oral drug carriers are reported aiming to assist researchers who focus their research on lipid based nanoparticles. PMID: 32753006 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - August 4, 2020 Category: Biotechnology Authors: Okur NÜ, Siafaka PI, Gökçe EH Tags: Curr Pharm Biotechnol Source Type: research

HIV-Tuberculous Meningitis Co-infection: A Systematic Review and Meta-analysis.
This study shows a high prevalence of TBM-HIV co-infection. Establishing proper diagnostic criteria and preventive measures for TBM infections could assist in the prevention and management of TBM infection, particularly TBM-HIV co-infection. PMID: 32744963 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 30, 2020 Category: Biotechnology Authors: Purmohamad A, Azimi T, Nasiri MJ, Goudarzi M, Zangiabadian M, Sedighian H, Fooladi AAI Tags: Curr Pharm Biotechnol Source Type: research

Antimicrobial properties of actively purified secondary metabolites isolated from different marine organisms.
CONCLUSION: A thorough literature search has been made and summarizes the list of antimicrobial compounds that are isolated from both prokaryotic and eukaryotic marine organisms. The information obtained from the present paper will be helpful for the application of marine compounds as antimicrobial agents against different antibiotic-resistant human pathogenic bacteria. PMID: 32744964 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 30, 2020 Category: Biotechnology Authors: Arachchige NIB, Khan F, Kim YM Tags: Curr Pharm Biotechnol Source Type: research

Leaf and Fruit Methanolic Extracts of Azadirachta indica Exhibit Anti-fertility Activity on Rats' Sperm Quality and Testicular Histology.
CONCLUSION: The methanolic extracts of Azadirachta indica have a modulating effect on the spermatogenesis of experimental rats through sperm morphological alterations. PMID: 32744965 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 30, 2020 Category: Biotechnology Authors: Castillo-Maldonado I, Borjón-Ríos C, Pedroza-Escobar D, Sharma A, García-Garza R, Ramírez-Moreno A, Del CarmenVega-Menchaca M, Rivera-Guillén MA, Serrano-Gallardo LB Tags: Curr Pharm Biotechnol Source Type: research

Leveraging on Active Site Similarities; Identification of Potential Inhibitors of Zinc-Finger and UFSP domain Protein (ZUFSP).
Abstract ZUFSP (Zinc-finger and UFSP domain protein) is a novel representative member of the recently characterized seventh class of Deubiquitinating Enzymes (DUBs). Due to the roles DUBs play in genetic instability, they have become a major drug target in cancer and neurodegenerative diseases. ZUFSP, being a DUB enzyme has also been implicated in genetic instability. However, no inhibitor has been developed to target ZUFSP. Therefore, in this study, we used a combined drug repurposing, virtual screening and per-Residue Energy Decomposition (PRED) to identify ZUFSP inhibitors with therapeutic potential. 3-bromo-6-...
Source: Current Pharmaceutical Biotechnology - July 30, 2020 Category: Biotechnology Authors: Ajadi MB, Soremekun OS, Adewumi AT, Kumalo HM, Soliman MES Tags: Curr Pharm Biotechnol Source Type: research

Roles and Biomedical Applications of Haemolymph Lectin.
Abstract Lectins are class of proteins characterized by their ability to selectively bind carbohydrate moieties of glycoproteins. Many invertebrate lectins, especially derived from hemolymph are being purified and yet their functions and medical applications are subjects of major interest. Hemolymph lectins in invertebrates play a major role in protecting against many pathogens and microbes. Further, many hemolymph lectins show anticancer properties towards various cancer cell lines which expresses globotriaosyl ceramides on their cell surface. These vast repertoires of hemolymph lectins in recognizing and inhibit...
Source: Current Pharmaceutical Biotechnology - July 30, 2020 Category: Biotechnology Authors: Kamei R, Devi OS, Singh SJ, Singh SS Tags: Curr Pharm Biotechnol Source Type: research

Palmatine Inhibits Up-Regulation of GRP78 and CALR Protein in a STZ-Induced Diabetic Rat Model.
CONCLUSION: Palmatine may have activated antioxidant proteins, which protected the cells against reactive oxygen species and endoplasmic stress. The result is in consonance with our previous report on Palmatine. PMID: 32744968 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 30, 2020 Category: Biotechnology Authors: Okechukwua PN, Kuan CH, Eluri K, Ekeuku SO, Froemming GRA Tags: Curr Pharm Biotechnol Source Type: research

Stereoselective pharmacokinetics and chiral inversions of some chiral hy-droxy group drugs.
CONCLUSION: In vitro and in vivo chiral inversion is a very complex problem and may occur during every process of ADME. Nowadays, research on chiral metabolism in the liver has the most attention, while neglecting the chiral transformation of other processes. Our review may provide basis for the drug R&D and the safety of drugs in clinical therapy. PMID: 32718284 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 27, 2020 Category: Biotechnology Authors: Chen F, Bai Q, Wang Q, Chen S, Ma X, Cai C, Wang D, Waqas A, Gong P Tags: Curr Pharm Biotechnol Source Type: research

Enhanced intracellular delivery of Curcumin by Chitosan-Lipoic acid as reduction-responsive nanoparticles.
CONCLUSION: CS-LANPs showed a remarkably increased accumulation in tumor cells and had a better tumor inhibitory activity in vitro. CS-LANPs could successfully deliver drugs to cancer cells and revealed better efficiency than free CUR. PMID: 32720599 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 27, 2020 Category: Biotechnology Authors: Rezaei S, Kashanian S, Bahrami Y, Zhaleh H, Cruz LJ Tags: Curr Pharm Biotechnol Source Type: research

Clinicopathological Significance of Long Non-Coding RNA GHET1 in Human cancers: A Meta-Analysis.
CONCLUSION: Taken together, the current study demonstrated that overexpression of lncRNA GHET1 is significantly associ-ated with clinicopathological features in human cancers. Our results suggested that lncRNA GHET1 can be utilized as a prognostic biomarker in human cancer. PMID: 32720600 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 27, 2020 Category: Biotechnology Authors: Poursheikhani A, Nokhandani N, Yousefi H, Rad DM, Sahebkar A Tags: Curr Pharm Biotechnol Source Type: research

Optimization, purification and antitumor Activity of Kodamaeoh MRI ANOMY L-Asparaginase MN611146 Isolated from Banana Peel.
This study described the isolation, screening of a local yeast isolate from banana peel for L-asparaginase production using submerged fermentation, optimization of the production, purification, and anticancer assay of L-asparaginase. The yeast isolate was identified as Kodamae ohmri ANOMY based on the analysis of nuclear large subunit (26S) rDNA partial sequences. It was a promising L-asparaginase producer with a specific activity of 3059±193 U/mg in a non-optimized medium. The classical one-variable-at-a-time method was used to optimize the production medium components, and it was found that the elimination of K2HP...
Source: Current Pharmaceutical Biotechnology - July 23, 2020 Category: Biotechnology Authors: Shabana AMI, Alfarouk OR, Abdelwahed NAM, Esawy MA, Shetaia YM Tags: Curr Pharm Biotechnol Source Type: research

Cytotoxic effects of blue scorpion venom (Rhopalurus junceus) in a glioblastoma cell line model.
CONCLUSION: It is possible that the action mechanism could be associated with a loss of membrane integrity. Additionally, some metalloproteinases as MMP2 and MMP9 may also participate in the potential action mechanism. PMID: 32679017 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 16, 2020 Category: Biotechnology Authors: Lozano-Trujillo LA, Garzón-Perdomo DK, Vargas ACR, de Los Reyes LM, Avila-Rodriguez MF, Gay OTG, Turner LF Tags: Curr Pharm Biotechnol Source Type: research

Dietary Quercetin Alleviated DSS-induced Colitis in Mice through Several Possible Pathways by Transcriptome Analysis.
CONCLUSION: We demonstrated that dietary quercetin alleviated the DSS-induced colitis in mice. This is most likely due to its beneficial effects on intestinal integrity and modulation of several key pathways. Based on our research quercetin was a promising candidate for IBD and its pharmaceutical effects on both IBD and colongenesis need further research. PMID: 32651963 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 11, 2020 Category: Biotechnology Authors: Dong Y, Lei J, Zhang B Tags: Curr Pharm Biotechnol Source Type: research

Efficacy of an aqueous Morinda citrifolia fruit extract-phytosome gel in treating oral inflammatory ulcer in rabbit model.
CONCLUSION: These findings demonstrated that 10% AMFE-P gel has potential as a safe and effective alternative therapeutic agent for oral ulcers. PMID: 32651964 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 11, 2020 Category: Biotechnology Authors: Kongpuckdee S, Ungphaiboon S, Sungkharak S, Phadoongsombut N, Mahattanadul S Tags: Curr Pharm Biotechnol Source Type: research

Evaluation of Variances in VEGF-A-D and VEGFR-1-3 Expression in the Ishikawa Endometrial Cancer Cell Line Treated with Salinomycin and An-ti-Angiogenic/Lymphangiogenic Effect.
Abstract BACKGROUND: In cancer, an excessive and uncontrolled process of creating new blood and lymphatic vessels that play a key role in the metastasis process can be observed. The vascular endothelial growth factor (VEGF-A,-B,-C,-D) family together with their specific receptors (VEGFR-1,-2,-3) plays a key role in these processes, therefore it would be reasonable to determine the correct pattern of their expression. OBJECTIVE: The study aimed to assess the use of salinomycin as an anti-angiogenic and anti-lymphangiogenic drug during endometrial cancer by examining changes in the expression pattern of VEGF-A,...
Source: Current Pharmaceutical Biotechnology - July 9, 2020 Category: Biotechnology Authors: Kras P, Talkowski K, Grabarek BO, Dziobek N, Boroń D, Oplawski M Tags: Curr Pharm Biotechnol Source Type: research

Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility.
Conclusion: nistration, which was probably caused by its low permeability and solubility. This study may provide a reference for the rational clinical use and further study on the pharmacology or toxicology of timosaponin A-III. PMID: 32634081 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 7, 2020 Category: Biotechnology Authors: Wang HQ, Gong XM, Lan F, Zhang YH, Xia JE, Wang L, Zhang H, Liu M Tags: Curr Pharm Biotechnol Source Type: research

Bacteriocins, a natural weapon against bacterial contamination for greater safety and preservation of food.
Abstract Nowadays, consumers have become increasingly attentive to human health and the use of more natural products. Consequently, the demand for natural preservatives in the food industry is more frequent. This has led to an intense research to discover new antimicrobial compounds of natural origin which could effectively fight foodborne pathogens. This research aims to safeguard the health of consumers and, above all, to avoid potentially harmful chemical compounds. Lactobacillus is a bacterial genus belonging to the Lactic Acid Bacteria and many strains are defined GRAS, generally recognized as safe. These str...
Source: Current Pharmaceutical Biotechnology - July 4, 2020 Category: Biotechnology Authors: Fuochi V, Emma R, Furneri PM Tags: Curr Pharm Biotechnol Source Type: research

Correlation Between BCL2 And Mcl1 Single Nucleotide Polymorphisms and Chemotherapy Response in Jordanian Patients with Colorectal Cancer.
CONCLUSION: The BCL2 SNPs (rs2279115) and MCL1 SNP (rs9803935) present as important determinants of the progress of CRC in Jordanian patients. PMID: 32619164 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 3, 2020 Category: Biotechnology Authors: Mhaidat NM, Amawi H, Alzoubi KH Tags: Curr Pharm Biotechnol Source Type: research

Long Term Prognostic Utility of Matrix Metalloproteinase-9 in Patients with Acute Coronary Syndrome - A Systematic Review.
CONCLUSION: MMP-9 can be a potential prognostic marker for ACS and aid in identifying high risk patients for intensive management during follow -up. PMID: 32619165 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 3, 2020 Category: Biotechnology Authors: Das A, George M, Jha D, Goenka L Tags: Curr Pharm Biotechnol Source Type: research

Nutraceutical Status and Scientific Strategies for Enhancing Production of Omega-3 Fatty Acids from Microalgae and Their Role in Healthcare.
Abstract Adherence to Omega-3 fatty acids (O3FAs) as Nutraceuticals for medicinal applications provides health improvement. The prevention and treatment of diseases with O3FAs hold promise clinical therapy and significantly reduces risk of chronic disorders. Polyunsaturated fatty acids (PUFA) O3FAs has beneficial effects in the treatment of cardiovascular disorders, diabetic disease, foetal development, Alzheimer's disease, retinal problem, growth and brain development of infants and antitumor effects. Association to current analysis promotes application of algal biomass for production of O3FAs, mode of action, fa...
Source: Current Pharmaceutical Biotechnology - July 3, 2020 Category: Biotechnology Authors: Gupta J, Gupta R Tags: Curr Pharm Biotechnol Source Type: research

Effect of the Phytochemical Agents Against the SARS-CoV and Selected Some of them for Application to COVID-19: A Mini-Review.
CONCLUSION: Nigella sativa has potent anti-SARS-CoV activity and it might be useful souce for developing novel antiviral therapies for coronaviruses. PMID: 32619167 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 3, 2020 Category: Biotechnology Authors: Idrees M, Khan S, Memon NH, Zhang Z Tags: Curr Pharm Biotechnol Source Type: research

Synthesis, in-vitro and in-silico evaluation of Silver Nanoparticles with Root Extract of Withania somnifera for antibacterial activity via binding of penicillin binding protein-4.
CONCLUSION: The in-silico and molecular docking analysis showed that active constituents of W. somnifera such as Somniferine, Withaferin A, Withanolide A, Withanolide G, Withanolide M, and Withanone possesses inhibition potential for PBP4 and responsible for the antibacterial property of W. somnifera extract. This study also establishes that AgNPs via the green synthesis with REWS showed enhanced antibacterial activity towards pathogenic bacteria. PMID: 32614743 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - July 2, 2020 Category: Biotechnology Authors: Gaurav I, Singh T, Thakur A, Kumar G, Rathee P, Kumari P, Sweta K Tags: Curr Pharm Biotechnol Source Type: research

Novel Therapeutic Approaches And Targets For Treatment Of Chronic Urticaria: New Insights And Promising Targets For A Challenging Disease.
CONCLUSION: Although omalizumab has been a breakthrough in the treatment of CSU, many patients do not completely benefit and even require more effective treatments. Novel drugs are under investigation with promising results. PMID: 32603278 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 30, 2020 Category: Biotechnology Authors: Martina E, Diotallevi F, Bianchelli T, Paolinelli M, Offidani A Tags: Curr Pharm Biotechnol Source Type: research

Matrix Metalloproteinase Inspired Therapeutic Strategies for Bone Diseases.
Abstract Matrix metalloproteinases (MMPs), as a family of zinc-containing enzymes, show the function of decomposing extracellular matrix (ECM) and participate in the physiological processes of cell migration, growth, inflammation, and metabolism. Clinical and experimental studies have indicated that MMPs play an essential role in tissue injury and repair as well as tumor diagnosis, metastasis, and prognosis. An increasing number of researchers have paid attention to their functions and mechanisms in bone health and diseases. The present review focuses on MMPs-inspired therapeutic strategies for the treatment of bo...
Source: Current Pharmaceutical Biotechnology - June 30, 2020 Category: Biotechnology Authors: Kou L, Jiang X, Lin X, Huang H, Wang J, Yao Q, Chen R Tags: Curr Pharm Biotechnol Source Type: research

Application of Phenotype Microarray for Profiling Carbon Sources Utilization between Biofilm and Non-Biofilm of Clinical Isolates Pseudomonas aeruginosa.
In this study, the biofilm isolates utilized uridine, threonine, and serine while non-biofilm isolates utilized adenosine, inosine, monomethyl, sorbic acid, and succinamic acid. Sugar utilization was seen between the isolates adhering that biofilm P. aeruginosa preferred glucoside, galactoside, glucuronide, glucosaminide, mannoside, and galactosaminide, but it was not utilized by the non-biofilm. The outcome of this result can be used for future studies to improve detection or inhibition of the growth of clinical P. aeruginosa biofilm and non-biofilm, respectively. PMID: 32598252 [PubMed - as supplied by publisher] (S...
Source: Current Pharmaceutical Biotechnology - June 29, 2020 Category: Biotechnology Authors: Ismail NS, Subbiah SK, Taib NM Tags: Curr Pharm Biotechnol Source Type: research

Novel Therapeutic Approaches And Targets For Treatment Of Psoriasis.
CONCLUSION: Courrently approved novel biologic therapies for moderate to severe psoriasis revealed an increasing effectivness compared to previous biological therapy and a good safety profile. PMID: 32598253 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 29, 2020 Category: Biotechnology Authors: Radi G, Campanati A, Diotallevi F, Bianchelli T, Offidani A Tags: Curr Pharm Biotechnol Source Type: research

Analysis of the differences in the Expression of mRNAs and miRNAs Asso-ciated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin.
CONCLUSIONS: Salinomycin induces changes in the activity of mRNA and miRNA participating in drug resistance, however the observed changes in character are an expected result of anti-cancer treatment. PMID: 32598254 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 29, 2020 Category: Biotechnology Authors: Januszyk P, Januszyk K, Wierzbik-Strońska M, Boroń D, Grabarek B Tags: Curr Pharm Biotechnol Source Type: research

Pitavastatin Combined with Ezetimibe Treatment was an Effective Approach to Non-IRA Lesion of ST-segment Elevation Myocardial Infarc-tion Patients with Primary Percutaneous Coronary Intervention.
In this study, we have evaluated the detailed therapeutic effect of statin plus ezetimibe intensive therapy. METHOD: For STEMI patients with non-IRA disease undergoing primary percutaneous coronary intervention (PCI), 183 control STEMI patients without non-IRA disease undergoing primary PCI, and 200 STEMI patients with non-IRA disease undergoing primary PCI were introduced into this study. 200 STEMI patients with non-IRA disease undergoing primary PCI were divided into Normal group, Intensive group, Normal & Combined group, and Intensive & Combined group. The baseline information for each participant was recor...
Source: Current Pharmaceutical Biotechnology - June 29, 2020 Category: Biotechnology Authors: Zhao B, Li GP, Peng JJ, Ren LH, Lei LC, Ye HM, Wang ZY, Zhao S Tags: Curr Pharm Biotechnol Source Type: research

In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase.
CONCLUSIONS: Findings suggest that J147 can stabilize the mutant protein and restore it to a similar structural state as the wild-type which depicts functionality. These details could be employed in drug design for potential drug resistance cases due to mATPase mutations that may present in the future. PMID: 32598251 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 28, 2020 Category: Biotechnology Authors: Emmanuel IA, Olotu FA, Agoni C, Soliman MES Tags: Curr Pharm Biotechnol Source Type: research

Unveiling Role of MicroRNAs as Treatment Strategy and Prognostic Markers in Triple Negative Breast cancer.
Abstract Triple negative breast cancer is the highly aggressive form of breast cancer with high re-occurrence rate and is short of effective treatment strategy. The prognostic markers of it are also not well understood. miRNAs are the global regulators of various cancers on virtue of its ability of post transcriptional regulation of genes involved in various pathways involved in complicating TNBC. In this review we studied the expression of miRNAs at different stages of TNBC and the role of miRNAs as tumor suppressor to inhibit cell proliferation, angiogenesis, invasion and metastasis and to induce apoptosis and t...
Source: Current Pharmaceutical Biotechnology - June 27, 2020 Category: Biotechnology Authors: Balkrishna A, Mittal R, Arya V Tags: Curr Pharm Biotechnol Source Type: research

Development of New Therapeutics to Meet the Current Challenge of Drug Resistant Tuberculosis.
Abstract Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/morbidity globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant proportion of human population. The increasing burden of tuberculosis is mainly caused due to drug and multi drug-resistant. The failure of conventional treatment has been observed in large number of cases. Drugs that are used to treat extensively drug-resistant tuberculosis are expensive, have limited efficacy and with more side effects for longer duration of time and is often associated with poor prognosis. To regulate t...
Source: Current Pharmaceutical Biotechnology - June 27, 2020 Category: Biotechnology Authors: Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, Mir MA Tags: Curr Pharm Biotechnol Source Type: research

Comparison of different molecular forms of astaxanthin in inhibiting lipogenesis and its mechanism.
CONCLUSION: At the cellular level, both two kinds of astaxanthins inhibit the synthesis of intracellular fatty acids and triglycerides. Notably, the inhibition effect of C8-AST is better than F-AST overall. PMID: 32589556 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 26, 2020 Category: Biotechnology Authors: Li Y, Liu Y, Tian Y, Guo Y, Xue C, Wang J Tags: Curr Pharm Biotechnol Source Type: research

Effects and Mechanisms of Anlotinib and Dihydroartemisinin Combination Therapy in Ameliorating Malignant Biological Behavior of Gastric Cancer Cells.
Conclusion:The combination of anlotinib and DHA showed synergistic antitumor activity, suggesting their potential in treating patients with gastric cancer. PMID: 32576126 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 23, 2020 Category: Biotechnology Authors: Luo Q, Zhang S, Zhang D, Feng R, Li N, Chen W, Chen X, Yang S Tags: Curr Pharm Biotechnol Source Type: research

In-vitro Screening and Biosynthesis of Secondary Metabolites from a New Streptomyces sp. SA1 from a Marine Environment.
CONCLUSION: Actinomycetes, especially Streptomyces play an important source for bioactive compounds that are used to treat infections, and many other diseases. The isolated Streptomyces sp. was a good producer of antibacterial agent, which required various nutritional supplements in the culture medium. The optimized medium components investigated in this study will be useful for future studies with mass production of secondary metabolites. PMID: 32568017 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 22, 2020 Category: Biotechnology Authors: Almalki MA Tags: Curr Pharm Biotechnol Source Type: research

A current perspective of plants as an antibacterial agent: A review.
Abstract With the emergence and evolution of bacterial strains, it is now becoming difficult for pharmaceutical industries to provide the remedies required for the betterment of mankind. Continuous exposure with available medication leads to development of new strains with a significant amount of resistance, due to which pharmaceutical industries are facing various challenges. Antimicrobial resistance is the phenomenon causing a challenge in new drug development via conventional methods. Therefore, requirement of an alternative medicine is of high demand. Recently, allopathic medicines have seen a disinterest and ...
Source: Current Pharmaceutical Biotechnology - June 22, 2020 Category: Biotechnology Authors: Garg S, Roy A Tags: Curr Pharm Biotechnol Source Type: research

Transcriptional factor-Mediated Regulation of Active Component Biosynthesis in Medicinal Plants.
CONCLUSION: Recent progress has been made in the cloning and characterization of transcription factors in medicinal plants on the genome scale. So far, several large transcription factors have been identified in MYB, WRKY, bHLH, ZIP, AP2/ERF transcription factors. These transcription factors have been predicted to regulate bioactive compound production. These transcription factors positively or negatively regulate the expression of multiple genes encoding key enzymes, and thereby control the metabolic flow through the biosynthetic pathway. Although the research addressing this niche topic is in its infancy, significant pro...
Source: Current Pharmaceutical Biotechnology - June 22, 2020 Category: Biotechnology Authors: Wang M, Qiu X, Pan X, Li C Tags: Curr Pharm Biotechnol Source Type: research

CRISPR Genome Editing Technology and its Application in Genetic Diseases: A Review.
Abstract Gene therapy has been a long-lasting goal of scientists and there are many ideal methods and tools that have been developed to correct disease-causing mutations in human. Recently, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology has been progressively used for the assessment or treatment of human diseases, including Thalassemia, Parkinson disease, Cystic Fibrosis, Glaucoma, Huntington's disease and Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS). CRISPR sequences is a part of the bacterial immune system, which includes nuclease Cas enzyme and a RNA ...
Source: Current Pharmaceutical Biotechnology - June 21, 2020 Category: Biotechnology Authors: Khatibi S, Sahebkar A, Bakhtiari SHA Tags: Curr Pharm Biotechnol Source Type: research

The Research Progress of taxol in Taxus.
CONCLUSION: The taxol content is not only dependent on the species, age and tissues, but also affected by light, moisture levels, temperature, soil fertility and microbes. Most of the enzymes in taxol biosynthesis pathway have been identified and characterized. Total chemical synthesis, semi-synthesis, plant cell culture and biosynthesis in endophytic fungi have been explored to product taxol. Multi-omics have been used to study on Taxus and taxol. Further efforts in the identification of unknown enzymes in taxol biosynthesis pathway, establishment of the genetic transformation system in Taxus and the regulatory mechanism ...
Source: Current Pharmaceutical Biotechnology - June 21, 2020 Category: Biotechnology Authors: Shao F, Wilson IW, Qiu D Tags: Curr Pharm Biotechnol Source Type: research

Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer.
CONCLUSION: It was confirmed that salinomycin has the influence for the stemness process. The most noticeable changes in the expression were noted for mRNA: TGFβ2; COL14A1; CDH2; WNT5A, as well as for miRNA: hsa-miR-200a; hsa-miR33a; hsa-miR-199a; hsa-miR-371-5p; hsa-miR-411; hsa-miR-374a; hsa-miR-374b. PMID: 32564748 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 21, 2020 Category: Biotechnology Authors: Talkowski K, Kiełbasiński K, Peszek W, Grabarek BO, Boroń D, Oplawski M Tags: Curr Pharm Biotechnol Source Type: research

The Spectrum of Thiazolidinediones Against Respiratory Tract Pathogenic Bacteria: An In-Vitro and In-Silico Approach.
CONCLUSION: DTZD12 and DTZD16 can be developed into antibacterial drugs for respiratory tract infections to oppose bacterial resistance, or can also be used as leads for repurposing the existing 2,4-thiazolidinediones. PMID: 32552647 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 18, 2020 Category: Biotechnology Authors: Al Bratty M, Hakami AQ, Masmali HA, Alam MS, Alhazmi HA, Thangavel N, Najmi A, Moni SS, Haque A Tags: Curr Pharm Biotechnol Source Type: research

Gallic acid protects from acute multiorgan injury induced by lipopolysaccharide and D-galactosamine.
CONCLUSION: Gallic acid minimized oxidative stress and provided best protection at 20 mg/kg dose against LPS and D-GalN induced multi organ acute injury. PMID: 32538720 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 15, 2020 Category: Biotechnology Authors: Rakshit S, Nirala SK, Bhadauria M Tags: Curr Pharm Biotechnol Source Type: research

Ameliorating Effects of Lithium on the Perinatal Ethanol-induced Behavioral and Cognitive Dysfunction and Brain Oxidative Stress in Postnatal Developing Mice Pups.
Conclusion: These results indicate that Li ameliorates significantly and dose-dependently EtOH induced developmental toxicities like morphological developments and dysfunctions in cognitive retention and oxidative stress in brain on a longterm basis in brain tissue. However, further detailed studies are required for the clinical use of lithium as an ameliorating agent for perinatal EtOH induced dysfunctions. PMID: 32538721 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 15, 2020 Category: Biotechnology Authors: Ahmad M, Taweel GMA Tags: Curr Pharm Biotechnol Source Type: research

Peptides from Euphausia superba Promote Longitudinal Bone Growth by Accelerating Growth Plate Chondrocyte Proliferation and Hypertrophy.
CONCLUSION: AKPs promoted longitudinal bone growth by activating GH/IGF-1 axis, BMP-2/Smads and Wnt/β-catenin pathways, suggesting AKPs to be a potential nutrient fortifier for longitudinal bone growth. PMID: 32532190 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - June 12, 2020 Category: Biotechnology Authors: Dai Y, Li Z, Fu M, Li Y, Xue C, Wang J Tags: Curr Pharm Biotechnol Source Type: research