The impact of physical exercise on hippocampus, in physiological condition and ageing-related decline: current evidence from animal and human studies
Curr Pharm Biotechnol. 2021 Apr 5. doi: 10.2174/1389201022666210405142611. Online ahead of print.ABSTRACTPhysical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results to be a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various districts of the body, determining biological and psychological benefits. Additionally, in elderly, PE might represent a remarkable tool reducing cognitive impairments re...
Source: Current Pharmaceutical Biotechnology - April 6, 2021 Category: Biotechnology Authors: Giovanni Lauretta Silvia Ravalli Grazia Maugeri Velia D'Agata Michelino Di Rosa Giuseppe Musumeci Source Type: research

The impact of physical exercise on hippocampus, in physiological condition and ageing-related decline: current evidence from animal and human studies
Curr Pharm Biotechnol. 2021 Apr 5. doi: 10.2174/1389201022666210405142611. Online ahead of print.ABSTRACTPhysical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results to be a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various districts of the body, determining biological and psychological benefits. Additionally, in elderly, PE might represent a remarkable tool reducing cognitive impairments re...
Source: Current Pharmaceutical Biotechnology - April 6, 2021 Category: Biotechnology Authors: Giovanni Lauretta Silvia Ravalli Grazia Maugeri Velia D'Agata Michelino Di Rosa Giuseppe Musumeci Source Type: research

The impact of physical exercise on hippocampus, in physiological condition and ageing-related decline: current evidence from animal and human studies
Curr Pharm Biotechnol. 2021 Apr 5. doi: 10.2174/1389201022666210405142611. Online ahead of print.ABSTRACTPhysical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results to be a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various districts of the body, determining biological and psychological benefits. Additionally, in elderly, PE might represent a remarkable tool reducing cognitive impairments re...
Source: Current Pharmaceutical Biotechnology - April 6, 2021 Category: Biotechnology Authors: Giovanni Lauretta Silvia Ravalli Grazia Maugeri Velia D'Agata Michelino Di Rosa Giuseppe Musumeci Source Type: research

The impact of physical exercise on hippocampus, in physiological condition and ageing-related decline: current evidence from animal and human studies
Curr Pharm Biotechnol. 2021 Apr 5. doi: 10.2174/1389201022666210405142611. Online ahead of print.ABSTRACTPhysical exercise (PE), notoriously, promotes a state of general well-being, throughout the entire human lifespan. Moreover, maintaining an adequate and regular PE habit results to be a powerful preventive factor towards many diseases and may also help in managing existing pathological conditions. PE induces structural and functional changes in various districts of the body, determining biological and psychological benefits. Additionally, in elderly, PE might represent a remarkable tool reducing cognitive impairments re...
Source: Current Pharmaceutical Biotechnology - April 6, 2021 Category: Biotechnology Authors: Giovanni Lauretta Silvia Ravalli Grazia Maugeri Velia D'Agata Michelino Di Rosa Giuseppe Musumeci Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Functional Properties of Kefiran in Medical field and food industry
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322121420. Online ahead of print.ABSTRACTKefir is produced through the fermentation of milk using kefir grain as a starter culture. Kefir grains include heterogeneous microorganisms embedded in a polysaccharide matrix called kefiran which is considered a biofilm, it also has many uses due to its therapeutic values. Kefiran is a microbial exopolysaccharide (EPS) obtained from the flora (acid- lactic bacteria and yeasts) of kefir grains and glucose units, in almost the same proportion. Kefiran has prebiotic nature agitating the growth of probiotics in the gastr...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Afsaneh Salari Mohammad Hashemi Asma Afshari Source Type: research

Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives
CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research

The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts
CONCLUSION: These findings indicate the potential of crotalicidin-related short peptides as structural motifs for the diversification of biological functionalities. Further, they set the stage to investigate the molecular mechanisms by which chemically modified vipericidin repeats modulate cell fate.PMID:33749557 | DOI:10.2174/1389201022666210322123903 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Hilania Valeria Doudou Lima Thales M árcio Cabral Dos Santos Mirelly Mirna Alves de Sousa Silva Jo ão Victor da Silva Albuquerque Luciana Magalh ães Melo Vicente Jos é de Figueirêdo Freitas Gandhi R ádis-Baptista Source Type: research

Herbal Medicine in Fighting Against COVID-19: New Battle with an Old Weapon
Curr Pharm Biotechnol. 2021 Mar 22. doi: 10.2174/1389201022666210322124348. Online ahead of print.ABSTRACTWorld population has been suffering due to the outbreak of present pandemic situation of COVID-19. The disease has become life-threatening in a very short time with touching on most of the citizenry and economic systems globally. The novel virus, SARS-CoV-2 has been known as the causative agent of COVID-19. The SARS-CoV-2 is single stranded RNA virus having ~30 kb genomic components which are 70% identical to SARS-CoV. The main process of pathophysiology of COVID-19 has been associated with the interaction of a novel c...
Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Ranjit K Harwansh Shiv Bahadur Source Type: research

Evaluation of decontamination efficacy of electrolytically generated hypochlorous acid for vesicating agent: A multimodel Study
Curr Pharm Biotechnol. 2021 Mar 11. doi: 10.2174/1389201022666210311140922. Online ahead of print.ABSTRACTBACKGROUND: Sulfur Mustard is a strong vesicant and chemical warfare agent that imposes toxicity to the lungs, eyes, and skin after accidental or intended exposure.OBJECTIVES: The current study was intended to explore in vitro and in vivo decontamination properties of electrolytically generated HOCl (hypochlorous acid) against CEES (2-chloroethyle ethyle sulphide), a known sulfur mustard simulant & vesicating agent.METHODS: In vitro studies were carried out using UV spectroscopy and GC-MS methods. In vivo studies w...
Source: Current Pharmaceutical Biotechnology - March 15, 2021 Category: Biotechnology Authors: Ajay Kumar Sharma Sandeep Kumar Shukla Aman Kalonia Priyanka Shaw Kushagra Khanna Richa Gupta M H Yashavarddhan Assem Bhatnagar Source Type: research

Evaluation of decontamination efficacy of electrolytically generated hypochlorous acid for vesicating agent: A multimodel Study
Curr Pharm Biotechnol. 2021 Mar 11. doi: 10.2174/1389201022666210311140922. Online ahead of print.ABSTRACTBACKGROUND: Sulfur Mustard is a strong vesicant and chemical warfare agent that imposes toxicity to the lungs, eyes, and skin after accidental or intended exposure.OBJECTIVES: The current study was intended to explore in vitro and in vivo decontamination properties of electrolytically generated HOCl (hypochlorous acid) against CEES (2-chloroethyle ethyle sulphide), a known sulfur mustard simulant & vesicating agent.METHODS: In vitro studies were carried out using UV spectroscopy and GC-MS methods. In vivo studies w...
Source: Current Pharmaceutical Biotechnology - March 15, 2021 Category: Biotechnology Authors: Ajay Kumar Sharma Sandeep Kumar Shukla Aman Kalonia Priyanka Shaw Kushagra Khanna Richa Gupta M H Yashavarddhan Assem Bhatnagar Source Type: research