Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Importin 7 enhances protective autophagy induced by nuclear translocation of homeobox A10 in oral squamous cell carcinoma
This study aimed to explore the function and mechanism of IPO7 in OSCC. IPO7 expression in tissues and cells was determined by RT-qPCR. Cell proliferative, migratory, and invasive capabilities were detected through transwell assay and colony formation assay. Mice xenograft models were established for evaluating tumor growth. Autophagy was estimated by the LC3 levels in cells through western blot and immunofluorescence (IF). Western blot was utilized to detect the key proteins in PERK/EIF2AK3/ATF4 pathway for assessing the endoplasmic reticulum stress (ERS). The interaction of IPO7 and homeobox A10 (HOXA10) was tested by GS...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Shanshan Chen Jianbo Pan Source Type: research
PD ‐1 inhibition with retifanlimab and/or arginase inhibition with INCB001158 in Japanese patients with solid tumors: A phase I study
ConclusionRetifanlimab, INCB001158, and their combination had acceptable safety profiles. Promising retifanlimab antitumor activity warrants further investigation in Japanese patients. (Source: Cancer Medicine)
Source: Cancer Medicine - April 23, 2024 Category: Cancer & Oncology Authors: Yasutoshi Kuboki,
Takafumi Koyama,
Nobuaki Matsubara,
Yoichi Naito,
Shunsuke Kondo,
Kenichi Harano,
Kan Yonemori,
Kiyotaka Yoh,
Yuan Gu,
Tetsuya Mita,
Xuejun Chen,
Eiji Ueda,
Noboru Yamamoto,
Toshihiko Doi,
Toshio Shimizu Tags: RESEARCH ARTICLE Source Type: research
Association between coca chewing (Erythroxylum coca) habit and oral squamous cell carcinoma. A case-control study from Argentina
Previous isolated reports have hypothesized that chewing coca leaves, a pre-Columbian tradition found in certain regions of South America, may be associated with the development of oral squamous cell carcinoma (OSCC). Coca chewing (CC) is a habit that shares many characteristics with the well-known practice of betel chewing observed in Asia. The aim of this study is to analyze the association between CC and OSCC among patients who attended the Se ñor del Milagro Hospital in Salta, Argentina. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 23, 2024 Category: ENT & OMF Authors: Ignacio Molina- Ávila, Juan Martín Pimentel-Solá, Emilio Buschiazzo, Adriana Echazú, Eduardo Piemonte, Gerardo Gilligan Source Type: research
Correction to: Second primary squamous cell carcinoma of the oral cavity – a retrospective cohort study of therapeutic procedures and oncological outcome
(Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Prevalence and implications of bilateral and solely contralateral lymph node metastases in oral squamous cell carcinoma
ConclusionsB/SC LNMs are rare in patients with OSCC, especially in those who present with clinico-radiologically negative ipsilateral necks. Higher rates of B/SC metastases occur in case of advanced tumors and those localized at the upper jaw or floor of the mouth. Ipsilateral LNMs significantly elevate the risk of contralateral LNMs, tripling the associated risk.Clinical relevanceThese findings provide valuable insights for surgeons considering contralateral ND or extended adjuvant treatment for OSCC patients. However, the absence of high-level evidence from randomized controlled trials impedes the establishment of a defi...
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Oral mucosa - an examination map for confocal laser endomicroscopy within the oral cavity: an experimental clinical study
ConclusionA physiological “CLE map” for the entire oral cavity could be created for the first time.Clinical relevanceThis will make it possible to take into account the existing physiological morphological features when differentiating between normal mucosa and oral squamous cell carcinoma in future work. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Diagnostic and therapeutic use of oral micronized progesterone in endocrinology
AbstractProgesterone is a natural steroid hormone, while progestins are synthetic molecules. In the female reproductive system,progesterone contributes to the control ofluteinizing hormone andfollicle-stimulating hormone secretion and their pulsatility,via itsreceptors on thekisspeptin,neurokinin B, anddynorphin neurons in the hypothalamus.Progesterone together withestradiol controls the cyclic changes of proliferation and decidualization of the endometrium; exerts anti-mitogenic actions on endometrial epithelial cells; regulates normal menstrual bleeding; contributes to fertilization and pregnancy maintenance; participate...
Source: Reviews in Endocrine and Metabolic Disorders - April 23, 2024 Category: Endocrinology Source Type: research
Neoadjuvant chemoimmunotherapy shows major pathological response and low recurrence in head and neck squamous cell carcinoma
ConclusionNeoadjuvant chemoimmunotherapy of HNSCC showed high rate of pathological response and low recurrence rate, holding promise for becoming the new standard of care for resectable HNSCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment
CONCLUSIONS: This phenotype/genotype investigation suggests that the FGFR4 p.G388R variant may serve as a new marker for identifying patients who are responsive to TAS-102. A mechanistic hypothesis is proposed to interpret these findings.PMID:38650006 | DOI:10.1186/s12967-024-05184-w (Source: Cancer Control)
Source: Cancer Control - April 22, 2024 Category: Cancer & Oncology Authors: Alessandro Ottaiano Mariachiara Santorsola Monica Ianniello Anna Ceccarelli Marika Casillo Francesco Sabbatino Nadia Petrillo Marco Cascella Francesco Caraglia Carmine Picone Francesco Perri Roberto Sirica Silvia Zappavigna Guglielmo Nasti Giovanni Savare Source Type: research
Increased cancer incidence among patients with hidradenitis suppurativa - a Danish nationwide register study 1977-2017
Acta Oncol. 2024 Apr 21;63:220-228. doi: 10.2340/1651-226X.2024.26182.ABSTRACTBACKGROUND: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%-1%, diagnostic delay: 7-10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce.MATERIALS AND METHODS: A nationwide retrospective register-based study assessing relative risk of cancer - overall and by anatomical site - following HS...
Source: Acta Oncologica - April 22, 2024 Category: Cancer & Oncology Authors: Rune Andersen Klaus Rostgaard Ole Pedersen Gregor Borut Ernst Jemec Henrik Hjalgrim Source Type: research
The Application of tDCS to Treat Pain and Psychocognitive Symptoms in Cancer Patients: A Scoping Review
CONCLUSION: Due to the limited number and high heterogeneity of the existing literature in this field, more investigation and the establishment of standardized protocols would be required to obtain more conclusive evidence.PMID:38645612 | PMC:PMC11032211 | DOI:10.1155/2024/6344925 (Source: Neural Plasticity)
Source: Neural Plasticity - April 22, 2024 Category: Neurology Authors: Benedetta Capetti Lorenzo Conti Chiara Marzorati Roberto Grasso Roberta Ferrucci Gabriella Pravettoni Source Type: research
Molecular docking, MMGBSA, and ADMET studies of phytoconstituents of < em > Ocimum gratissimum < /em > on multiple breast cancer targets
Nat Prod Res. 2024 Apr 22:1-9. doi: 10.1080/14786419.2024.2344193. Online ahead of print.ABSTRACTO. gratissimum is one of the most common medicinal plants in every community in Nigeria. This plant has been presumed to be useful in the management of diseases including breast cancer, which is one the commonest cancers affecting women globally. Hence, this study aimed to computationally investigate the phytochemicals present in O. gratissimum by elucidate their binding dynamics against five selected molecular targets of breast cancer and predict their pharmacokinetics properties. Molecular docking, MMGBSA calculation and ADME...
Source: Natural Product Research - April 22, 2024 Category: Biochemistry Authors: Basiru Olaitan Ajiboye Toluwase Hezekiah Fatoki Precious Ayorinde Akinnusi Olawale Rasaq Ajuwon Babatunji Emmanuel Oyinloye Temitope Olawale Jeje Olutunmise Victoria Owolabi Oluwatosin O Ogedengbe Claudia Genovese Source Type: research
Management of Type 2 Diabetes Mellitus With Noninsulin Pharmacotherapy
Am Fam Physician. 2024 Apr;109(4):333-342.ABSTRACTType 2 diabetes mellitus is a chronic disease that is increasing in global prevalence. An individualized approach to pharmacotherapy should consider costs, benefits beyond glucose control, and adverse events. Metformin is the first-line therapy due to its low cost and effectiveness. Sulfonylureas and thiazolidinediones are additional low-cost oral hypoglycemic classes available in the United States; however, evidence shows variability in weight gain and hypoglycemia. Thiazolidinediones increase fluid retention and are not recommended in patients with New York Heart Associat...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Elizabeth M Vaughan Zuleica M Santiago-Delgado Source Type: research
