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Cancers, Vol. 16, Pages 1548: Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review
ilva Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this system...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Ricardo Bragu ês Maria Francisca Marv ão Patr ícia Correia Raquel M. Silva Tags: Systematic Review Source Type: research

Role of Imaging in Predicting the Deep Surgical Margin in Gingivobuccal Complex Cancers: A Pilot Study
AbstractCancers arising from the gingivobuccal complex are one of the most common types of cancer in the oral cavity and are associated with poor prognosis. Among the various prognostic factors, positive surgical margin is the most important one that can be controlled by the operating surgeon. The deep surgical margins for buccal mucosa cancers is normally assessed by palpating the skin for induration and skin pinchability. The present study evaluates the role of imaging in assessing the deep surgical margin and its efficacy for skin preservation in buccal mucosa/ gingivobuccal carcinomas. The patients of gingivobuccal com...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 18, 2024 Category: ENT & OMF Source Type: research

The incidence of osteoradionecrosis of the jaws in oral cavity cancer patients treated with intensity-modulated radiotherapy: A systematic review and meta-analysis
A systematic review with meta-analysis was conducted to define the incidence of osteoradionecrosis (ORN) in patients with oral cavity cancer (OCC) treated with intensity-modulated radiotherapy (IMRT), and to identify the risk factors influencing its development. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 18, 2024 Category: ENT & OMF Authors: Luis Augusto de Almeida-Silva, Juliana dos Santos Lupp, Leonardo Alvares Sobral-Silva, Luiz Augusto Rodrigues dos Santos, Thays Oliveira Marques, Danillo Babinskas Ribeiro da Silva, Taciana Marco Ferraz Caneppele, Michelle Bianchi-de-Moraes Source Type: research

How good is ChatGPT at answering patients ’ questions related to early detection of oral (mouth) cancer?
To examine the quality, reliability, readability, and usefulness of ChatGPT in promoting oral cancer early detection. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 18, 2024 Category: ENT & OMF Authors: Yazan Hassona, Dua'a Alqaisi, Alaa AL-Haddad, Eleni Georgokopolo, Dimitris Malamos, Mohammad Alrashdan, Faleh Sawair Source Type: research

Construction of flake ball-shaped Bi 2 WO 6 embedded on phenyl functionalized g-C 3 N 4 nanosheet for efficient degradation insight of colorless pollutants and its biological application
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33294-x. Online ahead of print.ABSTRACTA facile solvent-free solid-state method was adapted to synthesize the spherical-shaped Bi2WO6 engraved on phenyl-doped g-C3N4 nanosheet, i.e., Bi2WO6/Ph-gC3N4 (or BPCN) composites with varying weights of Bi2WO6. Several spectral analyses were used to characterize all the synthesized nanomaterials. The synthesized photocatalyst showed good absorption under visible light as confirmed by UV-visible DRS analysis. Morphological analyses like SEM and TEM determine the successful fabrication of binary heterocomposite. Further,...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Ziyaur Rasool Mohammad Saud Athar Mohammad Muneer Source Type: research

Construction of flake ball-shaped Bi 2 WO 6 embedded on phenyl functionalized g-C 3 N 4 nanosheet for efficient degradation insight of colorless pollutants and its biological application
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33294-x. Online ahead of print.ABSTRACTA facile solvent-free solid-state method was adapted to synthesize the spherical-shaped Bi2WO6 engraved on phenyl-doped g-C3N4 nanosheet, i.e., Bi2WO6/Ph-gC3N4 (or BPCN) composites with varying weights of Bi2WO6. Several spectral analyses were used to characterize all the synthesized nanomaterials. The synthesized photocatalyst showed good absorption under visible light as confirmed by UV-visible DRS analysis. Morphological analyses like SEM and TEM determine the successful fabrication of binary heterocomposite. Further,...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Ziyaur Rasool Mohammad Saud Athar Mohammad Muneer Source Type: research

A Prospective Cohort Study Exploring the Effect of Lenvatinib Planned Drug Holidays in Treatment of Differentiated Thyroid Cancer
Conclusions: Planned drug holidays for lenvatinib were associated with significantly improved clinical outcomes compared to daily oral administration. Further investigation of the optimal treatment schedule for lenvatinib is warranted. Clinical Trial Registration: UMIN000022243.PMID:38629757 | DOI:10.1089/thy.2023.0553 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 17, 2024 Category: Endocrinology Authors: Makoto Tahara Hiroshi Takami Yasuhiro Ito Takahiro Okamoto Iwao Sugitani Kiminori Sugino Shunji Takahashi Hiroshi Takeyama Hidemitsu Tsutsui Hisato Hara Ayako Mitsuma Hiroyuki Yamashita Yasuo Ohashi Tsuneo Imai Source Type: research

Chylous leakage after esophagectomy for esophageal cancer: a systematic review
CONCLUSIONS: Ligation of the thoracic duct and direct oral feeding can reduce the incidence of chylous leakage after esophagectomy in patients with esophageal cancer. Other contributing factors remain unclear and require validation in further high-quality studies.PMID:38632619 | DOI:10.1186/s13019-024-02764-1 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Xing Zheng Xi Yang Sujuan Lei Source Type: research

Oncologic and functional results between sentinel lymph node biopsy and elective neck dissection in cT1/2N0 maxillary squamous cell carcinoma
CONCLUSION: SLNB could act as a viable alternative to END in cT1/2N0 maxillary squamous cell carcinoma with comparable prognosis and better quality of life.PMID:38631065 | DOI:10.1016/j.oraloncology.2024.106810 (Source: Cancer Control)
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Qigen Fang Junhui Yuan Xu Zhang Liyuan Dai Ruihua Luo Chunmiao Xu Source Type: research

Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma
In this study, we calculated fat-free body mass (FFM), defined as the skeletal muscle mass, and evaluated the expression of muscle atrophy markers and uncoupling protein markers as well as the cross-sectional area (CSA) to investigate whether transcutaneous application of CO2 to skeletal muscle could suppress skeletal muscle atrophy in cancer-bearing mice. Human oral squamous cell carcinoma was transplanted subcutaneously into the upper dorsal region of nude mice, and 1 week later, CO2 gas was applied to the legs twice a week for 4 weeks and FFM was calculated by bioimpedance spectroscopy. After the experiment concluded, t...
Source: Cancer Control - April 17, 2024 Category: Cancer & Oncology Authors: Aki Sasaki Daisuke Takeda Hotaka Kawai Yoshiaki Tadokoro Aki Murakami Nanae Yatagai Satomi Arimoto Hitoshi Nagatsuka Masaya Akashi Takumi Hasegawa Source Type: research

Model-Informed Assessment of Probability of Phase 3 Success for Ritlecitinib in Patients with Moderate-to-Severe Ulcerative Colitis
Clin Pharmacol Ther. 2024 Apr 16. doi: 10.1002/cpt.3251. Online ahead of print.ABSTRACTRitlecitinib, an oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family inhibitor, was evaluated in patients with ulcerative colitis (UC) in a phase 2b trial. Model-informed drug development strategies were applied to bridge observations from phase 2b to predictions for a proposed phase 3 study design to assess the probability of achieving the target efficacy outcome. A longitudinal exposure-response model of the time course of the 4 Mayo subscores (rectal bleeding, stool frequency, physician's global assessment...
Source: Clinical Pharmacology and Therapeutics - April 17, 2024 Category: Drugs & Pharmacology Authors: Jessica Wojciechowski Arnab Mukherjee Christopher Banfield Timothy Nicholas Source Type: research

Role of cone-beam computed tomography in evaluating osseous invasion from oral squamous cell carcinoma
Proc (Bayl Univ Med Cent). 2024 Feb 14;37(3):401-402. doi: 10.1080/08998280.2024.2312775. eCollection 2024.NO ABSTRACTPMID:38628348 | PMC:PMC11018003 | DOI:10.1080/08998280.2024.2312775 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - April 17, 2024 Category: Universities & Medical Training Authors: Madhu K Nair Source Type: research

The utility of cone-beam computed tomography and multislice computed tomography scan for the evaluation of invasion versus erosion by mandibular squamous cell carcinoma as viewed on medical PACS
DISCUSSION: CBCT provides meaningful data that may be useful in identifying bony involvement in patients with mandibular squamous cell carcinoma. The utility in delineating erosion versus invasion is limited.PMID:38628331 | PMC:PMC11018060 | DOI:10.1080/08998280.2024.2308477 (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - April 17, 2024 Category: Universities & Medical Training Authors: Timothy W Neal Jason Wahidi Fayette C Williams Thomas Schlieve Jyotsna Donepudi Roderick Y Kim Source Type: research

Quantum chemistry calculation-aided discovery of potent small-molecule mimics of glutathione peroxidases for the treatment of cisplatin-induced hearing loss
In this study, we employed the frontier molecular orbital (FMO) theory approach as a convenient prediction method for the glutathione peroxidase (GPx)-like activity of isoselenazolones and discovered new isoselenazolones with great GPx-like activity. Notably, compound 19 exhibited significant protective effects against cisplatin-induced hair cell (HC) damage in vitro and in vivo and effectively reverses cisplatin-induced hearing loss through oral administration. Further investigations revealed that this compound effectively alleviated hair cell oxidative stress, apoptosis and ferroptosis. This research highlights the poten...
Source: European Journal of Medicinal Chemistry - April 17, 2024 Category: Chemistry Authors: Wentao Wang Siyu Qiu Tianyi Zhang Zhiwei Zheng Kongkai Zhu Xing Gao Fengping Zhao Xinyuan Ma Hongyan Lin Yingzi He Canhui Zheng Source Type: research