Saliva ‑microbiome‑derived signatures: expected to become a potential biomarker for pulmonary nodules (MCEPN-1)
Oral microbiota imbalance is associated with the progression of various lung diseases, including lung cancer. Pulmonary nodules (PNs) are often considered a critical stage for the early detection of lung cance... (Source: BMC Microbiology)
Source: BMC Microbiology - April 20, 2024 Category: Microbiology Authors: Yifeng Ren, Qiong Ma, Xiao Zeng, Chunxia Huang, Shiyan Tan, Xi Fu, Chuan Zheng, Fengming You and Xueke Li Tags: Research Source Type: research
Pharmacokinetic study of capivasertib and the CYP3A4 substrate midazolam in patients with advanced solid tumors
ConclusionThe up to 1.75-fold increase in midazolam exposure indicates capivasertib is a weak CYP3A inhibitor at 400 mg BID on an intermittent schedule. Capivasertib was well tolerated; exploratory efficacy analysis demonstrated evidence of clinical activity in this heavily pre-treated population.ClinicalTrials.gov: NCT04958226. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - April 20, 2024 Category: Cancer & Oncology Source Type: research
The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
CONCLUSION: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.PMID:38638130 | PMC:PMC11025722 | DOI:10.1016/j.oor.2023.100092 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Vivian Salama Sara Youssef Tianlin Xu Kareem A Wahid Jaime Chen Jillian Rigert Anna Lee Katherine A Hutcheson Brandon Gunn Jack Phan Adam S Garden Steven J Frank William Morrison Jay P Reddy Michael T Spiotto Mohamed A Naser Cem Dede Renjie He Abdallah S Source Type: research
A practical guide for the use of apalutamide for non-metastatic castration-resistant prostate cancer in Australia
Asia Pac J Clin Oncol. 2024 Apr 19. doi: 10.1111/ajco.14054. Online ahead of print.ABSTRACTStudies of patients with castrate-resistant prostate cancer at high risk of developing overt metastases but with no current evidence of evaluable disease on computed tomography or bone scan non-metastatic castrate-resistant prostrate cancer have demonstrated increased metastasis-free survival and overall survival following treatment with the next-generation oral anti-androgen apalutamide (in addition to therapies that aim to lower testosterone to castrate levels) or luteinizing hormone-releasing hormone antagonist or surgical castrat...
Source: Clinical Prostate Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Gavin Marx Simon Chowdhury Laurence Krieger Elizabeth Hovey Jeremy Shapiro Ben Tran Thean Hsiang Tan Siobhan Ng Henry H Woo Source Type: research
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
CONCLUSION: This study provides insight on in-depth characterization and associations between dynamic pain, physiologic, and toxicity kinetics. Our findings support further needs of optimized pain control through temporal data-driven clinical decision support systems for acute pain management.PMID:38638130 | PMC:PMC11025722 | DOI:10.1016/j.oor.2023.100092 (Source: Pain Physician)
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Vivian Salama Sara Youssef Tianlin Xu Kareem A Wahid Jaime Chen Jillian Rigert Anna Lee Katherine A Hutcheson Brandon Gunn Jack Phan Adam S Garden Steven J Frank William Morrison Jay P Reddy Michael T Spiotto Mohamed A Naser Cem Dede Renjie He Abdallah S Source Type: research
A practical guide for the use of apalutamide for non-metastatic castration-resistant prostate cancer in Australia
Asia Pac J Clin Oncol. 2024 Apr 19. doi: 10.1111/ajco.14054. Online ahead of print.ABSTRACTStudies of patients with castrate-resistant prostate cancer at high risk of developing overt metastases but with no current evidence of evaluable disease on computed tomography or bone scan non-metastatic castrate-resistant prostrate cancer have demonstrated increased metastasis-free survival and overall survival following treatment with the next-generation oral anti-androgen apalutamide (in addition to therapies that aim to lower testosterone to castrate levels) or luteinizing hormone-releasing hormone antagonist or surgical castrat...
Source: Clinical Prostate Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Gavin Marx Simon Chowdhury Laurence Krieger Elizabeth Hovey Jeremy Shapiro Ben Tran Thean Hsiang Tan Siobhan Ng Henry H Woo Source Type: research
Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo
Biochem Pharmacol. 2024 Apr 17:116217. doi: 10.1016/j.bcp.2024.116217. Online ahead of print.ABSTRACTThe Hippo pathway is a key regulator of tissue growth, organ size, and tumorigenesis. Activating the Hippo pathway by gene editing or pharmaceutical intervention has been proven to be a new therapeutic strategy for treatment of the Hippo pathway-dependent cancers. To now, a number of compounds that directly target the downstream effector proteins of Hippo pathway, including YAP and TEADs, have been disclosed, but very few Hippo pathway activators are reported. Here, we discovered a new class of Hippo pathway activator, YL-6...
Source: Biochemical Pharmacology - April 19, 2024 Category: Drugs & Pharmacology Authors: Guifeng Lin Anjie Xia Jingxin Qiao Hailin Zhang Pei Chen Pei Zhou Qian Hu Zhiyu Xiang Shiyu Zhang Linli Li Shengyong Yang Source Type: research
Isolation and characterization of bioactive alkaloids and GC-MS based identification of volatile oil metabolites from fruits of Glycosmis pentaphylla and evaluation of their cytotoxic activity
The objective of this study is to isolate and identify the bioactive compounds found in the fruits of G. pentaphylla and then evaluate their potential for anti-cancer activity in oral cancer CAL 27 cell lines. The extraction of bioactive compounds from fruits was done by maceration, and the isolation of alkaloids and volatile oil fractions (F1-F5) was performed by column chromatography. The alkaloids, such as 3-O-methoxyglycocitrine II, noracronycine, 1-hydroxy-3-methoxy-10-methyl-9-acridone and kokusaginine, were first isolated from the fruits of G. pentaphylla. Additionally, GC-MS analysis identified 78 metabolites. The ...
Source: Fitoterapia - April 19, 2024 Category: Biochemistry Authors: Parusu Kavya Teja Sanjana Kyada Sourav Das Vinal Upadhyay Amit Mandoli Siddheshwar K Chauthe Source Type: research
The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research
Neoadjuvant chemoimmunotherapy shows major pathological response and low recurrence in head and neck squamous cell carcinoma
ConclusionNeoadjuvant chemoimmunotherapy of HNSCC showed high rate of pathological response and low recurrence rate, holding promise for becoming the new standard of care for resectable HNSCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Risk and safety profile of electronic nicotine delivery systems (ENDS): an umbrella review to inform ENDS health communication strategies
Conclusions
As evidence is accumulating, ENDS communication can focus on high-level evidence on ENDS association with toxicity, nicotine addiction, respiratory disease, ENDS-specific harm (explosion, poisoning) and anti-ENDS industry sentiment. Direct comparison between the harm of CCs and ENDS should be avoided.
PROSPERO registration number
CRD42021241630. (Source: Tobacco Control)
Source: Tobacco Control - April 19, 2024 Category: Respiratory Medicine Authors: Asfar, T., Jebai, R., Li, W., Oluwole, O. J., Ferdous, T., Gautam, P., Schmidt, M., Noar, S. M., Lindblom, E. N., Eissenberg, T., Bursac, Z., Vallone, D., Maziak, W. Tags: Editor's choice Systematic review Source Type: research
Cancers, Vol. 16, Pages 1575: The Role of Estrogen and Estrogen Receptors in Head and Neck Tumors
etić
Head and neck squamous cell carcinoma (HNSCC) is the most common histological form of head and neck tumors (HNTs), which originate from the epithelium of the lips and oral cavity, pharynx, larynx, salivary glands, nasal cavity, and sinuses. The main risk factors include consumption of tobacco in all forms and alcohol, as well as infections with high-risk human papillomaviruses or the Epstein–Barr virus. Regardless of the etiological agent, the risk of developing different types of HNTs is from two to more than six times higher in males than in females. The reason for such disparities probably lies i...
Source: Cancers - April 19, 2024 Category: Cancer & Oncology Authors: Kranj čević Čonkaš Ozreti ć Tags: Review Source Type: research
GPD1 relieves the proliferation, migration and invasion abilities of oral cancer cells by inhibiting mitochondrial function
ConclusionFor the first time, this work manifested that GPD1 inhibited the proliferation, migration and invasion of oral cancer cells by inhibiting mitochondrial function through triggering the PI3K/AKT/GSK-3 β pathway. This discovery hinted that GPD1 may be a serviceable biomarker for the treatment of oral cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 19, 2024 Category: Cytology Source Type: research
Bacterial Subspecies Linked With Aggressive Colorectal Cancer Tumors
Previous research has tied the presence of Fusobacterium nucleatum, a bacterium normally found in the mouth, with colorectal cancer tumors. High amounts of F nucleatum in the tumor are linked with worse prognosis. A recent study clarified that risk, showing that what was thought to be a single bacterial subspecies, F nucleatum animalis, is actually 2 clades: C1 and C2. Based on an analysis of human tissue and animal models, F nucleatum animalis C1 is found mostly in the mouth while C2 is the bacterium driving tumor growth, the researchers reported in Nature. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 19, 2024 Category: General Medicine Source Type: research
