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In Praise of Hospice
In this narrative medicine essay, a retired physician describes the kindness, companionship, and skill of the hospice workers who helped his wife and him prepare for her death. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 25, 2024 Category: General Medicine Source Type: research

Patient Information: Autism Spectrum Disorder
This JAMA Patient Page describes autism spectrum disorder (ASD) and its signs and symptoms, diagnosis, and therapy options. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 25, 2024 Category: General Medicine Source Type: research

Disparities in Mortality by Sexual Orientation in a Cohort of Female Nurses
This prospective cohort study compares the differences in time to mortality across sexual orientation in female nurses participating in the Nurses ’ Health Study II. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 25, 2024 Category: General Medicine Source Type: research

US Breast Cancer Mortality —Reply
In Reply Dr Jatoi suggests that a reduction in the incidence of ER-negative breast cancer over the past decades could have contributed to the decline in breast cancer mortality observed in SEER between 1975 and 2019. Indeed, a decline in cancer incidence can have a primary role in decline of cancer-specific mortality, as in the case of lung cancer. Similarly, a change in the composition of molecular subtypes among people diagnosed with incident breast cancer could affect mortality rates and even decrease mortality if the subtype with the higher mortality rate became less prevalent. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 25, 2024 Category: General Medicine Source Type: research

US Breast Cancer Mortality
To the Editor In their recent study, Dr Caswell-Jin and colleagues used 4 Cancer Intervention and Surveillance Modeling Network (CISNET) models and ascribe the 58% reduction in US breast cancer mortality between 1975 and 2019 to the use of effective treatments and screening. However, the CISNET models do not appear to account for the effect of declining estrogen receptor (ER) –negative breast cancer incidence on overall US breast cancer mortality rates. The US Surveillance, Epidemiology, and End Results (SEER) database first began recording breast cancer ER status in 1992, and between the years 1992 and 2016, age-adjuste...
Source: JAMA - Journal of the American Medical Association - April 25, 2024 Category: General Medicine Source Type: research

Rehabilitation
The family physician, after seeing a patient through the acute stages of an illness and subsequent convalescence, watched him until his ultimate return to work. The patient, usually stimulated by the daily needs of life on the farm and in the home, was chiefly interested in regaining his former place in his society. As he recuperated, he could make himself useful in many simple tasks. Gradually more difficult and strenuous skills would be regained. The relationship of the family physician to the home was sufficiently direct to permit him to help substantially in the process. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 25, 2024 Category: General Medicine Source Type: research

APOL1-Mediated Kidney Disease
This JAMA Insights reviews the origin of APOL1 high-risk genetic variants, defines APOL1-mediated kidney disease, and discusses recommendations for screening and management. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 25, 2024 Category: General Medicine Source Type: research

Is Myocardial Infarction Overdiagnosed?
This Viewpoint examines whether overdiagnosis rather than underdiagnosis may now be the dominant form of myocardial infarction misdiagnosis. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research

Toward the End of My Dad ’s Life We Go Back to Arguing, and Soon After He Dies, I Break My Elbow
—but I prefer not to disentangle it,because it is more accurate.Tony Hoagland, “Entanglement” (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research

Neurodevelopmental Outcomes After Late Preterm Corticosteroids
This prospective follow-up study of a randomized clinical trial evaluates whether antenatal corticosteroids administered to birthing parents at risk of late preterm delivery were associated with adverse neurodevelopmental effects on their offspring. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research

The Diagnosis of Cancer After Recent Weight Loss —Reply
In Reply We thank Mr Hung and colleagues for their interest in our recent article. In response to their first comment, it is important to note that body weights in this study were self-reported by participants approximately every 2 years and were not measured at clinic visits. Therefore, the frequency of clinic visits did not dictate the availability of weight data or the ability to assess recent weight change prior to a cancer diagnosis. However, we agree that outside this study, frequency of clinic visits could affect how promptly clinicians are informed of recent weight changes and when cancer-directed evaluations are i...
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research

The Diagnosis of Cancer After Recent Weight Loss
To the Editor A recent study provided valuable insights into the complex relationship between weight loss and cancer risk. In addition to the limitations mentioned by the authors, we have some concerns about the study methods and the interpretation of the results. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research

X (Formerly Twitter) Community Notes Addressing COVID-19 Vaccine Misinformation
This study evaluated the topics, accuracy, and credibility of X (formerly Twitter) Community Notes addressing COVID-19 vaccination. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research

Lower Gastrointestinal Hemorrhage
This JAMA Clinical Guidelines Synopsis summarizes the 2023 American College of Gastroenterology guidelines on management of patients with acute lower gastrointestinal bleeding. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research

Late Preterm Corticosteroids Exposure and Neurodevelopmental Outcomes
In recent years, there has been a reevaluation of the upper gestational age limit recommended for administration of antenatal corticosteroids. Seven randomized clinical trials (RCTs) published between 2010 and 2022 have evaluated the effects of expanding the limit from 34 to 37 weeks ’ gestation. The largest of these was the Antenatal Late Preterm Steroids (ALPS) trial published in 2016. In this trial, the administration of antenatal corticosteroids yielded a 20% relative reduction in the primary outcome (respiratory morbidity). The absolute reduction in the primary outcome wa s only 2.8% (from 14.4% to 11.65%), and the ...
Source: JAMA - Journal of the American Medical Association - April 24, 2024 Category: General Medicine Source Type: research