Physician Practice Interruptions in the Treatment of Medicare Patients During the COVID-19 Pandemic
This study uses Medicare data to assess physician practice interruptions during the 2019-2020 period of the COVID-19 pandemic and provides preliminary evidence on whether those interruptions suggest early retirements or exit from medical practice. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 20, 2021 Category: General Medicine Source Type: research

Ninth International Congress on Peer Review and Scientific Publication
In 2019, before the COVID-19 pandemic, we highlighted the unprecedented promise and peril surrounding the quantity, quality, and integrity of scientific research. The pandemic has been a crash test for scientific publishing, emphasizing the great successes and failures, and the promise and perils of current systems. In 2020, because of the pandemic, we announced a postponement of the Ninth International Congress on Peer Review and Scientific Publication. We now confirm plans to hold the meeting September 8-10, 2022, and we announce the official call for abstracts. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 20, 2021 Category: General Medicine Source Type: research

Interpreting SARS-CoV-2 Test Results
A 53-year-old woman presented to the gastroenterology clinic for endoscopy because of submucosal gastric nodule. Reverse transcriptase –polymerase chain reaction SARS-CoV-2 testing before the procedure was positive, and the patient reported testing positive for SARS-CoV-2 30 days prior. What would you do next? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 17, 2021 Category: General Medicine Source Type: research

Holding Hope for Patients With Serious Illness
This Viewpoint explains the complex emotion of hope and provides guidance to clinicians for supportively conversing about hope with seriously ill patients. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 16, 2021 Category: General Medicine Source Type: research

Our Best Judgment
In this narrative medicine essay, a palliative medicine physician describes his brother's hospitalization and death from COVID-19. He reflects on his brother's ability to achieve a dignified death because the physicians caring for him honestly assessed his prognosis. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 16, 2021 Category: General Medicine Source Type: research

Editorial on Screening for Chlamydia and Gonorrhea Corrected
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 16, 2021 Category: General Medicine Source Type: research

An International Agreement on Pandemic Prevention and Preparedness
This Viewpoint discusses international efforts to address the COVID-19 and future pandemics as well as offers steps that the international community can take to fix gaps in pandemic response. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 15, 2021 Category: General Medicine Source Type: research

COVID-19 Set Back Efforts to See the Person in the ICU Patient
This Medical News feature discusses with Vanderbilt University critical care specialist E. Wesley Ely, MD, MPH, the COVID-19 pandemic ’s impact on progress that had been made in intensive care units. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 15, 2021 Category: General Medicine Source Type: research

A Court Decision on “Skinny Labeling”: Another Challenge for Less Expensive Drugs
This Viewpoint explains how “skinny labeling” works (bioequivalent drugs approved for unpatented uses and excluding patented indications from the generic drug’s labeling), the uncertainty about this pathway, and how the government and generic manufacturers can help restore timely generic competition in the face of brand- name drugs protected by patents. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 13, 2021 Category: General Medicine Source Type: research

Policies to Promote Shared Responsibility for Safer Electronic Health Records
This Viewpoint discusses new Centers for Medicare& Medicaid Services rules that will require hospitals to verify completion of an annual self-assessment of their electronic health record using the Office of the National Coordinator for Health Information Technology –sponsored SAFER Guides and suggests 3 additional steps required to strengthen the effects of the new rules and ensure patient safety. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 10, 2021 Category: General Medicine Source Type: research

Estimated Savings From International Reference Pricing for Prescription Drugs
This study estimates what 2020 national US savings would have been using international reference pricing rather than US manufacturer and net prices for insulins and 50 top brand-name drugs. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 10, 2021 Category: General Medicine Source Type: research

Transposed Column Heads in Table
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 10, 2021 Category: General Medicine Source Type: research

World Trade Center Health Program 2012-2020
This Viewpoint reviews the World Trade Center Health Program, established in 2011 to fund health care for responders and survivors of the 9/11 attacks in the US, including covered conditions and changing factors such as an aging member population. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 9, 2021 Category: General Medicine Source Type: research

Representativeness of Participants Eligible to Be Enrolled in Clinical Trials of Aducanumab for AD Compared With Medicare Beneficiaries With AD and MCI
This study evaluates whether patients enrolled in trials of aducanumab, EMERGE and ENGAGE, were representative of patients with dementia enrolled in Medicare by estimating the proportions of Medicare beneficiaries with Alzheimer disease (AD) or mild cognitive impairment (MCI) who would have been excluded from these trials. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 9, 2021 Category: General Medicine Source Type: research

Why Farmworkers Need More Than New Laws for Protection From Heat-Related Illness
This Medical News article discusses farmworkers ’ heat-related health risks and efforts to establish a national standard to help protect them from dangerous working conditions. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 8, 2021 Category: General Medicine Source Type: research

Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy
This Research Letter presents findings from case-control surveillance of COVID-19 vaccination during pregnancy and spontaneous abortion. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 8, 2021 Category: General Medicine Source Type: research

Surveillance for Adverse Events After COVID-19 mRNA Vaccination
This study reports an interim analysis of safety surveillance data of 23 serious outcomes following vaccination with 1 of the mRNA COVID-19 vaccines based on comprehensive health records from a large US population. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 3, 2021 Category: General Medicine Source Type: research

Twenty Years After 9/11, Responders Are Still Healing
This Medical News article discusses ongoing physical and mental health effects for emergency personnel, recovery and cleanup workers, and volunteers who responded on and after the September 11, 2001, terrorist attacks. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 3, 2021 Category: General Medicine Source Type: research

Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink
Vaccines represent one of the greatest public health achievements of modern medicine. They must pass rigorous and predetermined efficacy and safety metrics prior to licensure. Additionally, postmarketing safety surveillance is essential to detect rare or severe vaccine-associated adverse events, particularly because of the large numbers of individuals exposed. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 3, 2021 Category: General Medicine Source Type: research

Estimated US Infection- and Vaccine-Induced SARS-CoV-2 Seroprevalence Based on Blood Donations, July 2020-May 2021
This study estimates trends in SARS-CoV-2 seroprevalence related to infection and vaccination in the US population. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 2, 2021 Category: General Medicine Source Type: research

Prevalence of SARS-CoV-2 Antibodies From a Serosurveillance of Kenyan Blood Donors, January to March 2021
This study examines the prevalence of SARS-CoV-2 antibodies among blood donors aged 16 to 64 years in Kenya from January to March 2021. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 2, 2021 Category: General Medicine Source Type: research

USPSTF Statement: Incorporation of Social Risk in USPSTF Recommendations
This report from the US Preventive Services Task Force (USPSTF) identifies how social risks have been considered in the USPSTF recommendation statements and provides a foundation for ongoing work to ensure that health equity and social risks are incorporated in USPSTF methods and recommendations. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 1, 2021 Category: General Medicine Source Type: research

USPSTF Technical Brief: Screening and Interventions for Social Risk Factors
This technical brief to support the US Preventive Services Task Force (USPSTF) describes current research on screening and interventions for social risk factors such as food insecurity, financial strain, and housing instability to inform USPSTF considerations of the implications for its portfolio of recommendations. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 1, 2021 Category: General Medicine Source Type: research

Strengthening Global Health Security and Reforming the International Health Regulations
This Viewpoint from the US Secretary of State and the US Secretary of Health and Human Services outlines how the US government, in partnership with other nations and organizations such as the WHO, should work to establish a more effective, innovative, responsive, and equitable system for global health security. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 31, 2021 Category: General Medicine Source Type: research

Lower Tidal Volume Using Extracorporeal Carbon Dioxide Removal in Acute Hypoxemic Respiratory Failure
This randomized clinical trial examines whether lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal, compared with standard care, will decrease mortality 90 days after randomization in patients with acute hypoxemic respiratory failure. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 31, 2021 Category: General Medicine Source Type: research

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients
This clinical trial compares the effectiveness of a low-normal Pao2 target vs a high-normal Pao2 target to reduce organ dysfunction in critically ill patients with systemic inflammatory response syndrome. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 31, 2021 Category: General Medicine Source Type: research

Titrating Oxygen Therapy in Critically Ill Patients
The development of oxygen therapy is one of the major advances of modern medicine. Oxygen therapy laid the groundwork for intensive care medicine as a specialty and has saved millions of lives. During the COVID-19 pandemic, millions of patients survived due to provision of supplemental oxygen, with or without mechanical ventilation. In some regions of the world, where oxygen supply is limited, however, there were many preventable deaths from acute hypoxemic respiratory failure. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 31, 2021 Category: General Medicine Source Type: research

Governing Human Germline Editing Through Patent Law
This Viewpoint discusses ethical considerations and use of patents for human germline editing in the context of a recent World Health Organization report and release of several auxiliary documents exploring international governance tools for human genome engineering. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 30, 2021 Category: General Medicine Source Type: research

Comparison of SARS-CoV-2 Antibody Response Following Vaccination With BNT162b2 and mRNA-1273
This study compares the immune responses to the BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccines in health care workers in Belgium. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 30, 2021 Category: General Medicine Source Type: research

Body Mass Index Among Children and Adolescents During the COVID-19
This study compared body mass index of youngsters during the COVID-19 pandemic to the same time in 2019 to determine whether they experienced pandemic-related weight gain. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 27, 2021 Category: General Medicine Source Type: research

The Helping to End Addiction Long-term Initiative of the National Institutes of Health
This Viewpoint discusses the Helping to End Addiction Long-term initiative of the National Institutes of Health that was launched in 2018 to provide scientific solutions to the evolving crisis of opioid misuse, addiction, and overdose. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 26, 2021 Category: General Medicine Source Type: research

After Mildest Flu Season Ever, Influenza Experts Wonder What Comes Next
This Medical News feature examines potential scenarios about how severe the upcoming flu season might be, given the dearth of influenza worldwide since the COVID-19 pandemic began. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 25, 2021 Category: General Medicine Source Type: research

Addition of Nonauthor Collaborator Names of the VICTAS Trial
The Original Investigation titled “Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial,” published in the February 23, 2021, issue of JAMA, has been updated to include the nonauthor collaborator (group) names in a supplement. Thi s article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 25, 2021 Category: General Medicine Source Type: research

COVID-19 in Canada: Experience and Response to Waves 2 and 3
This Viewpoint describes the Canadian experience and response to the larger second and third waves of COVID-19 infections. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 23, 2021 Category: General Medicine Source Type: research

Estimands, Estimators, and Estimates
This JAMA Guide to Statistics and Methods takes a look at estimands, estimators, and estimates in the context of randomized clinical trials and suggests several qualities that make for good estimands, including their scope, ability to summarize treatment effects, external validity, and ability to provide good estimates. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 23, 2021 Category: General Medicine Source Type: research

Association of Remote vs In-Person Benefit Delivery With WIC Participation During the COVID-19 Pandemic
This study assesses whether participation in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) differed before and during the COVID-19 pandemic in states with offline vs online electronic benefits transfer debit cards. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 20, 2021 Category: General Medicine Source Type: research

Preventing a Pandemic's Toll —We've Been Here Before
In this narrative medicine essay, an infectious diseases physician recalls the reluctance of some patients with AIDS who feared taking antiretroviral medications, offering the same arguments being raised for refusing COVID vaccinations, and suggests that story telling may be a compelling way to convince people to be vaccinated. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 19, 2021 Category: General Medicine Source Type: research

Detecting Kids ’ Broken Hearts—Cardiac Screening Advised During Well-Child Visits
This Medical News article discusses new American Academy of Pediatrics policy that advises universal cardiac screening for youngsters. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 18, 2021 Category: General Medicine Source Type: research

Confronting the Delta Variant of SARS-CoV-2
This Viewpoint discusses the Delta variant of SARS-CoV-2, including its epidemiology, transmissibility, how uneven vaccination coverage in the US encouraged its spread, and the most effective public health responses to curb it. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 18, 2021 Category: General Medicine Source Type: research

Setting the Stage for the Next 10 Years of Health Care Payment Innovation
This Viewpoint describes 4 health policy strategies that could help lead to improvements in cost and quality in the US health care system. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 16, 2021 Category: General Medicine Source Type: research

Mask-Wearing Behavior at the 2021 NCAA Men ’s Basketball Tournament
This cross-sectional study examines the mask-wearing behavior of attendees at the 2021 NCAA men ’s basketball tournament in an attempt to help other venues prepare for future events during the pandemic. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 16, 2021 Category: General Medicine Source Type: research

Disclosures Added to Medical News Story
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 16, 2021 Category: General Medicine Source Type: research

Patient Information: Variants of SARS-CoV-2
This JAMA Patient Page explains what virus variants are and describes several recent variants of the SARS-CoV-2 virus and the public health concerns relating to these variants. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 13, 2021 Category: General Medicine Source Type: research

Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection
This study investigates the timeframe that optimizes saliva sensitivity for SARS-CoV-2 detection using reverse transcriptase –polymerase chain reaction (RT-PCR) testing. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 13, 2021 Category: General Medicine Source Type: research

Incorrect Description in Patient Page
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 13, 2021 Category: General Medicine Source Type: research

Potential Implications of SARS CoV-2 Delta Variant Surges for Rural Areas and Hospitals
This Viewpoint discusses the Delta variant of SARS-CoV-2 and suggests potential solutions for institutions, governments, and society as they navigate the potentially rural-dominant surge in infections. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 12, 2021 Category: General Medicine Source Type: research

Making Vaccines Available to Other Countries Before Offering Domestic Booster Vaccinations
This Viewpoint highlights countries with higher concentrations of COVID-19 –vaccinated residents and and excess vaccine supply vs those without, and it emphasizes the clinical and ethical reasons for prioritizing distribution of excess vaccine to underserved countries instead of keeping it for booster administration. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 12, 2021 Category: General Medicine Source Type: research

Incorrect Classification of Pharmaceutical Agent
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 12, 2021 Category: General Medicine Source Type: research

Private Equity and Health Care Delivery
This Viewpoint considers how payment models may dictate the nature of private equity investment in health care delivery and how these investments may affect health care access, quality, equity, and affordability. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 11, 2021 Category: General Medicine Source Type: research

Enforcement of the Physician Payments Sunshine Act
This Viewpoint revisits the Open Payments Program, mandated by the Sunshine Act, and discusses alleged violations by device and pharmaceutical manufacturers and the future enforcement of the program. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 11, 2021 Category: General Medicine Source Type: research