New Antiviral on the Horizon for Mild to Moderate COVID-19
COVID-19 symptoms improved 24 hours sooner among patients with mild to moderate infection who received ensitrelvir, an investigational antiviral drug, than those who received a placebo, according to results from a randomized clinical trial involving more than 1000 patients from Japan, South Korea, and Vietnam. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 21, 2024 Category: General Medicine Source Type: research

Studies to Test How Well PREVENT Predicts Heart Disease in Diverse Groups
Researchers have begun studying how accurately a new tool, known as the Predicting Risk of Cardiovascular Disease Events (PREVENT) calculator, estimates risk in people from different racial and ethnic backgrounds as well as from a range of ages, the American Heart Association announced. Three research teams will evaluate the new scores using larger databases and will assess PREVENT ’s fairness and cost-effectiveness compared with the Pooled Cohort Equations (PCEs). (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 21, 2024 Category: General Medicine Source Type: research

Tirzepatide Lowered Blood Pressure in People With Obesity
People with obesity who received tirzepatide —a glucagon-like peptide 1 (GLP-1) receptor agonist—had lower blood pressure after 9 months compared with those who received a placebo, a study published in Hypertension found. The findings are the latest example of the ways in which GLP-1 receptor agonists might improve cardiometabolic conditio ns that are associated with obesity, the researchers reported. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 21, 2024 Category: General Medicine Source Type: research

Health Care AI and Patient Privacy
This Viewpoint summarizes a recent lawsuit alleging that a hospital violated patients ’ privacy by sharing electronic health record (EHR) data with Google for development of medical artificial intelligence (AI) and discusses how the federal court’s decision in the case provides key insights for hospitals planning to share EHR data with for-profit companies developing medical AI. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 19, 2024 Category: General Medicine Source Type: research

Thunderstorm Asthma and Climate Change
This JAMA Insights in the Climate Change and Health Series defines thunderstorm asthma, describes its effects and increased rate of occurrence, and highlights recommendations for improved response during future events. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 19, 2024 Category: General Medicine Source Type: research

Patient Information: Bipolar Disorder
This JAMA Patient Page describes bipolar disorder: diagnosis, treatment, and prognosis. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 16, 2024 Category: General Medicine Source Type: research

RNA Interference With Zilebesiran for Mild to Moderate Hypertension
This phase 2 randomized trial examines the antihypertensive efficacy and safety of different zilebesiran dosing regimens. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 16, 2024 Category: General Medicine Source Type: research

Silencing Angiotensinogen Gene to Lower Blood Pressure
Hypertension is the number one cause of disability-adjusted life-years worldwide and the world ’s leading risk factor for burden of disease and death. It is the most important risk factor for stroke and congestive heart failure, a major cause of kidney failure, and plays an important role in other forms of cardiovascular disease, including atherosclerosis and coronary artery disease. Hypert ension affects approximately 48% of adults in the US and nearly 1 billion adults worldwide. Control of hypertension worldwide is dismal, and even in the US only 25% of adults achieve goal blood pressure (BP). BP elevations above 115/7...
Source: JAMA - Journal of the American Medical Association - February 16, 2024 Category: General Medicine Source Type: research

Making Ends Meet
In this narrative medicine essay, a second-year medical student describes how slipping into poverty starting with her father ’s myocardial infarction has cast a long shadow that persists even in medical school. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 15, 2024 Category: General Medicine Source Type: research

Prevalence of Immunosuppression Among US Adults
This analysis presents population prevalence estimates of immunosuppression among US adults using data from the 2021 National Health Interview Survey. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 15, 2024 Category: General Medicine Source Type: research

Omitted Additional Contribution
This article was corrected online. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 15, 2024 Category: General Medicine Source Type: research

Type and Severity of Immunodeficiency Affect Speed of SARS-CoV-2 Clearance, Study Finds
This Medical News story discusses a recent study that found people who are immunocompromised clear SARS-CoV-2 at varying rates. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 14, 2024 Category: General Medicine Source Type: research

Primary Care Physicians Are Key to Improving Dementia Care and Access
A report from the nonprofit research organization RAND estimated that by 2028, about 1.6 million people in the US with mild cognitive impairment due to Alzheimer disease will wait an average of more than 1.5 years to see a dementia specialist, such as a neurologist or geriatric psychiatrist. These wait times are 3 times longer in rural areas. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 14, 2024 Category: General Medicine Source Type: research

Low Levels of Protein Biomarker Could Predict Sepsis Deaths
Lower amounts of a type of cytokine protein might help clinicians understand which patients with sepsis are at a higher risk of dying during the next month, a cohort study in Science Translational Medicine found. The study looked at data from 452 patients with sepsis and 80 healthy participants in China. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 14, 2024 Category: General Medicine Source Type: research

Millions of US Children Experience Range of Long COVID Effects
About 6 million children in the US might be living with post –COVID-19 condition, also known as long COVID. A recent narrative review in Pediatrics parsed the existing research from the past 3 years about how long COVID presents in children and what the risk factors are for developing the condition. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 14, 2024 Category: General Medicine Source Type: research