Oxygen Supplementation in COVID-19 —How Much Is Enough?
Humans are aerobic animals; we need oxygen to support metabolism and generate energy. Simply put, breathing oxygen is necessary for life. Consequently, it would make sense that diseases that inhibit the transfer of oxygen from the lung to the blood should be treated with supplementary oxygen to overcome problems associated with hypoxemia, and one should strive to achieve “normal” levels of arterial oxygen (Pao2). But is that reasoning supported by the understanding of physiology and the weight of clinical evidence? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 19, 2024 Category: General Medicine Source Type: research

Personalized Oxygen Supplementation
When car makers tout standard emission tests to demonstrate their car ’s fuel efficiency, they must disclose that the results are just estimates and that a prospective buyer’s experience may differ. The phrase. “your mileage may vary” is used to acknowledge that the average result from a standard test may not reflect an individual user’s experience. This phr ase is now so ubiquitously understood that the phrase appears on more than 70 million web pages and is routinely shortened to YMMV in online reviews of topics far beyond fuel efficiency. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 19, 2024 Category: General Medicine Source Type: research

Digital Redlining —The Invisible Structural Determinant of Health
This Viewpoint describes digital redlining as racialized inequities in access to technology infrastructure, including access to health care, education, employment, and social services. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Arteriovenous Access for Hemodialysis
This Review discusses the selection, creation, and maintenance of arteriovenous access for hemodialysis for patients with kidney failure. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Video Laryngoscopy vs Conventional Direct Laryngoscopy for Intubation
This cluster randomized clinical trial assesses the extent to which video laryngoscopy compared with direct laryngoscopy might facilitate intubation in patients undergoing surgical procedures during routine clinical practice. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Ableist Language in NIH ’s Mission Statement—Reply
In Reply Dr Jost ’s letter recounts his individual story of spinal cord stroke as a teenager, subsequent long and productive career as a practicing physician, and self-perceptions of his disability. As we note in our article, which recounts decades of evolving views of disability, disabilities are diverse, and dif ferent disabled people have different perspectives. For example, while Dr Jost takes no pride in having a disability, other individuals are proud of their identity as disabled people. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Ableist Language in NIH ’s Mission Statement
To the Editor As a physician with a disability, I read with interest the Viewpoint “Revising NIH’s Mission Statement to Remove Ableist Language.” I always wanted to be a physician, but had a spinal cord stroke in 1972 at age 17. Initially, I was unable to walk or stand. I learned to walk again, although always with some difficulty. Despite that difficulty, I stuck with my go al, finished high school, graduated from college and medical school, completed an internal medicine residency, and practiced for 6 years as an internist. I then completed an infectious diseases fellowship and went into practice as an infectious d...
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Multimodal Large Language Model Performance on Clinical Vignette Questions
This study compares 2 large language models and their performance vs that of competing open-source models. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Neuroimaging Findings in Individuals Involved in Anomalous Health Incidents
This study assesses whether participants with anomalous health incidents (AHIs) differ significantly from US government control participants with respect to magnetic resonance imaging –detectable brain lesions. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Clinical, Biomarker, and Research Findings in Individuals With Anomalous Health Incidents
This study assesses whether participants with anomalous health incidents (AHIs) differ significantly from US government control participants with respect to clinical, research, and biomarker assessments. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Neurological Illness and National Security
In 2016, a set of troubling neurological symptoms was reported through confidential channels by US government personnel based at the US Embassy in Havana, Cuba. As the number of cases in Havana escalated and then similar cases occurred over the next 5 years in other locations around the globe, efforts to understand this syndrome, now known as anomalous health incidents (AHIs), were hampered by their unusual features, incomplete information, nonstandardized clinical testing, delayed reporting, and the sensitive nature of the circumstances, individuals, and their work. A subset of individuals described the abrupt onset, some...
Source: JAMA - Journal of the American Medical Association - March 18, 2024 Category: General Medicine Source Type: research

Use of Lecanemab for Patients With Cardiovascular Disease
This Viewpoint discusses lecanemab use and the risk of cerebral macrohemorrhage for patients with mild cognitive impairment or early dementia. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 15, 2024 Category: General Medicine Source Type: research

Tree of Knowledge
In this narrative medicine essay, a medical student uses the analogy of a mature tree to describe the difference in knowledge of his medical school teachers compared with sapling first-year medical students. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 15, 2024 Category: General Medicine Source Type: research

Study Provides Insight Into ME/CFS
This Medical News article discusses a new US National Institutes of Health study of patients with the chronic —and chronically misunderstood—disease. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 15, 2024 Category: General Medicine Source Type: research

Questions Surround Blood Tests That Claim to Screen for Multiple Cancers
This Medical News story discusses questions about multiple cancer early detection tests, 2 of which are already on the US market. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 15, 2024 Category: General Medicine Source Type: research