JAMA - Journal of the American Medical Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke
This clinical trial assesses the efficacy and adverse events of adjunctive intravenous low-dose methylprednisolone to endovascular thrombectomy for patients with acute ischemic stroke secondary to large-vessel occlusion. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 8, 2024 Category: General Medicine Source Type: research

Adjunctive Steroids as Stroke Reperfusion Strategy
With recent advances in endovascular devices and techniques for the treatment of large-vessel occlusion (LVO) stroke, rates of successful recanalization are as high as 90%. While technologies may continue to improve, it would be unreasonable to anticipate significant gains in this measure of macroperfusion. Instead, efforts are increasingly turned toward neuroprotection and augmenting the microcirculation to promote tissue viability during acute cerebral ischemia. Adjunctive intra-arterial thrombolysis and the recombinant variant of human activated protein C (3K3A-APC) have shown promising preliminary results, but warrant ...
Source: JAMA - Journal of the American Medical Association - February 8, 2024 Category: General Medicine Source Type: research

Endovascular Thrombectomy for Large Ischemic Stroke
This exploratory analysis of the SELECT2 trial assesses the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and the association of mismatch with clinical outcomes and endovascular treatment effect in adult patients with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery and large ischemic core in 31 global centers between October 2019 and September 2022. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 7, 2024 Category: General Medicine Source Type: research

Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy
This clinical trial compares the effectiveness of anticoagulation vs antiplatelet therapy for secondary stroke prevention in patients with cryptogenic stroke and evidence of atrial cardiopathy. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - February 7, 2024 Category: General Medicine Source Type: research

Thrombectomy in Medium to Large Ischemic Core
In 2015, 5 randomized clinical trials irrefutably established the benefit of thrombectomy for the treatment of acute ischemic stroke due to large-vessel occlusions, marking the beginning of the era of endovascular thrombectomy (EVT) as a therapy for cerebral ischemia. This treatment was successful by achieving high rates of timely reperfusion that saved brain from infarction. Cerebral ischemic injury results from a critical imbalance of cerebral blood flow and energy demand, leading to irreversible infarction. Tissue already so severely injured as to be irretrievably destined to infarct is defined as ischemic core, while i...
Source: JAMA - Journal of the American Medical Association - February 7, 2024 Category: General Medicine Source Type: research