Deaths From Excessive Drinking Rose in the US During Pandemic
Deaths associated with excessive alcohol use have been rising over the past 20 years. But during 2020-2021 they went up dramatically —from an average of about 138 000 deaths during 2016-2017 to more than 178 000 deaths during the COVID-19 pandemic. The change represents a 29% increase in lives lost, according to results published in the MMWR. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 5, 2024 Category: General Medicine Source Type: research

Less Sleep Tied to Increased Risk of Diabetes Despite Healthy Diet
People who slept 5 or fewer hours each night had a higher risk of being diagnosed with type 2 diabetes than those who slept 7 to 8 hours, even if they followed a healthy diet, a cohort study published in JAMA Network Open found. Sleeping 5 hours or 3 to 4 hours per day was linked with a 16% and 41% increased risk of type 2 diabetes, respectively. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 5, 2024 Category: General Medicine Source Type: research

WHO Documents Rising Resistance to First-Line HIV Drug
Currently, the World Health Organization (WHO) recommends using dolutegravir, an integrase strand transfer inhibitor approved by the US Food and Drug Administration in 2013, as a first- and second-line drug for treating people with HIV. But resistance to the treatment is on the rise. About 4% to as many as about 20% of people in 4 countries reporting data —Malawi, Mozambique, Uganda, and Ukraine—who had not achieved viral suppression exhibited resistance while taking the drug as part of their antiretroviral therapy, a recent report by the WHO found. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 5, 2024 Category: General Medicine Source Type: research

Meta-Analysis: “Limited” Benefits to Rapid Viral Tests in EDs
Observational studies have suggested that rapid viral testing for respiratory viruses is tied to lower use of antibiotics. Now, a meta-analysis published in JAMA Internal Medicine suggests that may not be the case, based on results from 11 randomized clinical trials involving about 6100 participants. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 5, 2024 Category: General Medicine Source Type: research

Noninvasive Airway Management of Comatose Patients With Acute Poisoning —Reply
In Reply In response to our recent article, Dr Schober and colleagues suggest that reduction of length of stay in the ICU and hospital may not be considered a clinically relevant outcome. However, in the context of stretched resources and ICU bed shortages, we believe this is an important end point, and that improvement in the secondary end points in our trial also advocates for a clinical benefit of the intervention. As acknowledged, the reduced risk of pneumonia in the intervention group was not statistically significant, and we therefore did not make definitive claims about this. However, considering the absolute risk r...
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor We read with great interest the recent study about the effect of noninvasive airway management of comatose patients with acute poisoning, but are concerned about potential issues related to selection bias, confounding factors, and the unblinded study design that might have biased the results toward the intervention group (conservative strategy). (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor A recent study reported that withholding intubation among patients with acute poisoning and coma, defined by a GCS score of up to 8, was safe and led to lower rates of ICU admission and adverse events. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor We read with interest the recent article that reported among comatose patients with suspected acute poisoning, a conservative strategy of withholding intubation was associated with a greater clinical benefit for the composite end point of in-hospital death, length of ICU stay, and length of hospital stay. We think that some methodological issues about this study deserve consideration. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Noninvasive Airway Management of Comatose Patients With Acute Poisoning
To the Editor A recent study suggested clinical benefits of noninvasive airway management in comatose patients with acute poisoning. An accompanying editorial lauded the study as a practice-changing trial providing rigorous evidence. Although we have recommended against indiscriminate intubation of patients based on a low Glasgow Coma Scale (GCS) score, we are concerned about the ability of this study to provide conclusive evidence allowing a paradigm shift in clinical practice. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Prevalence of Type 1 Diabetes Among US Children and Adults by Age, Sex, Race, and Ethnicity
This study uses data from the 2019 to 2022 cycles of the National Health Interview Survey to estimate the prevalence of type 1 diabetes among US youths and adults. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Reported Political Participation by Physicians vs Nonphysicians
This study uses survey data to compare rates of political participation between US physicians and nonphysicians from 2017 to 2021. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Introducing the JAMA Summit
Over the past year, JAMA editors have been developing the concept of the JAMA Summit —forums for catalyzing discussion and action on pressing issues in science, medicine, and public health. Over its more than 140-year history, JAMA has been a leader in publishing on critical issues related to health. As a forum for eliciting new ideas, facilitating cross-sector dialogue, and ident ifying opportunities for progress that inspire discussion and action, the JAMA Summit represents the latest iteration of this long tradition of furthering our mission to advance the science and art of medicine and the betterment of public healt...
Source: JAMA - Journal of the American Medical Association - April 4, 2024 Category: General Medicine Source Type: research

Medicine —Both a Science (Care) and an Art (CARE)
This Viewpoint discusses the concept of CARE (compassion, assistance, respect, and empathy) as a way physicians can practice the art of medicine in the current era of care that increasingly incorporates predictive analytics and artificial intelligence. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 3, 2024 Category: General Medicine Source Type: research

Integrated Hepatitis C –Opioid Use Disorder Care Through Telemedicine
This study discusses whether facilitated telemedicine for hepatitis C treatment increases cure rates compared with standard-of-care referral to hepatitis specialists. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 3, 2024 Category: General Medicine Source Type: research

Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Pregnancy —Reply
In Reply We thank Drs Pourkarim and Entezari-Maleki for their thoughtful comment about our recent study that described outcomes following metformin plus insulin for the treatment of early gestational and preexisting type 2 diabetes in pregnancy. We agree that based on available data, the use of metformin during pregnancy remains controversial and that long-term health data following in utero exposure should be collected prior to asserting that there are no unintended negative health consequences in childhood or adulthood. About reproductive health in males, a 2022 review article summarized the published data on the effect ...
Source: JAMA - Journal of the American Medical Association - April 3, 2024 Category: General Medicine Source Type: research