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Radiotherapy in soft-tissue sarcoma of the extremities
AbstractSarcomas are an infrequent and heterogeneous group of neoplasia. Surgery with or without associated radiotherapy (RT) is the basic treatment for this type of tumour. To increase the therapeutic ratio (the index between cytotoxic effects in tumours and normal tissue complications with a certain dose of radiation), new advances are being investigated to increase local and distant control and to decrease the morbidity of the treatment. The aim of this review was to analyse the different strategies, based on technology and biology, which are being investigated to increase the therapeutic ratio of this disease (Source: ...
Source: Clinical and Translational Oncology - February 23, 2018 Category: Cancer & Oncology Source Type: research

Pleiotropic effects of heparins: does anticoagulant treatment increase survival in cancer patients?
AbstractThe association between venous thromboembolism (VTE) and cancer has been recognized for more than 100  years. Numerous studies have been performed to investigate strategies to decrease VTE incidence and to establish whether treating VTE impacts cancer progression and overall survival. Accordingly, it is important to understand the role of the hemostatic system in tumorigenesis and progression, as t here is abundant evidence associating it with cell survival and proliferation, tumor angiogenesis, invasion, and dissemination, and metastasis formation. In attempts to further the scientific evidence, several studi...
Source: Clinical and Translational Oncology - February 22, 2018 Category: Cancer & Oncology Source Type: research

Frequent genomic alterations and better prognosis among young patients with non-small-cell lung cancer aged 40  years or younger
ConclusionsYoung patients are associated with an increased likelihood of gene mutations and can receive a better prognosis when patients harboring gene mutations are treated with EGFR-TKIs or ALK inhibitors. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 19, 2018 Category: Cancer & Oncology Source Type: research

Cancer and aging in Ibero-America
This article provides an overview of the current landscape of geriatric oncology in Ibero-America, highlighting its critical challenges, opportunities for improvement and collaboration, and future directions. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 12, 2018 Category: Cancer & Oncology Source Type: research

The glycosyltransferase ST6Gal-I is enriched in cancer stem-like cells in colorectal carcinoma and contributes to their chemo-resistance
ConclusionST6Gal-I may be highly expressed in the cancer stem-like cells in CRC and enhances cancer cell resistance to chemotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 8, 2018 Category: Cancer & Oncology Source Type: research

Thanks to reviewers
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 8, 2018 Category: Cancer & Oncology Source Type: research

Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma
ConclusionJNK1 and VDR act as tumor suppressors, and their stromal expression levels are associated with prognosis in esophageal squamous cell carcinoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 8, 2018 Category: Cancer & Oncology Source Type: research

Correction to: SEOM clinical guidelines for endometrial cancer (2017)
In the original version of this article Figure  1 was shown incorrectly. The correct Figure 1 is shown here: (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 7, 2018 Category: Cancer & Oncology Source Type: research

Germline promoter hypermethylation in BRCA1 and BRCA2 genes is not present in hereditary breast cancer patients
ConclusionsDespite the results achieved at somatic levels by other researchers, these were not confirmed in our study at the germline level. Our results show the need to establish more predictive CpG sites in theBRCA promoter regions to optimize the MS-MLPA assay for the detection of germline hypermethylation as an effective pre-screening tool for whole-BRCA genetic analysis in HBOC, because we can not rule out the existence of germline promoter hypermethylation inBRCA. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 5, 2018 Category: Cancer & Oncology Source Type: research

Association of urinary and plasma DNA in early breast cancer patients and its links to disease relapse
ConclusionUrinary DNA offers a unique opportunity to glimpse upon dynamic changes in early breast cancer. Our results demonstrated good correlation to plasma DNA and post monitoring of cancer patients to identify individuals susceptible to a high risk of relapse. This potentially allows for early intervention such as adjuvant chemotherapy to be administered to better manage these patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 1, 2018 Category: Cancer & Oncology Source Type: research

miR-328 mediates a metabolic shift in colon cancer cells by targeting SLC2A1/GLUT1
ConclusionsOur results show that miR-328 targets SLC2A1/GLUT1. We suggest that miR-328 may be involved in the orchestration of the Warburg effect in colon cancer cells. Furthermore, miR ‐328 expression is reduced in colon cancer patients and thus inversely correlates with the classically reported upregulated SLC2A1/GLUT1 expression in tumors. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 26, 2018 Category: Cancer & Oncology Source Type: research

Predictive and prognostic clinical and pathological factors of nivolumab efficacy in non-small-cell lung cancer patients
AbstractBackgroundImmunotherapy increases overall response rate (ORR) and overall survival (OS) in patients with non-small-cell lung cancer (NSCLC). Prognostic and predictive factors are a high need.Patients and methodsRetrospective review of NSCLC patients treated with nivolumab was performed. Analyzed variables included age, sex, stage, performance status (PS), location of metastases, presence of tumour-related symptoms and comorbidities, number of metastasis locations, previous chemotherapy, anti-angiogenic and radiotherapy treatments, and analytical data from the standard blood count and biochemistry.ResultsA total of ...
Source: Clinical and Translational Oncology - January 24, 2018 Category: Cancer & Oncology Source Type: research

2017 SEOM guidelines: a multidisciplinary approach
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 23, 2018 Category: Cancer & Oncology Source Type: research

Inhibiting 6-phosphogluconate dehydrogenase selectively targets breast cancer through AMPK activation
ConclusionsOur work provides experimental evidence on the association of 6PGD with poor prognosis in breast cancer and suggests that 6PGD inhibition may represent a potential therapeutic strategy to augment chemotherapy efficacy in breast cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 16, 2018 Category: Cancer & Oncology Source Type: research

From imaging to biology of glioblastoma: new clinical oncology perspectives to the problem of local recurrence
AbstractGBM is one of the most common and aggressive brain tumors. Surgery and adjuvant chemoradiation have succeeded in providing a survival benefit. Although most patients will eventually experience local recurrence, the means to fight recurrence are limited and prognosis remains poor. In a disease where local control remains the major challenge, few trials have addressed the efficacy of local treatments, either surgery or radiation therapy. The present article reviews recent advances in the biology, imaging and biomarker science of GBM as well as the current treatment status of GBM, providing new perspectives to the pro...
Source: Clinical and Translational Oncology - January 15, 2018 Category: Cancer & Oncology Source Type: research

Pancreaticoduodenectomy for periampullary tumours: a review article based on Surveillance, End Results and Epidemiology (SEER) database
This study set to examine relative survival of patients with periampullary cancers undergoing pancreaticoduodenectomy (PD).MethodsUsing the Surveillance, End Results and Epidemiology (SEER) database, this study identified 9877 patients with non-metastatic pancreatic adenocarcinoma who underwent PD between 2004 and 2013.ResultsAmpullary carcinomas have the best survival among periampullary malignancies. Lymph node ratio is a significant prognostic factor, even when stratified by tumour types. Patients receiving adjuvant radiotherapy following PD have superior survival than patients without radiotherapy (median 25 vs 20  months,p 
Source: Clinical and Translational Oncology - January 15, 2018 Category: Cancer & Oncology Source Type: research

A SUV max -based propensity matched analysis of stereotactic body radiotherapy versus surgery in stage I non-small cell lung cancer: unveiling the role of 18F-FDG PET/CT in clinical decision-making
ConclusionsThe study found a superior PFS after surgery while OS and LRC did not differ between SBRT and surgery. Surgery should be recommended for tumor of high SUVmax. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 11, 2018 Category: Cancer & Oncology Source Type: research

Reduction –oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics
AbstractEvery year, millions of cancer patients undergo radiation therapy for treating and destroying abnormal cell growths within normal cell environmental conditions. Thus, ionizing radiation can have positive therapeutic effects on cancer cells as well as post-detrimental effects on surrounding normal tissues. Previous studies in the past years have proposed that the reduction and oxidation metabolism in cells changes in response to ionizing radiation and has a key role in radiation toxicity to normal tissue. Free radicals generated from ionizing radiation result in upregulation of cyclooxygenases (COXs), nitric oxide s...
Source: Clinical and Translational Oncology - January 9, 2018 Category: Cancer & Oncology Source Type: research

Perspective on immune oncology with liquid biopsy, peripheral blood mononuclear cells, and microbiome with non-invasive biomarkers in cancer patients
Abstract Antibodies against immune checkpoint inhibitors such as anti-programmed cell death protein 1 (PD-1) and anti-programmed death ligand 1 (PD-L1) play a key role in the treatment of advanced lung cancer. To examine the clinical benefits of these agents, preclinical and clinical studies have been conducted to identify definitive biomarkers associated with cancer status. Analysis of the blood and feces of tumor patients has attracted attention in recent studies attempting to identify non-invasive biomarkers such as cytokines, soluble PD-L1, peripheral blood mononuclear cells, and gut microbiota. These factors are bel...
Source: Clinical and Translational Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Survey on paediatric tumour boards in Europe: current situation and results from the ExPo-r-Net project
ConclusionPaediatric tumor boards are a common feature in Europe. To reduce inequalities and have equal access to healthcare, a virtual network is needed. Important differences on the functioning and access to technology between regions in Europe have been observed and need to be addressed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

CXCL12 gene silencing down-regulates metastatic potential via blockage of MAPK/PI3K/AP-1 signaling pathway in colon cancer
AbstractBackgroundTo investigate the effect of CXCL12 gene silencing on proliferation,invasion, angiogenesis and the relationship of MAPK/PI3K/AP-1 signaling pathway in colon cancer cells.MethodsRT-PCR and Western-blot were used to detect the expression of CXCL12 mRNA and protein in four colon cancer cell lines. Human colon cancer cells were transfected with CXCL12 siRNA carrying by Lipofectamine 2000. The expression of CXCL12 protein was confirmed by immunoblotting. WST-1, invasion and angiogenesis assay were used to examine the effect on proliferation, invasion and angiogenesis in colon cancer cells after CXCL12 siRNA si...
Source: Clinical and Translational Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

Correction to: SEOM clinical guidelines for the treatment of metastatic prostate cancer (2017)
AbstractThe original article shows two mistakes, which are listed here: (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 5, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Recommendations for the follow-up care of female breast cancer survivors: a guideline of the Spanish Society of Medical Oncology (SEOM), Spanish Society of Primary Care Physicians (SEMERGEN), Spanish Society for Family and Community Medicine (SEMFYC), Spanish Society for General and Family Physicians (SEMG), Spanish Society of Obstetrics and Gynecology (SEGO), Spanish Society of Radiation Oncology (SEOR), Spanish Society of Senology and Breast Pathology (SESPM), and Spanish Society of Cardiology (SEC)
AbstractCorrection to: Clin Transl Oncolhttps://doi.org/10.1007/s12094-017-1801-4 (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 2, 2018 Category: Cancer & Oncology Source Type: research

Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology
AbstractThis consensus statement revises and updates the recommendations for biomarkers use in the diagnosis and treatment of breast cancer, and is a joint initiative of the Spanish Society of Medical Oncology and the Spanish Society of Pathology. This expert group recommends determining in all cases of breast cancer the histologic grade and the alpha-estrogen receptor (ER), progesterone receptor, Ki-67 and HER2 status, in order to assist prognosis and establish therapeutic options, including hormone therapy, chemotherapy and anti-HER2 therapy. One of the four available genetic prognostic platforms (MammaPrint®, Oncoty...
Source: Clinical and Translational Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Oncological strategies for locally advanced rectal cancer with synchronous liver metastases, interval strategy versus rectum first strategy: a comparison of short-term outcomes
ConclusionThe IS is a feasible and safe strategy that procures higher level of complete resection rate in a shorter period of time compared to RF strategy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Adjuvant concurrent chemoradiation therapy in patients with microscopic residual tumor after curative resection for extrahepatic cholangiocarcinoma
ConclusionsA lack of significant survival difference between R0  + S group and R1 + CCRT group suggests that adjuvant CCRT ameliorates the negative effect of microscopic positive resection margin. In contrast, adjuvant RT alone is appeared to be inadequate for controlling microscopically residual tumor. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 18, 2017 Category: Cancer & Oncology Source Type: research

SEOM –SERAM–SEMNIM guidelines on the use of functional and molecular imaging techniques in advanced non-small-cell lung cancer
AbstractImaging in oncology is an essential tool for patient management but its potential is being profoundly underutilized. Each of the techniques used in the diagnostic process also conveys functional information that can be relevant in treatment decision-making. New imaging algorithms and techniques enhance our knowledge about the phenotype of the tumor and its potential response to different therapies. Functional imaging can be defined as the one that provides information beyond the purely morphological data, and include all the techniques that make it possible to measure specific physiological functions of the tumor, ...
Source: Clinical and Translational Oncology - December 18, 2017 Category: Cancer & Oncology Source Type: research

The effect of aspirin on circulating tumor cells in metastatic colorectal and breast cancer patients: a phase II trial study
AbstractPurposeAspirin could reduce the risk of cancer metastasis. Circulating tumor cells (CTCs) are a key factor of cancer metastasis, but no evidence has revealed how aspirin affects CTCs and its epithelial –mesenchymal transition (EMT). Here, we conducted a clinical trial to investigate how aspirin affects CTCs in metastatic colorectal cancer (MCC) and breast cancer patients (MBC).MethodsThe trial is retrospective registered at clinicaltrials.gov (NCT02602938). The eligible patients are given 100  mg aspirin q.d. for 8 weeks, and CTCs are evaluated at baseline, 4 and 8 weeks for absolute number, ph...
Source: Clinical and Translational Oncology - December 14, 2017 Category: Cancer & Oncology Source Type: research

Predictive factors and the important role of detectable prostate-specific antigen for detection of clinical recurrence and cancer-specific mortality following robot-assisted radical prostatectomy
AbstractPurposeTo evaluate predictive factors associated with detectable prostate-specific antigen (PSA) and describe clinical recurrence (CR) and cancer-specific mortality (CSM) after robot-assisted radical prostatectomy (RARP).MethodsThe study included 2500 patients who were treated with RARP at a single institution between 2000 and 2016. All patients had clinically localized PCa. Patients were divided into two groups according to PSA value at 6  weeks after surgery: undetectable (n = 2271; PSA 
Source: Clinical and Translational Oncology - December 14, 2017 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines for endometrial cancer (2017)
Abstract Endometrial cancer (EC) is the most common gynecological cancer in developed countries. Most patients are diagnosed at an early stage with a low risk of relapse. However, there is a group of patients with a high risk of relapse and poor prognosis. Despite the recent publication of randomized trials, the adjuvant treatment of high-risk EC is still to be defined and there are many open questions about the best approach and the right timing. Unfortunately, the survival of metastatic or recurrent EC is short, due to the poor results of chemotherapy and the lack of a second line of treatment. Advances in the knowledg...
Source: Clinical and Translational Oncology - December 13, 2017 Category: Cancer & Oncology Source Type: research

Geriatric oncology in Spain: survey results and analysis of the current situation
ConclusionsFrom the nationwide survey promoted by the Spanish Geriatric Oncology Working Group on behalf of SEOM, we conclude that there is currently no defined care structure for elderly cancer patients. There is an increasing perception of the need for training in GO. This survey reflects a reality in which specific needs are perceived. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 11, 2017 Category: Cancer & Oncology Source Type: research

Clinical implications of the deregulated TP73 isoforms expression in cancer
AbstractTP73 is a member of theTP53 family whose expression has been observed altered in most human cancers and associated with the prognosis.TP73 translates into a complex number of isoforms with both oncogenic and tumour-suppressor functions and presents a complex cross-talk with other members of the family (TP53 andTP63). In this revision, we focus on the evidence that may supportTP73 variants as prognostic markers in cancer. Nowadays, most publications in this topic highlight the association between overexpression of the oncogenic variants and failure to respond to chemotherapy and/or shorter survival. In addition, we ...
Source: Clinical and Translational Oncology - December 11, 2017 Category: Cancer & Oncology Source Type: research

SEOM clinical guideline on unknown primary cancer (2017)
AbstractCancer of unknown primary site is a histologically confirmed cancer that manifests in advanced stage, with no identifiable primary site following standard diagnostic procedures. Patients are initially categorized based on the findings of the initial biopsy: adenocarcinoma, squamous-cell carcinoma, neuroendocrine carcinoma, and poorly differentiated carcinoma. Appropriate patient management requires understanding several clinical and pathological features that aid in identifying several subsets of patients with more responsive tumors. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 11, 2017 Category: Cancer & Oncology Source Type: research

Bevacizumab for recurrent, persistent or advanced cervical cancer: reproducibility of GOG 240 study results in “real world” patients
ConclusionFinally, although our study does have certain limitations, we believe that it can provide useful information and encouraging evidence that the routine use of bevacizumab as part of first-line treatment of patients with advanced cervical cancer may be associated with outcomes comparable with those obtained in GOG240 study. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 8, 2017 Category: Cancer & Oncology Source Type: research

Treatment-related changes in glioblastoma: a review on the controversies in response assessment criteria and the concepts of true progression, pseudoprogression, pseudoresponse and radionecrosis
AbstractThe assessment of response to therapy in glioblastoma remains a challenge, because the surrogate measures of survival are subject to radiographic misinterpretation. A solid and reliable definition of progression is needed for both clinical decision-making and for evaluating response within the clinical trials. Historically, assessment criteria have used radiologic and clinical features aimed to correctly classify patients into progressive or non-progressive disease. The widely used RANO criteria are a valuable tool in disease evaluation, both in the clinical setting and in the clinical trials. However, assessment c...
Source: Clinical and Translational Oncology - December 7, 2017 Category: Cancer & Oncology Source Type: research

Top ten errors of statistical analysis in observational studies for cancer research
AbstractObservational studies using registry data make it possible to compile quality information and can surpass clinical trials in some contexts. However, data heterogeneity, analytical complexity, and the diversity of aspects to be taken into account when interpreting results makes it easy for mistakes to be made and calls for mastery of statistical methodology. Some questionable research practices that include poor analytical data management are responsible for the low reproducibility of some results; yet, there is a paucity of information in the literature regarding specific statistical pitfalls of cancer studies. In ...
Source: Clinical and Translational Oncology - December 7, 2017 Category: Cancer & Oncology Source Type: research

Correction to: SEOM clinical guideline of diagnosis and management of low-grade glioma (2017)
AbstractThe original version of this article unfortunately contained a mistake. Figure  3 was incorrect. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 5, 2017 Category: Cancer & Oncology Source Type: research

Correction to: SEOM clinical guideline of diagnosis and management of lowgrade glioma (2017)
AbstractThe original version of this article unfortunately contained a mistake. Figure  3 was incorrect. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 5, 2017 Category: Cancer & Oncology Source Type: research

The MTHFR polymorphism affect the susceptibility of HCC and the prognosis of HCC liver transplantation
This study enrolled 244 HCC patients and 487 healthy individuals in Chinese Han population to analyze the influence of MTHFR polymorphism on HCC susceptibility first. Furthermore, this research choose another 100 donors ’ and 104 recipients’ specimens to detect the association between polymorphism of MTHFR and post-transplant HCC recurrence.Resultrs1801131 polymorphism A to C was associated with the occurrence of HCC in Chinese Han population (p 
Source: Clinical and Translational Oncology - November 28, 2017 Category: Cancer & Oncology Source Type: research

Comparison of clinical remission and survival between CLAG and FLAG induction chemotherapy in patients with refractory or relapsed acute myeloid leukemia: a prospective cohort study
ConclusionCLAG was equally effective to FLAG induction chemotherapy in total R/R AML patients, while CLAG seemed to be a better option than FLAG in patients with relapsed disease, poor risk stratification, CR at first induction or second or higher salvage therapies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 27, 2017 Category: Cancer & Oncology Source Type: research

Efficacy of fulvestrant in the treatment of postmenopausal women with endocrine-resistant advanced breast cancer in routine clinical practice
ConclusionsFulvestrant 500  mg administered in clinical practice was shown to be effective (PFS, 10.6 months; CBR, 56.5%) and well tolerated, in accordance with previous trials. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 24, 2017 Category: Cancer & Oncology Source Type: research

Predictive factors of trastuzumab-based chemotherapy in HER2 positive advanced gastric cancer: a single-center prospective observational study
ConclusionsIn routine clinical practice, the addition of trastuzumab to chemotherapy was effective and safe in real-world setting in Chinese patients with HER2 positive AGC, regardless of most of the clinicopathological factors. Further studies are needed to improve the prognosis of HER2 positive patients with liver metastasis or poor PS.Trial Registration clinicaltrials.gov Identifier: NCT03024450 (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 22, 2017 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines for the treatment of head and neck cancer (2017)
AbstractHead and neck cancer (HNC) is defined as malignant tumours located in the upper aerodigestive tract and represents 5% of oncologic cases in adults in Spain. More than 90% of these tumours have squamous histology. In an effort to incorporate evidence obtained since 2013 publication, Spanish Society of Medical Oncology (SEOM) presents an update of HNC diagnosis and treatment guideline. The eighth edition of TNM classification, published in January 2017, introduces important changes for p16-positive oropharyngeal tumours, for lip and oral cavity cancer and for N3 category. In addition, there are new data about inducti...
Source: Clinical and Translational Oncology - November 20, 2017 Category: Cancer & Oncology Source Type: research

Curative radiation therapy for very elderly bladder cancer patients with localized disease
ConclusionRT with contemporary 3D-CRT techniques after TURBT for MIBC in elderly patients is feasible and well-tolerated. Achieving a maximal response and shortening the total radiation treatment time may improve outcomes and quality of life. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 20, 2017 Category: Cancer & Oncology Source Type: research

Determining personalized treatment by gene expression profiling in metastatic breast carcinoma patients: a pilot study
ConclusionData presented here indicate that the use of MAGE provides relevant information to establish personalized treatment in frail patients with limited life expectancy in which therapeutic futility is a particularly difficult burden to assume. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 20, 2017 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines in gestational trophoblastic disease (2017)
AbstractGestational trophoblastic disease (GTD) is a rare but curable disease. Recent improvements in diagnosis and molecular biology have resulted in changes in staging and treatment. These guidelines provide evidence-based recommendation on how to manage GTD. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 17, 2017 Category: Cancer & Oncology Source Type: research

Meta-analysis of survival benefit with postoperative chemoradiotherapy in patients of lymph node positive esophageal carcinoma
AbstractBackgroundThe effect of postoperative chemoradiotherapy (CRT) for esophageal carcinoma (EC) was investigated. Patients who can obtain benefit from this treatment modality have not yet been well identified.MethodsWe searched PubMed, Embase, Web of Science, and the Cochrane Library for studies published from January 1993 to July 2016. Research comparing surgery alone (SA) with postoperative CRT in patients with resectable EC was procured; collected articles were written in English.ResultsNine studies comparing of postoperative CRT versus SA (n = 1650) in patients with resectable EC met the inclusion criteri...
Source: Clinical and Translational Oncology - November 15, 2017 Category: Cancer & Oncology Source Type: research

Effect of exosome biomarkers for diagnosis and prognosis of breast cancer patients
ConclusionsExosome biomarkers can be used for early diagnosis and prognosis of breast cancer patients in clinic. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 15, 2017 Category: Cancer & Oncology Source Type: research

Recommendations for the follow-up care of female breast cancer survivors: a guideline of the Spanish Society of Medical Oncology (SEOM), Spanish Society of General Medicine (SEMERGEN), Spanish Society for Family and Community Medicine (SEMFYC), Spanish Society for General and Family Physicians (SEMG), Spanish Society of Obstetrics and Gynecology (SEGO), Spanish Society of Radiation Oncology (SEOR), Spanish Society of Senology and Breast Pathology (SESPM), and Spanish Society of Cardiology (SEC)
AbstractThe increased incidence and decreased mortality of breast cancer have produced an increased number of breast cancer survivors. The type of sequelae and comorbidities that these patients present call for a collaborative follow-up by hospital-based specialized care and primary care. In this document, we present a guideline drafted and agreed among scientific societies whose members care for breast cancer survivors. The purpose of this guideline is to achieve the shared and coordinated follow-up of these patients by specialized care and primary care professionals. In it, we review the health issues derived from the...
Source: Clinical and Translational Oncology - November 14, 2017 Category: Cancer & Oncology Source Type: research

Genetic screening and molecular characterization of MET alterations in non-small cell lung cancer
ConclusionsMET activation, by eitherMETex14 mutations or amplification, is characteristic of a subset of early stage NSCLCs and may coexist withERBB2 amplification. This may have potential therapeutic implications. The presence ofMETex14 mutations was associated with low levels of MET protein, which may limit the use of total MET immunostaining as a marker for preselecting patients for MET-targeted therapies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - November 14, 2017 Category: Cancer & Oncology Source Type: research