Evaluation of safety and efficacy of p53MVA vaccine combined with pembrolizumab in patients with advanced solid cancers
ConclusionWe have shown that the combination of p53MVA vaccine with pembrolizumab is feasible, safe, and may offer clinical benefit in select group of patients that should be identified through further studies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 9, 2018 Category: Cancer & Oncology Source Type: research

Active study: undetected prevalence and clinical inertia in the treatment of breakthrough cancer pain (BTcP)
ConclusionsClinical inertia is a serious problem in the handling of BTcP in medical oncology services, where it is the subject of a significantly low level of detection and treatment, despite the contrasting perception of specialists. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 9, 2018 Category: Cancer & Oncology Source Type: research

Measurement of circulating tumor cells in squamous cell carcinoma of the head and neck and patient outcomes
ConclusionLiquid biopsy techniques in HNSCC show promise as a means of identifying patients at greater risk of disease progression. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 6, 2018 Category: Cancer & Oncology Source Type: research

TIPE1 suppresses osteosarcoma tumor growth by regulating macrophage infiltration
ConclusionCollectively, our results demonstrate the anti-tumor role of TIPE1 in osteosarcoma and reveal a novel therapy target for osteosarcoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 30, 2018 Category: Cancer & Oncology Source Type: research

The Medical Oncology resident mentor: situation and workload
ConclusionsThe study reveals the substantial dedication and growing complexity of MO resident mentoring. A series of recommendations are issued to improve the conditions in which it is carried out, including the design of systems that adapt to the professional activity in those departments that have time set aside for mentoring tasks. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 30, 2018 Category: Cancer & Oncology Source Type: research

Tumor-derived exosomes in cancer metastasis risk diagnosis and metastasis therapy
AbstractExosomes are endosomes secreted from the membrane by exocytosis as multivesicular bodies and are generally defined by their spherical, unilamellar morphology, size and the expression of specific biomarkers used for diagnosis or therapy targets. Recent research has reported a higher relationship between exosome enrichment and tumor disease development. In this review, we discuss exosome intercellular communication and functions in the pathology of disease, especially on the cancer metastasis related with exosome. We introduce how exosomes from cancer and stem cancer cells target different organs through transporting...
Source: Clinical and Translational Oncology - July 26, 2018 Category: Cancer & Oncology Source Type: research

Chemotherapy management for unfit patients with metastatic castration-resistant prostate cancer
AbstractAdministration of chemotherapy in prostate cancer depends on patient fitness. In unfit patients, physiological impairment determines the optimum treatment. Although no consensus on assessing patient fitness currently exists, this article proposes an algorithm combining the available information for administering chemotherapy, and in particular docetaxel, in unfit patients. It was constructed by reviewing factors that can influence treatment, such as performance status, taxane-related comorbidities and nutritional status. Geriatric scales for prostate cancer patients and alternative treatment regimens for this popul...
Source: Clinical and Translational Oncology - July 26, 2018 Category: Cancer & Oncology Source Type: research

Differences on metabolic behavior between intra and extrahepatic cholangiocarcinomas at 18 F-FDG –PET/CT: prognostic implication of metabolic parameters and tumor markers
ConclusionsIntra and extrahepatic cholangiocarcinomas behave differently on PET/CT, though no differences between both groups exist in its capacity to detect regional or distant disease. Metabolic parameters and levels of tumor markers seem to relate with tumor burden, impacting in prognosis. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 18, 2018 Category: Cancer & Oncology Source Type: research

Prognostic implication of EGFR mutation status and subtype in resected lung adenocarcinoma patients irrespective of therapy
ConclusionsThis study suggests that there is no difference on survival between patients withEGFR mutations and those without, but the patients harboringEGFR 19del mutation have survival advantage compared to those harboringEGFR L858R mutation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 18, 2018 Category: Cancer & Oncology Source Type: research

Baseline 18 F-Fluorocholine PET/CT and bone scan in the outcome prediction of patients treated with radium 223 dichloride
ConclusionFCH PET/CT and BS had prognostic aim in the prediction of OS. None clinical or imaging variable was able to predict the PFS, probably due to the high rate of progressive disease. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 13, 2018 Category: Cancer & Oncology Source Type: research

CalliSpheres ® drug-eluting beads (DEB) transarterial chemoembolization (TACE) is equally efficient and safe in liver cancer patients with different times of previous conventional TACE treatments: a result from CTILC study
ConclusionDEB-TACE treatment was equally efficient and tolerated in liver cancer patients with different times of previous cTACE treatments. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 12, 2018 Category: Cancer & Oncology Source Type: research

Molecular biomarkers for prognosis of gastrointestinal stromal tumor
AbstractGastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. However, the development of molecular markers, especially circulating biomarkers, remains largely undone for the prognosis of GIST. We discussed the clinical-pathological characteristics of GIST and identified potential biomarkers for guidance of therapy and prognosis of GIST. Around 90% of GISTs contain mutations inKIT orPDGFRA and the remaining 10% of GISTs are wild-type. Recent studies have indicated that various DNAs and miRNAs could serve as potential biomarkers for prognosis of GIST, includingKIT,PDGFRA, ...
Source: Clinical and Translational Oncology - July 12, 2018 Category: Cancer & Oncology Source Type: research

Controversies in the management of stage I seminoma: adjuvant carboplatin revisited
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Multiparametric MRI for prostate cancer: a national survey of patterns of practice among radiation oncologists in Spain
ConclusionsThis survey shows that prostate mpMRI is routinely used by radiation oncologists in Spain in a wide range of clinical scenarios. The findings reported here underscore the need to standardize treatment protocols for definitive and salvage radiotherapy in patients evaluated with mpMRI. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 10, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Predictive and prognostic clinical and pathological factors of nivolumab efficacy in non-small-cell lung cancer patients
Clinical and Translational Oncology. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - July 9, 2018 Category: Cancer & Oncology Source Type: research

Prognostic analysis of stage III gastric cancer after curative surgery according to the newest TNM classification
This study retrospectively enrolled 279 patients who underwent radical gastrectomy from January 2012 to December 2014 at our hospital and who were diagnosed with stage III GC according to the new 8th edition of the TNM classification. The patient data that were collected included age, sex, pathological parameters, survival, lymph node ratio, neo-adjuvant chemotherapy with oxaliplatin and S-1, and operation type. The characteristics, survival, and prognostic factors of the patients were analyzed by univariate and multivariate analyses.ResultsThe median OS of the patients after curative surgery was 19  months, and the 3...
Source: Clinical and Translational Oncology - July 2, 2018 Category: Cancer & Oncology Source Type: research

iTRAQ-based proteomic analysis of DMH-induced colorectal cancer in mice reveals the expressions of β-catenin, decorin, septin-7, and S100A10 expression in 53 cases of human hereditary polyposis colorectal cancer
ConclusionsThe subcellular localization of β-catenin and decorin, septin-7, and S100A10 expressions are associated with the development of colorectal cancer in mice afterN,N-dimethylhydrazine treatment and in human hereditary polyposis colorectal cancers. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 28, 2018 Category: Cancer & Oncology Source Type: research

Outcomes of early-stage breast cancer patients treated with sequential anthracyclines –taxanes in relationship to relative dosing intensity: a secondary analysis of a randomized controlled trial
AbstractPurposeTo assess the impact of relative dosing intensity (RDI) on the outcomes of breast cancer patients referred for adjuvant anthracycline –taxane chemotherapy.MethodsThis is a secondary analysis of the outcomes of patients in the comparator arm of the BCIRG005 study who received adjuvant adriamycin/cyclophosphamide (AC) –docetaxel regimen. Overall survival was assessed according to RDI through Kaplan–Meier analysis. Univariate and multivariate analyses of parameters affecting overall survival were then conducted through Cox regression analysis.ResultsKaplan –Meier analysis of overall surv...
Source: Clinical and Translational Oncology - June 28, 2018 Category: Cancer & Oncology Source Type: research

The microRNA signatures: aberrantly expressed miRNAs in prostate cancer
AbstractMicroRNAs (miRNAs) are short, non-coding, conserved, oligonucleotides that are regulatory in nature and are often dysregulated in many cancers including prostate cancer. Depending on the level of complementarity between the miRNA and mRNA target, they can either inhibit translation or degrade the target mRNA. MiRNAs expression is specific to the type of cancer, its stage and level of metastasis, making miRNAs potential stage-specific biomarkers of cancer. Recent research has shown that these miRNAs have the potential to be a diagnostic and prognostic non-invasive biomarker for various cancers including prostate can...
Source: Clinical and Translational Oncology - June 27, 2018 Category: Cancer & Oncology Source Type: research

The value of radical radiotherapy in the primary tumor of newly diagnosed oligo-metastatic nasopharyngeal carcinoma patients
ConclusionRadical radiotherapy is important for newly diagnosed oligo-metastatic nasopharyngeal carcinoma patients, which can still achieve long-term survival after chemo-radiotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 25, 2018 Category: Cancer & Oncology Source Type: research

New horizons in breast cancer: the promise of immunotherapy
AbstractImmunology and immunotherapy of cancer is an expanding field in oncology, with recent great achievements obtained through the new successful approaches implemented to circumvent immune evasion, which is undoubtedly considered a novel hallmark of cancer. Translational research in this topic has revealed targets that can be modulated in the clinical setting with new compounds and strategies. Like most of the tumors, breast cancer is considered a complex and heterogeneous disease in which host immune responses have been also recently demonstrated of critical relevance. T infiltrating lymphocyte measurement is suggeste...
Source: Clinical and Translational Oncology - June 18, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Biomarkers in breast cancer: A consensus statement by the Spanish Society of Medical Oncology and the Spanish Society of Pathology
On page 5 of the article, in the last paragraph of the section “Prognostic genetic platforms: molecular phenotypes and translation to the clinic” a relevant discrepancy between the text and Table 1 could be misunderstood, therefore the paragraph was corrected (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 18, 2018 Category: Cancer & Oncology Source Type: research

The absolute lymphocyte count can predict the overall survival of patients with non-small cell lung cancer on nivolumab: a clinical study
ConclusionOur finding that ALC at baseline and at 6  weeks on treatment is positively correlated with the OS provides an easily obtained predictive marker. Our result that the previous radiation is associated with higher ANC and lower ALC during treatment supports that the combination of radiation therapy with immunotherapy should be carefully appli ed and potentially peripheral blood counts can be utilized to stratify patients for this approach. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 13, 2018 Category: Cancer & Oncology Source Type: research

Differential molecular markers of primary lung tumors and metastatic sites indicate different possible treatment selections in patients with metastatic lung adenocarcinoma
ConclusionMolecular profiling of 228 lung adenocarcinomas determined a significant difference between biomarkers such as EGFR and KRAS subtypes at primary and metastatic sites. Our results serve as a reference for individual treatment based on different potential targets in metastatic lung adenocarcinoma directed by molecular profiling. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 11, 2018 Category: Cancer & Oncology Source Type: research

Bloodstream infection in patients with head and neck cancer: a major challenge in the cetuximab era
ConclusionsBSI causes high mortality in patients with HNC and is most often secondary to pneumonia. It occurs mainly among patients with hypoalbuminemia who receive treatment with cetuximab or chemotherapy. The development of BSI in patients with HNC impairs their outcome, especially in the presence of hypoalbuminemia and comorbidities. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 11, 2018 Category: Cancer & Oncology Source Type: research

New wind for the Spanish Federation of Scientific Oncological Societies (FESEO)
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 6, 2018 Category: Cancer & Oncology Source Type: research

Inter-observer variation of hippocampus delineation in hippocampal avoidance prophylactic cranial irradiation
ConclusionThe relatively low ICC and CIgen indicate that delineation variability among observers for both left and right hippocampus was large. The posterior and anterior-medial border have the largest delineation inaccuracy. The hippocampusDmean constraint was not violated. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 6, 2018 Category: Cancer & Oncology Source Type: research

Patterns of increased incidence and survival of cutaneous melanoma in Girona (Spain) 1994 –2013: a population-based study
ConclusionsWe found an increasing trend in the incidence of low-risk melanoma and a survival rate similar to that reported elsewhere in Europe. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 5, 2018 Category: Cancer & Oncology Source Type: research

New physical approaches to treat cancer stem cells: a review
AbstractCancer stem cells (CSCs) have been identified as the main center of tumor therapeutic resistance. They are highly resistant against current cancer therapy approaches particularly radiation therapy (RT). Recently, a wide spectrum of physical methods has been proposed to treat CSCs, including high energetic particles, hyperthermia (HT), nanoparticles (NPs) and combination of these approaches. In this review article, the importance and benefits of the physical CSCs therapy methods such as nanomaterial-based heat treatments and particle therapy will be highlighted. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 4, 2018 Category: Cancer & Oncology Source Type: research

Prospective analysis of psychological differences between adult and elderly cancer patients during postoperative adjuvant chemotherapy
ConclusionAlthough there were clear psychological differences between adults and senior cancer patients, their evolution during adjuvant chemotherapy was similar, with deterioration in quality of life and coping. This negative psychological impact of adjuvant chemotherapy should be taken into account when considering interventions. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 4, 2018 Category: Cancer & Oncology Source Type: research

Choice of antiepileptic drugs affects the outcome in cancer patients with seizures
ConclusionsPatients with primary or metastatic brain tumors have the same overall survival with or without seizures. However, patients with seizures not treated with antiepileptics exhibit worse overall survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 4, 2018 Category: Cancer & Oncology Source Type: research

Correction to: SEOM clinical guidelines for anaplastic gliomas (2017)
The SEOM/GEINO clinical guidelines provide recommendations for radiological, and molecular diagnosis, treatment and follow-up of adult patients with anaplastic gliomas (AG). We followed the 2016 WHO classification which specifies the major diagnostic/prognostic and predictive value of IDH1/IDH2 missense mutations and 1p/19q codeletions in AG. The diagnosis of anaplastic oligoastrocytoma is discouraged. Surgery, radiotherapy and chemotherapy with PCV or TMZ are the first-line standard of care for AG with slight modifications according to molecular variables. A multidisciplinary team is highly recommended in the management o...
Source: Clinical and Translational Oncology - June 1, 2018 Category: Cancer & Oncology Source Type: research

2018 consensus statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology on the diagnosis and treatment of cancer of unknown primary
This article reviews the main clinical, pathological, and molecular studies conducted to analyse and determine the origin of CUP. The main strategies for patient management and treatment, by both clinicians and pathologists, are also ad dressed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 28, 2018 Category: Cancer & Oncology Source Type: research

Letter to the Editor
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 28, 2018 Category: Cancer & Oncology Source Type: research

Molecular subtypes in early colorectal cancer associated with clinical features and patient prognosis
AbstractPurposeAfter surgical resection, an ample prognosis variability among stages is observed. Multiple prognostic factors are individually studied and some CRC classifiers have been proposed. Not one have been implemented into clinical practice.Methods/patientsWe classified 105 patients with resected CRC (stage I –III) into five molecular subtypes usingBRAFV600E andRAS (KRAS;NRAS) status, and the expression of DNA mismatch repair (MMR) proteins (MLH1 and MSH2). Clinicopathological features and DFS) of distincts groups were evaluated.Results and conclusionsRAS andBRAFV600E mutations were detected in 43.8 and 11.4%...
Source: Clinical and Translational Oncology - May 25, 2018 Category: Cancer & Oncology Source Type: research

Cutaneous toxicities of new treatments for melanoma
AbstractNew drugs against advanced melanoma have emerged during last decade. Target therapy and immunotherapy have changed the management of patients with metastatic disease. Along with its generalized use, drug toxicities have appeared and the skin is the target organ of a significant part of them. This revision summarizes the most common side effects and consensus management to improve the compliance of therapies and patients ’ quality of life. Among the BRAF inhibitors, main cutaneous side effects are photosensitivity, plantar hyperkeratosis, and the appearance of verrucal keratosis or squamous cell carcinoma. Spe...
Source: Clinical and Translational Oncology - May 24, 2018 Category: Cancer & Oncology Source Type: research

Incidence and survival of primary central nervous system lymphoma (PCNSL): results from the Girona cancer registry (1994 –2013)
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research

Spanish National Oncological Research Center (CNIO): a bibliometric portrait
ConclusionsFrom this study on a number of bibliometric characteristics of the Spanish National Oncological Research Center (CNIO), we conclude that the publication activity (since 2006 its scientific production has increased in about 83%), the number of high-quality journals used per year, the high influence, and impact of the journals and organizations citing the institution, consolidate its image as a top-notch oncological research center. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research

Characterization of tumor-derived mesenchymal stem cells potentially differentiating into cancer-associated fibroblasts in lung cancer
ConclusionsMSCs isolated from tumor tissue displayed distinct properties compared to MSCs isolated from healthy tissue, suggesting T-MSCs differentiation towards a CAF-related phenotype under the influence of the tumoral microenvironment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research

Radiolabeled F(ab ′) 2 -cetuximab for theranostic purposes in colorectal and skin tumor-bearing mice models
Conclusions111In-DOTAGA-F(ab ′)2-cetuximab is a reliable and stable tool for specific in vivo tumor targeting and is suitable for therapy efficacy assessment.177Lu-DOTAGA-F(ab ′)2-cetuximab is an interesting theranostic tool allowing therapy and imaging. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 17, 2018 Category: Cancer & Oncology Source Type: research

Influence of age on variation in patterns of care in patients with rectal cancer in Catalonia (Spain)
This study evaluates the adherence to clinical practice guidelines (CPGs) and patient outcomes in rectal cancer, with a particular focus on variation according to age.MethodsThis is a multicentre retrospective cohort study of all patients surgically treated for the first time for primary rectal cancer with curative intent in public hospitals in Catalonia during two study periods: first, with data from 2005 to 2007, and then with data from 2011 to 2012. We obtained the study data through a comprehensive review of patients ’ clinical records. Information on diagnosis, treatment and follow-up was collected and then comp...
Source: Clinical and Translational Oncology - May 15, 2018 Category: Cancer & Oncology Source Type: research

Prognostic role for the derived neutrophil-to-lymphocyte ratio in early breast cancer: a GEICAM/9906 substudy
ConclusionElevated dNLR appears to be an adverse prognostic factor in hormone receptor-negative early breast cancer.Trial registrationEudraCT: 2005-003108-12 (retrospectively registered 28/06/2005). ClinicalTrials.gov Identifier: NCT00129922 (retrospectively registered 10/08/2005). Results of this study were presented in part at the 2016 ESMO conference October 7 –11, 2016, Copenhagen, Denmark (oral presentation). (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 15, 2018 Category: Cancer & Oncology Source Type: research

Consensus document on the progression and treatment response criteria in gastroenteropancreatic neuroendocrine tumors
AbstractPurposeGastroenteropancreatic neuroendocrine tumors are a heterogeneous group of low incidence neoplasms characterized by a low proliferative activity and slow growth. Their response to targeted therapies is heterogeneous and often does not lead to tumor shrinkage. Thus, evaluation of the therapeutic response should differ from other kind of tumors.MethodsTo answer relevant questions about which techniques are best in the assessment of progression or treatment response a RAND/UCLA-based consensus process was implemented. Relevant clinical questions were listed followed by a systematic search of the literature. The ...
Source: Clinical and Translational Oncology - May 15, 2018 Category: Cancer & Oncology Source Type: research

Evaluation of thyroid gland as an organ at risk after breast cancer radiotherapy: a systematic review and meta-analysis
ConclusionThis study demonstrated that thyroid gland is affected by radiotherapy significantly and the TSH increased after radiotherapy. Protecting thyroid gland during radiation and follow-up of patients with breast cancer RT are suggested for the assessment of thyroid gland dysfunction. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 14, 2018 Category: Cancer & Oncology Source Type: research

Prognostic factors for relapse in stage I testicular seminoma: tumor size and rete testis invasion revisited
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 9, 2018 Category: Cancer & Oncology Source Type: research

Delay in starting radiotherapy due to neoadjuvant therapy does not worsen survival in unresected glioblastoma patients
ConclusionIn our series of unresected patients receiving neoadjuvant treatment, in spite of the delay in starting radiotherapy, OS was not inferior to that of a similar group of patients with no delay in starting radiotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 8, 2018 Category: Cancer & Oncology Source Type: research

Pre-surgical trial of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer: a New York Cancer Consortium trial
AbstractIntroductionThe PI3K/AKT/mTOR pathway is an oncogenic driver in breast cancer (BC). In this multi-center, pre-surgical study, we evaluated the tissue effects of the AKT inhibitor MK-2206 in women with stage I –III BC.Materials and methodsTwo doses of weekly oral MK2206 were administered at days − 9 and − 2 before surgery. The primary endpoint was reduction of pAktSer473 in breast tumor tissue from diagnostic biopsy to surgery. Secondary endpoints included changes in PI3K/AKT pathway tumor markers, tumor proliferation (ki-67), insulin growth factor pathway blood markers, pharmacokinet...
Source: Clinical and Translational Oncology - May 7, 2018 Category: Cancer & Oncology Source Type: research

A survey of perceptions, attitudes, knowledge and practices of medical oncologists about cancer pain management in Spain
ConclusionsUnlike in previous surveys, medical oncologists reported in general good knowledge and few perceived limitations and barriers for pain management. However, multi-disciplinary management and collaboration with other specialists are still uncommon. Oncologists ’ commitment to optimize pain management seems important to improve and maintain good practices. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research

Radiotherapy volume delineation using 18F-FDG-PET/CT modifies gross node volume in patients with oesophageal cancer
ConclusionsOur study shows that the volume definition by PET/CT and CT data differs. CT simulation, without taking into account PET/CT information, might leave cancer-involved nodes out of the radiotherapy-delineated volumes. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research

Management of extravasation of oxaliplatin by mimicking its biotransformation
AbstractAlthough oxaliplatin (Oxali) plays a key role in the treatment of many types of cancer and has been reported to be an irritant, there is no specific and effective method for its extravasation and failure in Oxali extravasation management results in the need for plastic surgery. In the body, Oxali bio-transforms upon dilution in chloride-containing buffer salts to its di-chloro derivative and loses an oxalate molecule. Consequently, the chloride ions exchange with water molecules in the intracellular environment to produce the di-aqua derivative, which is the most active biotransformation product of Oxali in terms o...
Source: Clinical and Translational Oncology - April 27, 2018 Category: Cancer & Oncology Source Type: research