Cutaneous toxicities of new treatments for melanoma
AbstractNew drugs against advanced melanoma have emerged during last decade. Target therapy and immunotherapy have changed the management of patients with metastatic disease. Along with its generalized use, drug toxicities have appeared and the skin is the target organ of a significant part of them. This revision summarizes the most common side effects and consensus management to improve the compliance of therapies and patients ’ quality of life. Among the BRAF inhibitors, main cutaneous side effects are photosensitivity, plantar hyperkeratosis, and the appearance of verrucal keratosis or squamous cell carcinoma. Spe...
Source: Clinical and Translational Oncology - May 24, 2018 Category: Cancer & Oncology Source Type: research

Incidence and survival of primary central nervous system lymphoma (PCNSL): results from the Girona cancer registry (1994 –2013)
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research

Spanish National Oncological Research Center (CNIO): a bibliometric portrait
ConclusionsFrom this study on a number of bibliometric characteristics of the Spanish National Oncological Research Center (CNIO), we conclude that the publication activity (since 2006 its scientific production has increased in about 83%), the number of high-quality journals used per year, the high influence, and impact of the journals and organizations citing the institution, consolidate its image as a top-notch oncological research center. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research

Characterization of tumor-derived mesenchymal stem cells potentially differentiating into cancer-associated fibroblasts in lung cancer
ConclusionsMSCs isolated from tumor tissue displayed distinct properties compared to MSCs isolated from healthy tissue, suggesting T-MSCs differentiation towards a CAF-related phenotype under the influence of the tumoral microenvironment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 23, 2018 Category: Cancer & Oncology Source Type: research

Radiolabeled F(ab ′) 2 -cetuximab for theranostic purposes in colorectal and skin tumor-bearing mice models
Conclusions111In-DOTAGA-F(ab ′)2-cetuximab is a reliable and stable tool for specific in vivo tumor targeting and is suitable for therapy efficacy assessment.177Lu-DOTAGA-F(ab ′)2-cetuximab is an interesting theranostic tool allowing therapy and imaging. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 17, 2018 Category: Cancer & Oncology Source Type: research

Influence of age on variation in patterns of care in patients with rectal cancer in Catalonia (Spain)
This study evaluates the adherence to clinical practice guidelines (CPGs) and patient outcomes in rectal cancer, with a particular focus on variation according to age.MethodsThis is a multicentre retrospective cohort study of all patients surgically treated for the first time for primary rectal cancer with curative intent in public hospitals in Catalonia during two study periods: first, with data from 2005 to 2007, and then with data from 2011 to 2012. We obtained the study data through a comprehensive review of patients ’ clinical records. Information on diagnosis, treatment and follow-up was collected and then comp...
Source: Clinical and Translational Oncology - May 15, 2018 Category: Cancer & Oncology Source Type: research

Prognostic role for the derived neutrophil-to-lymphocyte ratio in early breast cancer: a GEICAM/9906 substudy
ConclusionElevated dNLR appears to be an adverse prognostic factor in hormone receptor-negative early breast cancer.Trial registrationEudraCT: 2005-003108-12 (retrospectively registered 28/06/2005). ClinicalTrials.gov Identifier: NCT00129922 (retrospectively registered 10/08/2005). Results of this study were presented in part at the 2016 ESMO conference October 7 –11, 2016, Copenhagen, Denmark (oral presentation). (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 15, 2018 Category: Cancer & Oncology Source Type: research

Consensus document on the progression and treatment response criteria in gastroenteropancreatic neuroendocrine tumors
AbstractPurposeGastroenteropancreatic neuroendocrine tumors are a heterogeneous group of low incidence neoplasms characterized by a low proliferative activity and slow growth. Their response to targeted therapies is heterogeneous and often does not lead to tumor shrinkage. Thus, evaluation of the therapeutic response should differ from other kind of tumors.MethodsTo answer relevant questions about which techniques are best in the assessment of progression or treatment response a RAND/UCLA-based consensus process was implemented. Relevant clinical questions were listed followed by a systematic search of the literature. The ...
Source: Clinical and Translational Oncology - May 15, 2018 Category: Cancer & Oncology Source Type: research

Evaluation of thyroid gland as an organ at risk after breast cancer radiotherapy: a systematic review and meta-analysis
ConclusionThis study demonstrated that thyroid gland is affected by radiotherapy significantly and the TSH increased after radiotherapy. Protecting thyroid gland during radiation and follow-up of patients with breast cancer RT are suggested for the assessment of thyroid gland dysfunction. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 14, 2018 Category: Cancer & Oncology Source Type: research

Prognostic factors for relapse in stage I testicular seminoma: tumor size and rete testis invasion revisited
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 9, 2018 Category: Cancer & Oncology Source Type: research

Delay in starting radiotherapy due to neoadjuvant therapy does not worsen survival in unresected glioblastoma patients
ConclusionIn our series of unresected patients receiving neoadjuvant treatment, in spite of the delay in starting radiotherapy, OS was not inferior to that of a similar group of patients with no delay in starting radiotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 8, 2018 Category: Cancer & Oncology Source Type: research

Pre-surgical trial of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer: a New York Cancer Consortium trial
AbstractIntroductionThe PI3K/AKT/mTOR pathway is an oncogenic driver in breast cancer (BC). In this multi-center, pre-surgical study, we evaluated the tissue effects of the AKT inhibitor MK-2206 in women with stage I –III BC.Materials and methodsTwo doses of weekly oral MK2206 were administered at days − 9 and − 2 before surgery. The primary endpoint was reduction of pAktSer473 in breast tumor tissue from diagnostic biopsy to surgery. Secondary endpoints included changes in PI3K/AKT pathway tumor markers, tumor proliferation (ki-67), insulin growth factor pathway blood markers, pharmacokinet...
Source: Clinical and Translational Oncology - May 7, 2018 Category: Cancer & Oncology Source Type: research

A survey of perceptions, attitudes, knowledge and practices of medical oncologists about cancer pain management in Spain
ConclusionsUnlike in previous surveys, medical oncologists reported in general good knowledge and few perceived limitations and barriers for pain management. However, multi-disciplinary management and collaboration with other specialists are still uncommon. Oncologists ’ commitment to optimize pain management seems important to improve and maintain good practices. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research

Radiotherapy volume delineation using 18F-FDG-PET/CT modifies gross node volume in patients with oesophageal cancer
ConclusionsOur study shows that the volume definition by PET/CT and CT data differs. CT simulation, without taking into account PET/CT information, might leave cancer-involved nodes out of the radiotherapy-delineated volumes. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 2, 2018 Category: Cancer & Oncology Source Type: research

Management of extravasation of oxaliplatin by mimicking its biotransformation
AbstractAlthough oxaliplatin (Oxali) plays a key role in the treatment of many types of cancer and has been reported to be an irritant, there is no specific and effective method for its extravasation and failure in Oxali extravasation management results in the need for plastic surgery. In the body, Oxali bio-transforms upon dilution in chloride-containing buffer salts to its di-chloro derivative and loses an oxalate molecule. Consequently, the chloride ions exchange with water molecules in the intracellular environment to produce the di-aqua derivative, which is the most active biotransformation product of Oxali in terms o...
Source: Clinical and Translational Oncology - April 27, 2018 Category: Cancer & Oncology Source Type: research

Prognostic and microRNA profile analysis for CD44 positive expression pediatric posterior fossa ependymoma
ConclusionsCD44 is of great clinical significance as a prognostic biomarker. The survival difference between CD44 positive and negative P-PF-EPN is determined by a complex functional miRNA-mRNA-signaling pathway regulatory network. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 27, 2018 Category: Cancer & Oncology Source Type: research

Concurrent chemoradiation for locally advanced stage III non-small cell lung cancer with cisplatin, vinorelbine, and thoracic radiotherapy: a phase II study from the Galician Lung Cancer Group
ConclusionThis combined regimen shows efficacy and a manageable safety profile. PFS and OS outcomes are encouraging and warrant further research. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Systematic review of the mesopancreas: concept and clinical implications
ConclusionMP is a difficult-to-excise retropancreatic area. In theory, it is agreed that MP excision raises the rate of R0 resections, which in turn reflected in an improvement in the oncological results; however, at present there are no randomized studies to prove this. Achieving a worldwide consensus on its concept, landmarks, excision technique and oncological results is essential. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2018 Category: Cancer & Oncology Source Type: research

Prognostic value of Ki-67 according to age in patients with triple-negative breast cancer
AbstractPurposeThe prognostic value of Ki-67 in triple-negative breast cancer (TNBC) is yet unclear because the cut-off points employed differ widely and its predictive effect may vary according to age. The purpose of this study was to analyze the role of Ki-67 among patients with TNBC, and determine the optimal Ki-67 cut-off point to demonstrate its prognostic relevance associated with patient age and treatment strategy.Methods/patients201 consecutive patients treated for primary TNBC from 1999 to 2014 were analyzed. Clinicopathological characteristics and outcomes were compared between patients treated with neoadjuvan...
Source: Clinical and Translational Oncology - April 18, 2018 Category: Cancer & Oncology Source Type: research

Laparoscopic paraaortic surgical staging in locally advanced cervical cancer: a single-center experience
ConclusionsPretherapeutic laparoscopic paraaortic lymphadenectomy for locally advanced cervical carcinoma allows the adaption of radiotherapy fields to avoid false-positive and false-negative imaging results. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 18, 2018 Category: Cancer & Oncology Source Type: research

Peritoneal carcinomatosis arising from rectal or colonic adenocarcinoma treated with cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC): two different diseases
ConclusionRectal origin PC has a more aggressive behavior compared to colonic origin, reflecting in a worst prognosis of patients affected by rectal origin PC. According to our data and literature, indications of multi-modal treatment including CRS and HIPEC should be more restrictive for rectal cancer PC. Authors should differentiate colonic and rectal origin of PC when reporting cases in the literature. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 17, 2018 Category: Cancer & Oncology Source Type: research

Are endometrial cancer radiotherapy results age related?
AbstractObjectiveTo analyze the impact of age on radiotherapy results based on cancer-specific survival (CSS), vaginal-cuff relapses (VCR) and complications analysis in 438 patients with endometrial carcinoma (EC) receiving postoperative radiotherapy (PRT) divided into three age groups for analysis.Materials and methodsFrom 2003 to 2015, 438 patients with EC were treated with PRT and divided into three age groups: Group-1: 202 patients
Source: Clinical and Translational Oncology - April 12, 2018 Category: Cancer & Oncology Source Type: research

Factors associated with anxiety and depression in cancer patients prior to initiating adjuvant therapy
AbstractObjectiveAnxiety and depression affect cancer patients ’ quality of life. Our objectives were to determine the prevalence of anxiety and depression and analyze the association between positive psychological factors, sociodemographic factors, and clinical factors in oncological patients initiating adjuvant treatment.MethodsA prospective, multicenter cohort of 600 consecutive patients completed the Brief Symptom Inventory, Mini-Mental Adjustment to Cancer, Life Orientation Scale-Revised, and Multidimensional Scale of Perceived Social Support questionnaires.ResultsPrevalence of anxiety and depression was 49.8 an...
Source: Clinical and Translational Oncology - April 12, 2018 Category: Cancer & Oncology Source Type: research

Evaluation of waiting times for breast cancer diagnosis and surgical treatment
ConclusionsDelays in diagnosis and surgery in the case of women diagnosed on the basis of symptoms may be improved. There is a temporary tendency to a greater delay in surgery. Some clinical and biological factors must be taken into account to optimise delays. Survival results are not adversely affected by delays. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 9, 2018 Category: Cancer & Oncology Source Type: research

General recommendations paper on the management of older patients with cancer: the SEOM geriatric oncology task force ’s position statement
AbstractPopulation aging is associated with greater numbers of older people with cancer. Thanks to treatment advances, not only are more seniors diagnosed with cancer, but there are also more and more older cancer survivors. This upward trend will continue. Given the heterogeneity of aging, managing older patients with cancer poses a significant challenge for Medical Oncology. In Spain, a Geriatric Oncology Task Force has been set up within the framework of the Spanish Society for Medical Oncology (SEOM). With the aim of generating evidence and raising awareness, as well as helping medical oncologists in their training wit...
Source: Clinical and Translational Oncology - April 9, 2018 Category: Cancer & Oncology Source Type: research

Re-expression of microRNA-4319 inhibits growth of prostate cancer via Her-2 suppression
ConclusionThe growth and chemo-resistance of PC cells may be suppressed via re-expression of miR-4319 that inhibits Her-2 signaling. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 9, 2018 Category: Cancer & Oncology Source Type: research

Recurrent non-functioning pituitary adenomas: a review on the new pathological classification, management guidelines and treatment options
AbstractAt least 50% of surgically resected non-functioning pituitary adenomas (NFPA) recur. Either early or late adjuvant radiotherapy is highly efficacious in controlling recurrent NFPA but associates potentially burdensome complications like hypopituitarism, vascular complications or secondary neoplasm. Reoperation is indicated in bulky tumor rests compressing the optic pathway. To date, no standardized medical therapy is available for recurrent NFPA although cabergoline and temozolomide show promising results. Guidelines on the management of recurrent NFPAs are now available. The new 2017 WHO pituitary tumor classifica...
Source: Clinical and Translational Oncology - April 5, 2018 Category: Cancer & Oncology Source Type: research

Dosimetry study of 18 F-FMISO  + PET/CT hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer
ConclusionIt is feasible in dosiology that the dosages in NSCLC hypoxic area were added to 72, 78 and 84  Gy by simultaneous integrated boost with the guidance of18F-FMISO PET/CT. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 5, 2018 Category: Cancer & Oncology Source Type: research

Pathology findings and clinical outcomes after risk reduction salpingo-oophorectomy in BRCA mutation carriers: a multicenter Spanish study
ConclusionThe incidence of STIC after RRSO in BRCA mutation carriers is low (0.8%) and it presents an excellent oncological outcome. Patients after RRSO, however, run the risk to develop other types of cancer during follow-up and should be properly advised before the prophylactic surgery. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 5, 2018 Category: Cancer & Oncology Source Type: research

The effect of dose escalation for large squamous cell carcinomas of the anal canal
AbstractPurposeChemoradiation allows for organ preservation in patients with anal cancer, but patients with large tumors (>  5 cm) have elevated rates of locoregional recurrence. With conformal radiation techniques, there is interest in dose escalation to decrease local recurrence in patients with large tumor size.Methods/patientsThe National Cancer Database (NCDB) was used to identify patients with anal cancer from 2004 to 2013 with tumors  >  5 cm. Adult patients who received definitive chemoradiation were included. Patients with prior resection were excluded. High dose was defined as...
Source: Clinical and Translational Oncology - April 5, 2018 Category: Cancer & Oncology Source Type: research

Postoperative intra-abdominal infection is an independent prognostic factor of disease-free survival and disease-specific survival in patients with stage II colon cancer
AbstractBackgroundRecurrence occurs in up to 20% of patients with stage II colon cancer operated on for cure. Although postoperative intra-abdominal infection has been linked with an increased risk of recurrence, the association is controversial. The aim was to investigate the impact of postoperative intra-abdominal infection on disease-free survival and disease-specific survival in patients with stage II colon cancer.MethodsPatients undergoing elective surgery for colon cancer stage II, between 2003 and 2014, were included. Patients with anastomotic leak or intra-abdominal abscess were included in the infection group. We ...
Source: Clinical and Translational Oncology - April 5, 2018 Category: Cancer & Oncology Source Type: research

Comparison of plasma ctDNA and tissue/cytology-based techniques for the detection of EGFR mutation status in advanced NSCLC: Spanish data subset from ASSESS
ConclusionsThe high concordance between the different DNA sources forEGFR mutation testing supports the use of plasma samples when tumor tissue is unavailable. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 5, 2018 Category: Cancer & Oncology Source Type: research

Childhood and adolescent lymphoma in Spain: incidence and survival trends over 20  years
ConclusionsSystematic monitoring and analysis of lymphoma paediatric data would provide clinical and epidemiological information to improve the health care of these patients and the outcomes for these malignancies in Spain. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 5, 2018 Category: Cancer & Oncology Source Type: research

The relationship between physician and cancer patient when initiating adjuvant treatment and its association with sociodemographic and clinical variables
ConclusionPhysicians must be mindful of the importance of emotional support and individual characteristics when communicating treatment options, benefits, and adverse effects of each alternative to oncological patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 2, 2018 Category: Cancer & Oncology Source Type: research

Nur77 suppression facilitates androgen deprivation-induced cell invasion of prostate cancer cells mediated by TGF- β signaling
ConclusionConsidering the limited success of management of prostate cancer metastasis following ADT, our data strongly suggest that Nur77 regulation could be a promising direction for search of complementary therapeutic strategy on top of classic ADT therapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 28, 2018 Category: Cancer & Oncology Source Type: research

Bevacizumab improves survival in patients with synchronous colorectal liver metastases provided the primary tumor is resected first
ConclusionsNeoadjuvant Bevacizumab-based chemotherapy was associated with improved OS in patients who underwent liver resection of synchronous CRLM, especially in those who underwent primary tumor resection first. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 28, 2018 Category: Cancer & Oncology Source Type: research

Concurrent use of capecitabine with radiation therapy and survival in breast cancer (BC) after neoadjuvant chemotherapy
AbstractPurposeCapecitabine has been studied as a radiosensitizer, and our study seeks to examine the association of concurrent capecitabine/radiation therapy (RT) on event-free- (EFS) and overall survival (OS) in women with breast cancer (BC) with residual disease after neoadjuvant chemotherapy (NAC).Methods/patientsIn a retrospective study of women with BC who received adriamycin/taxane-based NAC from 2004 –2016, we identified 21 women administered concurrent capecitabine/RT. To assess differences in survival, we selected a clinical control cohort (n = 57) based on criteria used to select patients for...
Source: Clinical and Translational Oncology - March 28, 2018 Category: Cancer & Oncology Source Type: research

Recommendations of the Spanish brachytherapy group (GEB) of Spanish Society of Radiation Oncology (SEOR) and the Spanish Society of Medical Physics (SEFM) for high-dose rate (HDR) non melanoma skin cancer brachytherapy
Abstract Clinical indications of brachytherapy in non-melanoma skin cancers, description of applicators and dosimetry recommendations are described based on the literature review, clinical practice and experience of Spanish Group of Brachytherapy and Spanish Society of Medical Physics reported in the XIV Annual Consensus Meeting on Non Melanoma Skin Cancer Brachytherapy held in Benidorm, Alicante (Spain) on October 21st, 2016. All the recommendations for which consensus was achieved are highlighted in blue. Regular and small surfaces may be treated with Leipzig, Valencia, flap applicators or electronic brachytherapy (EBT)....
Source: Clinical and Translational Oncology - March 23, 2018 Category: Cancer & Oncology Source Type: research

Preclinical and clinical development of palbociclib and future perspectives
AbstractCyclin-dependent kinases (CDKs) play a key role in cell cycle regulation, which makes them a clear therapeutic target to interfere with cell division and proliferation in cancer patients. Palbociclib, a specific inhibitor of CDK4/6 with outstanding clinical efficacy data and limited toxicity, has been recently approved for the treatment of hormone receptor (HR)-positive human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer, either in combination with an aromatase inhibitor or in combination with fulvestrant in women who have received prior endocrine therapy. This revi...
Source: Clinical and Translational Oncology - March 21, 2018 Category: Cancer & Oncology Source Type: research

Histopathologic analysis of stage pT1b kidney neoplasms for optimal surgical margins of nephron-sparing surgery
ConclusionsOur report indicates a 3  mm excisional margin is acceptable to ensure negative SM when operating NSS on stage pT1b kidney neoplasms. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 21, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Curative radiation therapy for very elderly bladder cancer patients with localized disease
In the original version of this article the figure captions of Figs.  1 and 2 were interchanged. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 15, 2018 Category: Cancer & Oncology Source Type: research

Comparative analysis of the effect of different radiotherapy regimes on lymphocyte and its subpopulations in breast cancer patients
AbstractPurposeThe aim of this study was to determine whether different radiotherapy (RT) fractionation schemes induce disparate effects on lymphocyte and its subsets in breast cancer patients.Methods60 female patients diagnosed with breast cancer were recruited in this study after receiving modified radical mastectomy and were randomly divided into two groups. One group received irradiation at a standard dose of 50  Gy in 25 fractions and the other at a dose of 40.3 Gy in 13 fractions. Both total lymphocyte count and its composition were recorded at three timepoints: right before the radiation treatment (T0), im...
Source: Clinical and Translational Oncology - March 13, 2018 Category: Cancer & Oncology Source Type: research

Circular RNAs and exosomes in cancer: a mysterious connection
AbstractCircular RNAs (CircRNAs) are a type of non-coding RNAs (NcRNAs) with a closed annular structure. Until next-generation sequencing (NGS) is developed, the misunderstanding of circRNAs ‘splicing error’ has changed, and the mysterious veil of circRNAs has been revealed. NGS provides an approach to investigate circRNAs. Many scholars point out that circRNAs may play an important role in many diseases, especially cancer. At the same time, exosomes, as a kind of extracellular vesi cles loaded with many contents, are a hotspot in recent years. They can act as ‘messengers’ between cells, especially ...
Source: Clinical and Translational Oncology - March 13, 2018 Category: Cancer & Oncology Source Type: research

Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona –Tarragona 1985–2004)
ConclusionsIn our study, women diagnosed with breast cancer had higher long-term probability to die from breast cancer than from other causes. The improvements in treatment and the lead-time bias in detecting cancer in an early stage resulted in a reduction of 19% in the risk of death between diagnostic periods. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 6, 2018 Category: Cancer & Oncology Source Type: research

Integral nutritional approach to the care of cancer patients: results from a Delphi panel
This study aimed to reach a consensus on nutritional needs and optimize nutritional care in the management of cancer patients at a national level.MethodsA qualitative, multicenter, two-round Delphi study involving 52 specialists with experience in nutritional support in cancer patients was conducted.ResultsRegarding the presence of malnutrition, 57.7% of the participants stated that  50% at the end of the treatment. Forty percent of participants believed that the main objective of nutritional treatment was to improve quality of life and 34.6% to improve tolerability and adherence to chemotherapy. The quality nutrition...
Source: Clinical and Translational Oncology - March 2, 2018 Category: Cancer & Oncology Source Type: research

Adjuvant radiotherapy following pancreaticoduodenectomy for ampullary adenocarcinoma improves survival in node-positive patients: a propensity score analysis
ConclusionIn summary, adjuvant radiotherapy following PD for ampullary adenocarcinoma significantly improves survival in patients with N2 disease. Future studies defining “high-risk” groups using larger cohorts will enable reliable appraisal on the benefit of adjuvant radiotherapy to allow for a more personalized approach in treating patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 1, 2018 Category: Cancer & Oncology Source Type: research

Role of intestinal microbiome in American ginseng-mediated colon cancer protection in high fat diet-fed AOM/DSS mice
ConclusionOur results suggest that the CRC chemopreventive effects of American ginseng are mediated through enteric microbiome population-shift recovery and dysbiosis restoration. Ginseng ’s regulation of the microbiome balance contributes to the maintenance of enteric homeostasis. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 27, 2018 Category: Cancer & Oncology Source Type: research

Deep sequencing reveals the molecular pathology characteristics between primary uterine leiomyoma and pulmonary benign metastasizing leiomyoma
ConclusionThis study indicates that the metastatic lung lesions were derived from the same malignant cell clone of uterine LMs and later acquired the novel driver mutations in the evolution of the tumor. In addition, driver gene sequencing can discriminate somatic driver mutations as biological indicators of potential malignant leiomyoma and can identify pathogenic variation driver mutations, which could be used for individualized therapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 26, 2018 Category: Cancer & Oncology Source Type: research

Radiotherapy in soft-tissue sarcoma of the extremities
AbstractSarcomas are an infrequent and heterogeneous group of neoplasia. Surgery with or without associated radiotherapy (RT) is the basic treatment for this type of tumour. To increase the therapeutic ratio (the index between cytotoxic effects in tumours and normal tissue complications with a certain dose of radiation), new advances are being investigated to increase local and distant control and to decrease the morbidity of the treatment. The aim of this review was to analyse the different strategies, based on technology and biology, which are being investigated to increase the therapeutic ratio of this disease (Source: ...
Source: Clinical and Translational Oncology - February 23, 2018 Category: Cancer & Oncology Source Type: research

Pleiotropic effects of heparins: does anticoagulant treatment increase survival in cancer patients?
AbstractThe association between venous thromboembolism (VTE) and cancer has been recognized for more than 100  years. Numerous studies have been performed to investigate strategies to decrease VTE incidence and to establish whether treating VTE impacts cancer progression and overall survival. Accordingly, it is important to understand the role of the hemostatic system in tumorigenesis and progression, as t here is abundant evidence associating it with cell survival and proliferation, tumor angiogenesis, invasion, and dissemination, and metastasis formation. In attempts to further the scientific evidence, several studi...
Source: Clinical and Translational Oncology - February 22, 2018 Category: Cancer & Oncology Source Type: research