Baicalein, an enteric microbial metabolite, suppresses gut inflammation and cancer progression in Apc Min/+ mice
AbstractObjectiveChronic inflammation is recognized as a risk factor for colorectal cancer (CRC) development. Baicalin (BI), a major constituent in an anti-inflammatory herbScutellaria baicalensis, can be biotransformed into baicalein (BE) by the intestinal microbiota. We evaluated the anti-inflammation and anti-CRC effects of the metabolite BE.MethodsThe in vitro biotransformation by human intestinal microbiota from BI into BE has been determined with HPLC. Using a gut-specificApcMin/+ mouse model, the effects of oral BE on the life span, organ index, and tumor multiplicity were evaluated. The expressions of inflammatory ...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Novel exosomal miR-46146 transfer oxaliplatin chemoresistance in colorectal cancer
ConclusionsThese results indicate that exosomal miR-46146 functions as a vital mediator of OX resistance by targeting PDCD10 and could be a potential target to re-sensitize CRC cell to OX. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

The efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer patients of different age groups: a meta-analysis
ConclusionRegardless of the NSCLC patients who were less or more than 65  years, immune checkpoint inhibitors could achieve better OS than chemotherapy. But there was no significant difference when NSCLC patients who were more than 75 years old. Older patient should be offered immune therapies if it is possible and the mechanism in old age treatment should be further s tudied. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer
ConclusionOur findings suggest that PRDM14 is involved in progression and chemoresistance of CRC, and is a potential prognostic biomarker and therapeutic target in the CRC patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Spanish validation of Charlson index applied to prostate cancer
DiscussionThe RCI may be used to aid medical decision making in older Spanish men with PC, especially in those with a high RCI 5 and higher. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Therapeutic potential of natural products in glioblastoma treatment: targeting key glioblastoma signaling pathways and epigenetic alterations
AbstractGlioma is the most common primary tumor of the nervous system, and approximately 50% of patients exhibit the most aggressive form of the cancer, glioblastoma. Currently, considerable research in glioblastoma therapeutics is aimed at developing vaccines or drugs to target key molecules for combating this disease. Studies on plant natural products from spices, vegetables, fruits, teas, and traditional medicinal herbs display that these plant-derived natural products can act as effective antioxidant and anti-tumor agents. The advancements in metabolomics and in genomics have enabled researchers to better evaluate the ...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

The prognostic role of FZD6 in esophageal squamous cell carcinoma patients
In this study, GSE20347, GSE23400 and GSE45670 datasets were retrieved from Gene Expression Omnibus (GEO) database, and the overlapping differentially expressed genes (DEGs) in three datasets were screened. Then the overlapping DEGs function was annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway-enrichment analysis. The prognostic value of the top five KEGG pathway-related genes were further validated in The Cancer Genome Atlas (TCGA) database. After extensive statistical analysis, four genes (CDC25B, CXCL8, FZD6 and MCM4) were identified as potential prognostic markers. Among the four candidate genes, the...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth
ConclusionGA-A/DM may be a promising natural therapeutic reagent in the treatment of AM by suppressing growth via NDRG2 modulation and altering of intracellular signal pathways. We have shown it could potentially be an effective treatment for AM with decreased cellular proliferation in vitro, decreased tumor volume and increased survival in vivo. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Cross-talk between ribosome biogenesis, translation, and mTOR in CD133+  4/CD44+ prostate cancer stem cells
ConclusionsThe increase in a number of genes associated with ribosome biogenesis, translation, and mTOR signaling may be important to evaluate prognosis and determine treatment approach for prostate cancer (PCa). A better understanding of the molecular pathways associated with CSCs may be promising to develop targeted therapies to prolong survival in PCa. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Prognostic value of peptidyl-prolyl cis – trans isomerase 1 (PIN1) in human malignant tumors
ConclusionsThese results suggest that high expression of PIN1 can be considered as a risk factor for progression and invasion of malignant tumors and thus may serve as a promising therapeutic target and prognostic biomarker for human solid tumors. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Splenic volume as a biomarker of hepatic damage after chemotherapy in patients with resected colorectal liver metastases (CRLM)
ConclusionsPatients who receive neoadjuvant chemotherapy for liver metastasis surgery have a greater splenic volume increase, which correlates with NAFLD and a lower survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Calcium-sensing receptor bridges calcium and telomerase reverse transcriptase in gastric cancers via Akt
ConclusionsOur findings established a functional linkage between CaSR and hTERT in the development of gastric cancers and CaSR –hTERT coupling might serve as a novel target for therapeutic strategy against human gastric cancers. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Paradoxical prognostic phenomenon of plasma T-cell-derived circulating DNA level in advanced non-small cell lung cancer
ConclusionT-cirDNA could be a novel biomarker representing adaptive immune resistance in NSCLC patients. Further exploration as a predictive biomarker for EGFR inhibitors in setting ofEGFR mutation might be warranted. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Constitutive expression of c-REL in uveal melanoma patients: correlation with clinicopathological parameters and patient outcome
AbstractPurposeUveal melanoma (UM) is the most common intraocular cancer with a high mortality rate that requires new research in the field of prevention and treatment. c-REL is a member of the nuclear factor κB (NF-κB) transcription factor family and an emerging regulator of tumorigenesis. Therefore, the objective of the study is to evaluate the constitutive expression of c-REL in uveal melanoma patients and its prognostic significance.MethodsDetection of c-REL expression was carried out by immunohistochemistry in all 75 patients, and qRT-PCR performed on 58 fresh cases of uveal melanoma along with IL-6 status...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Dynamic monitoring of HER2 amplification in circulating DNA of patients with metastatic colorectal cancer treated with cetuximab
ConclusionPlasmaHER2 amplification detected by ddPCR changed over time and predicted resistance to CTX, by an average lead time of 2  months. Further study is needed to validate our findings. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 28, 2020 Category: Cancer & Oncology Source Type: research

Important prognostic factors in leiomyosarcoma survival: a National Cancer Database (NCDB) analysis
In this study, females comprised 68.3% of the cohort with a median age of 58  years. The most common primary anatomical sites were the extremities followed by female reproductive organs, abdomen, pelvis, thorax or lung, and head or neck. Tumors localized in the female reproductive organs had the worst survival (5-year survival probability: 45.3%), while tumors localized in the extremities had the best survival outcomes (5-year survival probability: 73.4%). Surgery with adjuvant radiation yielded better outcomes compared to surgery alone (HR 0.82, 95% CI 0.74–0.91). Microscopic and macroscopic margins resulted in...
Source: Clinical and Translational Oncology - April 28, 2020 Category: Cancer & Oncology Source Type: research

Treatment of radiation-induced myelopathy with bevacizumab
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 28, 2020 Category: Cancer & Oncology Source Type: research

Urinary microRNAs expression in prostate cancer diagnosis: a systematic review
ConclusionThese results suggested that large-scale prospective studies are still needed to validate our findings, using standardized protocols for analysis. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2020 Category: Cancer & Oncology Source Type: research

Multidisciplinary consensus statement on the clinical management of patients with pancreatic cancer
AbstractPancreatic cancer (PC) remains one of the most aggressive tumors with an increasing incidence rate and reduced survival. Although surgical resection is the only potentially curative treatment for PC, only 15 –20% of patients are resectable at diagnosis. To select the most appropriate treatment and thus improve outcomes, the diagnostic and therapeutic strategy for each patient with PC should be discussed within a multidisciplinary expert team. Clinical decision-making should be evidence-based, consider ing the staging of the tumor, the performance status and preferences of the patient. The aim of this guidelin...
Source: Clinical and Translational Oncology - April 21, 2020 Category: Cancer & Oncology Source Type: research

Immunotherapy ‑based combinations versus standard first‑line and hypothyroidism risk
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 20, 2020 Category: Cancer & Oncology Source Type: research

Apolipoproteins, as the carrier proteins for lipids, are involved in the development of breast cancer
AbstractApolipoproteins, the key components of lipoproteins, play vital roles in the combination and transportation of lipids. Numerous research articles have accumulated solid evidence that lipoproteins are closely related to various types of tumorigenesis. In this review, we focused on the associations between several apolipoproteins and breast carcinoma and distinguished the effects and significance of apolipoproteins in different locations to validate their roles in breast carcinoma development. For example, apoD and apoE in serum are viewed as risk factors for breast carcinoma. ApoD, apoE and apoA-I in mammary tissues...
Source: Clinical and Translational Oncology - April 18, 2020 Category: Cancer & Oncology Source Type: research

Letter to Editor regarding “The risk of malignancies in patients receiving hematopoietic stem cell transplantation: a systematic review and meta‑analysis”
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 17, 2020 Category: Cancer & Oncology Source Type: research

Radiation-induced lymphopenia: the main aspects to consider in immunotherapy trials for endometrial and cervical cancer patients
AbstractBackgroundAlthough the chemotherapy-induced depletion of circulating white blood cells (WBC) is well recognized, the impact of exclusive radiotherapy (RT) on the different subpopulations of WBC remains unexplored. This may be important for immunotherapy administrated in combination with radiation, especially in malignant tumors usually treated with RT or chemoradiotherapy (CRT), and characterized by a high mutational burden, such as endometrial (EC) or cervical cancer (CC). We aimed to evaluate the impact of RT and CRT on circulating WBC in uterine cancers and its correlation with survival.Material and methodsA tot...
Source: Clinical and Translational Oncology - April 13, 2020 Category: Cancer & Oncology Source Type: research

The role of macrophages during breast cancer development and response to chemotherapy
AbstractMacrophages play an important role in the immune system as a key host defense against pathogens. Non-polarized macrophages can differentiate into pro-inflammatory classical pathway-activated macrophages or anti-inflammatory alternative pathway-activated macrophages, both of which play central roles in breast cancer growth and progression in a process called polarization of macrophages. Classical pathway-activated and alternative pathway-activated macrophages can transform into each other and their transformational properties and orientation are determined by cytokines in the tumor microenvironment. Tumor-associated...
Source: Clinical and Translational Oncology - April 11, 2020 Category: Cancer & Oncology Source Type: research

Hepatic resection and blood transfusion increase morbidity after cytoreductive surgery and HIPEC for colorectal carcinomatosis
AbstractBackground and objectivesCytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is an effective but complex treatment for peritoneal metastasis (PM). Our objective was to identify risk factors for postoperative morbidity and mortality following CRS-HIPEC.MethodsRetrospective study of prospectively collected data of patients undergoing CRS-HIPEC for PM arises from colorectal cancer between January 2008 and December 2017. Perioperative variables were correlated with morbidity outcomes using a logistic regression model.ResultsSixty-seven patients underwent CRS-HIPEC, and overall morbidity and...
Source: Clinical and Translational Oncology - April 10, 2020 Category: Cancer & Oncology Source Type: research

Incidence of venous thromboembolism in patients with colorectal cancer according to oncogenic status
ConclusionsIn our study, biomarkers have not been associated with an increased risk of VTE in CRC patients. A high incidence of VTE in BRAF-mutated patients has been observed and should be explored in further studies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 8, 2020 Category: Cancer & Oncology Source Type: research

Cellular immunotherapy: a clinical state-of-the-art of a new paradigm for cancer treatment
AbstractCancer immunotherapy has opened a new chapter in Medical Oncology. Many novel therapies are under clinical testing and some have already been approved and implemented in cancer treatment protocols. In particular, cellular immunotherapies take advantage of the antitumor capabilities of the immune system. From dendritic cell-based vaccines to treatments centered on genetically engineered T cells, this form of personalized cancer therapy has taken the field by storm. They commonly share the ex vivo genetic modification of the patient ’s immune cells to generate or induce tumor antigen-specific immune responses. ...
Source: Clinical and Translational Oncology - April 7, 2020 Category: Cancer & Oncology Source Type: research

Axillary nodal involvement by primary tumor features in early breast cancer: an analysis of 2600 patients
ConclusionsThese results raise the question whether axillary node status is redundant in cases with exceptionally good features, i.e., small tumors with low Ki67, or in those candidate to adjuvant systemic treatment/radiotherapy anyway including TNBC, and support the incorporation of primary BC tumor characteristics as stratification factors in ongoing trials aiming at de-escalating axillary surgical procedures. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

Emerging roles of aerobic glycolysis in breast cancer
AbstractAltered aerobic glycolysis is a well-recognized characteristic of cancer cell energy metabolism, known as the Warburg effect. Even in the presence of abundant oxygen, a majority of tumor cells produce substantial amounts of energy through a high glycolytic metabolism, and breast cancer (BC) is no exception. Breast cancer continues to be the second leading cause of cancer-associated mortality in women worldwide. However, the precise role of aerobic glycolysis in the development of BC remains elusive. Therefore, the present review attempts to address the implication of key enzymes of the aerobic glycolytic pathway in...
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

Multidisciplinary management of liver metastases in patients with colorectal cancer: a consensus of SEOM, AEC, SEOR, SERVEI, and SEMNIM
AbstractColorectal cancer (CRC) has the second-highest tumor incidence and is a leading cause of death by cancer. Nearly 20% of patients with CRC will have metastases at the time of diagnosis, and more than 50% of patients with CRC develop metastatic disease during the course of their disease. A group of experts from the Spanish Society of Medical Oncology, the Spanish Association of Surgeons, the Spanish Society of Radiation Oncology, the Spanish Society of Vascular and Interventional Radiology, and the Spanish Society of Nuclear Medicine and Molecular Imaging met to discuss and provide a multidisciplinary consensus on th...
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

The impact of PTEN deletion and ERG rearrangement on recurrence after treatment for prostate cancer: a systematic review and meta-analysis
AbstractBackgroundThe specific association between PTEN deletion or ERG rearrangement and the recurrence of prostate cancer (PC) treated with radical prostatectomy (RP) or brachytherapy is still unelaborated. Therefore, we performed a comprehensive meta ‑analysis to understand the impact of these factors on cancer recurrence.MethodsA comprehensive literature search was performed in November 2018 based on PUBMED, EMBASE and Web of science database. Hazard ratio (HR) for biochemical recurrence free (BRF) which was defined as a PSA greater than or equal to 0.4  ng/mL after RP or another therapy for any detectable PSA a...
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

Treatment options beyond immunotherapy in patients with wild-type lung adenocarcinoma: a Delphi consensus
ConclusionsTo support decision making following progression to immunotherapy-based treatment in patients with advanced wild-type lung adenocarcinoma, a consensus document has been developed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

A new therapeutic approach in very refractory diffuse large B-cell lymphoma
AbstractPurposePatients with diagnosis of diffuse large B-cell lymphoma, who relapse after stem cell transplant (SCT) or are no candidates to SCT, have a poor prognosis and no current treatment is available. Thus, we conduct a rotatory chemotherapy schedule that employed low doses of chemotherapy agents to assess efficacy and toxicity in this setting of patients; the end point was the improved outcome.MethodsRetrospectively we revised an analysis of 461 patients who were treated with a low-doses regimen of cytotoxic agents, who were treated in a single institution, all patients has been treated with at least two salvage re...
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

Orphan nuclear receptor COUP-TFII is an oncogenic gene in renal cell carcinoma
ConclusionsIn summary, the present study indicated that COUP-TFII is an oncogenic gene in RCC, and a potential therapeutic target for the treatment of the disease. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

Expression of CD47 antigen in Reed –Sternberg cells as a new potential biomarker for classical Hodgkin lymphoma
DiscussionWe propose that HRS cells, by up-regulating CD47, might avoid innate immunity check on tumor growth, which could be circumvented using blocking monoclonal antibodies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

Evaluating anti-tumor activity of palbociclib plus radiation in anaplastic and radiation-induced meningiomas: pre-clinical investigations
ConclusionA pre-clinical murine model provides preclinical evidence for use of palbociclib plus radiation as a therapeutic agent for Rb+  meningiomas. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 6, 2020 Category: Cancer & Oncology Source Type: research

The effectiveness and safety of thromboprophylaxis in cancer patients based on Khorana score: a meta-analysis and systematic review of randomized controlled trials
ConclusionThromoboprophylaxis is effective and safe in cancer patients that are at high risk for developing VTE with chemotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 3, 2020 Category: Cancer & Oncology Source Type: research

Invasive and in situ cervical cancer associated with pregnancy: analysis from the French cancer network (CALG: Cancer Associ é à La Grossesse)
ConclusionManagement of cervical cancer during pregnancy is challenging especially in terms of maternal outcomes with a relative poor prognosis requiring a multidisciplinary expert advice. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 2, 2020 Category: Cancer & Oncology Source Type: research

Immune status and the efficacy of adjuvant radiotherapy for patients with localized Merkel cell carcinoma of the head and neck
ConclusionsIn this NCDB analysis, adjuvant RT was associated with decreased hazard of death for patients with localized MCC of the head and neck regardless of immune status and should be considered for both IS and IC patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 2, 2020 Category: Cancer & Oncology Source Type: research

RUNX1-activated upregulation of lncRNA RNCR3 promotes cell proliferation, invasion, and suppresses apoptosis in colorectal cancer via miR-1301-3p/AKT1 axis in vitro and in vivo
ConclusionRUNX1-activated upregulation of RNCR3 promoted colorectal cancer progression by sponging miR-1301-3p to elevate AKT1 levels in vitro and in vivo. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 1, 2020 Category: Cancer & Oncology Source Type: research

Radiotherapy after prostatectomy in high ‑risk prostate cancer
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 30, 2020 Category: Cancer & Oncology Source Type: research

A comprehensive overview on the molecular biology of human glioma: what the clinician needs to know
AbstractThe molecular biology of human glioma is a complex and fast-growing field in which basic research needs to meet clinical expectations in terms of anti-tumor efficacy. Although much effort is being done in molecular biology research, significant contribution to the quality of life and overall survival still lacks. The vastness of molecular biology literature makes it virtually impossible for clinicians to keep up to date in the field. This paper reviews some practical concepts regarding glioma tumorigenesis from the clinician ’s perspective. Five main aspects are discussed: major intracellular signaling pathwa...
Source: Clinical and Translational Oncology - March 28, 2020 Category: Cancer & Oncology Source Type: research

Challenges in the treatment of breast cancer brain metastases: evidence, unresolved questions, and a practical algorithm
AbstractBreast cancer is the leading cause of brain metastases in women. Large randomized clinical trials that have evaluated local therapies in patients with brain metastases include patients with brain metastases from a variety of cancer types. The incidence of brain metastases in the breast cancer population continues to grow, which is, aside from the rising breast cancer incidence, mainly attributable to improvements in systemic therapies leading to more durable control of extracranial metastatic disease and prolonged survival. The management of breast cancer brain metastases remains challenging, even more so with the ...
Source: Clinical and Translational Oncology - March 21, 2020 Category: Cancer & Oncology Source Type: research

Combination of statin/vitamin D and metastatic castration-resistant prostate cancer (CRPC): a post hoc analysis of two randomized clinical trials
AbstractIn castration-resistant prostate cancer (CRPC) patients, observational studies have reported that statins may boost the antitumor activity of abiraterone (AA) and data suggest an improvement in efficacy; conclusions with vitamin D are less clear but an eventual benefit has been pointed. We conducted a post hoc analysis of individual patient data of CRPC patients treated with prednisone and/or AA with or without statins/vitamin D on randomized clinical trials. In the COU-AA-301 trial, use of AA with statin and vitamin D reduced the risk of death by 38% (p = 0.0007) while AA alone was associated with a ...
Source: Clinical and Translational Oncology - March 20, 2020 Category: Cancer & Oncology Source Type: research

Current updates on the role of reactive oxygen species in bladder cancer pathogenesis and therapeutics
AbstractBladder cancer (BCa) is the fourth most common urological malignancy in the world, it has become the costliest cancer to manage due to its high rate of recurrence and lack of effective treatment modalities. As a natural byproduct of cellular metabolism, reactive oxygen species (ROS) have an important role in cell signaling and homeostasis. Although up-regulation of ROS is known to induce tumorigenesis, growing evidence suggests a number of agents that can selectively kill cancer cells through ROS induction. In particular, accumulation of ROS results in oxidative stress-induced apoptosis in cancer cells. So, ROS is ...
Source: Clinical and Translational Oncology - March 18, 2020 Category: Cancer & Oncology Source Type: research

Expression-based, consistent biomarkers for prognosis and diagnosis in lung cancer
ConclusionsThis prospective study presents evidences for the diagnostic and prognostic capabilities of expression changes inCAPN8-2, TMC5 andMUC1 in LUAD, while they are non-significant in SCLC and lSCC. Their translation to clinical practice is proposed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 16, 2020 Category: Cancer & Oncology Source Type: research

Everolimus plus exemestane in hormone-receptor-positive, HER2-negative locally advanced or metastatic breast cancer: incidence and time course of adverse events in the phase IIIb BALLET population
ConclusionsEverolimus plus exemestane is a well-known therapeutic option for aromatase inhibitor pretreated advanced breast cancer patients, and its toxicity profile is similar to that described in previous studies. Close monitoring, especially within the first three months, early intervention with preventive measures and patient education to help recognize the first signs and symptoms of AEs, will help to reduce their incidence and severity. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 13, 2020 Category: Cancer & Oncology Source Type: research

Multifunctional nanocomposites MGO/FU-MI inhibit the proliferation of tumor cells and enhance the effect of chemoradiotherapy in vivo and in vitro
ConclusionThe MGO/FU-MI NCs are very effective in the treatment of tumors when combined with radiotherapy and chemotherapy, and have the potential to be a combination of radiotherapy and chemotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - March 13, 2020 Category: Cancer & Oncology Source Type: research

Drug-metabolizing enzymes: role in drug resistance in cancer
AbstractAlthough continuous researches are going on for the discovery of new chemotherapeutic agents, resistance to these anticancer agents has made it really difficult to reach the fruitful results. There are many causes for this resistance that are being studied by the researchers across the world, but still, success is far because there are several factors that are going along unattended or have been studied less. Drug-metabolizing enzymes (DMEs) are one of these factors, on which less study has been conducted. DMEs include Phase I and Phase II enzymes. Cytochrome P450s (CYPs) are major Phase I enzymes while glutathione...
Source: Clinical and Translational Oncology - March 13, 2020 Category: Cancer & Oncology Source Type: research

Clinicopathological and prognostic value of hypoxia-inducible factor-1 α in breast cancer: a meta-analysis including 5177 patients
AbstractPurposeMounting studies have investigated the clinicopathological and prognostic value of hypoxia-inducible factor-1 α (HIF-1α) in breast cancer (BC), yet conclusions remain controversial. Therefore, we conducted this meta-analysis to clarify this issue.MethodsAll relevant studies were searched using Cochrane Library, Web of Science, PubMed, and EMBASE online databases. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CIs) were applied to evaluate the clinicopathological and prognostic value of HIF-1 α, respectively. Subgroup analysis and sensitivity analysis were pe...
Source: Clinical and Translational Oncology - March 12, 2020 Category: Cancer & Oncology Source Type: research