DAZAP1 overexpression promotes growth of HCC cell lines: a primary study using CEUS
ConclusionsDAZAP1 is highly expressed in hepatic carcinoma and related to the blood flow, and high DAZAP1 expression predicts poor prognosis. DAZAP1 may promote liver carcinoma cell proliferation, migration, and invasion of HEPG2 cells. CEUS parameters are related to the high DAZAP1 expression, and will help to differentiate the HCC tumor. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 14, 2022 Category: Cancer & Oncology Source Type: research

LncRNA ABHD11-AS1 promotes tumor progression in papillary thyroid carcinoma by regulating EPS15L1/EGFR signaling pathway
ConclusionABHD11 ‐AS1 promotes tumor progression in PTC by regulating EPS15L1/EGFR pathway. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 14, 2022 Category: Cancer & Oncology Source Type: research

Current status and future perspectives in HER2 positive advanced gastric cancer
AbstractGastric cancer is one of the most common malignancy worldwide with a prognosis less than 1 year in unresectable or metastatic disease. HER2 expression is the main biomarker to lead the addition of trastuzumab to first line systemic chemotherapy improving the overall survival in advanced HER2-positivegastric adenocarcinoma. The inevitable development of resistance to trastuzumab remains a great problem inasmuch several treatment strategies that have proven effective in breast cancer failed to show clinical benefit in advanced gastric cancer. In this review, we summarize the available data on the mechanisms underlyin...
Source: Clinical and Translational Oncology - May 14, 2022 Category: Cancer & Oncology Source Type: research

Impact of cranial stereotactic radiotherapy associated with immunotherapy with nivolumab and ipilimumab on overall survival in patients with melanoma brain metastases: a real-world evidence
ConclusionsThis real-world analysis showed that CNI  + SRT led to an improvement in OS compared to CNI. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 11, 2022 Category: Cancer & Oncology Source Type: research

An effective algorithm to detect the possibility of being MSI phenotype in endometrial cancer given the BMI status and histological subtype: a statistical study
In this study, we aim to identify the MSI phenotype in patients who underwent hysterectomy for endometrial cancer. We a ssessed the correlation of this phenotype with anatomoclinical parameters such as obesity and histological subtype.Methods/patientsClinical and anatomopathological data were collected from 147 patients diagnosed with endometrial cancer and an immunohistochemical study of MMR system proteins was performed. PMS2 and MSH6 proteins were evaluated as primary screening and subsequent evaluation of MLH1 and MSH6, respectively, if the former were negative. Statistical association between the anatomopathological d...
Source: Clinical and Translational Oncology - May 5, 2022 Category: Cancer & Oncology Source Type: research

Cell-free circulating tumor DNA in colorectal cancer: a proof of concept with simplified methodology
ConclusionThis exploratory analysis of cfDNA based on fluorometry and electrophoresis methods showed promising results discriminating colorectal cancer and non-cancer patients, as well as different colorectal cancer stages and disease profiles. Further studies are needed to increase our knowledge and to help to overcome barriers to broader implementation and applications. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 2, 2022 Category: Cancer & Oncology Source Type: research

Minimally invasive surgery for pediatric dumbbell neuroblastoma: systematic literature review and report of a single-stage neurosurgical and thoracoscopic approach
ConclusionSurgical resection of dumbbell neuroblastomas is challenging. There is no consensus on best surgical approach. Dumbbell tumors should not be considered a contraindication for minimally invasive surgery. A single stage and minimally invasive strategy is proposed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 18, 2022 Category: Cancer & Oncology Source Type: research

Analgesic effects of low-dose radiotherapy in greater trochanteric pain syndrome: results in a clinical series of 155 patients with recurrent or refractory symptoms
ConclusionLow dose radiotherapy effectively improved pain in the trochanteric area in most patients with recurrent or refractory GTPS, allowing a reduction in the need for analgesic medications and, more, importantly, better functioning and mobility. Further randomized studies in selected populations of GTPS are needed to define the treatment position of low-dose radiotherapy in this clinical setting. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 17, 2022 Category: Cancer & Oncology Source Type: research

Prevention of venous thromboembolism in hematologic neoplasms: an expert consensus from SEHH –SETH
AbstractVenous thromboembolism (VTE) is a serious complication in hematologic neoplasms, so finding adequate prevention strategies is an urgent requirement. However, prospective studies with large enough cohorts are scarce, limiting the development of evidence-based thromboprophylaxis guidelines. The present position paper is addressed to all hematologists treating patients affected by hematologic neoplasms with the aim to provide clinicians with a useful tool for the prevention of VTE. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 17, 2022 Category: Cancer & Oncology Source Type: research

Cancer-associated fibroblasts in colorectal cancer
AbstractColorectal cancer (CRC) is one of the leading causes of mortality among cancers. Many aspects of this cancer are under investigation to find established markers of diagnosis, prognosis, and also potential drug targets. In this review article, we are going to discuss the possible solution to all these aims by investigating the literature about cancer-associated fibroblasts (CAFs) involved in CRC. Moreover, we are going to review their interaction with the tumor microenvironment (TME) and vitamin D and their role in tumorigenesis and metastasis. Moreover, we are going to expand more on some markers produced by them o...
Source: Clinical and Translational Oncology - April 17, 2022 Category: Cancer & Oncology Source Type: research

Minimally invasive surgery for pediatric dumbbell neuroblastoma: systematic literature review and report of a single-stage neurosurgical and thoracoscopic approach
ConclusionSurgical resection of dumbbell neuroblastomas is challenging. There is no consensus on best surgical approach. Dumbbell tumors should not be considered a contraindication for minimally invasive surgery. A single stage and minimally invasive strategy is proposed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 17, 2022 Category: Cancer & Oncology Source Type: research

CircRNAs: promising factors for regulating angiogenesis in colorectal cancer
AbstractColorectal cancer (CRC) is one of the most common cancers in the world. The incidence rate of cancer is high. The overall response to traditional treatment methods such as surgery, radiotherapy, and chemotherapy is not very satisfactory. Therefore, finding new therapeutic targets is very important for improving CRC treatment. In recent reports, the role of circRNAs in regulating colorectal angiogenesis has been gradually revealed. CircRNAs can indirectly act on angiogenesis pathways and regulate the expression of growth factors such as vascular endothelial growth factor (VEGF). CircRNAs are endogenous noncoding RNA...
Source: Clinical and Translational Oncology - April 13, 2022 Category: Cancer & Oncology Source Type: research