A seven-nuclear receptor-based prognostic signature in breast cancer
ConclusionThe seven-NR-based Risk Score represents a promising signature for estimating overall survival in patients with BRCA, and is correlated with the immune microenvironment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 11, 2021 Category: Cancer & Oncology Source Type: research

Use of healthcare REsources and associated COsts in controlled versus uncontrolled carcinoid SYndrome in patients with neuroendocrine tumours: the RECOSY study
AbstractPurposeTo report healthcare resource use and associated costs in controlled versus uncontrolled carcinoid syndrome (CS) in patients with neuroendocrine tumours.MethodsA cross-sectional, non-interventional multicentre study was conducted with retrospective data analysis. Resource use was compared between two patient groups: those with controlled CS (>  12 months with no uncontrolled CS episodes) and uncontrolled CS (
Source: Clinical and Translational Oncology - June 9, 2021 Category: Cancer & Oncology Source Type: research

Physio-pathological effects of m6A modification and its potential contribution to melanoma
AbstractMethylation of N6-adenosine (m6A) is the most prevalent internal RNA modification and is especially common among the messenger RNAs. These m6A modifications regulate splicing, translocation, stability and translation of RNA through dynamic and reversible interactions with m6A-binding proteins, namely the writers, erasers and readers. RNA methyltransferases catalyze the m6A modifications, while demethylases reverse this methylation. Deregulation of the m6A modification process has been implicated in human carcinogenesis, including melanoma —which carries one of the highest mutant rates. In this review, we prov...
Source: Clinical and Translational Oncology - June 8, 2021 Category: Cancer & Oncology Source Type: research

Mechanisms of regulating NIS transport to the cell membrane and redifferentiation therapy in thyroid cancer
AbstractIodine is an essential constituent of thyroid hormone. Active iodide accumulation in the thyroid is mediated by the sodium iodide symporter (NIS), comprising the first step in thyroid hormone biosynthesis, which relies on the functional expression of NIS on the cell membrane. The retention of NIS expressed in differentiated thyroid cancer (DTC) cells allows further treatment with post-operative radioactive iodine (RAI) therapy. However, compared with normal thyroid tissue, differentiated thyroid tumors usually show a decrease in the active iodide conveyance and NIS is generally retained within the cells, indicating...
Source: Clinical and Translational Oncology - June 8, 2021 Category: Cancer & Oncology Source Type: research

COPB2: a transport protein  with multifaceted roles in cancer development and progression
AbstractThe Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the transport of vesicles between the Golgi apparatus and the endoplasmic reticulum. It plays an important role in maintaining the integrity of these cellular organelles, as well as in maintaining cell homeostasis. More importantly, COPB2 plays key roles in embryonic development and tumor progression. COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the curr...
Source: Clinical and Translational Oncology - June 8, 2021 Category: Cancer & Oncology Source Type: research

Letter to the editor
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 7, 2021 Category: Cancer & Oncology Source Type: research

To the editor, response letter
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 7, 2021 Category: Cancer & Oncology Source Type: research

Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherapy
ConclusionhWBI in high-risk localized breast cancer patients treated by chemotherapy seems to have similar toxicity and cosmetic results than conventionally fractionated WBI in combination to photon-IORT after BCS. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 5, 2021 Category: Cancer & Oncology Source Type: research

Tumor microenvironment in triple-negative breast cancer: the correlation of tumor-associated macrophages and tumor-infiltrating lymphocytes
ConclusionsOur study suggests that TAMs further create an optimal tumor microenvironment (TME) for growth and invasion of cancer cells when evasion of immunoreactions due to T and B TILs occurs. In TNBCs, all these events combine to affect prognosis. The process of TME is highly complex in TNBCs and for an improved understanding, larger validation studies are necessary to confirm these findings. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 5, 2021 Category: Cancer & Oncology Source Type: research

Study on effects of miR-141-3p in proliferation, migration, invasion and apoptosis of colon cancer cells by inhibiting Bcl2
ConclusionsIn conclusion, miR-141-3p can inhibit the cancer by regulating Bcl2, and miR-141-3p has the potential to become a potential therapeutic target for colon cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 4, 2021 Category: Cancer & Oncology Source Type: research

Short-course radiotherapy in stage IV rectal cancer with resectable disease
ConclusionIn stage IV with resectable metastatic disease, the proposed therapeutic regimen seems very appropriate in well selected patients able to tolerate the treatment. We bet on the role of pelvic RT, due to the good local control of the disease in our series. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 3, 2021 Category: Cancer & Oncology Source Type: research

The paediatric cancer clinical research landscape in Spain: a 13-year multicentre experience of the new agents group of the Spanish Society of Paediatric Haematology and Oncology (SEHOP)
ConclusionsThe number of available trials, and the number of participating patients, has increased in Spain from 2007. Studies focused on molecular-specific targets are now being implemented. Barriers to accessing new drugs for all ranges of age and cancer diseases remain. Additionally, opportunities to improve academic research are still required in Spain. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 2, 2021 Category: Cancer & Oncology Source Type: research

HPV16 infection promotes an M2 macrophage phenotype to promote the invasion and metastasis of esophageal squamous cell carcinoma
AbstractObjectivesHigh-risk human papillomavirus (HR-HPV) is an important risk factor for esophageal cancer. Macrophages constitute a crucial immune medium for regulating HPV-related tumors; however, the specific regulatory mechanisms remain unknown. Therefore, the purpose of our current study was to investigate the mechanism by which HPV16E6 regulates macrophages to promote the invasion and metastasis of esophageal cancer.MethodsHPV16E6 infection was detected by polymerase chain reaction. Immunohistochemistry was used to verify the distribution of tumor-associated macrophages (TAMs) and MMP-9 expression in esophageal squa...
Source: Clinical and Translational Oncology - June 1, 2021 Category: Cancer & Oncology Source Type: research

Predictive value of transcriptional expression of Kr üppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy
ConclusionTranscriptional expression of KLF6 was significantly related to local control in HNSCC patients treated with radiotherapy. Patients with high levels of KLF6 expression had a significantly higher risk of local recurrence after treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 1, 2021 Category: Cancer & Oncology Source Type: research

Direct oral anticoagulants for the treatment and prevention of venous thromboembolism in patients with cancer: current evidence
AbstractVenous thromboembolic disease (VTED) is a common and clinically important complication in patients with cancer, contributing to its mortality and morbidity. Direct oral anticoagulant agents (DOACs), including direct thrombin inhibitors and direct factor Xa inhibitors, are as effective as vitamin K antagonists for the treatment of VTED and are associated with less frequent and severe bleeding. They have advantages over low-molecular-weight heparin, but comparative long-term efficacy and safety data are lacking for these compounds. Recent randomized clinical trials suggest a role for DOACs in the treatment of VTED in...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Consensus and recommendations on vaginal-cuff Brachytherapy of the Spanish Brachytherapy Groups of SEOR and SEFM
AbstractPurpose/objective(s)On October 5, 2018, a meeting of the Spanish Society of Radiation Oncology (SEOR) Brachytherapy Group was held, in collaboration with the Spanish  Society of Medical Physics (SEFM), with the aim of preparing a consensus document on postoperative vaginal-cuff brachytherapy (VCBT).Materials/methodsA survey including 42 questions was sent to Spanish Radiation Oncology Centres before the meeting. The survey items included: experience in VCBT, technique indications, previous patient preparation, applicator type, implant procedure, computerized tomography (CT) simulation, definition of target vol...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Comparison of clinical diagnostic value of spiral CT with different dose in patients with early-stage peripheral lung cancer
ConclusionLow-dose MSCT scanning can meet the clinical requirements for imaging diagnosis of peripheral lung cancer, and can reduce the radiation dose of patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

The effect of PD-1 expression on tumor-associated macrophage in T cell lymphoma
AbstractPurposeOur study aimed to explore the programmed death 1 (PD-1) expression on tumor-associated macrophage (TAM) in T cell non-Hodgkin lymphoma (T-NHL) and its relationship with lymphoma prognosis. The effect of PD-1 expression on the function of macrophages was also studied.MethodsMultispectral image quantitative analysis was applied for detecting PD-1 expression on macrophages in T cell lymphoma tissues. The Kaplan –Meier analysis was performed to evaluate the value of PD-1 expression of TAM in predicting the overall survival of T-NHL. PD-1 overexpression THP-1-derived macrophage was constructed and was cocu...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Incidence of venous thromboembolic events in cancer patients receiving immunotherapy: a single-institution experience
ConclusionsThe incidence of VTE in cancer patients receiving immunotherapy in our study appeared to be similar to the incidence previously reported in other series of cancer patients treated with systemic therapies. VTE occurrence did not correlate with the prognosis. Further and prospective studies are needed to derive definitive conclusions. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Multidisciplinary consensus on cancer management during pregnancy
AbstractCancer during pregnancy is a challenge for multi- and interdisciplinary collaboration due to the diagnostic, prognostic and therapeutic implications, the need for an integrated harmonization of medical action for the pregnant patient and the embryo or foetus and the characteristics of each gestational period, which will determine the protocol to be proposed and its limitations. For this reason, a group of experts appointed by participating scientific societies, which includes the Spanish Society of Medical Oncology (Sociedad Espa ñola de Oncología Médica—SEOM), the Spanish Association of ...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

TWIST1 upregulation affects E-cadherin expression in brain metastases
ConclusionThis research provides valuable data regarding molecular events involving two EMT key components that could give directions for new possibilities for brain metastases diagnosis and treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Survival outcomes and prognostic factors of endometrial stromal sarcoma and undifferentiated uterine sarcoma
AbstractPurposeTo review the diagnostic and therapeutic procedures of patients diagnosed with Endometrial Stromal Sarcoma (ESS) and Undifferentiated Uterine Sarcoma (USS) at our institution and investigate their clinical outcomes and factors affecting prognosis.MethodsWe retrospectively collected demographic data, preoperative diagnostic methods and therapeutic management of patients treated for ESS and UUS between January 1995 and December 2019 at Vall d ’Hebron Barcelona Hospital Campus, Spain. Overall survival and disease-free survival were calculated. Cox proportional-hazards regression models were calculated.Res...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Enhanced anticancer activity and endocytic mechanisms by polymeric nanocarriers of n -butylidenephthalide in leukemia cells
ConclusionsLPPC encapsulation enhanced the cytotoxic activity of BP and did not influence the effects of BP induction that suggested LPPC-encapsulated BP might be developed as anti-leukemia drugs in future. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Statistical control of processes applied to geometric uncertainties for CTV expansion margins determination in prostate cancer patients treated with VMAT: a prospective study in 57 patients
ConclusionsThe use of control charts allows tracking geometric deviations both inter and intra-fraction, variability real-time control and to detect situations in which it can change for non-random reasons, and require immediate investigation. Maintaining geometric deviations in the control state decreases the margins needed to administer a high dose to CTV in a high percentage of cancer prostate patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

The optimal immune checkpoint inhibitors combined with chemotherapy for advanced non-small-cell lung cancer: a systematic review and meta-analysis
AbstractBackgroundImmune checkpoint inhibitors (ICIs) plus chemotherapy (CT) have strikingly expanded the therapeutic landscape for advanced non-small cell lung cancer (NSCLC), but little is known about which is superior. We performed a meta-analysis that compared the efficacy and safety of PD-1 inhibitor  + CT with PD-L1 inhibitor + CT.MethodsPubMed, Embase, Web of Science, Cochrane Library, and major international scientific meetings were searched for relevant randomized controlled trials (RCTs), and the indirect analysis was performed for PD-1  + CT vs PD-L1 + CT. ...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

The diagnostic value of miR-21 combined with CT in patients with liver cancer
AbstractPurposeTo explore the diagnostic value of miR-21 combined with computed tomography (CT) in patients with liver cancer.MethodsA total of 112 patients in our hospital were confirmed liver cancer by examination, and were collected as cancer group. Another 100 patients with hepatic focal nodular hyperplasia in the same period were collected as control group. The diagnostic value of miR-21 and CT on liver cancer was observed.ResultsThe level of miR-21 in cancer group was significantly higher than that in control group, the difference was statistically significant (p 
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Programmable and multi-targeted CARs: a new breakthrough in cancer CAR-T cell therapy
AbstractCAR-T cell therapy, as a novel immunotherapy approach, has indicated successful results in the treatment of hematological malignancies; however, distinct results have been achieved regarding solid tumors. Tumor immunosuppressive microenvironment has been identified as the most critical barrier in CAR-T cell therapy of solid tumors. Developing novel strategies to augment the safety and efficacy of CAR-T cells could be useful to overcome the solid tumor hurdles. Similar to other cancer treatments, CAR-T cell therapy can cause some side effects, which can disturb the healthy tissues. In the current review, we will dis...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

ABVD and BEACOPP regimens ’ effects on fertility in young males with Hodgkin lymphoma
ConclusionsABVD and BEACOPP regimens significantly reduce fertility function to varying effects depending on treatment duration. ABVD temporarily causes significant reductions in male fertility, whereas BEACOPP ’s effects are more permanent. Therefore, clinicians should discuss fertility preservation with male patients receiving infertility-inducing gonadotoxic therapy. Further high-quality studies are required to more adequality describe the risk to fertility by chemotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Expression and DNA methylation profiles of EZH2-target genes in plasma exosomes and matched primary tumor tissues of the patients with diffuse large B-cell lymphoma
This study was designed to compare epigenetic alterations observed in Enhancer of Zeste Homolog 2 (EZH2)-target genes between plasma-derived exosomes and primary tumors in DLBCL patients.Main methodsExosomes were isolated from plasma of 21 DLBCL patients and 21 controls. We analyzed the methylation status of the target genes using methylation-specific PCR. We also examined whether the exosomes and the tumor samples contained transcripts of the target genes.Key findingsWe found thatCDKN2A andCDKN2B were methylated in both plasma exosomes and primary tumor tissue samples. None of the transcripts were found in the exosomes ex...
Source: Clinical and Translational Oncology - April 29, 2021 Category: Cancer & Oncology Source Type: research

Dosimetric impact of rectum and bladder anatomy and intrafractional prostate motion on hypofractionated prostate radiation therapy
ConclusionsA better control of bladder filling is recommended to minimize the number of fractions in which the bladder volume is lower than planned. Fiducial mark tracking with a displacement threshold of 5  mm in any direction is recommended to ensure that the prescribed dose criteria are met. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 28, 2021 Category: Cancer & Oncology Source Type: research

COL4A1, negatively regulated by XPD and miR-29a-3p, promotes cell proliferation, migration, invasion and epithelial –mesenchymal transition in liver cancer cells
ConclusionCOL4A1 is negatively regulated by XPD-miR-29a-3p axis and promotes liver cancer progression in vitro. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 23, 2021 Category: Cancer & Oncology Source Type: research

Knockdown of long non-coding RNA RP11-297P16.3 inhibits the migration and invasion of laryngeal squamous carcinoma cells
ConclusionThese results suggested that RP11-297P16.3 may inhibit the migration and invasion of LSCC cells by regulating the epithelial –mesenchymal transition process, suggesting that RP11-297P16.3 is a potential new target for treating LSCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 23, 2021 Category: Cancer & Oncology Source Type: research

A systematic review of craniospinal irradiation for leptomeningeal disease: past, present, and future
ConclusionsDespite advances in systemic and radiation therapies, LMD remains a devastating end-stage complication of some malignancies. Treatment-related toxicities can be a significant barrier to CSI delivery. In select patients with LMD, marrow-sparing proton CSI may provide safer palliation of symptoms and prolong survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 21, 2021 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines for anaemia treatment in cancer patients (2020)
AbstractAnaemia is defined by the presence of haemoglobin (Hb) levels  
Source: Clinical and Translational Oncology - April 20, 2021 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines 2020
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 20, 2021 Category: Cancer & Oncology Source Type: research

Systematic review and meta-analysis efficacy and safety of immune checkpoint inhibitors in advanced melanoma patients with anti-PD-1 progression: a systematic review and meta-analysis
ConclusionOur findings provide the best current evidence that patients who progress on anti-PD-1 can still respond to different ICI modalities (ipilimumab with or without nivolumab, and retreatment or continuation beyond progression with anti-PD-1) with tolerable grade 3/4 irAEs. However, more prospective clinical trials are needed to confirm these results. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 20, 2021 Category: Cancer & Oncology Source Type: research

Long-term results of a randomized partial irradiation trial compared to whole breast irradiation in the early stage and low-risk breast cancer patients after conservative surgery
ConclusionAfter a follow-up of 10  years, there were no differences in efficacy between the 2 treatment arms. Despite slight greater toxicity in the APBI group, the cosmesis was similar and satisfactory in both groups. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 20, 2021 Category: Cancer & Oncology Source Type: research

Sequential chemotherapy regimen of induction with panitumumab and paclitaxel followed by radiotherapy and panitumumab in patients with locally advanced head and neck cancer unfit for platinum derivatives. The phase II, PANTERA/TTCC-2010-06 study
ConclusionsAlthough underpowered, ORR was higher than the pre-specified boundary for considering the treatment active. Although Px  + Pb as IT provides some benefit, the safety profile is worse than expected. To consider Pb + Px as IT as an alternative for platinum-unsuitable LA-SCCHN, further research/investigation would be needed. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2021 Category: Cancer & Oncology Source Type: research

Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel
ConclusionsChemotherapy with FOLFIRNOX or gemcitabine/nab-paclitaxel induces variable changes in circulating T-cell populations that may provide prognostic information in PDAC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2021 Category: Cancer & Oncology Source Type: research

Novel combinatorial strategies for boosting the efficacy of immune checkpoint inhibitors in advanced breast cancers
AbstractThe year 2019 witnessed the first approval of an immune checkpoint inhibitor (ICI) for the management of triple negative breast cancers (TNBC) that are metastatic  and programmed death ligand (PD)-L1 positive. Extensive research has focused on testing ICI-based combinatorial strategies, with the ultimate goal of enhancing the response of breast tumors to immunotherapy to increase the number of breast cancer patients benefiting from this transformative treat ment. The promising investigational strategies included immunotherapy combinations with monoclonal antibodies (mAbs) against human epidermal grow...
Source: Clinical and Translational Oncology - April 19, 2021 Category: Cancer & Oncology Source Type: research

Prognostic factors in advanced pancreatic ductal adenocarcinoma patients-receiving second-line treatment: a single institution experience
AbstractBackgroundSecond-line (2L) treatments for advanced pancreatic ductal adenocarcinoma (PDAC) achieve a modest benefit at the expense of potential toxicity. In the absence of predictive factors of response, the identification of prognostic factors could help in the therapeutic decisions-making. The purpose of this study was to assess the prognostic factors associated with shorter survival in patients with advanced PDAC who received 2L treatment.MethodsWe conducted a single institution retrospective study, which included all patients with advanced PDAC who received 2L treatment between September 2006 and February 2020 ...
Source: Clinical and Translational Oncology - April 17, 2021 Category: Cancer & Oncology Source Type: research

Electronic health records and patient registries in medical oncology departments in Spain
ConclusionOur study indicates that EHRs are almost universally implemented in the hospitals surveyed and are considered to have a positive impact on work organization and clinical practice. However, EHRs currently have several drawbacks that limit their use for investigational purposes.Clinical trial registrationNot applicable (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 17, 2021 Category: Cancer & Oncology Source Type: research

Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1 α axis
ConclusionsTaken together, circ_03955 functions as a tumor promoter through miR-3662/HIF-1 α axis, which might provide a novel sight for PC treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 17, 2021 Category: Cancer & Oncology Source Type: research

Mutations in chronic myelomonocytic leukemia and their prognostic relevance
AbstractChronic myelomonocytic leukemia (CMML) is a hematologic malignancy that overlaps with myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) and tends to transform into acute myeloid leukemia (AML). Among cases of CMML,> 90% have gene mutations, primarily involving TET2 (~  60%), ASXL1 (~ 40%), SRSF2 (~ 50%), and the RAS pathways (~ 30%). These gene mutations are associated with both the clinical phenotypes and the prognosis of CMML, special CMML variants and pre-phases of CMML. Cytogenetic abnormalities and the size of genome are also associated with prognosi s. Meanw...
Source: Clinical and Translational Oncology - April 16, 2021 Category: Cancer & Oncology Source Type: research

Investigation on potential biomarkers of hyperprogressive disease (HPD) triggered by immune checkpoint inhibitors (ICIs)
AbstractPurposeThis project aimed to survey the clinical characteristics and survivals of hyperprogressive disease (HPD) mediated by immune checkpoint inhibitors (ICIs) in an attempt to explore the potential predictors.MethodsAfter searching PubMed, MEDLINE, Google Scholar and Cochrane Library databases, 12 studies incorporating 1766 individuals were enrolled. The data were analyzed with Review manager 5.3 software.ResultsThe results revealed HPD correlated with previous metastatic sites  >  2 (OR = 1.86, 95% CI 1.33–2.59,P = 0.0003), liver metastasis (OR = 3...
Source: Clinical and Translational Oncology - April 13, 2021 Category: Cancer & Oncology Source Type: research

Review of biomarker systems as an alternative for early diagnosis of ovarian carcinoma
AbstractEarly diagnosis of ovarian carcinoma is bound to boost the long-term endurance rate of the patients. Most ovarian tumors happen post menopause when the ovaries have no vital operation and therefore irregular ovarian role causes no signs. According to Muinao T. et al. (Heliyon. 5(12):e02826, 2019), if we consider the frequency of ovarian carcinoma to be moderate, a screening technique must accomplish a base specificity of 99.6% and sensitivity of over 75%. The classification and approval of early diagnostic biomarkers explicit to ovarian carcinoma are essentially required. Prevailing methods for early diagnosis of o...
Source: Clinical and Translational Oncology - April 11, 2021 Category: Cancer & Oncology Source Type: research

Surface-guided radiation therapy for breast cancer: more precise positioning
ConclusionsSGRT improves patient positioning accuracy compared to skin markers. Optimal breast SGRT can accurately verify the localisation of the tumour bed, ensuring matching with  ≥ 3 surgical clips. SGRT can eliminate unwanted radiation from IGRT verification systems. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 11, 2021 Category: Cancer & Oncology Source Type: research

A multi-institutional analysis of fractionated versus single-fraction stereotactic body radiotherapy (SBRT) in the treatment of primary lung tumors: a comparison between two antipodal fractionations
ConclusionSF and TF seems to be equally safe and effective in the treatment of primary inoperable lung tumors especially for smaller lesion. The SF may be preferentially offered to reduce patient access to hospital with no negative impact on tumor control and survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 10, 2021 Category: Cancer & Oncology Source Type: research

Social support, coping strategies and sociodemographic factors in women with breast cancer
ConclusionYoung people, a high level of education, having a partner, low psychological distress, and seeking social support were associated with the use of adaptive cancer coping strategies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 10, 2021 Category: Cancer & Oncology Source Type: research

Malignant pleural mesothelioma: clinical experience and prognostic value of derived neutrophil-to-lymphocyte ratio and PD-L1 expression
ConclusionThe survival data obtained in our sample are consistent with those previously reported. Pretreatment levels of dNLR greater than 3 and positive PD-L1 expression could be significant prognostic factors for poor survival in patients with MPM. Further and prospective studies are needed to explore this relationship and to derive definitive conclusions. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 10, 2021 Category: Cancer & Oncology Source Type: research