The free amino acid profiles and metabolic biomarkers of predicting the chemotherapeutic response in advanced sarcoma patients
ConclusionOur study suggests the potential specific PFAAs in sarcoma patients. The unusual amino acids and metabolic pathways may provide ideas for clinical drugs targeting therapy. Three amino acids including Car, GABA and Abu may be metabolic biomarkers playing a role in dynamic monitoring of the therapeutic effect. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Potential roles of lymphovascular space invasion based on tumor characteristics provide important prognostic information in T1 tumors with ER and HER2 positive breast cancer
ConclusionThe presence of LVSI was highlighted as a variable significant to survival. In further clinical practice, patients with LVSI may need more intensive treatment in certain populations. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

A population perspective on the use of external beam radiotherapy in Catalonia, Spain
ConclusionsPopulation-based data show that external beam radiotherapy is underutilized in Catalonia. This situation requires a careful analysis to understand the causes, as well as an improvement of the available resources, oriented toward achieving realistic targets for the optimal use of external beam radiotherapy in our country. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Clinical activity of brigatinib in ROS1-rearranged non-small cell lung cancer
ConclusionBrigatinib demonstrated modest activity in crizotinib-resistant ROS1-rearranged NSCLC. Its intracranial and systemic activity should be assessed in correlation with the underlying molecular mechanism of crizotinib resistance. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

The new function of circRNA: translation
AbstractCircular RNAs (circRNAs) have been considered a special class of non-coding RNAs without 5 ′ caps and 3′ tails which are covalently closed RNA molecules generated by back splicing of mRNA. For a long time, circRNAs have been considered to be directly involved in various biological processes as functional RNA. In recent years, a variety of circRNAs have been found to have translational functions, and the resultant peptides also play biological roles in the emergence and progression of human disease. The discovery of these circRNAs and their encoded peptides has enriched genomics, helped us to study the c...
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Tumor microenvironment, immune response and post-radiotherapy tumor clearance
AbstractRadiotherapy is the treatment of choice for many cancer patients. Residual tumor leads to local recurrence after a period of an equilibrium created between proliferating, quiescent and dying cancer cells. The tumor microenvironment is a main obstacle for the efficacy of radiotherapy, as impaired blood flow leads to hypoxia, acidity and reduced accessibility of radiosensitizers. Eradication of remnant disease is an intractable clinical quest. After more than a century of research, anti-tumor immunity has gained a dominant position in oncology research and therapy. Immune cells play a significant role in the eradicat...
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Salvage radiotherapy in patients affected by oligorecurrent pelvic nodal prostate cancer
ConclusionsThe number of metastatic lymph nodes and PSA doubling time seems to be important prognostic factors in the pelvic oligorecurrent setting. Salvage radiotherapy combined with short-course ADT might be a valid treatment strategy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Latest progress in molecular biology and treatment in genitourinary tumours
AbstractThe management of genitourinary cancer, including bladder, prostate, renal and testicular cancer, has evolved dramatically in recent years due to a better understanding of tumour genetic mutations, alterations in molecular pathways, and to the development of new kinds of drugs such as targeted therapies and immunotherapies. In the field of immunotherapy, new drugs focused on stimulating, enhancing and modulating the immune system to detect and destroy cancer, have been recently discovered. Research in oncology moves quickly and new data of great relevance for clinical practice are communicated every year. For this ...
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Study of the Spanish Society of Medical Oncology (SEOM) on the access to oncology drugs and predictive biomarkers in Spain
ConclusionsThe SEOM considers it necessary to reduce the differences identified, increase homogeneity, and improve conditions of access to oncology drugs and biomarkers, and makes proposals to address these issues. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

100% peer review in radiation oncology: is it feasible?
ConclusionEveryday group consensus peer review is an efficient manner to recollect clinical and technical data of cases presented to ensure quality radiation care before initiation of treatment as well as ensuring department quality in a feedback team environment. This model is feasible within the normal operation of every radiation oncology Department. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas
This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients.ResultsClaudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p 
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Cytotoxic T lymphocyte antigen-4 (CTLA-4) expression in chordoma and tumor-infiltrating lymphocytes (TILs) predicts prognosis of spinal chordoma
ConclusionsTargeting CTLA-4 may be a potential novel therapeutic strategy for chordoma patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Stereotactic body radiation therapy for liver metastasis from colorectal cancer: size matters
ConclusionsLiver  SBRT is a safe and effective treatment that achieves high local control rates. We found a significant correlation between larger LMCRC and worse local control. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database
ConclusionThis study illustrated that tumors in the oropharynx, lower age, adjuvant chemoradiation and radiation, and microscopic margins were associated with greater survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Indicators of a pro-tumor immune response are evident at early stages of breast cancer
AbstractWith advances in checkpoint inhibitor and CAR T-cell therapies, among other advances in immunotherapy, this is an exciting time to be a tumor immunologist. We are witnessing the transition of decades of work at the bench leading to substantial success in the clinic. While work continues developing new and improving existing immunotherapies, there remains a great deal of basic tumor immunology still to learn, information that can only lead to greater success in the clinic. One area in need of more attention is understanding the immune response at early stages of breast cancer. While there is no question that early d...
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Dynamic evaluation of neutrophil-to-lymphocyte ratio as prognostic factor in stage III non-small cell lung cancer treated with chemoradiotherapy
AbstractPurposeLocally advanced non-small cell lung cancer (LA-NSCLC) is frequently treated with chemoradiotherapy (CRT). Despite the efforts, long-term outcomes are poor, and novel therapies have been introduced to improve results. Biomarkers are needed to detect early treatment failure and plan future follow-up and therapies. Our aim is to evaluate the role of dynamics of neutrophil-to-lymphocyte ratio (NLR) in patients with locally advanced NSCLC treated with CRT.MethodsWe retrospectively reviewed patients diagnosed with LA-NSCLC receiving definitive CRT at our center from 2010 to 2015. Baseline and post-treatment NLR w...
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

hsa_circ_0121582 inhibits leukemia growth by dampening Wnt/ β-catenin signaling
ConclusionsThis study found that hsa_circ_0121582 was involved in the inhibition of tumor proliferation, and the restoration of hsa_circ_0121582 could be an effective treatment strategy for patients with leukemia. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

LncRNA DCST1-AS1 downregulates miR-29b through methylation in glioblastoma (GBM) to promote cancer cell proliferation
ConclusionDCST1-AS1 may downregulate miR-29b through methylation in GBM to promote cancer cell proliferation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

FHOD3 promotes carcinogenesis by regulating RhoA/ROCK1/LIMK1 signaling pathway in medulloblastoma
ConclusionsFHOD3 was associated with overall survival time in medulloblastoma patients and was essential to cell proliferation, growth and survival in medulloblastoma and might regulates activation of RhoA/ROCK1/LIMK1 signaling pathway. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

FAM83H overexpression predicts worse prognosis and correlates with less CD8 + T cells infiltration and Ras-PI3K-Akt-mTOR signaling pathway in pancreatic cancer
ConclusionThe study suggests that FAM83H overexpression predicts poor prognosis and correlates with less CD8+ T cells infiltration and Ras-PI3K-Akt-mTOR signaling pathway in PC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2020 Category: Cancer & Oncology Source Type: research

Update of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
AbstractIn this update of the consensus of the Spanish Society of Medical Oncology (Sociedad Espa ñola de Oncología Médica—SEOM) and the Spanish Society of Pathology (Sociedad Española de Anatomía Patológica—SEAP), advances in the analysis of biomarkers in advanced colorectal cancer (CRC) as well as susceptibility markers of hereditary CRC and molecular biomarkers of localized CRC are reviewed. Recently published information on the essential determination ofKRAS,NRAS andBRAF mutations and the convenience of determining the amplification of human epidermal growth factor ...
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

The low expression of miR-1976 in plasma samples indicating its biological functions in the progression of breast cancer
ConclusionmiR-1976 may serve as a promising non-invasive biomarker for the diagnosis of BC in the future. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

Safety in radiation oncology: transposition of directive 2013/59/EURATOM in the Spanish Radiation Oncology Departments —recommendations for its adequate and effective application
ConclusionsThe implementation of what the transposition of the Directive to our legal order implies, besides the implication of the professionals, Centers and Administration, a need and a consumption of resources. If not enough are allocated, there is a risk that the innovation and improvement that the transposition would imply in order to raise the level of patient safety and the quality of Radiation Oncology in Spain will remain a paper tiger and, as the Romans said, “Non progredi est regredi”, that is, when it does not go forward, it goes backwards. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

ECO-SEOM-SEEO safety recommendations guideline for cancer patients receiving intravenous therapy
ConclusionsIn conclusion, both the venous access catheter selection algorithm and the proposed recommendations aim to respond to the needs revealed in clinical practice and to become an integrable tool in electronic prescription systems to offer homogeneous criteria for action in cancer patients that require venous access, optimizing the use of available health resources with the highest safety and quality of life for the patient. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

Neutrophil-to-lymphocyte ratio and lactate dehydrogenase as biomarkers for urothelial cancer treated with immunotherapy
AbstractPurposeTo identify patients with metastatic urothelial cancer (mUC) unlikely to benefit from immune-checkpoint inhibitors (ICIs).Methods/PatientsWe explored the predictive and prognostic values of baseline neutrophil-to-lymphocyte ratio (NLR), with cut-offs  ≥ 3 and ≥ 5, and of a urothelial immune prognostic index (UIPI, based on increased NLR and LDH), on 146 patients.ResultsNLR and UIPI significantly predicted progressive disease and progression-free survival with both cut-offs (p = 0.0069,p = 0.0034,p = 0.0160,p = 0.0063;p 
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

Reduce proliferation of human bone marrow cells from acute myeloblastic leukemia with minimally differentiation by blocking lncRNA PVT1
ConclusionThe findings declare that inhibition ofPVT1 could be a new target in the treatment of AML-M0 and help to approach more to treatments with fewer side effects. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

The impact of surgical margin status on prostate cancer-specific mortality after radical prostatectomy: a systematic review and meta-analysis
AbstractBackgroundUntil now, there is no clear conclusion on the relationship between the surgical margin status after radical prostatectomy (RP) and prostate cancer-specific mortality (PCSM). Therefore, we conducted this systematic review and meta-analysis based on all eligible case –control studies.MethodsA systematic and comprehensive literature search was performed based on PUBMED and EMBASE to identify all of the potentially relevant publications which were published before September 2019. Hazard ratio (HR) for PCSM was independently extracted by two reviewers from all eligible studies. Pooled HR estimates with ...
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

Comment on: “ECO-SEOM-SEEO safety recommendations guideline for cancer patients receiving intravenous therapy”, looking to the future
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2020 Category: Cancer & Oncology Source Type: research

Long noncoding RNA SNHG12 suppresses esophageal squamous cell carcinoma progression through competing endogenous RNA networks
ConclusionThis is the first study to reveal thatSNHG12 is downregulated in ESCC tissues and could be used as a prognostic tool.SNHG12 suppressed tumor progression in ESCC cells, serving as a potential biomarker. TheSNHG12/miRNA-195-5p/BCL9 network is proposed to be the mechanism leading to ESCC progression. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 13, 2020 Category: Cancer & Oncology Source Type: research

The efficacy and safety of immunotherapy targeting the PD-1 pathway for advanced urothelial carcinoma: a meta-analysis of published clinical trials
ConclusionThis study showed that the immunotherapy targeting the PD-1 pathway had durable efficacy and acceptable safety in patients with advanced UC. The comprehensive role of immune checkpoint inhibitors in comparison to other treatments needs further confirmation basing on RCTs. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 13, 2020 Category: Cancer & Oncology Source Type: research

Baseline neutrophil-to-lymphocyte ratio (NLR) is associated with outcome of patients treated with BRAF inhibitors
AbstractPurposeThe aim of this study is to verify if baseline hematological markers, in patients with advanced melanoma receiving BRAF inhibitor (BRAFi)-based therapies, are independently associated with progression free survival (PFS) and overall survival (OS).MethodsWe retrospectively analyzed 90 patients with metastatic melanoma harboring BRAF V600 mutation, who received treatment with either BRAFi alone or combined with a MEK inhibitor (MEKi) at the recommended dosages. Study population included 28 women and 62 men. Median age was 53  years. Seventy-three (82%) patients presented with M1c disease, 49 (56%) had ele...
Source: Clinical and Translational Oncology - August 13, 2020 Category: Cancer & Oncology Source Type: research

Malignancies after renal transplantation: experience of a Mexican referral center
ConclusionTo date, there is paucity of data from developing countries. We reported the results from a National Health Institute in Mexico including a large cohort with a long follow-up, demonstrating differences within frequencies and risks compared to other regions of the world. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 13, 2020 Category: Cancer & Oncology Source Type: research

Reply to: “The risk of malignancies in patients receiving hematopoietic stem cell transplantation: a systematic review and meta-analysis”
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 13, 2020 Category: Cancer & Oncology Source Type: research

Impact of pre-radiation therapy quality of life in lung cancer survival: a prospective, intention-to-treat, multicenter study
AbstractPurposeLung cancer (LC) has a significant impact on patients ’ health-related quality of life (HRQoL). We investigate the correlations between pre-radiation therapy HRQoL and survival.Materials and methodsA prospective, intention-to-treat, multicentre study of 437 patients with LC recruited at the radiation oncology departments of three different institutions was conducted between 2012 and 2016. QoL was assessed using the EORTC-QLQ-C30 (v3.0) and EORTC-QLQ-LC13 questionnaires. Global health status (GHS), physical (PF), role functioning (RF), emotional (EF), cognitive (CF), and social functioning (SF) as well ...
Source: Clinical and Translational Oncology - July 24, 2020 Category: Cancer & Oncology Source Type: research

Baicalein, an enteric microbial metabolite, suppresses gut inflammation and cancer progression in Apc Min/+ mice
AbstractObjectiveChronic inflammation is recognized as a risk factor for colorectal cancer (CRC) development. Baicalin (BI), a major constituent in an anti-inflammatory herbScutellaria baicalensis, can be biotransformed into baicalein (BE) by the intestinal microbiota. We evaluated the anti-inflammation and anti-CRC effects of the metabolite BE.MethodsThe in vitro biotransformation by human intestinal microbiota from BI into BE has been determined with HPLC. Using a gut-specificApcMin/+ mouse model, the effects of oral BE on the life span, organ index, and tumor multiplicity were evaluated. The expressions of inflammatory ...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Novel exosomal miR-46146 transfer oxaliplatin chemoresistance in colorectal cancer
ConclusionsThese results indicate that exosomal miR-46146 functions as a vital mediator of OX resistance by targeting PDCD10 and could be a potential target to re-sensitize CRC cell to OX. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

The efficacy and safety of immune checkpoint inhibitors in non-small cell lung cancer patients of different age groups: a meta-analysis
ConclusionRegardless of the NSCLC patients who were less or more than 65  years, immune checkpoint inhibitors could achieve better OS than chemotherapy. But there was no significant difference when NSCLC patients who were more than 75 years old. Older patient should be offered immune therapies if it is possible and the mechanism in old age treatment should be further s tudied. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer
ConclusionOur findings suggest that PRDM14 is involved in progression and chemoresistance of CRC, and is a potential prognostic biomarker and therapeutic target in the CRC patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Spanish validation of Charlson index applied to prostate cancer
DiscussionThe RCI may be used to aid medical decision making in older Spanish men with PC, especially in those with a high RCI 5 and higher. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Therapeutic potential of natural products in glioblastoma treatment: targeting key glioblastoma signaling pathways and epigenetic alterations
AbstractGlioma is the most common primary tumor of the nervous system, and approximately 50% of patients exhibit the most aggressive form of the cancer, glioblastoma. Currently, considerable research in glioblastoma therapeutics is aimed at developing vaccines or drugs to target key molecules for combating this disease. Studies on plant natural products from spices, vegetables, fruits, teas, and traditional medicinal herbs display that these plant-derived natural products can act as effective antioxidant and anti-tumor agents. The advancements in metabolomics and in genomics have enabled researchers to better evaluate the ...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

The prognostic role of FZD6 in esophageal squamous cell carcinoma patients
In this study, GSE20347, GSE23400 and GSE45670 datasets were retrieved from Gene Expression Omnibus (GEO) database, and the overlapping differentially expressed genes (DEGs) in three datasets were screened. Then the overlapping DEGs function was annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway-enrichment analysis. The prognostic value of the top five KEGG pathway-related genes were further validated in The Cancer Genome Atlas (TCGA) database. After extensive statistical analysis, four genes (CDC25B, CXCL8, FZD6 and MCM4) were identified as potential prognostic markers. Among the four candidate genes, the...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth
ConclusionGA-A/DM may be a promising natural therapeutic reagent in the treatment of AM by suppressing growth via NDRG2 modulation and altering of intracellular signal pathways. We have shown it could potentially be an effective treatment for AM with decreased cellular proliferation in vitro, decreased tumor volume and increased survival in vivo. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Cross-talk between ribosome biogenesis, translation, and mTOR in CD133+  4/CD44+ prostate cancer stem cells
ConclusionsThe increase in a number of genes associated with ribosome biogenesis, translation, and mTOR signaling may be important to evaluate prognosis and determine treatment approach for prostate cancer (PCa). A better understanding of the molecular pathways associated with CSCs may be promising to develop targeted therapies to prolong survival in PCa. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Prognostic value of peptidyl-prolyl cis – trans isomerase 1 (PIN1) in human malignant tumors
ConclusionsThese results suggest that high expression of PIN1 can be considered as a risk factor for progression and invasion of malignant tumors and thus may serve as a promising therapeutic target and prognostic biomarker for human solid tumors. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Splenic volume as a biomarker of hepatic damage after chemotherapy in patients with resected colorectal liver metastases (CRLM)
ConclusionsPatients who receive neoadjuvant chemotherapy for liver metastasis surgery have a greater splenic volume increase, which correlates with NAFLD and a lower survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Calcium-sensing receptor bridges calcium and telomerase reverse transcriptase in gastric cancers via Akt
ConclusionsOur findings established a functional linkage between CaSR and hTERT in the development of gastric cancers and CaSR –hTERT coupling might serve as a novel target for therapeutic strategy against human gastric cancers. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Paradoxical prognostic phenomenon of plasma T-cell-derived circulating DNA level in advanced non-small cell lung cancer
ConclusionT-cirDNA could be a novel biomarker representing adaptive immune resistance in NSCLC patients. Further exploration as a predictive biomarker for EGFR inhibitors in setting ofEGFR mutation might be warranted. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Constitutive expression of c-REL in uveal melanoma patients: correlation with clinicopathological parameters and patient outcome
AbstractPurposeUveal melanoma (UM) is the most common intraocular cancer with a high mortality rate that requires new research in the field of prevention and treatment. c-REL is a member of the nuclear factor κB (NF-κB) transcription factor family and an emerging regulator of tumorigenesis. Therefore, the objective of the study is to evaluate the constitutive expression of c-REL in uveal melanoma patients and its prognostic significance.MethodsDetection of c-REL expression was carried out by immunohistochemistry in all 75 patients, and qRT-PCR performed on 58 fresh cases of uveal melanoma along with IL-6 status...
Source: Clinical and Translational Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Dynamic monitoring of HER2 amplification in circulating DNA of patients with metastatic colorectal cancer treated with cetuximab
ConclusionPlasmaHER2 amplification detected by ddPCR changed over time and predicted resistance to CTX, by an average lead time of 2  months. Further study is needed to validate our findings. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 28, 2020 Category: Cancer & Oncology Source Type: research

Important prognostic factors in leiomyosarcoma survival: a National Cancer Database (NCDB) analysis
In this study, females comprised 68.3% of the cohort with a median age of 58  years. The most common primary anatomical sites were the extremities followed by female reproductive organs, abdomen, pelvis, thorax or lung, and head or neck. Tumors localized in the female reproductive organs had the worst survival (5-year survival probability: 45.3%), while tumors localized in the extremities had the best survival outcomes (5-year survival probability: 73.4%). Surgery with adjuvant radiation yielded better outcomes compared to surgery alone (HR 0.82, 95% CI 0.74–0.91). Microscopic and macroscopic margins resulted in...
Source: Clinical and Translational Oncology - April 28, 2020 Category: Cancer & Oncology Source Type: research