Single hormone receptor-positive breast cancer patients experienced poor survival outcomes: a systematic review and meta-analysis
ConclusionsAmong patients with hormone receptor-positive breast cancer, patients with either ER+PR − tumours or ER−PR+ tumours have a higher risk of recurrence and a shorter survival time than those with ER+PR+ tumours. Patients with both types of breast cancer need additional or better treatments. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 20, 2019 Category: Cancer & Oncology Source Type: research

Human colorectal cancer derived-MSCs promote tumor cells escape from senescence via P53/P21 pathway
ConclusionCollectively, these results reveal that MSCs can help colorectal cancer cells defend against senescence through P53/P21 pathway, which may be a new strategy for colorectal cancer therapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 19, 2019 Category: Cancer & Oncology Source Type: research

Bemiparin as a long-term treatment for venous thrombosis in cancer patients: the ELEBAMA study
ConclusionsThe incidence of events in this study is lower than that reported in randomized trials. Bemiparin is effective and safe for the long-term treatment of cancer-associated VTE in routine clinical practice. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 19, 2019 Category: Cancer & Oncology Source Type: research

Evaluation of axillary lymph node metastasis burden by preoperative ultrasound in early-stage breast cancer with needle biopsy-proven metastasis
In this study, our aim was to evaluate axillary nodal metastasis burden in patients with early-stage breast cancer who presented with metastatic lymph nodes diagnosed by fine needle aspiration biopsy (FNAB).MethodsThe data from 346 patients with cT1 –T2 breast cancer who showed positive FNAB results and were seen at Tianjin Medical University Cancer Hospital from January 2014 to December 2017 were retrospectively analyzed. The patients were divided into high axillary nodal burden (≥ 3 positive lymph nodes) or low axillary nodal burden (on e to two positive lymph nodes) groups. The clinical, radiological, an...
Source: Clinical and Translational Oncology - June 18, 2019 Category: Cancer & Oncology Source Type: research

Trifluridine/Tipiracil (TAS-102) for refractory metastatic colorectal cancer in clinical practice: a feasible alternative for patients with good performance status
ConclusionResults suggest reconsidering TAS-102 in patients with ECOG>  0, something that should be investigated in prospective randomized clinical trials. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 17, 2019 Category: Cancer & Oncology Source Type: research

The potential markers of endocrine resistance among HR+  /HER2+ breast cancer patients
AbstractPurposeBreast cancer with positive hormone receptor (HR) and human epidermal growth factor receptor-2 (HER2) is a special subgroup with different clinical features and survival, especially the endocrine therapy resistance. The main purpose of the study is to find the potential markers to predict the survival and endocrine therapy resistance of patients with HR+  /HER2+ breast cancer.MethodsSurveillance, Epidemiology, and End Results (SEER) database was used to collect patients ’ clinical information and tumor features including age, tumor size, grade, stage and long-term survival; the BioPortal ...
Source: Clinical and Translational Oncology - June 17, 2019 Category: Cancer & Oncology Source Type: research

A retrospective, multicenter study of the efficacy of lapatinib plus trastuzumab in HER2-positive metastatic breast cancer patients previously treated with trastuzumab, lapatinib, or both: the Trastyvere study
AbstractPurposeTo evaluate the efficacy and safety of lapatinib (L) and trastuzumab (T) combination in HER2-positive metastatic breast cancer (MBC) patients previously treated with T and/or L.Materials and methodsWe conducted a retrospective, post-authorized, multicenter study including patients with HER2-positive MBC or locally advanced breast cancer (ABC) treated with the combination of L –T. Concomitant endocrine therapy, as well as brain metastasis and/or prior exposure to L, were allowed.ResultsOne hundred and fifteen patients from 14 institutions were included. The median age was 59.8  years. The median nu...
Source: Clinical and Translational Oncology - June 15, 2019 Category: Cancer & Oncology Source Type: research

ILC3 cells promote the proliferation and invasion of pancreatic cancer cells through IL-22/AKT signaling
ConclusionOur data demonstrated that ILC3s may promote PC pathogenesis through IL-22/IL-22R-AKT signaling, suggesting a potential intervention target for PC treatment in the future. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 15, 2019 Category: Cancer & Oncology Source Type: research

Controlling nutritional status (CONUT) score-based nomogram to predict overall survival of patients with HBV-associated hepatocellular carcinoma after curative hepatectomy
AbstractPurposeAs a novel immune-nutritional biomarker, the controlling nutritional status (CONUT) score has been reported to predict outcomes in cancer patients. We aimed to elucidate the prognostic value of preoperative CONUT score and construct a CONUT score-based nomogram to predict individual survival of patients with hepatitis B viral (HBV)-associated hepatocellular carcinoma (HCC) after curative hepatectomy.MethodsPreoperative CONUT score was retrospectively calculated in 380 HBV-associated HCC patients undergoing radical resection between 2006 and 2012. Patients were assigned to two groups: CONUT-low (  
Source: Clinical and Translational Oncology - June 14, 2019 Category: Cancer & Oncology Source Type: research

Anti-tumor activity of the MDM2-TP53 inhibitor BI-907828 in dedifferentiated liposarcoma patient-derived xenograft models harboring MDM2 amplification
AbstractPurposeDedifferentiated liposarcoma (DDLPS) is a soft tissue malignancy characterized by amplification of the mouse double minute 2 homolog (MDM2) gene. MDM2 is a negative regulator of tumor protein 53 (TP53). We tested the in vivo efficacy of BI-907828, a small molecule inhibitor of the MDM2-TP53 interaction, in two DDLPS patient-derived xenografts (PDX).MethodsPartially immunodeficient mice were bilaterally engrafted with UZLX-STS3 (n = 24) and UZLX-STS5 (n = 24) human DDLPS tissue harboringMDM2 amplifications. Mice were grouped as follows: (a) vehicle (0.5% hydroxyethylcellullose) 10 ...
Source: Clinical and Translational Oncology - June 14, 2019 Category: Cancer & Oncology Source Type: research

Outpatient management of incidental pulmonary embolism in cancer patient
ConclusionsOutpatient management for iPE in cancer patients appears to be feasible and safe in selected cancer patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 13, 2019 Category: Cancer & Oncology Source Type: research

Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling
AbstractBackgroundThe tumor microenvironment (TME) regulates tumor progression, and cancer-associated fibroblasts (CAFs) are the primary stromal components of the TME, with the potential to drive tumor metastasis via the secretion of paracrine factors, but the specific mechanisms driving this process have not been defined.MethodsProteins secreted from CAFs and normal fibroblasts (NFs) were analyzed via proteomic analysis (fold change>  2,p 
Source: Clinical and Translational Oncology - June 12, 2019 Category: Cancer & Oncology Source Type: research

25-OH-vitamin D deficiency identifies poor tumor response in hepatocellular carcinoma treated with transarterial chemoembolization
ConclusionOur study suggested that 25-OHD deficiency at baseline is a prognostic indicator for a poor tumor response in hepatocellular carcinoma treated with TACE. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 10, 2019 Category: Cancer & Oncology Source Type: research

Outcome and toxicity of intensity-modulated radiotherapy with simultaneous integrated boost in patients with pharyngo-laryngeal cancer
AbstractPurposeThe present work aims at evaluating intensity-modulated radiation therapy with simultaneous integrated boost (IMRT-SIB) in squamous cell carcinomas (SCC) of the larynx and hypopharynx.Methods/patientsWe performed a single institutional retrospective analysis on 116 pharyngo (29%)-laryngeal (71%) SCC patients (93% male) treated with IMRT-SIB to 66 –69.96 Gy in 33 fractions between 2008 and 2016. Those who underwent surgery (54%) received adjuvant radiation of 66 Gy at 2 Gy/fraction to the surgical bed. 16 patients (14%) were treated for a local recurrence after prior surgery. High-risk ly...
Source: Clinical and Translational Oncology - June 8, 2019 Category: Cancer & Oncology Source Type: research

The effect of fenofibrate, a PPAR α activator on toll-like receptor-4 signal transduction in melanoma both in vitro and in vivo
ConclusionOur data indicate that fenofibrate may exert its anti-melanoma effects via interaction with TLR4-dependent signaling pathway (TLR-4/MyD-88/ NF-kB). (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 7, 2019 Category: Cancer & Oncology Source Type: research

Outcomes after hepatectomy of patients with positive HBcAb Non-B Non-C hepatocellular carcinoma compared to overt hepatitis B virus hepatocellular carcinoma
ConclusionsHBcAb-positive NBNC-HCC group had more advanced tumors, but their prognosis was relatively comparable to that of the other group. Therefore, we believe that screening is also necessary in HBcAb-positive patients for early detection of HCC, especially in the elderly. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 6, 2019 Category: Cancer & Oncology Source Type: research

Multidisciplinary consensus statement on the clinical management of patients with stage III non-small cell lung cancer
AbstractStage III non-small cell lung cancer (NSCLC) is a very heterogeneous disease that encompasses patients with resected, potentially resectable and unresectable tumours. To improve the prognostic capacity of the TNM classification, it has been agreed to divide stage III into sub-stages IIIA, IIIB and IIIC that have very different 5-year survival rates (36, 26 and 13%, respectively). Currently, it is considered that both staging and optimal treatment of stage III NSCLC requires the joint work of a multidisciplinary team of expert physicians within the tumour committee. To improve the care of patients with stage III NSC...
Source: Clinical and Translational Oncology - June 6, 2019 Category: Cancer & Oncology Source Type: research

A new and simple scoring system to predict overall survival after irradiation for metastatic spinal cord compression
AbstractPurposeTo develop a model that predicts survival in patients irradiated for metastatic spinal cord compression (MSCC), hence assisting in the decision between a short and a long-course radiotherapy (RT) regimen.Methods138 patients diagnosed with MSCC and treated with RT alone were included. Based on a multivariate analysis, a scoring system was developed. It included four prognostic variables: age, number of vertebrae, ECOG and histology. Total scores ranged between 14 and 24 points and patients were divided into two groups.ResultsThe 6-month survival rate was 22% for patients with a score of 14 –18 points; a...
Source: Clinical and Translational Oncology - June 5, 2019 Category: Cancer & Oncology Source Type: research

The efficacy and safety of docetaxel, cisplatin and fluorouracil (TPF)-based induction chemotherapy followed by concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: a meta-analysis
AbstractObjectivesIn recent years, docetaxel, cisplatin and fluorouracil (TPF)-based induction chemotherapy (IC) has been widely applied in the treatment of locoregionally advanced nasopharyngeal carcinoma (LA-NPC). However, it remains unclear whether TPF is the ideal IC regimen. Thus, we carried out a meta-analysis to compare the efficacy and safety of TPF-based IC plus concurrent chemoradiotherapy (CCRT) versus CCRT alone or double-drug-based IC plus CCRT for LA-NPC.MethodsWe systematically searched PubMed, Embase and the Cochrane Library from inception until December 2018. After rigorous screening of all relevant studie...
Source: Clinical and Translational Oncology - June 4, 2019 Category: Cancer & Oncology Source Type: research

Hypofractionation vs. conventional radiotherapy fractionation in the conservative treatment of T1 glottic cancer: a prospective cohort study
ConclusionRadiotherapy offers high rate survival, local control, and larynx preservation after 5 –10-year follow-up. A hypofractionation could be preferable, since it offers the same results as conventional with fewer treatment sessions. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - June 1, 2019 Category: Cancer & Oncology Source Type: research

Some remarks to SEOM clinical guidelines on cardiovascular toxicity (2018)
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 29, 2019 Category: Cancer & Oncology Source Type: research

Assessment of neurocognitive decline in cancer patients, except brain cancer, under long-term treatment with bevacizumab
ConclusionsNeurocognitive impairment was seen even in patients treated with local non-brain radiotherapy. Treatment with bevacizumab for a long period of time does not seem to worsen neurocognitive function to a greater extent than chemotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 29, 2019 Category: Cancer & Oncology Source Type: research

Overview on the role of preoperative therapy in the management of kidney cancer
AbstractThe advent of molecular therapy through targeted kinase inhibitors (TKI) has revolutionized the management of renal cell carcinoma. Although surgical resection remains the cornerstone of any therapeutic plan, an increased risk of morbidity and mortality can be of concern in large and complex bulky tumors. Preoperative therapy with TKIs is hypothesized to facilitate resectability, reduce surgical morbidity and allow nephron-sparing surgery. Many concerns on the safety, efficacy and tolerability of these agents before surgery have halted the progress in this setting. In this paper, we will review the indications and ...
Source: Clinical and Translational Oncology - May 29, 2019 Category: Cancer & Oncology Source Type: research

Circulating tumor cells in the clinical cancer diagnosis
AbstractCirculating tumor cells (CTCs) are  cells that have shed into the vasculature or lymphatics from a primary tumor and are carried around the body in the blood circulation. CTCs undergo a series of migration, adhesion and aggregation to form metastases, leading to post-operative recurrence and metastasis in patients with malignant tumors. The detection and analysis of CTCs, as a new non-invasive diagnostic tool, plays an important role in tumor diagnosis, therapeutic efficacy, monitoring recurrence, prognosis assessment and tumor precision medical treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 28, 2019 Category: Cancer & Oncology Source Type: research

Clinical significance of epithelial –mesenchymal transition-related markers expression in the micrometastatic sentinel lymph node of NSCLC
ConclusionsThe molecular EMT status of SLN could be used as an independent prognosis predictor in early stage NSLCL patients, and as a new tool to better stratify and predict patient outcomes. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 28, 2019 Category: Cancer & Oncology Source Type: research

Immunomodulation in leukemia: cellular aspects of anti-leukemic properties
This study will review the role of cytokines and chemotherapy in the modulation of immune responses in leukemia. We searched the PubMed database and Google scholar search engine of English-language papers (1995 –2018) using the “Immunomodulation”, “Leukemia”, “Tregs”, “Natural killer cells”, “Mesenchymal stem cells”, “Macrophages” and “chemotherapy” as keywords. In leukemias, T regulatory cells (Tregs), natural killer cells (NK), macrophages (MQs) and mesenchymal stem cells (M SCs) alter their functional and secretion patterns. Some o...
Source: Clinical and Translational Oncology - May 24, 2019 Category: Cancer & Oncology Source Type: research

Predictive factors for persistent and late radiation complications in breast cancer survivors
AbstractPurposeWith improved diagnostic techniques and treatments of breast cancer, overall survival times are longer, giving more opportunity for normal tissue complications of treatment to manifest. Radiation late effects (RLEs) could have profound long-term impacts on the quality of life of the survivors. The aim of this study was to identify predictive factors influencing timing and types of complications in patients referred to the Adult Radiation Late Effects Clinic (ARLEC).MethodsIn a period of 16  years, 296 breast cancer patients were referred to the ARLEC. The clinical records were retrospectively studied to...
Source: Clinical and Translational Oncology - May 23, 2019 Category: Cancer & Oncology Source Type: research

Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience
ConclusionsRegional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 17, 2019 Category: Cancer & Oncology Source Type: research

Active surveillance as a successful management strategy for patients with clinical stage I germ cell testicular cancer
ConclusionsThe clinical outcomes of patients with CSI GCTC managed by AS in this series were excellent. This strategy limited the administration of active treatments specifically to the minority of patients who relapsed without compromising performance. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 15, 2019 Category: Cancer & Oncology Source Type: research

Synergistic anti-tumor effect of paclitaxel and miR-34a combined with ultrasound microbubbles on cervical cancer in vivo and in vitro
AbstractPurposeImproved therapeutic options for cervical cancer are needed. The purpose of this study was to evaluate the synergetic, inhibitory effects of ultrasound-mediated paclitaxel (PTX)- and miR-34a-loaded microbubbles (MBs) on cervical cancer.MethodsU14 cervical cancer cells and xenograft mouse tumors were treated with PTX-miR-34a-MBs.ResultsLevels of miR-34a increased in vitro and vivo after treatment with ultrasound-mediated PTX-miR-34a-MBs. Furthermore, this treatment decreased the proliferation of cervical cancer cells, microvessel density, and the expression of Bcl-2 and CDK6, both in vitro and in vivo. Furthe...
Source: Clinical and Translational Oncology - May 15, 2019 Category: Cancer & Oncology Source Type: research

Effectiveness of fentanyl pectin nasal citrate in controlling episodes of breakthrough cancer pain triggered by routine radiotherapy procedures
ConclusionsIn our knowledge, our study is the one of highest recruitment, and with the fastest response of BTCP treated with FPNS reported in advanced cancer patients undergoing radiotherapy. FPNS has proven to be highly effective in reducing the intensity of procedural BTCP in a very short period of time. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 15, 2019 Category: Cancer & Oncology Source Type: research

Differences of the immune cell landscape between normal and tumor tissue in human prostate
ConclusionsResting mast cells and M1 macrophages has an important role in the prognosis of prostate cancer. Our data provides valuable information about the future treatment of PC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 10, 2019 Category: Cancer & Oncology Source Type: research

Coping strategies and depressive symptoms in cancer patients
ConclusionEarly psychological intervention in patients with maladaptive coping strategies may modulate the onset of depressive symptoms, especially in those at higher risk for depression. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 10, 2019 Category: Cancer & Oncology Source Type: research

Is it time to change follow-up recommendations in colorectal cancer?
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 10, 2019 Category: Cancer & Oncology Source Type: research

Efficacy and safety of trifluridine/tipiracil in third-line and beyond for the treatment of patients with metastatic colorectal cancer in routine clinical practice: patterns of use and prognostic nomogram
ConclusionThe results of this study confirm the efficacy and safety of trifluridine/tipiracil in chemorefractory mCRC patients. However, patients in clinical practice differ from patients in clinical trials. Due to this, prognostic factors have special importance to offer the best therapeutic approach. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

De-escalation treatment of axilla in breast cancer
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 9, 2019 Category: Cancer & Oncology Source Type: research

Two-dimensional versus three-dimensional laparoscopic gastrectomy in surgical efficacy for gastric cancer: a systematic review and meta-analysis
Conclusion3D laparoscopic gastrectomy decreases the operation time, intraoperative blood loss, and numbers of retrieved lymph nodes compared with 2D laparoscopic gastrectomy for gastric cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 7, 2019 Category: Cancer & Oncology Source Type: research

Cost-effectiveness analysis of capecitabine plus bevacizumab versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer from Chinese societal perspective
ConclusionsThe results of the study showed that capecitabine plus bevacizumab is unlikely to be a cost-effective treatment option for elderly patients with metastatic CRC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 6, 2019 Category: Cancer & Oncology Source Type: research

Combined strategies for tumor immunotherapy with nanoparticles
AbstractA brief review of tumor immunotherapies shows significant advancements in academic research and preclinical studies. Analysis of different immune cell pathways, including macrophage activation, natural killer cells, and dendritic cell presentation show promising  clinical results when targeted with different nanoparticle polymer and gold materials. Following a brief discussion on immuno-oncology successes, detailed results are discussed in macrophage activation, dendritic cell presentation, and lysis of tumor cells with natural killer cells. Common target s include tumor-associated macrophages and inducti...
Source: Clinical and Translational Oncology - May 4, 2019 Category: Cancer & Oncology Source Type: research

Myeloid leukemia with high EVI1 expression is sensitive to 5-aza-2 ′-deoxycytidine by targeting miR-9
ConclusionsOur results suggest that EVI1 may be involved in leukemia cell proliferation and apoptosis via the regulation of miR-9 promoter methylation. 5-AZA may represent a promising therapeutic option for EVI1-high leukemia patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 3, 2019 Category: Cancer & Oncology Source Type: research

Survival outcomes in patients aged 75  years and over with peritoneal colorectal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): multicenter study of the Spanish Group of Peritoneal Cancer Surgery (GECOP)
ConclusionsAge is not an absolute contraindication to perform cytoreduction surgery with HIPEC in highly selected elderly patients with colorectal peritoneal carcinomatosis. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Efficacy and safety of a simplified SBRT regimen for central and peripheral lung tumours
ConclusionsSBRT in lung cancer with three sessions for peripheral tumours and five sessions for central tumours may be safely delivered, with low morbidity. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

The tumor diameter cut-off for predicting microscopic intrahepatic metastasis of hepatocellular carcinoma patients without treatment history differs from that of hepatocellular carcinoma patients with a treatment history
ConclusionsThe tumor diameter cut-off value for predicting MIM differed between HCC patients without treatment history and with a treatment history and slightly smaller than those for predicting MVI beyond our expectation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 30, 2019 Category: Cancer & Oncology Source Type: research

Cost-effectiveness of trifluridine/tipiracil (TAS102) for heavily pretreated metastatic gastric cancer
ConclusionTrifluridine/tipiracil (TAS102) is not a cost-effective choice for patients with heavily pretreated metastatic gastric cancer from an American payer perspective. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 30, 2019 Category: Cancer & Oncology Source Type: research

First-line carboplatin/nab-paclitaxel in advanced ovarian cancer patients, after hypersensitivity reaction to solvent-based taxanes: a single-institution experience
AbstractOne of the major challenges related to solvent-based taxanes administration in clinical practice is the high rate of hypersensitivity reactions (HSRs). Nab-paclitaxel is a solvent-free, albumin-bound, paclitaxel, which minimize the risk of HSR occurrence. In this single-institution, retrospective analysis, we evaluated stage IIIc –IV epithelial ovarian cancer (EOC) patients, treated with first-line carboplatin/nab-paclitaxel (± bevacizumab), after the occurrence of an HSR with solvent-based paclitaxel (and/or docetaxel). Between April 2012 and December 2018, ten patients (20.8%) received carbopl...
Source: Clinical and Translational Oncology - April 30, 2019 Category: Cancer & Oncology Source Type: research

ΔNp73 status in peritoneal and ovarian dissemination of appendicular adenocarcinoids (goblet cells)
ConclusionGoblet cell carcinoma of the appendix is very rate. It tends to seed throughout the peritoneum, making aggressive surgical cytoreduction and chemotherapy viable treatment options. Investigation into the molecular basis of these tumors may improve the diagnosis, prognosis and therapeutic decisions regarding these patients. ∆Np73 seems a good candidate for further analysis in longer series. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 25, 2019 Category: Cancer & Oncology Source Type: research

The effect of metformin on biomarkers associated with breast cancer outcomes: a systematic review, meta-analysis, and dose –response of randomized clinical trials
ConclusionsBreast cancer patients receiving metformin as treatment for diabetes showed significant reduction in levels of insulin, fasting glucose, CRP, HOMA, leptin, BMI, and Ki-67. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 22, 2019 Category: Cancer & Oncology Source Type: research

Response to immunohistochemical markers ’ conversion after neoadjuvant chemotherapy in breast cancer patients: association between imaging and histopathologic analysis
AbstractBackgroundBreast ultrasound and mammography were used in the detection of residual tumor after neoadjuvant chemotherapy. The aim of this study was to evaluate the correlation between clinical and pathological responses with breast density and IHC marker conversion to understand how this information might be used in the future to direct treatment.MethodsWe included 119 patients who underwent CNB and followed NACT. The breast density assessment was based on the mammography examination performed at the time of diagnosis. We evaluated the clinical and pathological responses to NACT by the UICC and Miller –Payne g...
Source: Clinical and Translational Oncology - April 20, 2019 Category: Cancer & Oncology Source Type: research

Comparison of overall survival and quality of life between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection
ConclusionsThere was no difference in survival time between group A and group B, but compared with the patients with left lower abdominal stoma(group A), the quality of life was better in patients with reconstruction of the anus in situ (group B). It is significant to improve the traditional lower abdominal stoma operation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 20, 2019 Category: Cancer & Oncology Source Type: research

Unveiling the mechanisms of immune evasion in pancreatic cancer: may it be a systemic inflammation responsible for dismal survival?
ConclusionsThe host ’s immune response influences survival outcomes of PC patients and may be of interest for future research. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 19, 2019 Category: Cancer & Oncology Source Type: research