Patient, tumor, and healthcare factors associated with regional variability in lung cancer survival: a Spanish high-resolution population-based study
ABSTRACTPurposeThe third most frequently diagnosed cancer in Europe in 2018 was lung cancer; it is also the leading cause of cancer death in Europe. We studied patient and tumor characteristics, and patterns of healthcare provision explaining regional variability in lung cancer survival in southern Spain.MethodsA population-based cohort study included all 1196 incident first invasive primary lung cancer (C33 –C34 according to ICD-10) cases diagnosed between 2010 and 2011 with follow-up until April 2015. Data were drawn from local population-based cancer registries and patients’ hospital medical records from all...
Source: Clinical and Translational Oncology - October 19, 2018 Category: Cancer & Oncology Source Type: research

Impact of rectum and bladder anatomy in intrafractional prostate motion during hypofractionated radiation therapy
ConclusionsThe treatment margin should not be reduced for those patients who were treated with hormone therapy and/or whose rectum or bladder was far from complying the preparation protocol conditions. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 17, 2018 Category: Cancer & Oncology Source Type: research

Status of hydration assessed by bioelectrical impedance analysis: a valuable predictive factor for radiation-induced oral mucositis in head and neck cancer patients
ConclusionOur study indicates that HNC patients undergo changes in hydration in the course of RTH. We have also confirmed that the intensification of OM leads to ICW decrease and the increase of ECW, TBW as well as ECW/ICW and ECW/TBW values. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 16, 2018 Category: Cancer & Oncology Source Type: research

Optimization of oral chemotherapy in outpatient clinics in Spain: results from a survey of the Spanish Society of Medical Oncology (SEOM)
ConclusionsPatients ’ waiting times and individual dedication of oncologists might be reduced by administering OC, and general management might be improved. This should be considered when planning therapies if OC is an option. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 16, 2018 Category: Cancer & Oncology Source Type: research

Quality indicators in radiation oncology: proposal of the Spanish Society of Radiation Oncology (SEOR) for a continuous improvement of the quality of care in oncology
ConclusionsThere is a high degree of consensus in Spanish Radiation Oncology specialists on which indicators in routine clinical practice can best measure quality. These indicators can be used to classify services based on several parameters (patients, equipments, complexity of the techniques used, and scientific research). Furthermore, these indicators allow assess our current situation and set improvements ’ objectives. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 11, 2018 Category: Cancer & Oncology Source Type: research

HER2 in stemness and epithelial –mesenchymal plasticity of breast cancer
AbstractBreast cancer had been the first non-hematologic malignancy where sub-types based on molecular characterization had entered clinical practice. HER2 over-expression, due to either gene amplification or protein up-regulation, defines one of these sub-types and is clinically exploited by addition of HER2-targeted treatments to the regimens of treatment. Nevertheless, in many occasions HER2-positive cancers are resistant or become refractory to these therapies. Several mechanisms, such as activation of alternative pathways or loss of expression of the receptor in cancer cells, have been proposed as the cause of these t...
Source: Clinical and Translational Oncology - October 10, 2018 Category: Cancer & Oncology Source Type: research

Transarterial chemoembolization with raltitrexed-based or floxuridine-based chemotherapy for unresectable colorectal cancer liver metastasis
ConclusionTACE treatment based on raltitrexed or FUDR is an efficient and safe alternative choice for treating unresectable CRCLM. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 10, 2018 Category: Cancer & Oncology Source Type: research

Recommendations by the Spanish Society of Hospital Pharmacy, the Spanish Society of Oncology Nursing and the Spanish Society of Medical Oncology for the safe management of antineoplastic medication in cancer patients
ConclusionsIt is essential for healthcare establishments to implement specific measures designed to prevent medication errors, in order to ensure the safety of cancer patients treated with antineoplastic medication. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 8, 2018 Category: Cancer & Oncology Source Type: research

Modulation of cancer cells ’ radiation response in the presence of folate conjugated Au@Fe 2 O 3 nanocomplex as a targeted radiosensitizer
ConclusionOur findings provide a new perspective on high ability of the synthesized FA-targeted Au@Fe2O3 NPs which may be considered as an efficient radiosensitizer in the process of targeted radiation therapy of cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 8, 2018 Category: Cancer & Oncology Source Type: research

A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study
ConclusionsThe combination of hydroxytyrosol, omega-3 fatty acids, and curcumin reduced inflammation as indicated by a reduction in CRP and reduced pain in patients with aromatase-induced musculoskeletal symptoms. Longer studies comparing this combination to other anti-inflammatories in larger groups of patients with clinical outcome endpoints are warranted. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 6, 2018 Category: Cancer & Oncology Source Type: research

Consensus on management of castration-resistant prostate cancer on behalf of the Urological Tumours Working Group (URONCOR) of the Spanish Society of Radiation Oncology
ConclusionsThe recommendations based on the radiation oncology experts ’ opinions are intended to provide cancer specialists with expert guidance and to standardise CRPC patient management in Spain, facilitating decision-making in different clinically relevant issues regarding CRPC patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 6, 2018 Category: Cancer & Oncology Source Type: research

Real-world data on the efficacy and safety of weekly oral vinorelbine in breast cancer patients previously treated with anthracycline or taxane-based regimens
ConclusionOur study provides real-world data on the use of oral weekly vinorelbine, which proves an effective and well-tolerated regimen for MBC patients previously treated with taxanes or anthracyclines. Patients with HER2-positive disease could also benefit from this treatment in combination with trastuzumab. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 6, 2018 Category: Cancer & Oncology Source Type: research

Anti-tumor effect of endostatin in a sleep-apnea mouse model with tumor
This study aims to evaluate the influence of intermittent hypoxia (IH), a novel hallmark of OSA, on tumor and to access the anti-tumor effect of endostatin on a mouse model with OSA.MethodsThe C57BL/6  J mice were randomly classified into four groups: control (normoxia) (CTL), control plus endostatin (CTL + ED), IH, and IH plus endostatin (IH + ED). Mice in IH and IH + ED groups were subjected to IH 8 h per day in 5 weeks. Lewis lung cancer cells were injected into the flank of eac h mouse after 1 week of IH exposure. Endostatin was also intraperitoneally inject...
Source: Clinical and Translational Oncology - October 6, 2018 Category: Cancer & Oncology Source Type: research

Macrophage polarization as a novel weapon in conditioning tumor microenvironment for bladder cancer: can we turn demons into gods?
AbstractMacrophages are major components of the immune infiltration in cancer where they can affect tumor behavior. In the bladder, they play important roles during the resolution of infectious processes and they have been associated with a worse clinical prognosis in bladder cancer. The present review focused on the characteristics of these important immune cells, not only eliciting an innate immune surveillance, but also on their importance during the cancer immunoediting process. We further discuss the potential of targeting macrophages for anticancer therapy, the current strategies and the state of the art as well as t...
Source: Clinical and Translational Oncology - October 5, 2018 Category: Cancer & Oncology Source Type: research

Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology
This article reviews the various dermatological toxicities associated with targeted therapies and immunotherapies, along with their diagnosis and therapeutic management. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Re-irradiation of recurrent glioblastoma as part of a sequential multimodality treatment concept
ConclusionCarefully planned re-irradiation of the brain is a safe therapy for recurrent glioblastoma. Younger and well-performing patients benefit from all available therapy options. Every patient should be discussed in a multidisciplinary setting at each time point of tumor progression. Further prospective studies are needed to define the optimal time, dose and volume of re-irradiation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Risk of malnutrition and emotional distress as factors affecting health-related quality of life in patients with resected cancer
ConclusionThe risk of malnutrition and psychological symptoms is strongly associated with HRQoL in cancer patients; thus, medical oncologists should develop effective interventions that contribute to lowering the risk of malnutrition and psychological distress, thereby improving subjects ’ HRQoL before initiating adjuvant chemotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1
ConclusionsHydrogen peroxide upregulated the expression of FUNDC1 through the activation of ERK1/2 signal to trigger a mitophagic response, giving laryngeal cancer cells a befit for survival. These findings suggested that FUNDC1 might be a potential target for the treatment of laryngeal cancer accompanied with high lipid peroxidation status. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Efficacy of fulvestrant in the treatment of postmenopausal women with endocrine-resistant advanced breast cancer in routine clinical practice
A sentence under ‘Results’ heading in the Abstract section was published incorrectly. The correct sentence should read as follows: (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology
This article reviews the various dermatological toxicities associated with targeted therapies and immunotherapies, along with their diagnosis and therapeutic management. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Re-irradiation of recurrent glioblastoma as part of a sequential multimodality treatment concept
ConclusionCarefully planned re-irradiation of the brain is a safe therapy for recurrent glioblastoma. Younger and well-performing patients benefit from all available therapy options. Every patient should be discussed in a multidisciplinary setting at each time point of tumor progression. Further prospective studies are needed to define the optimal time, dose and volume of re-irradiation. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Risk of malnutrition and emotional distress as factors affecting health-related quality of life in patients with resected cancer
ConclusionThe risk of malnutrition and psychological symptoms is strongly associated with HRQoL in cancer patients; thus, medical oncologists should develop effective interventions that contribute to lowering the risk of malnutrition and psychological distress, thereby improving subjects ’ HRQoL before initiating adjuvant chemotherapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Hydrogen peroxide-induced mitophagy contributes to laryngeal cancer cells survival via the upregulation of FUNDC1
ConclusionsHydrogen peroxide upregulated the expression of FUNDC1 through the activation of ERK1/2 signal to trigger a mitophagic response, giving laryngeal cancer cells a befit for survival. These findings suggested that FUNDC1 might be a potential target for the treatment of laryngeal cancer accompanied with high lipid peroxidation status. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Correction to: Efficacy of fulvestrant in the treatment of postmenopausal women with endocrine-resistant advanced breast cancer in routine clinical practice
A sentence under ‘Results’ heading in the Abstract section was published incorrectly. The correct sentence should read as follows: (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 3, 2018 Category: Cancer & Oncology Source Type: research

Efficacy of Huaier granule in patients with breast cancer
In this study, we aimed to evaluate the efficacy of Huaier granule in breast cancer patients.MethodsOur study included 284 breast cancer patients treated with or without Huaier granule between January 2005 and October 2016 at Qilu Hospital, Shandong University, Jinan, China. Retrospective data obtained included demographics, clinicopathological characteristics, disease-free survival (DFS), serum concentrations of tumor markers, the Karnofsky performance scale (KPS), and incidences of emotional symptoms. DFS was the main outcome measure.ResultsOf the patients included, 144 were classified into the control group and 140 into...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Nur77 suppression facilitates androgen deprivation-induced cell invasion of prostate cancer cells mediated by TGF- β signaling
ConclusionConsidering the limited success of management of prostate cancer metastasis following ADT, our data strongly suggest that Nur77 regulation could be a promising direction for search of complementary therapeutic strategy on top of classic ADT therapy. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Recurrent non-functioning pituitary adenomas: a review on the new pathological classification, management guidelines and treatment options
AbstractAt least 50% of surgically resected non-functioning pituitary adenomas (NFPA) recur. Either early or late adjuvant radiotherapy is highly efficacious in controlling recurrent NFPA but associates potentially burdensome complications like hypopituitarism, vascular complications or secondary neoplasm. Reoperation is indicated in bulky tumor rests compressing the optic pathway. To date, no standardized medical therapy is available for recurrent NFPA although cabergoline and temozolomide show promising results. Guidelines on the management of recurrent NFPAs are now available. The new 2017 WHO pituitary tumor classifica...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Dosimetry study of 18 F-FMISO  + PET/CT hypoxia imaging guidance on intensity-modulated radiation therapy for non-small cell lung cancer
ConclusionIt is feasible in dosiology that the dosages in NSCLC hypoxic area were added to 72, 78 and 84  Gy by simultaneous integrated boost with the guidance of18F-FMISO PET/CT. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Pathology findings and clinical outcomes after risk reduction salpingo-oophorectomy in BRCA mutation carriers: a multicenter Spanish study
ConclusionThe incidence of STIC after RRSO in BRCA mutation carriers is low (0.8%) and it presents an excellent oncological outcome. Patients after RRSO, however, run the risk to develop other types of cancer during follow-up and should be properly advised before the prophylactic surgery. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Bevacizumab improves survival in patients with synchronous colorectal liver metastases provided the primary tumor is resected first
ConclusionsNeoadjuvant Bevacizumab-based chemotherapy was associated with improved OS in patients who underwent liver resection of synchronous CRLM, especially in those who underwent primary tumor resection first. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Management of extravasation of oxaliplatin by mimicking its biotransformation
AbstractAlthough oxaliplatin (Oxali) plays a key role in the treatment of many types of cancer and has been reported to be an irritant, there is no specific and effective method for its extravasation and failure in Oxali extravasation management results in the need for plastic surgery. In the body, Oxali bio-transforms upon dilution in chloride-containing buffer salts to its di-chloro derivative and loses an oxalate molecule. Consequently, the chloride ions exchange with water molecules in the intracellular environment to produce the di-aqua derivative, which is the most active biotransformation product of Oxali in terms o...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Evaluation of waiting times for breast cancer diagnosis and surgical treatment
ConclusionsDelays in diagnosis and surgery in the case of women diagnosed on the basis of symptoms may be improved. There is a temporary tendency to a greater delay in surgery. Some clinical and biological factors must be taken into account to optimise delays. Survival results are not adversely affected by delays. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Prognostic factors for relapse in stage I testicular seminoma: tumor size and rete testis invasion revisited
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Efficacy of Huaier granule in patients with breast cancer
In this study, we aimed to evaluate the efficacy of Huaier granule in breast cancer patients.MethodsOur study included 284 breast cancer patients treated with or without Huaier granule between January 2005 and October 2016 at Qilu Hospital, Shandong University, Jinan, China. Retrospective data obtained included demographics, clinicopathological characteristics, disease-free survival (DFS), serum concentrations of tumor markers, the Karnofsky performance scale (KPS), and incidences of emotional symptoms. DFS was the main outcome measure.ResultsOf the patients included, 144 were classified into the control group and 140 into...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

The effect of dose escalation for large squamous cell carcinomas of the anal canal
AbstractPurposeChemoradiation allows for organ preservation in patients with anal cancer, but patients with large tumors (>  5 cm) have elevated rates of locoregional recurrence. With conformal radiation techniques, there is interest in dose escalation to decrease local recurrence in patients with large tumor size.Methods/patientsThe National Cancer Database (NCDB) was used to identify patients with anal cancer from 2004 to 2013 with tumors  >  5 cm. Adult patients who received definitive chemoradiation were included. Patients with prior resection were excluded. High dose was defined as...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

General recommendations paper on the management of older patients with cancer: the SEOM geriatric oncology task force ’s position statement
AbstractPopulation aging is associated with greater numbers of older people with cancer. Thanks to treatment advances, not only are more seniors diagnosed with cancer, but there are also more and more older cancer survivors. This upward trend will continue. Given the heterogeneity of aging, managing older patients with cancer poses a significant challenge for Medical Oncology. In Spain, a Geriatric Oncology Task Force has been set up within the framework of the Spanish Society for Medical Oncology (SEOM). With the aim of generating evidence and raising awareness, as well as helping medical oncologists in their training wit...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Peritoneal carcinomatosis arising from rectal or colonic adenocarcinoma treated with cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC): two different diseases
ConclusionRectal origin PC has a more aggressive behavior compared to colonic origin, reflecting in a worst prognosis of patients affected by rectal origin PC. According to our data and literature, indications of multi-modal treatment including CRS and HIPEC should be more restrictive for rectal cancer PC. Authors should differentiate colonic and rectal origin of PC when reporting cases in the literature. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Postoperative intra-abdominal infection is an independent prognostic factor of disease-free survival and disease-specific survival in patients with stage II colon cancer
AbstractBackgroundRecurrence occurs in up to 20% of patients with stage II colon cancer operated on for cure. Although postoperative intra-abdominal infection has been linked with an increased risk of recurrence, the association is controversial. The aim was to investigate the impact of postoperative intra-abdominal infection on disease-free survival and disease-specific survival in patients with stage II colon cancer.MethodsPatients undergoing elective surgery for colon cancer stage II, between 2003 and 2014, were included. Patients with anastomotic leak or intra-abdominal abscess were included in the infection group. We ...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Concurrent use of capecitabine with radiation therapy and survival in breast cancer (BC) after neoadjuvant chemotherapy
AbstractPurposeCapecitabine has been studied as a radiosensitizer, and our study seeks to examine the association of concurrent capecitabine/radiation therapy (RT) on event-free- (EFS) and overall survival (OS) in women with breast cancer (BC) with residual disease after neoadjuvant chemotherapy (NAC).Methods/patientsIn a retrospective study of women with BC who received adriamycin/taxane-based NAC from 2004 –2016, we identified 21 women administered concurrent capecitabine/RT. To assess differences in survival, we selected a clinical control cohort (n = 57) based on criteria used to select patients for...
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Comparison of plasma ctDNA and tissue/cytology-based techniques for the detection of EGFR mutation status in advanced NSCLC: Spanish data subset from ASSESS
ConclusionsThe high concordance between the different DNA sources forEGFR mutation testing supports the use of plasma samples when tumor tissue is unavailable. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 1, 2018 Category: Cancer & Oncology Source Type: research

Effect of PET/CT standardized uptake values on complete response to treatment before definitive chemoradiotherapy in stage III non-small cell lung cancer
AbstractPurposeThe standard treatment for patients with stage III non-small cell lung cancer (NSCLC), unsuitable for resection and with good performance, is definitive radiotherapy with cisplatin-based chemotherapy. Our aim is to evaluate the effect of the maximum value of standardized uptake values (SUVmax) of the primary tumor in positron emission tomography-computed tomography (PET/CT) before treatment on complete response (CR) and overall survival.MethodsThe data of 73 stage III NSCLC patients treated with concurrent definitive chemoradiotherapy (CRT) between 2008 and 2017 and had PET/CT staging in the pretreatment per...
Source: Clinical and Translational Oncology - September 18, 2018 Category: Cancer & Oncology Source Type: research

Effect of Paclitaxel-based Hyperthermic Intraperitoneal Chemotherapy (HIPEC) on colonic anastomosis in a rat model
ConclusionStrength of colonic anastomosis was improved by isolated hyperthermia and negatively affected by Paclitaxel-based HIPEC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 18, 2018 Category: Cancer & Oncology Source Type: research

Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer
ConclusionsEMP2 is superior to EpCAM for capturing both MCF7 and MDA-MB-231 cells. Additionally, EMP2 is a novel biomarker and capable of capturing breast cancer cells in patient blood samples. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 14, 2018 Category: Cancer & Oncology Source Type: research

Goal-directed therapy in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a prospective observational study
AbstractBackgroundCytoreductive surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in peritoneal carcinomatosis treatment causes significant hemodynamic, metabolic, and hematological alterations. Studies on the anesthetic intraoperative management are heterogeneous and scarce. There is a great heterogeneity in the anesthetic management of CRS and HIPEC. The aim of this study is to analyze perioperative hemodynamic goal-directed management and to evaluate the complications arisen until the seventh postoperative day.MethodsProspective, observational study of all CRS and HIPEC patients from March 2014 to May...
Source: Clinical and Translational Oncology - September 14, 2018 Category: Cancer & Oncology Source Type: research

Beyond first-line systemic treatment for metastatic urothelial carcinoma of the bladder
AbstractMetastatic urothelial carcinoma of the bladder is a rarely curable disease. Patients receive systemic therapy with limited response rates and survival benefits. The rescue regimens of these patients who have failed first-line treatment had remained problematic until the recent advances. Several trials with novel regimens, including immune checkpoint inhibitors and targeted therapy, to salvage relapsed urothelial carcinoma of the bladder have recently been published. However, the choice of an optimal treatment regimen remains challenging in the absence of randomized trials comparing regimen sequences. Daily clinical...
Source: Clinical and Translational Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1
ConclusionsOur work is the first to demonstrate the aberrant expression of 6PGD and its predominant roles in cervical cancer cell growth and migration, via a AMPK-dependent activation. Our findings suggest 6PGD as a potential therapeutic target to enhance chemosensitivity in cervical cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Relapse patterns in patients with local and regional cutaneous melanoma
ConclusionPotential differences among early-stage melanoma patients, who developed recurrence, were noted and mitotic rate was found as the single significant prognostic factor for recurrence in both stage I –II and III patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Retroperitoneal fibrosis secondary to non-urology carcinomas: a clinical and outcome analysis of 97 cases
ConclusionsAll patients with newly diagnosed unexplained hydronephrosis should undergo an age-appropriate carcinoma screening. The prognosis of RPF secondary to non-urology carcinoma was dismal. When dealing with hydronephrosis affecting renal function, pyelostomy instead of double J tube catheterization should be performed ahead of time. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Impact of diabetes comorbidity on the efficacy and safety of FOLFOX first-line chemotherapy among patients with metastatic colorectal cancer: a pooled analysis of two phase-III studies
ConclusionDM does not seem to affect overall or progression-free survival of mCRC patients treated with first-line FOLFOX chemotherapy. Moreover, DM does not influence the incidence or severity of oxaliplatin-induced paresthesia in those patients while it might lead to a shorter time to develop oxaliplatin-induced paresthesia compared to non-diabetic patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 4, 2018 Category: Cancer & Oncology Source Type: research

Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization
AbstractIt is estimated that more than half of cancer patients undergo radiotherapy during the course of their treatment. Despite its beneficial therapeutic effects on tumor cells, exposure to high doses of ionizing radiation (IR) is associated with several side effects. Although improvements in radiotherapy techniques and instruments could reduce these side effects, there are still important concerns for cancer patients. For several years, scientists have been trying to modulate tumor and normal tissue responses to IR, leading to an increase in therapeutic ratio. So far, several types of radioprotectors and radiosensitize...
Source: Clinical and Translational Oncology - August 22, 2018 Category: Cancer & Oncology Source Type: research