Quality indicators and excellence requirements for a multidisciplinary lung cancer tumor board by the Spanish Lung Cancer Group
AbstractMultidisciplinary care is needed to decide the best therapeutic approach and to provide optimal care to patients with lung cancer (LC). Multidisciplinary teams (MDTs) are optimal strategies for the management of patients with LC and have been associated with better outcomes, such as an increase in quality of life and survival. The Spanish Lung Cancer Group has promoted this review about the current situation of the existing national LC-MDTs, which also offers a set of excellence requirements and quality indicators to achieve the best care in any patient with LC. Time and sufficient resources; leadership; administra...
Source: Clinical and Translational Oncology - October 19, 2021 Category: Cancer & Oncology Source Type: research

Traditional Chinese medicine reverses cancer multidrug resistance and its mechanism
AbstractChemotherapy is one of the most commonly used clinical treatments among the currently available cancer therapies. However, the phenomenon of Multidrug resistance (MDR) has become a challenge in the treatment process, weakening the impact of chemotherapy. Extensive research on elucidating the development of cancer MDR has identified the following mechanisms that play a critical role in the development of several MDR reversal agents: abnormal expression of cell membrane transporters, adaptation of cancer cells to the microenvironment, regulation of hypoxia, repair of DNA damage and reduction of apoptosis, the enhance...
Source: Clinical and Translational Oncology - October 13, 2021 Category: Cancer & Oncology Source Type: research

The TRIM proteins in cancer: from expression to emerging regulatory mechanisms
AbstractNew clinical evidence suggests that dysregulation of the ubiquitin-mediated destruction of tumor suppressors or oncogene products is probably engaged in the etiology of leukemia and carcinoma. The superfamily of tripartite motif (TRIM)-containing protein family is among the biggest recognized single protein RING finger E3 ubiquitin ligases that are considered vital carcinogenesis regulators, which is not shocking since TRIM proteins are engaged in various biological processes, including cell growth, development, and differentiation; hence, TRIM proteins ’ alterations may influence apoptosis, cell proliferatio...
Source: Clinical and Translational Oncology - October 13, 2021 Category: Cancer & Oncology Source Type: research

Traditional Chinese medicine reverses cancer multidrug resistance and its mechanism
AbstractChemotherapy is one of the most commonly used clinical treatments among the currently available cancer therapies. However, the phenomenon of Multidrug resistance (MDR) has become a challenge in the treatment process, weakening the impact of chemotherapy. Extensive research on elucidating the development of cancer MDR has identified the following mechanisms that play a critical role in the development of several MDR reversal agents: abnormal expression of cell membrane transporters, adaptation of cancer cells to the microenvironment, regulation of hypoxia, repair of DNA damage and reduction of apoptosis, the enhance...
Source: Clinical and Translational Oncology - October 13, 2021 Category: Cancer & Oncology Source Type: research

The TRIM proteins in cancer: from expression to emerging regulatory mechanisms
AbstractNew clinical evidence suggests that dysregulation of the ubiquitin-mediated destruction of tumor suppressors or oncogene products is probably engaged in the etiology of leukemia and carcinoma. The superfamily of tripartite motif (TRIM)-containing protein family is among the biggest recognized single protein RING finger E3 ubiquitin ligases that are considered vital carcinogenesis regulators, which is not shocking since TRIM proteins are engaged in various biological processes, including cell growth, development, and differentiation; hence, TRIM proteins ’ alterations may influence apoptosis, cell proliferatio...
Source: Clinical and Translational Oncology - October 13, 2021 Category: Cancer & Oncology Source Type: research

SEOR  SBRT-SG stereotactic body radiation therapy consensus guidelines for non-spine bone metastasis
AbstractThe use of stereotactic body radiation therapy (SBRT) to treat non-spine bone metastases (NSBM) is becoming increasingly common in clinical practice. The clinical advantages of SBRT include good pain control and high local control rates, although only limited data are available. The Spanish Society of Radiation Oncology (SEOR) SBRT group  recently convened a task force of experts in the field to address key questions related to SBRT for NSBM, including treatment indications, planning, techniques, and dose fractionation. The task force reviewed the available literature to develop evidence-based recommendations ...
Source: Clinical and Translational Oncology - October 11, 2021 Category: Cancer & Oncology Source Type: research

Multidisciplinary consensus on the criteria for fertility preservation in cancer patients
AbstractInfertility is one of the main sequelae of cancer and its treatment in both children and adults of reproductive age. It is, therefore, essential that oncologists and haematologists provide adequate information about the risk of infertility and the possibilities for its preservation before starting treatment. Although many international clinical guidelines address this issue, this document is the first Spanish multidisciplinary guideline in paediatric and adult oncological patients. Experts from the Spanish Society of Medical Oncology, the Spanish Fertility Society, the Spanish Society of Haematology and Haemotherap...
Source: Clinical and Translational Oncology - October 11, 2021 Category: Cancer & Oncology Source Type: research

SEOR  SBRT-SG stereotactic body radiation therapy consensus guidelines for non-spine bone metastasis
AbstractThe use of stereotactic body radiation therapy (SBRT) to treat non-spine bone metastases (NSBM) is becoming increasingly common in clinical practice. The clinical advantages of SBRT include good pain control and high local control rates, although only limited data are available. The Spanish Society of Radiation Oncology (SEOR) SBRT group  recently convened a task force of experts in the field to address key questions related to SBRT for NSBM, including treatment indications, planning, techniques, and dose fractionation. The task force reviewed the available literature to develop evidence-based recommendations ...
Source: Clinical and Translational Oncology - October 11, 2021 Category: Cancer & Oncology Source Type: research

Multidisciplinary consensus on the criteria for fertility preservation in cancer patients
AbstractInfertility is one of the main sequelae of cancer and its treatment in both children and adults of reproductive age. It is, therefore, essential that oncologists and haematologists provide adequate information about the risk of infertility and the possibilities for its preservation before starting treatment. Although many international clinical guidelines address this issue, this document is the first Spanish multidisciplinary guideline in paediatric and adult oncological patients. Experts from the Spanish Society of Medical Oncology, the Spanish Fertility Society, the Spanish Society of Haematology and Haemotherap...
Source: Clinical and Translational Oncology - October 11, 2021 Category: Cancer & Oncology Source Type: research

Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: a review
AbstractNatural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their no or less adverse effects, excess availability, high accuracy, and secure mode of action. In the present review, potential anticancer mechanisms of action of some polyphenols including phenolic acids, lignans, and stilbenes are discussed based on clinical, epidemiological, in vivo, and in vitro  studies. The emerging evidence revealed that phenolic acids, lignans, and stilbenes induced apoptosis in the treatment of breast (MCF-7), colon (Caco-2), lung (SKLU-1), pr...
Source: Clinical and Translational Oncology - October 5, 2021 Category: Cancer & Oncology Source Type: research

Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis
ConclusionsCirc_0091579 accelerated Warburg effect and tumor growth via upregulating H3F3B via adsorbing miR-624 in HCC, providing evidence to support the involvement of circ_0091579 in the progression of HCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Circulating non-coding RNAs as new biomarkers and novel therapeutic targets in colorectal cancer
AbstractColorectal cancer (CRC) is one of the most common malignant tumors, and a large number of patients are diagnosed and die every year. Due to the lack of appropriate diagnosis, prediction and treatment, early diagnosis rate of CRC is low and the prognosis is poor. Studies have found that abnormally expressed non-coding RNAs (ncRNAs) (including microRNAs (miRNAs), circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs),etc.) play an important regulatory role in the occurrence and development of CRC. Some studies have shown that they are stable in the blood and can be detected repeatedly. They are expected to be no...
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

5-year results of accelerated partial breast irradiation (APBI) with SBRT (stereotactic body radiation therapy) and exactrac adaptive gating (Novalis ®) for very early breast cancer patients: was it all worth it?
ConclusionAPBI with SBRT and ExacTrac Adaptive Gating System was feasible. The acute and late toxicities were almost null and cosmesis was excellent. We also found that the margins of 5  mm applied from CTV to PTV were sufficient to compensate for geometric uncertainties. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

PD-1 and PD-L1 gene expressions and their association with Epstein-Barr virus infection in chronic lymphocytic leukemia
ConclusionHigh expression of PD-1 and PD-L1, together with high EBD-DNA load were linked to worse prognosis in CLL. In addition, PD-1 and PD-L1 might represent suitable therapeutic targets for patients suffering from aggressive CLL. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Comparative genomic characterization of melanoma of known and unknown primary
ConclusionsThe differences in somatic mutation patterns and survival outcomes were not statistically significant. These findings may allude to similar carcinogenic processes but should be considered exploratory and interpreted with caution. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/ β-catenin signaling pathway
ConclusionsCollectively, all the above findings revealed that miR-377-3p exerted anti-OS functions viaCUL1 and EMT and Wnt/β-catenin pathways. These results may contribute to the development of clinical OS treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Targeting GLS1 to cancer therapy through glutamine metabolism
AbstractGlutamine metabolism is one of the hallmarks of cancers which is described as an essential role in serving as a major energy and building blocks supply to cell proliferation in cancer cells. Many malignant tumor cells always display glutamine addiction. The “kidney-type” glutaminase (GLS1) is a metabolism enzyme which plays a significant part in glutaminolysis. Interestingly, GLS1 is often overexpressed in highly proliferative cancer cells to fulfill enhanced glutamine demand. So far, GLS1 has been proved to be a significant target during the carci nogenesis process, and emerging evidence reveals that i...
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

A novel 12-gene signature as independent prognostic model in stage IA and IB lung squamous cell carcinoma patients
ConclusionThe 12-gene prognostic model may serve as a useful complementary clinical risk-stratification tool for stage I and especially stage IA lung squamous cell carcinoma patients to guide clinical decision making. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer
ConclusionTaken together, miR-143-3p and miR-495-3p co-target CDK1, thereby inhibiting the occurrence and development of cervical cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Stance of MRD in Non-Hodgkin ’s Lymphoma and its upsurge in the novel era of cell-free DNA
AbstractCancer genomics has evolved over the years from understanding the pathogenesis of cancer to screening the future possibilities of cancer occurrence. Understanding the genetic profile of tumors holds a prognostic as well as a predictive value in this era of therapeutic surveillance, molecular remission, and precision medicine. Identifying molecular markers in tumors is the current standard of approach, and requires an efficient combination of an accessible sample type and a profoundly sensitive technique. Liquid biopsy or cell-free DNA has evolved as a novel sample type with promising results in recent years. Althou...
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Sexual, bladder and bowel function following different minimally invasive techniques of radical hysterectomy in patients with early-stage cervical cancer
ConclusionPelvic floor dysfunction commonly deteriorates and negatively impacts on quality of life after minimally invasive radical hysterectomy, especially bowel function after TMMR. Pelvic floor symptoms should routinely be addressed pre- and postoperatively. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Mechanisms of primary and acquired resistance to PD-1/PD-L1 blockade and the emerging role of gut microbiome
AbstractAs a very promising immunotherapy, PD-1/PD-L1 blockade has revolutionized the treatment of a variety of tumor types, resulting in significant clinical efficacy and lasting responses. However, these therapies do not work for a large proportion of patients initially, which is called primary resistance. And more frustrating is that most patients eventually develop acquired resistance after an initial response to PD-1/PD-L1 blockade. The mechanisms that lead to primary and acquired resistance to PD-1/PD-L1 inhibition have remained largely unclear. Recently, the gut microbiome has emerged as a potential regulator for PD...
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Saving time in the radiotherapy procedures for COVID-19 pneumonia treatment. A single-institution experience
ConclusionsLD-RT is not only an encouraging option for COVID-19 pneumonia patients, but a convenient and feasible procedure if performed in a coordinated way by reducing procedure times. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 22, 2021 Category: Cancer & Oncology Source Type: research

Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis
ConclusionsCirc_0091579 accelerated Warburg effect and tumor growth via upregulating H3F3B via adsorbing miR-624 in HCC, providing evidence to support the involvement of circ_0091579 in the progression of HCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Circulating non-coding RNAs as new biomarkers and novel therapeutic targets in colorectal cancer
AbstractColorectal cancer (CRC) is one of the most common malignant tumors, and a large number of patients are diagnosed and die every year. Due to the lack of appropriate diagnosis, prediction and treatment, early diagnosis rate of CRC is low and the prognosis is poor. Studies have found that abnormally expressed non-coding RNAs (ncRNAs) (including microRNAs (miRNAs), circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs),etc.) play an important regulatory role in the occurrence and development of CRC. Some studies have shown that they are stable in the blood and can be detected repeatedly. They are expected to be no...
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

5-year results of accelerated partial breast irradiation (APBI) with SBRT (stereotactic body radiation therapy) and exactrac adaptive gating (Novalis ®) for very early breast cancer patients: was it all worth it?
ConclusionAPBI with SBRT and ExacTrac Adaptive Gating System was feasible. The acute and late toxicities were almost null and cosmesis was excellent. We also found that the margins of 5  mm applied from CTV to PTV were sufficient to compensate for geometric uncertainties. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

PD-1 and PD-L1 gene expressions and their association with Epstein-Barr virus infection in chronic lymphocytic leukemia
ConclusionHigh expression of PD-1 and PD-L1, together with high EBD-DNA load were linked to worse prognosis in CLL. In addition, PD-1 and PD-L1 might represent suitable therapeutic targets for patients suffering from aggressive CLL. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Comparative genomic characterization of melanoma of known and unknown primary
ConclusionsThe differences in somatic mutation patterns and survival outcomes were not statistically significant. These findings may allude to similar carcinogenic processes but should be considered exploratory and interpreted with caution. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

microRNA-377-3p inhibits osteosarcoma progression by targeting CUL1 and regulating Wnt/ β-catenin signaling pathway
ConclusionsCollectively, all the above findings revealed that miR-377-3p exerted anti-OS functions viaCUL1 and EMT and Wnt/β-catenin pathways. These results may contribute to the development of clinical OS treatment. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Targeting GLS1 to cancer therapy through glutamine metabolism
AbstractGlutamine metabolism is one of the hallmarks of cancers which is described as an essential role in serving as a major energy and building blocks supply to cell proliferation in cancer cells. Many malignant tumor cells always display glutamine addiction. The “kidney-type” glutaminase (GLS1) is a metabolism enzyme which plays a significant part in glutaminolysis. Interestingly, GLS1 is often overexpressed in highly proliferative cancer cells to fulfill enhanced glutamine demand. So far, GLS1 has been proved to be a significant target during the carci nogenesis process, and emerging evidence reveals that i...
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

A novel 12-gene signature as independent prognostic model in stage IA and IB lung squamous cell carcinoma patients
ConclusionThe 12-gene prognostic model may serve as a useful complementary clinical risk-stratification tool for stage I and especially stage IA lung squamous cell carcinoma patients to guide clinical decision making. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

COPB2: a transport protein  with multifaceted roles in cancer development and progression
AbstractThe Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the transport of vesicles between the Golgi apparatus and the endoplasmic reticulum. It plays an important role in maintaining the integrity of these cellular organelles, as well as in maintaining cell homeostasis. More importantly, COPB2 plays key roles in embryonic development and tumor progression. COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the curr...
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

HPV16 infection promotes an M2 macrophage phenotype to promote the invasion and metastasis of esophageal squamous cell carcinoma
AbstractObjectivesHigh-risk human papillomavirus (HR-HPV) is an important risk factor for esophageal cancer. Macrophages constitute a crucial immune medium for regulating HPV-related tumors; however, the specific regulatory mechanisms remain unknown. Therefore, the purpose of our current study was to investigate the mechanism by which HPV16E6 regulates macrophages to promote the invasion and metastasis of esophageal cancer.MethodsHPV16E6 infection was detected by polymerase chain reaction. Immunohistochemistry was used to verify the distribution of tumor-associated macrophages (TAMs) and MMP-9 expression in esophageal squa...
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

MiR-495-3p and miR-143-3p co-target CDK1 to inhibit the development of cervical cancer
ConclusionTaken together, miR-143-3p and miR-495-3p co-target CDK1, thereby inhibiting the occurrence and development of cervical cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Stance of MRD in Non-Hodgkin ’s Lymphoma and its upsurge in the novel era of cell-free DNA
AbstractCancer genomics has evolved over the years from understanding the pathogenesis of cancer to screening the future possibilities of cancer occurrence. Understanding the genetic profile of tumors holds a prognostic as well as a predictive value in this era of therapeutic surveillance, molecular remission, and precision medicine. Identifying molecular markers in tumors is the current standard of approach, and requires an efficient combination of an accessible sample type and a profoundly sensitive technique. Liquid biopsy or cell-free DNA has evolved as a novel sample type with promising results in recent years. Althou...
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Dosimetric impact of rectum and bladder anatomy and intrafractional prostate motion on hypofractionated prostate radiation therapy
ConclusionsA better control of bladder filling is recommended to minimize the number of fractions in which the bladder volume is lower than planned. Fiducial mark tracking with a displacement threshold of 5  mm in any direction is recommended to ensure that the prescribed dose criteria are met. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Sexual, bladder and bowel function following different minimally invasive techniques of radical hysterectomy in patients with early-stage cervical cancer
ConclusionPelvic floor dysfunction commonly deteriorates and negatively impacts on quality of life after minimally invasive radical hysterectomy, especially bowel function after TMMR. Pelvic floor symptoms should routinely be addressed pre- and postoperatively. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Physio-pathological effects of m6A modification and its potential contribution to melanoma
AbstractMethylation of N6-adenosine (m6A) is the most prevalent internal RNA modification and is especially common among the messenger RNAs. These m6A modifications regulate splicing, translocation, stability and translation of RNA through dynamic and reversible interactions with m6A-binding proteins, namely the writers, erasers and readers. RNA methyltransferases catalyze the m6A modifications, while demethylases reverse this methylation. Deregulation of the m6A modification process has been implicated in human carcinogenesis, including melanoma —which carries one of the highest mutant rates. In this review, we prov...
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel
ConclusionsChemotherapy with FOLFIRNOX or gemcitabine/nab-paclitaxel induces variable changes in circulating T-cell populations that may provide prognostic information in PDAC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Mechanisms of primary and acquired resistance to PD-1/PD-L1 blockade and the emerging role of gut microbiome
AbstractAs a very promising immunotherapy, PD-1/PD-L1 blockade has revolutionized the treatment of a variety of tumor types, resulting in significant clinical efficacy and lasting responses. However, these therapies do not work for a large proportion of patients initially, which is called primary resistance. And more frustrating is that most patients eventually develop acquired resistance after an initial response to PD-1/PD-L1 blockade. The mechanisms that lead to primary and acquired resistance to PD-1/PD-L1 inhibition have remained largely unclear. Recently, the gut microbiome has emerged as a potential regulator for PD...
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Saving time in the radiotherapy procedures for COVID-19 pneumonia treatment. A single-institution experience
ConclusionsLD-RT is not only an encouraging option for COVID-19 pneumonia patients, but a convenient and feasible procedure if performed in a coordinated way by reducing procedure times. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - September 21, 2021 Category: Cancer & Oncology Source Type: research

Effects of PIM3 in prognosis of colon cancer
ConclusionsPIM3 is an independent prognostic factor of colon cancer and may be a target for the diagnosis and treatment of colon cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

Surface-guided radiation therapy for breast cancer: more precise positioning
ConclusionsSGRT improves patient positioning accuracy compared to skin markers. Optimal breast SGRT can accurately verify the localisation of the tumour bed, ensuring matching with  ≥ 3 surgical clips. SGRT can eliminate unwanted radiation from IGRT verification systems. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

Scapular winging in surgical treatment of breast cancer, prospective study to optimize the follow-up protocol
ConclusionsThe axillary lymph node dissection technique is a risk factor for developing a winged scapula. No evidence was found for any other significant risk factor. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

Malignant pleural mesothelioma: clinical experience and prognostic value of derived neutrophil-to-lymphocyte ratio and PD-L1 expression
ConclusionThe survival data obtained in our sample are consistent with those previously reported. Pretreatment levels of dNLR greater than 3 and positive PD-L1 expression could be significant prognostic factors for poor survival in patients with MPM. Further and prospective studies are needed to explore this relationship and to derive definitive conclusions. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

Electronic health records and patient registries in medical oncology departments in Spain
ConclusionOur study indicates that EHRs are almost universally implemented in the hospitals surveyed and are considered to have a positive impact on work organization and clinical practice. However, EHRs currently have several drawbacks that limit their use for investigational purposes.Clinical trial registrationNot applicable (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

Characterization of a xenograft model for anti-CD19 CAR T cell studies
AbstractPurposeChimeric antigen receptor (CAR) T cell development for B cell malignancies treatment has triggered a paradigm shift in oncology. The development of anti-CD19 CAR T cells relies primarily on a panel of cell line-derived xenograft models, including Raji cells; however, the behavior of this model is under debate. We attempted to characterize this lymphoma model and propose outcome measures for CAR T cell studiesMethodsRaji cell line was inoculated into NOG mice via intra-venous (IV), intra-peritoneal (IP), and subcutaneous (SC) routes with different inoculum sizes, and consequent clinical and histopathological ...
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

Outcomes after stereotactic radiosurgery of brain metastases in patients with malignant melanoma and validation of the melanoma molGPA
ConclusionThe present survival outcomes support the use of the disease-specific melanoma molGPA as reliable prognostic score. Favorable outcomes for SRS compared to other studies were observed. In the treatment of brain metastases of malignant melanoma patients, a multidisciplinary approach consisting of surgery, SRS, chemotherapy, and immunotherapy should be considered. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

Aberrantly low STAT3 and STAT5 responses are associated with poor outcome and an inflammatory gene expression signature in pediatric acute myeloid leukemia
AbstractThe relapse rate for children with acute myeloid leukemia is nearly 40% despite aggressive chemotherapy and often stem cell transplant. We sought to understand how environment-induced signaling responses are associated with clinical response to treatment. We previously reported that patients whose AML cells showed low G-CSF-induced STAT3 activation had inferior event-free survival compared to patients with stronger STAT3 responses. Here, we expanded the paradigm to evaluate multiple signaling parameters induced by a more physiological stimulus. We measured STAT3, STAT5 and ERK1/2 responses to G-CSF and to stromal c...
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research

A multi-institutional analysis of fractionated versus single-fraction stereotactic body radiotherapy (SBRT) in the treatment of primary lung tumors: a comparison between two antipodal fractionations
ConclusionSF and TF seems to be equally safe and effective in the treatment of primary inoperable lung tumors especially for smaller lesion. The SF may be preferentially offered to reduce patient access to hospital with no negative impact on tumor control and survival. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - August 29, 2021 Category: Cancer & Oncology Source Type: research