Efficacy of nintedanib and docetaxel in patients with advanced lung adenocarcinoma treated with first-line chemotherapy and second-line immunotherapy in the nintedanib NPU program
ConclusionOur experience suggests an encouraging efficacy of nintedanib/docetaxel in patients with adenocarcinoma NSCLC pretreated with platinum ‐based doublet chemotherapy and immunotherapy, reinforcing the importance of an optimal therapeutic sequence for managing advanced lung adenocarcinoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 15, 2019 Category: Cancer & Oncology Source Type: research

Seven genes for the prognostic prediction in patients with glioma
ConclusionWe identified a novel seven-gene signature in patients with glioma, which could be used as a predictor for the prognosis of patients with glioma in the future. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 14, 2019 Category: Cancer & Oncology Source Type: research

Elevated expression of GNAS promotes breast cancer cell proliferation and migration via the PI3K/AKT/Snail1/E-cadherin axis
ConclusionThe data suggested that GNAS promoted breast cancer cell proliferation and migration (EMT) through the PI3K/AKT/Snail1/E-cadherin signaling pathway. These findings also indicate that GNAS can serve as a potential prognostic indicator and novel therapeutic target in breast cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 14, 2019 Category: Cancer & Oncology Source Type: research

Recommendations for follow-up of colorectal cancer survivors
AbstractColorectal cancer (CRC) is one of the tumours with the highest incidence and mortality in the Spanish population. Nevertheless, the advances in prevention and treatment have contributed to an increased number of patients who survive for prolonged periods of time. In addition, despite recurrences, improved survival following metastasis resection is likewise on the rise. This underscores the importance of carrying out follow-up programmes even in low-risk patients for the early detection of recurrence. The main objective of this article is to provide a set of recommendations for optimising the follow-up of CRC surviv...
Source: Clinical and Translational Oncology - February 14, 2019 Category: Cancer & Oncology Source Type: research

Laparoscopic cytoreductive surgery and HIPEC is effective regarding peritoneum tissue paclitaxel distribution
ConclusionsA total laparoscopic approach for ctoreductive surgery and closed HIPEC with CO2 recirculation may be safe and feasible. In our experimental model there was no significant difference in tissue drug distribution respect the conventional techniques and there was a less toxicity because the serum drug concentration was significantly lower with laparoscopic approach respect the other groups. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 14, 2019 Category: Cancer & Oncology Source Type: research

Expression of PDK1 in malignant pheochromocytoma as a new promising potential therapeutic target
ConclusionWe have demonstrated for the first time that PDK1 is overexpressed in human malignant PCC and plays an important role in the malignant biological behaviors of PC12 cell. Specifically, we have revealed that knockdown of PDK1 could attenuate activation of the Akt signaling. These data suggest that PDK1 could be a new promising potential therapeutic target in human cancer treatment for malignant PCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research

A candidate for lung cancer treatment: arsenic trioxide
AbstractArsenic trioxide (ATO), a highly effective drug in treating acute promyelocytic leukemia with low toxicity, demonstrates a significant effect on lung cancer. The anti-cancer mechanisms of ATO include inhibition of cancer stem-like cells, induction of apoptosis, anti-angiogenesis, sensitization of chemotherapy and radiotherapy, anti-cancer effects of hypoxia, and immunoregulation properties. In addition, some studies have reported that different lung cancers respond differently to ATO. It was concluded on numerous studies that the rational combination of administration and encapsulation of ATO have promising potenti...
Source: Clinical and Translational Oncology - February 12, 2019 Category: Cancer & Oncology Source Type: research

Classical Protein Kinase C: a novel kinase target in breast cancer
AbstractClassical protein kinase C (cPKC) enzymes are ser/thr protein kinases that have been an important factor in regulating a variety of cellular functions required for both in terms of health and disease. Therefore, precise control of cPKC-mediated signal is necessary for cellular homeostasis; however, their dysregulation leads to the development of several pathophysiological conditions including cancer. In cellular microenvironment, cPKC-mediated signaling is accompanied by multiple molecular mechanisms including phosphorylation, second messenger binding, and scaffold proteins. Functional cPKC interacts with a number ...
Source: Clinical and Translational Oncology - February 9, 2019 Category: Cancer & Oncology Source Type: research

Effectiveness, safety and cost of abiraterone acetate in patients with metastatic castration-resistant prostate cancer: a real-world data analysis
ConclusionsCT-na ïve patients treated with AA obtained a better clinical benefit in terms of effectiveness, safety and cost-effectiveness ratio than post-CT patients. The effectiveness outcomes were poorer than those reported previously in the clinical trial setting. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 9, 2019 Category: Cancer & Oncology Source Type: research

Efficacy of nivolumab as checkpoint inhibitor drug on survival rate of patients with relapsed/refractory classical Hodgkin lymphoma: a meta-analysis of prospective clinical study
ConclusionsThe results of the study indicate that nivolumab as a PD1 pathway inhibitor can be effective in treating relapsed and refractory cHL patients compared to other therapies, and lead to more effective treatment over the long term. Furthermore, the adverse effects of nivolumab are controllable and have a good safety profile. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 9, 2019 Category: Cancer & Oncology Source Type: research

Results of a nationwide survey on multidisciplinary teams on thyroid cancer in Spain
ConclusionsThese results suggest that there are some hopeful signs that international recommendations of having multidisciplinary approach to patients with thyroid cancer are being followed in Spain. This gives us the opportunity to proceed with further studies to analyze the real impact of this high standard of care on patient outcomes. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 5, 2019 Category: Cancer & Oncology Source Type: research

Differential expression of S1P receptor subtypes in human bladder transitional cell carcinoma
ConclusionsOverexpression of S1PR1, S1PR2 and S1PR3 in bladder tumor biopsies which were corroborated with the pathological grades and stages may suggest that S1PR profile in tumor biopsies is a promising marker in the diagnosis of bladder carcinoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 2, 2019 Category: Cancer & Oncology Source Type: research

Incidence and survival of central nervous system tumors in childhood and adolescence in Girona (Spain) 1990 –2013: national and international comparisons
ConclusionsThe incidence in our area was among the highest in Spain and worldwide, while survival was comparable to others reported. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 2, 2019 Category: Cancer & Oncology Source Type: research

Quality of life in elderly breast cancer patients with localized disease receiving endocrine treatment: a prospective study
AbstractPurposeIn this paper we study the quality of life (QoL) of elderly breast cancer patients receiving endocrine treatment (ET). More QoL data on elderly patients treated with ET are needed. Our aims are to study QoL in early-stage breast cancer patients throughout the treatment period and compare the QoL of ET groups.Methods148 patients  >  65 years who began ET with either tamoxifen or aromatase inhibitor (AI) completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) questionnaires three times over 3 years of ET. Linear mixed...
Source: Clinical and Translational Oncology - February 2, 2019 Category: Cancer & Oncology Source Type: research

Letrozole improves the sensitivity of breast cancer cells overexpressing aromatase to cisplatin via down-regulation of FEN1
ConclusionsOur findings clearly demonstrate that letrozole improves cisplatin sensitivity of breast cancer cells overexpressing aromatase via down-regulation of FEN1 and suggest that a combined use of letrozole and cisplatin may be a potential treatment protocol for relieving cisplatin resistance in human breast cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 2, 2019 Category: Cancer & Oncology Source Type: research

Incidence of sleep problems and their mediating role on depression and anxious preoccupation in patients with resected, non-advanced cancer: data from NEOcoping study
ConclusionOur findings point toward the importance of developing interventions that decrease depression and sleep problems in cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - February 2, 2019 Category: Cancer & Oncology Source Type: research

Distinct prognostic values of Annexin family members expression in acute myeloid leukemia
AbstractBackgroundAnnexin family consist of 12 members, many of them are frequently dysregulated in human cancers. However, the diagnosis and prognosis of Annexin family expression in acute myeloid leukemia (AML) remain elusive. The aim of the present study was to assess the prognostic value of Annexin expressions in adult and pediatric AML.MethodsGenomicScape tool was used to assess the prognostic value of the expressions of Annexin family members in a cohort of 162 adult AML patients. Quantitative reverse transcript real-time PCR (QRT-PCR) was performed to detect the ANXA2 expression level in the bone marrow-derived mono...
Source: Clinical and Translational Oncology - January 29, 2019 Category: Cancer & Oncology Source Type: research

Hypoxia-induced LncRNA PCGEM1 promotes invasion and metastasis of gastric cancer through regulating SNAI1
ConclusionOur findings indicated that PCGEM1 is a hypoxia-responsive lncRNA, and contributes to the invasion and metastasis of GC. The potential mechanism is attributed to the regulation of EMT by PCGEM1 and its influence on the expression of SNAI1. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 28, 2019 Category: Cancer & Oncology Source Type: research

Intraoperative blood loss does not independently affect the survival outcome of gastric cancer patients who underwent curative resection
AbstractBackgroundWhether intraoperative blood loss (IBL) was independently associated with poor prognosis of gastric cancer (GC) patients remains controversial. In the present study, we evaluated the impact of IBL on the disease-free survival (DFS) of GC patients.MethodsA total of 1669 patients who underwent curative gastrectomy for GC were reviewed retrospectively. All patients were classified as IBL  
Source: Clinical and Translational Oncology - January 28, 2019 Category: Cancer & Oncology Source Type: research

Blockage of autophagic flux is associated with lymphocytosis and higher percentage of tumoral cells in chronic lymphocytic leukemia of B cells
ConclusionAlterations in autophagic flux could play an important role in the physiopathology of chronic lymphocytic leukemia. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 24, 2019 Category: Cancer & Oncology Source Type: research

Cardiovascular disease and survival in non-small cell lung cancer: a multicenter prospective assessment
AbstractPurposeChronic inflammation contributes to cancer development via multiple mechanisms. We hypothesized that cardiovascular diseases (CVD) are also an independent risk factor for survival in non-small cell lung cancer (NSCLC).Materials and methodsProspective multicenter data from 345 consecutive NSCLC patients treated from January 2013 to January 2017 were assessed. Median follow-up for all patients was 13  months (range 3–60 months). There were 109 patients with baseline heart disease (HD 32%), 149 with arterial hypertension (43%), 85 with diabetes mellitus (25%), 129 with hyperlipidemia (37%) and 4...
Source: Clinical and Translational Oncology - January 24, 2019 Category: Cancer & Oncology Source Type: research

Critical evaluation of platelet size as a prognostic biomarker in colorectal cancer across multiple treatment settings: a retrospective cohort study
ConclusionSmall platelets are not predicting CRC outcomes, and thus are hardly useful for influencing clinical decision making. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 22, 2019 Category: Cancer & Oncology Source Type: research

Nodal FDG-PET/CT uptake influences outcome and relapse location among esophageal cancer patients submitted to chemotherapy or radiochemotherapy
AbstractPurposeOur aim was investigate whether lymph node uptake is associated with survival and regional relapses, and relapse patterns with respect to the radiotherapy fields in esophageal cancer (EC).Materials and methodsThe FDG-PET/CT image datasets of 56 patients were analyzed. All patients underwent definitive or neoadjuvant radio/chemotherapy (RCT). All patients suffering from persistent or recurrent local/regional-only disease after RCT were considered for salvage resection. Patients with adenocarcinoma without metastatic disease were considered for planned resection (usually within 3  months of treatment).Res...
Source: Clinical and Translational Oncology - January 19, 2019 Category: Cancer & Oncology Source Type: research

Neoadjuvant isolated limb perfusion in newly diagnosed untreated patients with locally advanced soft tissue sarcomas of the extremities: the Gustave Roussy experience
ConclusionUpfront ILP is an efficient and well-tolerated limb-sparing procedure in borderline or unresectable LA STS without hampering OS. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 17, 2019 Category: Cancer & Oncology Source Type: research

The RANK –RANKL axis: an opportunity for drug repurposing in cancer?
AbstractDrug repurposing offers advantages over traditional drug development in terms of cost, speed and improved patient outcomes. The receptor activator of nuclear factor kappa B (RANK) ligand (RANKL) inhibitor denosumab is approved for the prevention of skeletal-related events in patients with advanced malignancies involving bone, including solid tumours and multiple myeloma. Following improved understanding of the role of RANK/RANKL in cancer biology, denosumab has already been repurposed as a treatment for giant cell tumour of bone. Here, we review the role of RANK/RANKL in tumourigenesis, including effects on tumour ...
Source: Clinical and Translational Oncology - January 17, 2019 Category: Cancer & Oncology Source Type: research

The incidence proportion of erectile dysfunction in patients treated with cryotherapy for prostate cancer: a meta-analysis
ConclusionED is one of the major complications after cryotherapy for PCa. Furthermore, subgroup analysis revealed a higher incidence rate in PCa undergoing radiotherapy. Significantly, with the development of cryotherapy technology, the incidence of ED after cryotherapy for prostate cancer is decreasing. While we still need further researches to advance knowledge in this field. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 16, 2019 Category: Cancer & Oncology Source Type: research

Time for radioimmunotherapy: an overview to bring improvements in clinical practice
AbstractHarnessing the patient ’s own immune system against an established cancer has proven to be a successful strategy. Within the last years, several antibodies blocking critical “checkpoints” that control the activation of T cells, the immune cells able to kill cancer cells, have been approved for the use in patients wi th different tumours. Unfortunately, these cases remain a minority. Over the last years, radiotherapy has been reported as a means to turn a patient’s own tumour into an in situ vaccine and generate anti-tumour T cells in patients who lack sufficient anti-tumour immunity. Indeed,...
Source: Clinical and Translational Oncology - January 14, 2019 Category: Cancer & Oncology Source Type: research

Identification a novel set of 6 differential expressed genes in prostate cancer that can potentially predict biochemical recurrence after curative surgery
In this study, we intended to identify a novel set of differentially expressed gene (DEG) signature that can predict BCR after RP.Materials/patients358 patients after RP with follow-up data were extracted from The Cancer Genome Atlas (TCGA), among which 61 patients had undergone BCR. Key DEGs were confirmed by the intersection of GSE35988 and TCGA_PCa dataset, and their gene expression data were also extracted from TCGA_PCa dataset. Kaplan –Meier plot and Cox proportion hazard regression model were applied to assess the relationship between risk score and survival outcome (BCR).Results310 DEGs were confirmed in two p...
Source: Clinical and Translational Oncology - January 12, 2019 Category: Cancer & Oncology Source Type: research

Clinical significance of serum EGFR gene mutation and serum tumor markers in predicting tyrosine kinase inhibitor efficacy in lung adenocarcinoma
ConclusionCombined detection of EGFR gene mutations as well as CA19-9 and CEA levels in peripheral blood can predict the efficacy of EGFR-TKI in the treatment of patients with lung adenocarcinoma. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 12, 2019 Category: Cancer & Oncology Source Type: research

The role of immunotherapy in small cell lung cancer
AbstractDespite decades of research, prognosis for SCLC patients remains poor, and treatment options limited. SCLC is an immunogenic tumor with high somatic mutation rates due to tobacco exposure resulting in potential neo-antigens, the presence of suppressed immune responses, and occurrence of paraneoplastic disorders. The use of T cell immune-checkpoint inhibitors (anti-PD1: nivolumab, pembrolizumab; anti-PD-L1: atezolizumab, durvalumab; anti-CTLA-4: ipilimumab, tremelimumab) have shown promising antitumor activity with the potential to prolong survival in SCLC patients. In fact, atezolizumab when combined with chemother...
Source: Clinical and Translational Oncology - January 12, 2019 Category: Cancer & Oncology Source Type: research

Positive nonsentinel lymph nodes are associated with poor survival in breast cancer: results from a retrospective study
This study was designed to investigate the prognostic value of NSLN status in SLN-positive breast cancer.MethodsRetrospective 873 consecutive primary breast cancer patients from a single institution who were SLN-positive and underwent axillary lymph-node dissection (ALND) were included. Patients with incomplete clinical information or loss of follow-up were excluded. Survival analysis in patients with the same number of positive LNs and patients belonging to the same American Joint Committee on Cancer (AJCC) node (N) classification was performed to establish a proposal for incorporating the NSLN status into the breast canc...
Source: Clinical and Translational Oncology - January 10, 2019 Category: Cancer & Oncology Source Type: research

A comparative assessment of the effects of integrin inhibitor cilengitide on primary culture of head and neck squamous cell carcinoma (HNSCC) and HNSCC cell lines
ConclusionsRGD-containing small-molecule synthetic peptides might be considered in tumor chemotherapy in the near future. The different reactions of primary culture cells and cell lines demonstrated that individualized chemotherapy plans may be a feasible option. However, research on the role of cilengitide in HNSCC therapy is still in its early stages, and further investigations are required. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 10, 2019 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines on cardiovascular toxicity (2018)
AbstractOne of the most common side effects of cancer treatment is cardiovascular disease, which substantially impacts long-term survivor ’s prognosis. Cardiotoxicity can be related with either a direct side effect of antitumor therapies or an accelerated development of cardiovascular diseases in the presence of preexisting risk factors. Even though it is widely recognized as an alarming clinical problem, scientific evidence is scar ce in the management of these complications in cancer patients. Consequently, current recommendations are based on expert consensus. This Guideline represents SEOM’s ongoing commitm...
Source: Clinical and Translational Oncology - January 9, 2019 Category: Cancer & Oncology Source Type: research

SEOM guidelines 2018
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 9, 2019 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines in advanced and recurrent breast cancer (2018)
AbstractAlthough the metastasic breast cancer is still an incurable disease, recent advances have increased significantly the time to progression and the overall survival. However, too much information has been produced in the last 2 years, so a well-based guideline is a valuable document in treatment decision making. The SEOM guidelines are intended to make evidence-based recommendations on how to manage patients with advanced and recurrent breast cancer to achieve the best patient outcomes based on a rational use of the currently available therapies. To assign a level of certainty and a grade of recommendation the United...
Source: Clinical and Translational Oncology - January 8, 2019 Category: Cancer & Oncology Source Type: research

Cost –utility analysis of germline BRCA1/2 testing in women with high-grade epithelial ovarian cancer in Spain
ConclusionProviding this screening test to HGEOC patients and their relatives is cost-effective and it allows one to identify a target population with high risk of cancer to provide effective prevention strategies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 8, 2019 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines on nutrition in cancer patients (2018)
AbstractNutritional deficiency is a common medical problem that affects 15 –40% of cancer patients. It negatively impacts their quality of life and can compromise treatment completion. Oncological therapies, such as surgery, radiation therapy, and drug therapies are improving survival rates. However, all these treatments can play a role in the development of malnutrition and/or metabolic alterations in cancer patients, induced by the tumor or by its treatment. Nutritional assessment of cancer patients is necessary at the time of diagnosis and throughout treatment, so as to detect nutritional deficiencies. The Patient...
Source: Clinical and Translational Oncology - January 8, 2019 Category: Cancer & Oncology Source Type: research

Survival after biochemical failure in prostate cancer treated with radiotherapy: Spanish Registry of Prostate Cancer (RECAP) database outcomes
ConclusionsIn PCa treated with radiotherapy, median survival after BF is relatively long. In this sample, no differences in survival rates at 8-years have been found, regardless of the time of radiotherapy administered. AD was the most common treatment after BF. Metastases and high Gleason score are adverse variables. To our knowledge, this is the first study to compare outcomes after BF among patients treated with primary RT vs. those treated with postoperative RT and to evaluate recurrence patterns, treatments administered, and causes of death. The results allow avoiding overtreatment, improving quality of life, without ...
Source: Clinical and Translational Oncology - January 7, 2019 Category: Cancer & Oncology Source Type: research

Cause-specific mortality after a breast cancer diagnosis: a cohort study of 10,195 women in Girona and Tarragona
ConclusionsWomen who did not die from BC at 10 or 20  years after the BC diagnosis had 20% higher risk of dying from other causes than women without BC. This excess risk must be clinically considered during 20 years after the BC diagnosis. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

Neurotrophic tropomyosin receptor kinase (NTRK) and nerve growth factor (NGF) are not expressed in Caucasian patients with biliary tract cancers: pooled data from three independent cohorts
ConclusionsIn a large cohort of Caucasian patients with BTC, NTRK and NGF-beta were not detectable, underscoring potential differences between Caucasian and Asian patient populations. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

SEOM clinical  guidelines to primary prevention of cancer (2018)
We present the scientific evidence and recommendations for primary prevention of the major modifiable risk factors: smoking, alcohol, diet, obesity, physical activity, occupational and environmental factors, ultraviolet radiation, infections, and socioeconomic factors. Primary prevention is a simple, effective means to lower the incidence of cancer. Preventive measures must be circulated in the fight against cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

Efficacy of rechallenge with BRAF inhibition therapy in patients with advanced BRAFV600 mutant melanoma
ConclusionAlthough no comparative studies have been conducted, rechallenging with BRAF inhibition therapy seems a plausible treatment option. Randomized trials are needed to confirm these results. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

Common misconceptions in the prognostic evaluation of clinically stable patients with febrile neutropenia and solid tumors
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

Thanks to reviewers 2018
(Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

CEP55 promotes epithelial –mesenchymal transition in renal cell carcinoma through PI3K/AKT/mTOR pathway
ConclusionOur study showed that CEP55 could promote EMT through PI3K/AKT/mTOR pathway and might be an effective prognostic marker in RCC. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 3, 2019 Category: Cancer & Oncology Source Type: research

Integrative diagnosis of cancer by combining CTCs and associated peripheral blood cells in liquid biopsy
AbstractCirculating tumor cells (CTCs), as cells shed from solid tumor into the vasculature, play a significant role in tumor metastasis. In the peripheral blood, immune cells and stromal cells can interact with CTCs and influence their biological behaviors of survival, proliferation, dissemination, and immune evasion. These peripheral blood cells can evolve synergistically with CTCs to constitute the liquid microenvironment which is essential for tumor progression. Here, we review the mechanisms of peripheral blood cells interacting with CTCs and uncover their effects on both CTCs and tumor metastasis. Then, we introduce ...
Source: Clinical and Translational Oncology - December 19, 2018 Category: Cancer & Oncology Source Type: research

Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism
ConclusionsThis study demonstrated that CIT-K is associated with aggressive breast cancer behavior and targeting CIT-K may be a novel strategy for the future control of breast cancer. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 18, 2018 Category: Cancer & Oncology Source Type: research

Still a place for conventional histopathological analysis in the era of molecular medicine: predicting prognosis of resectable ductal pancreatic adenocarcinoma
DiscussionOur series show that patients with symptomatic disease at the time of diagnosis and females showed a shorter progression-free and overall survival. We herein propose a regression model to predict outcome. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 18, 2018 Category: Cancer & Oncology Source Type: research

Benefit of ablative versus palliative-only radiotherapy in combination with nivolumab in patients affected by metastatic kidney and lung cancer
ConclusionsOur data showed significant advantage for oligoprogressive patients treated with RT during nivolumab therapy. No safety alert emerged. These results underline the potential synergistic effects of RT and Immune therapy combination. Our analysis prompts further prospective studies exploring the benefit of integrated treatment strategies. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 18, 2018 Category: Cancer & Oncology Source Type: research

SEOM clinical guidelines for diagnosis and treatment of metastatic colorectal cancer (2018)
AbstractColorectal cancer (CRC) is the second cause of cancer death in Spain, the objective of this guide published by the Spanish Society of Medical Oncology is to develop a consensus for the diagnosis and management of metastatic disease. The optimal treatment strategy for patients with metastatic CRC should be discussed in a multidisciplinary expert team to select the most appropriate treatment, and integrate systemic treatment and other options such as surgery and ablative techniques depending on the characteristics of the tumour, the patient and the location of the disease and metastases. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - December 18, 2018 Category: Cancer & Oncology Source Type: research