High expression of Testin predicted worse prognosis in pancreatic adenocarcinoma associated with immune infiltration
ConclusionsThe present study suggested thatTES could function as a supporter and prognostic marker of PAAD, and it might work via inducing immune infiltration. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 30, 2024 Category: Cytology Source Type: research
Oncheong-eum alleviated hepatic lipid accumulation and intestinal barrier disruption in nonalcoholic steatohepatitis in vivo model
ConclusionOCE reduces body weight, increases the weight of organs when fed a high-fat diet, and improves the lipid composition of the serum and liver. Therefore, OCE has shown great application potential as a material for obesity-related medicines and health-functional food. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 29, 2024 Category: Cytology Source Type: research
Unlocking the potential: Baicalin's apoptosis-reducing power and activation of NRF2/P62 for alleviating diabetic cardiomyopathy in rats
ConclusionBaicalin may reduce the effects of DCM by activating NRF2 through KEAP1 suppression and regulating autophagy activation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 27, 2024 Category: Cytology Source Type: research
Decreased LTBP2 expression inhibits proliferation and migration of glioma
ConclusionLTBP2 could serve as a potential therapeutic target for the treatment of gliomas. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 26, 2024 Category: Cytology Source Type: research
Circ_0000277 promotes the malignant progression of oesophageal squamous cell carcinoma through miR-1294-dependent regulation of DVL3
ConclusionCirc_0000277 promoted ESCC malignant progression through the miR-1294/DVL3 pathway.HighlightsCirc_0000277 expression was upregulated in ESCC tissues and cells.Circ_0000277 contributed to ESCC cell proliferation, migration and invasion.Circ_0000277 induced DVL3 expression through sponging miR-1294. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 22, 2024 Category: Cytology Source Type: research
Toxicological implications of storage conditions on yeast vacuole properties and activities
ConclusionThese findings underscore the importance of appropriate storage methods for vacuoles, particularly in the context of their potential as valuable materials that efficiently harness their antibacterial and anticancer properties, while also shedding light on their toxicological implications in the field of cellular toxicology. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 22, 2024 Category: Cytology Source Type: research
Cobrotoxin, a single peptide from snake venom, ameliorates atopic dermatitis via suppression of MK2 modulated by IgE and IL-33
ConclusionThe study suggests that CoTX has anti-allergic and anti-inflammatory effects in allergic AD. By targeting IL-33 and IgE pathways, CoTX demonstrated potential in regulating mast cell activation and inflammatory cytokine production. The observed improvements in the AD mouse model indicate CoTX as a promising candidate for further research towards developing effective and safe treatments for AD. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 21, 2024 Category: Cytology Source Type: research
GPD1 relieves the proliferation, migration and invasion abilities of oral cancer cells by inhibiting mitochondrial function
ConclusionFor the first time, this work manifested that GPD1 inhibited the proliferation, migration and invasion of oral cancer cells by inhibiting mitochondrial function through triggering the PI3K/AKT/GSK-3 β pathway. This discovery hinted that GPD1 may be a serviceable biomarker for the treatment of oral cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 19, 2024 Category: Cytology Source Type: research
Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection
ConclusionsMitochondrial bioenergetics- and neuroinflammation-related molecular targets of HDACi may be the key to the use of HDACi therapy for neurodegenerative diseases.Purpose of reviewWe aimed to discover molecular targets of HDACi in progressive neurodegeneration and to use these targets in potential therapeutics to induce neuroprotection.Recent findingsHDACi reverse cellular pathology in a mechanism involving mitochondrial bioenergetics and neuroinflammation, and the result is alleviation of pathologic phenotypes of neurodegenerative diseases. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 17, 2024 Category: Cytology Source Type: research
New insight of exercise on dementia; combinatory effects of physical and cognitive exercise
ConclusionIn this review, we discuss the effects of conventional mode of physical exercise, cognitive (neuromuscular) exercise, and combined exercise in the prevention of dementia, and highlight the prospects for new exercise programs using digital technology that are being recently developed to reduce cognitive decline. Exercise should be importantly considered as a non-pharmacological therapeutic strategy for cognitive decline and dementia. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 13, 2024 Category: Cytology Source Type: research
MicroRNA-29b-3p reduces cisplatin resistance in non-small cell lung cancer by targeting myeloid cell leukemia-1
ConclusionmiR-29b-3p targeted MCL-1, thus promoting apoptosis and enhancing A549/DDP cell sensitivity to cisplatin. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 12, 2024 Category: Cytology Source Type: research
Licochalcone B, a natural anti-inflammatory agent, inhibits the inflammatory response and oxidative stress of periodontal ligament cells in periodontitis
ConclusionThis study for the first time demonstrated that LicB inhibited the inflammatory response and oxidative stress of PDLCs in periodontitis, suggesting that LicB may be a useful drug for periodontitis treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 7, 2024 Category: Cytology Source Type: research
Tolylfluanid induces developmental toxicity via liver dysfunction in zebrafish embryos
ConclusionTolylfluanid disrupts organogenesis, particularly in motor neurons and the liver, during early development in zebrafish. Additionally, the results provide reference points for the concentration conditions that can be used in aquatic ecosystems. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 2, 2024 Category: Cytology Source Type: research
PCSK9 regulates myocardial ischemia –reperfusion injury through parkin/pink1-mediated autophagy pathway
ConclusionsOur results demonstrated that increased PCSK9 via the parkin/pink1 signaling pathway contributes to I/R and H/R by exaggerating excessive autophagy during reperfusion/reoxygenation. In addition, the PCSK9 inhibitor blocked the development of inflammation and improved Infarct size, myocardial function, and myocardial fibrosis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 21, 2024 Category: Cytology Source Type: research
A novel immune-related LncRNA prognostic signature for cutaneous melanoma
ConclusionThe prognostic model identified in this study is a reliable biomarker for SKCM. The Nomogram survival prediction model based on it is a reliable way to predict the median survival time of patients, which may lay the foundation for future treatment of this disease. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 21, 2024 Category: Cytology Source Type: research
