Nonylphenol induces mortality and reduces hatching rate through increase of oxidative stress and dysfunction of antioxidant defense system in marine medaka embryo
ConclusionOur study provides evidence of cellular stress induction/toxicity caused by 4-NP and endocrine disrupting potential in marine medaka embryos. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

The effect of calcium gluconate with natural extracts on skin toxicity of hydrofluoric acid
ConclusionOur study demonstrated that CG in combination with natural extracts show superior wound healing in treating HF burn compared to CG monotherapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Physiological effects of various light spectra on oxidative stress by starvation in olive flounder, Paralichthys olivaceus
ConclusionThese results suggest that green and blue wavelengths can inhibit oxidative stress and apoptosis in starved olive flounder and that green light is particularly efficient for this. Furthermore, the irradiation of green wavelength can play a role in protecting against starvation stress. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Cellular toxicity of zinc can be attenuated by sodium hydrogen sulfide in neuronal SH-SY5Y cell
ConclusionThese results demonstrate that NaHS has the capacity to chelate extracellular and intracellular Zn2+, and could therefore be used in the protection against Zn2+ neurotoxicity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Trends in gene expression changes during adipogenesis in human adipose derived mesenchymal stem cells under dichlorodiphenyldichloroethylene exposure
ConclusionOur findings suggest that DDE exposure changes the differentiation of adipocytes, enhances the lipid metabolism and so may play a role in the development of obesity and metabolic diseases by affecting the insulin signalling pathway. The influence of DDE seems to be similar to the effect of insulin itself. However, further studies to elucidate the mechanism of action of DDE are necessary. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

PGA 2 -induced expression of HO-1 is mediated by transcriptional upregulation of Nrf2
ConclusionThese findings suggest that PGA2 inducesHO-1 transcription via an increase in Nrf2 protein, the transcription of which is initiated by an accumulation of ROS that is independent of the p38MAPK activation pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Complete genome sequence of Methylobacterium sp. 17Sr1-43, a radiation-resistant bacterium
ConclusionThe new strains ofMethylobacterium sp. 17Sr1-43 showed both gamma and UV-C irradiation resistance, and their complete genome sequence annotation features correspondingly showed the presence of the genes involved in the radiation-resistance. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Profiling of miRNA expression in mice kidney with diabetic nephropathy
ConclusionOur findings may provide that changes in miRNA expression in mice with diabetic nephropathy influences disease progression and might provide insights into the molecular mechanisms underlying DN. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Differential use-dependent inactivation of Na v 1.8 in the subpopulation of cultured dorsal root ganglion
ConclusionOur data suggest that the time-dependent change of the use-dependent inactivation of the Nav1.8 channel in DRG neurons culturedin vitro would contribute to the excitability of a subpopulation of DRG neurons and could play an important role in the development of inflammatory and neuropathic pain. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

MAC inhibits c-Myc and induces autophagy by downregulation of CIP2A in leukemia cells
ConclusionThese findings significantly contributed to the understanding of the mechanism that accounts for the anticancer activity of MAC, and it may be novel anti-cancer therapeutic agents for leukemia cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Bioengineered aptamer-nanoconjugates for cancer theragnosis
AbstractEarly detection and treatment of cancer is of global interest as cancer is one of the leading causes of death worldwide. As the survival rate of cancer patients is closely related to its detection at an early stage, there is an urgent need to develop detection techniques that are fast, reliable, and easily available. Aptamers are single stranded DNA- and RNA- based oligonucleotides that can bind to their targets with high affinity and specificity. Their small size, excellent chemical stability, and low immunogenicity enable them to become alternatives to antibodies in cancer theragnostic approaches with cancer imag...
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

The environmental effects of microplastics on aquatic ecosystems
In this study, we aimed to present solutions to the problem of MPs through a review of the current state of research on the definition of MPs, usage, leakage, toxicity, and domestic and overseas circulation of plastics.Recent findingsLong-term exposure to MPs results in ecotoxicity. MPs not only deliver chemical substances within organisms, but also act as mediators for chemicals or other contaminants in aquatic environments. Co-exposure to MPs and chemical contaminants has been reported to increase toxicity in several organisms. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Nonylphenol induces mortality and reduces hatching rate through increase of oxidative stress and dysfunction of antioxidant defense system in marine medaka embryo
ConclusionOur study provides evidence of cellular stress induction/toxicity caused by 4-NP and endocrine disrupting potential in marine medaka embryos. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

The effect of calcium gluconate with natural extracts on skin toxicity of hydrofluoric acid
ConclusionOur study demonstrated that CG in combination with natural extracts show superior wound healing in treating HF burn compared to CG monotherapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Physiological effects of various light spectra on oxidative stress by starvation in olive flounder, Paralichthys olivaceus
ConclusionThese results suggest that green and blue wavelengths can inhibit oxidative stress and apoptosis in starved olive flounder and that green light is particularly efficient for this. Furthermore, the irradiation of green wavelength can play a role in protecting against starvation stress. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Cellular toxicity of zinc can be attenuated by sodium hydrogen sulfide in neuronal SH-SY5Y cell
ConclusionThese results demonstrate that NaHS has the capacity to chelate extracellular and intracellular Zn2+, and could therefore be used in the protection against Zn2+ neurotoxicity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Trends in gene expression changes during adipogenesis in human adipose derived mesenchymal stem cells under dichlorodiphenyldichloroethylene exposure
ConclusionOur findings suggest that DDE exposure changes the differentiation of adipocytes, enhances the lipid metabolism and so may play a role in the development of obesity and metabolic diseases by affecting the insulin signalling pathway. The influence of DDE seems to be similar to the effect of insulin itself. However, further studies to elucidate the mechanism of action of DDE are necessary. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

PGA 2 -induced expression of HO-1 is mediated by transcriptional upregulation of Nrf2
ConclusionThese findings suggest that PGA2 inducesHO-1 transcription via an increase in Nrf2 protein, the transcription of which is initiated by an accumulation of ROS that is independent of the p38MAPK activation pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Complete genome sequence of Methylobacterium sp. 17Sr1-43, a radiation-resistant bacterium
ConclusionThe new strains ofMethylobacterium sp. 17Sr1-43 showed both gamma and UV-C irradiation resistance, and their complete genome sequence annotation features correspondingly showed the presence of the genes involved in the radiation-resistance. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Profiling of miRNA expression in mice kidney with diabetic nephropathy
ConclusionOur findings may provide that changes in miRNA expression in mice with diabetic nephropathy influences disease progression and might provide insights into the molecular mechanisms underlying DN. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Differential use-dependent inactivation of Na v 1.8 in the subpopulation of cultured dorsal root ganglion
ConclusionOur data suggest that the time-dependent change of the use-dependent inactivation of the Nav1.8 channel in DRG neurons culturedin vitro would contribute to the excitability of a subpopulation of DRG neurons and could play an important role in the development of inflammatory and neuropathic pain. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

MAC inhibits c-Myc and induces autophagy by downregulation of CIP2A in leukemia cells
ConclusionThese findings significantly contributed to the understanding of the mechanism that accounts for the anticancer activity of MAC, and it may be novel anti-cancer therapeutic agents for leukemia cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Bioengineered aptamer-nanoconjugates for cancer theragnosis
AbstractEarly detection and treatment of cancer is of global interest as cancer is one of the leading causes of death worldwide. As the survival rate of cancer patients is closely related to its detection at an early stage, there is an urgent need to develop detection techniques that are fast, reliable, and easily available. Aptamers are single stranded DNA- and RNA- based oligonucleotides that can bind to their targets with high affinity and specificity. Their small size, excellent chemical stability, and low immunogenicity enable them to become alternatives to antibodies in cancer theragnostic approaches with cancer imag...
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

The environmental effects of microplastics on aquatic ecosystems
In this study, we aimed to present solutions to the problem of MPs through a review of the current state of research on the definition of MPs, usage, leakage, toxicity, and domestic and overseas circulation of plastics.Recent findingsLong-term exposure to MPs results in ecotoxicity. MPs not only deliver chemical substances within organisms, but also act as mediators for chemicals or other contaminants in aquatic environments. Co-exposure to MPs and chemical contaminants has been reported to increase toxicity in several organisms. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2018 Category: Cytology Source Type: research

Complete genome sequence of Microvirga sp. 17mud 1 –3, a radiation-resistant bacterium
ConclusionThe new strains showed both gamma and UV-C irradiation resistance and their complete genome sequence annotation features showed the presence of the genes involved in the radiation-resistance. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

Effects of waterborne copper on oxidative stress and immune responses in red seabream, Pagrus major
ConclusionThese results indicate that Cu2+ concentrations of 30 and 40 μg/L can induce an acute toxic oxidative stress and decrease the immune response in red seabream in aquarium conditions. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

Cardiotoxicity associated with tyrosine kinase-targeted anticancer therapy
AbstractPurpose of reviewTyrosine kinase inhibitors (TKIs) have shown clear survival benefits as effective targeted therapies in various hematological and solid malignancies. Important evidence, however, has shown that TKIs may lead to adverse effects such as cardiovascular toxicities, via off-target as well as on-target mechanisms. This review presents an overview of TKI-induced cardiotoxicity mechanisms, clinical manifestations, diagnosis, monitoring, and management options. Furthermore, we discuss current preclinical efforts and future investigations into alternative therapeutics for minimizing the cardiotoxicities asso...
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

Identification of lung cancer specific differentially methylated regions using genome-wide DNA methylation study
ConclusionThis genome-wide DNA methylation study showed an association between newly identified DMRs in CpG island promoter regions and previously known target genes for lung cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

Chemotactic effect of S100A8 and S100A9 on human eosinophilic leukemia cells, EoL-1 through TLR4
ConclusionThese findings suggest that S100A8 and S100A9 induce the cell movement and contribute to an understanding of S100A8 and S100A9 in eosinophil biology and the pathogenic mechanism of hematological malignancy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

Substance P blocks the impairment of paracrine potential of MSC due to long term culture
ConclusionCollectively, SP can block the loss of therapeutic potential of MSCs by preserving their proliferative and paracrine potential. This study indicates the potential of SP as a supplement in stem cell culture for therapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage
ConclusionThe Hepatocyte cell line derived from liver injury model were used for hepatocyte transplantation and showed the significantly higher survival rate. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

Differentially expressed genes between intestinal- and diffuse-type gastric cancers
ConclusionThese data provide insights into type-specific gastric carcinogenesis, suggesting new approaches for a more profound investigation of the pathologic events that drive intestinal- and diffuse-type gastric cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 1, 2018 Category: Cytology Source Type: research

Complete genome sequence of Nibribacter radioresistens DG15C, a radiation resistant bacterium
ConclusionThe genome annotation as confirmed the presence of gene clusters involved in the toxicity resistance of radiation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Intrinsic toxicity of stable nanosized titanium dioxide using polyacrylate in human keratinocytes
ConclusionOur findings indicated that the anti-coagulant PAA is suitable for preparing homologous dispersed nTiO2 under realistic physiological culture test conditions. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Humanized model mice by genome editing and engraftment technologies
AbstractPurpose of reviewIn drug development, non-clinical studies are performed to evaluate the feasibility, iterative testing and safety of a drug. To harness this process, small animal models which are inexpensive, and easy to breed and maintain such as mice and rats are preferred for non-clinical studies. However, humans and these animals share a large portion of genetic makeup, but genetic and physiological gaps are unavoidable. Efforts to address this innate difference between humans and animals have been made by establishing a so called ‘humanized’ mouse. In this review, we summarize the scope of the &ls...
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Effect of Prunus yedoensis Matsumura extract on the gene expression in HaCaT cells
ConclusionThe present study demonstrated that PYE at 313 μg/mL, a concentration which is not cytotoxic but generates intracellular ROS, affected gene regulation in HaCaT human keratinocytes through multiple toxicity mechanisms and could therefore disturb skin homeostasis or lead to skin aging. We propose that for the safe use of PYE in herbal cosmetic or medicines, further evaluations of the toxicity and safety in the skin must be performed. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Complete genome sequence of Microvirga sp. 17mud 1 –3, a radiation-resistant bacterium
ConclusionThe new strains showed both gamma and UV-C irradiation resistance and their complete genome sequence annotation features showed the presence of the genes involved in the radiation-resistance. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Effects of waterborne copper on oxidative stress and immune responses in red seabream, Pagrus major
ConclusionThese results indicate that Cu2+ concentrations of 30 and 40 μg/L can induce an acute toxic oxidative stress and decrease the immune response in red seabream in aquarium conditions. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Cardiotoxicity associated with tyrosine kinase-targeted anticancer therapy
AbstractPurpose of reviewTyrosine kinase inhibitors (TKIs) have shown clear survival benefits as effective targeted therapies in various hematological and solid malignancies. Important evidence, however, has shown that TKIs may lead to adverse effects such as cardiovascular toxicities, via off-target as well as on-target mechanisms. This review presents an overview of TKI-induced cardiotoxicity mechanisms, clinical manifestations, diagnosis, monitoring, and management options. Furthermore, we discuss current preclinical efforts and future investigations into alternative therapeutics for minimizing the cardiotoxicities asso...
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Identification of lung cancer specific differentially methylated regions using genome-wide DNA methylation study
ConclusionThis genome-wide DNA methylation study showed an association between newly identified DMRs in CpG island promoter regions and previously known target genes for lung cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Chemotactic effect of S100A8 and S100A9 on human eosinophilic leukemia cells, EoL-1 through TLR4
ConclusionThese findings suggest that S100A8 and S100A9 induce the cell movement and contribute to an understanding of S100A8 and S100A9 in eosinophil biology and the pathogenic mechanism of hematological malignancy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Substance P blocks the impairment of paracrine potential of MSC due to long term culture
ConclusionCollectively, SP can block the loss of therapeutic potential of MSCs by preserving their proliferative and paracrine potential. This study indicates the potential of SP as a supplement in stem cell culture for therapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage
ConclusionThe Hepatocyte cell line derived from liver injury model were used for hepatocyte transplantation and showed the significantly higher survival rate. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Differentially expressed genes between intestinal- and diffuse-type gastric cancers
ConclusionThese data provide insights into type-specific gastric carcinogenesis, suggesting new approaches for a more profound investigation of the pathologic events that drive intestinal- and diffuse-type gastric cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 23, 2018 Category: Cytology Source Type: research

Diethylamino-curcumin mimic with trizolyl benzene enhances TRAIL-mediated cell death on human glioblastoma cells
ConclusionThese results demonstrated that YM-4 can be an anticancer candidate that can be effective on human glioblastoma cells in combination with TRAIL. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 24, 2018 Category: Cytology Source Type: research

Igongsan reduces testosterone-induced benign prostate hyperplasia by regulating 5 α-reductase in rats
ConclusionBased on our findings, this study shows that IG S can alleviate BPH by regulating 5AR, suggesting its potential as a new, effective medication for BPH treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 24, 2018 Category: Cytology Source Type: research

Low-dose diethylhexyl phthalate exposure does not impair the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in mouse mammary glands
ConclusionThese finding showed no impact of DEHP on the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in pregnant mouse mammary gland cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 24, 2018 Category: Cytology Source Type: research

Fisetin protects H9c2 cardiomyoblast cells against H 2 O 2 -induced apoptosis through Akt and ERK1/2 signaling pathways
ConclusionTaken together, these data suggest that the potential cardioprotective effect of fisetin may involve Cu/Zn-SOD-mediated activation of Bcl-2 through the Akt and ERK1/2 pathways. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 24, 2018 Category: Cytology Source Type: research

Proteins isolated of Pueraria Radix possible to cause allergenic react with immunoglobulin E in human sera
ConclusionThe results imply thatPueraria Radix can act as an allergen given the identification of IgE binding proteins among the isolated proteins ofPueraria Radix. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 24, 2018 Category: Cytology Source Type: research

A study of cytotoxicity and genotoxicity of particulate matter (PM 2.5 ) in human lung epithelial cells (A549)
ConclusionOur study suggests that ROS-mediated DNA damage may play a major role in PM2.5-induced cell death. This finding represents the basis for further studies addressing the pathophysiological mechanisms of PM2.5 exposure. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 24, 2018 Category: Cytology Source Type: research