Molecular targets of histone deacetylase inhibitors in neurodegeneration and neuroprotection

ConclusionsMitochondrial bioenergetics- and neuroinflammation-related molecular targets of HDACi may be the key to the use of HDACi therapy for neurodegenerative diseases.Purpose of reviewWe aimed to discover molecular targets of HDACi in progressive neurodegeneration and to use these targets in potential therapeutics to induce neuroprotection.Recent findingsHDACi reverse cellular pathology in a mechanism involving mitochondrial bioenergetics and neuroinflammation, and the result is alleviation of pathologic phenotypes of neurodegenerative diseases.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research