Knockdown of UHRF1 ameliorates high glucose-induced podocyte injury by activating SIRT4
ConclusionsKnockdown of UHRF1 ameliorates HG-induced podocyte injury by upregulating SIRT4, indicating that UHRF1 may be a novel target for preventing DN in podocytes. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 27, 2023 Category: Cytology Source Type: research
KLF4 overexpression facilitates proliferation and represses apoptosis of granulosa cells in polycystic ovary syndrome
Conclusion
KLF4 overexpression promoted RUNX2 expression by binding to the RUNX2 promoter, thereby further accelerating GC proliferation and repressing GC apoptosis in PCOS. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 27, 2023 Category: Cytology Source Type: research
Double homeobox a pseudogene 8/miR-223-3p/PFN2 modulates radiosensitivity in lung cancer
ConclusionDUXAP8/miR-223-3p/PFN2 axis modulated radiosensitivity in lung cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 26, 2023 Category: Cytology Source Type: research
FEZF2 inhibits the growth of triple-negative breast cancer cells through EZH2/PD-L1 and enhances anti-tumor immunity in vivo
ConclusionOverexpression of FEZF2 inhibited the proliferation and enhanced the apoptosis of TNBC cells through EZH2/PD-L1 axis, as well as promoted anti-tumor immunity in vivo. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 19, 2023 Category: Cytology Source Type: research
Theaflavin indicates protection on vascular endothelium via hydrogen sulfide production
ConclusionThese results indicate that the protective effect of VECs is dependent on NO production and that both EGCG and theaflavin have therapeutic potential for VECs. Theaflavin has a relatively higher therapeutic potential than EGCG due to its ability to increase H2S production, which in turn affects NO production and biological activity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 14, 2023 Category: Cytology Source Type: research
USP13 promotes proliferation and angiogenesis of diffuse large B-cell lymphoma cells by promoting MCL-1 expression
ConclusionUSP13 modulated DLBCL cell proliferation, migration, invasion, and angiogenesis by promoting MCL-1 expression. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 12, 2023 Category: Cytology Source Type: research
Targeting cathepsin L in the regulation of apoptosis in peripheral T-cell lymphoma
ConclusionTaken together, we demonstrated a role of cathepsin L in apoptosis by regulation of p53 signaling pathway. Our finding might provide a new possible candidate drug target for clinical treatment of PTCL in future. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 9, 2023 Category: Cytology Source Type: research
ZNF252P-AS1 enhances myeloid-derived suppressor cell expansion and tumor glycolysis to accelerate laryngeal squamous cell carcinoma development via the miR-377-3p/ lactate dehydrogenase a axis
ConclusionOur results indicated that ZNF252P-AS1 was important in LSCC development, and has been identified as an oncogenic promoter, making it a potential therapeutic target for LSCC therapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 8, 2023 Category: Cytology Source Type: research
Improvement of ventricular remodeling and regulation of PI3K/Akt/mTOR signaling pathway in rats with heart failure by polysaccharides from Stropharia rugosoannulata
ConclusionsPolysaccharides fromStropharia rugosoannulata can improve ventricular remodeling and cardiac function, reduce inflammatory response and protect cardiac function in rats with heart failure in a dose-dependent manner, and the mechanism of action may be related to the regulation of MMPs/TIMPs balance, inhibition of RAAS system and activation of PI3K/Akt/mTOR signaling pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 8, 2023 Category: Cytology Source Type: research
VCAN activates JAK/STAT signaling pathway to promote the progression of LPS-induced acute pneumonia
ConclusionsVCAN knockdown alleviates lung injury of mice with pneumonia by inhibiting the JAK/STAT signaling pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 3, 2023 Category: Cytology Source Type: research
Clinical anesthetic effect of esketamine on children undergoing tonsillectomy
ConclusionEsketamine can reduce the incidence of cough during anesthesia recovery period in children underwent tonsillectomy, reduce postoperative agitation, improve postoperative analgesia, and has mild adverse reactions. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 2, 2023 Category: Cytology Source Type: research
Dexmedetomidine promotes autophagy and apoptosis of colon cancer cells by activating endoplasmic reticulum (ER) stress-mediated PERK/eIF2 α/ATF4 signaling pathway
ConclusionThis work revealed the anti-cancer effect of DEX treatment by inhibiting colon cancer cell proliferation while promoting cancer cell apoptosis and autophagy via the PERK/eIF2 α/ATF4 pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 2, 2023 Category: Cytology Source Type: research
YTHDC1 inhibits cell proliferation and angiogenesis in cervical cancer by regulating m6A modification of SOCS4 mRNA
ConclusionOur study for the first time showed that YTHDC1 inhibited cell proliferation and angiogenesis of cervical cancer by regulating m6A modification of SOCS4 mRNA. This finding may provide a potential therapeutic molecular target for CC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 30, 2023 Category: Cytology Source Type: research
CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway
ConclusionCircSLCO3A1 absence assuaged LPS-induced HPAEpiC inflammation and apoptosis through the miR-424-5p/HMGB3 axis.HighlightsCircSLCO3A1 expression was upregulated in LPS-induced HPAEpiCs and sepsis-induced ALI patients.CircSLCO3A1 depletion protected against LPS-induced HPAEpiC disorders.CircSLCO3A1 bound to miR-424-5p in HPAEpiCs.MiR-424-5p targeted HMGB3 in HPAEpiCs.CircSLCO3A1 regulated HMGB3 expression through miR-424-5p. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 25, 2023 Category: Cytology Source Type: research
CircKLHL2 mitigates septic lung injury via circKLHL2-miR-338-3p-ATF6 ceRNA pathway
ConclusionDepleting circKLHL2 suppressed LPS-induced ALI through suppressing mitochondrial dysfunction and cytotoxicity and oxidative and ER stresses-induced apoptosis via circKLHL2-miR-338-3p/ATF6 axis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 9, 2023 Category: Cytology Source Type: research
