Dexmedetomidine promotes autophagy and apoptosis of colon cancer cells by activating endoplasmic reticulum (ER) stress-mediated PERK/eIF2 α/ATF4 signaling pathway
ConclusionThis work revealed the anti-cancer effect of DEX treatment by inhibiting colon cancer cell proliferation while promoting cancer cell apoptosis and autophagy via the PERK/eIF2 α/ATF4 pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 2, 2023 Category: Cytology Source Type: research
YTHDC1 inhibits cell proliferation and angiogenesis in cervical cancer by regulating m6A modification of SOCS4 mRNA
ConclusionOur study for the first time showed that YTHDC1 inhibited cell proliferation and angiogenesis of cervical cancer by regulating m6A modification of SOCS4 mRNA. This finding may provide a potential therapeutic molecular target for CC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 30, 2023 Category: Cytology Source Type: research
CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway
ConclusionCircSLCO3A1 absence assuaged LPS-induced HPAEpiC inflammation and apoptosis through the miR-424-5p/HMGB3 axis.HighlightsCircSLCO3A1 expression was upregulated in LPS-induced HPAEpiCs and sepsis-induced ALI patients.CircSLCO3A1 depletion protected against LPS-induced HPAEpiC disorders.CircSLCO3A1 bound to miR-424-5p in HPAEpiCs.MiR-424-5p targeted HMGB3 in HPAEpiCs.CircSLCO3A1 regulated HMGB3 expression through miR-424-5p. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 25, 2023 Category: Cytology Source Type: research
CircKLHL2 mitigates septic lung injury via circKLHL2-miR-338-3p-ATF6 ceRNA pathway
ConclusionDepleting circKLHL2 suppressed LPS-induced ALI through suppressing mitochondrial dysfunction and cytotoxicity and oxidative and ER stresses-induced apoptosis via circKLHL2-miR-338-3p/ATF6 axis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 9, 2023 Category: Cytology Source Type: research
Premature ovarian insufficiency associated with environmental chemical exposure among Korean women: a study based on the Korean National Environmental Health Survey (2009 –2012)
ConclusionsOur study shows relationships between exposure to environmental chemicals and POI in spite of low exposure levels, suggesting that exposure to environmental chemicals may affect the female reproductive system even under the human monitoring reference value (RV) threshold. Further study is needed to evaluate the causal relationship between low level chemical exposure and women's health. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 5, 2023 Category: Cytology Source Type: research
Low-dose-rate gamma radiation aggravates titanium dioxide nanoparticle-induced lung injury in mice
ConclusionWe conclude that while exposure to each of these two distinct stimuli alone does not cause notable lung damage, they may potentially cause lung damage when combined owing to their synergistic effects. Therefore, we should pay attention to the possible combined effects of low-dose radiation and exposure to TiO2NPs, considering their potential danger in patients with respiratory problems. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 4, 2023 Category: Cytology Source Type: research
FGD5-AS1 promotes growth and mobility of trophoblast cells by regulating IGF2 via sponging miR-16-5p in pre-eclampsia
ConclusionOverall, our findings demonstrated that FGD5-AS1 promoted growth and mobility of trophoblast cells by regulating miR-16-5p/IGF2 axis in PE. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 26, 2023 Category: Cytology Source Type: research
The efficacy of Plantago asiatica L. water extract on lipid metabolism in a high-fat diet-induced obese C57BL/6 mice
ConclusionOur results indicated that with less toxicity, PAE was effective in preventing obesity by being involved in the AMPK pathway and adipogenesis, so it might be a safe potential material for an anti-obesity agent or functional supplements. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 20, 2023 Category: Cytology Source Type: research
Reduced cellular process and developmental process genotoxicity of polystyrene nanoplastics in zebrafish embryogenesis using Aurelia aurita proteins
ConclusionOur results showed that PS-NP induced changes in mRNA expression and had toxic effects that caused phenotypic anomalies in the zebrafish embryos. However, further studies are necessary to investigate the effects of different types of plastic and properties on genotoxicity and phenotypic anomalies in aquatic organisms. A trend of reduction was found in genotoxicity and phenotypic anomalies when the embryos were exposed to PS-NP together with Mu, suggesting that Mu extracted from Aurelia aurita could reduce the genotoxicity of PS-NP. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 20, 2023 Category: Cytology Source Type: research
PCDH8 protects MPP+-induced neuronal injury in SH-SY5Y cells by inhibiting MAPK pathway
ConclusionPCDH8 was down-regulated in PD, and PCDH8 protected MPP+-induced neuronal injury in SH-SY5Y cells via inhibiting MAPK pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 23, 2023 Category: Cytology Source Type: research
Effects of Agarum clathratum extract on cell death and calcium ion levels of ovarian cancer cell
ConclusionTaken together, our findings suggest that ACE might possess anti-cancer effects on epithelial ovarian cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 23, 2023 Category: Cytology Source Type: research
Biological characterization of mulberry leaves bioconverted with Viscozyme L
ConclusionThese results indicate that the enhanced activities of α-glucosidase, tyrosinase, xanthine oxidase inhibitory activities, and the anti-oxidant properties bioconverted from mulberry leaves with Viscozyme L. One of them, the quercetin which is a potent α-glucosidase inhibitor bioconverted from mulberry leaves with Viscozyme L has an anti-diabetic effect . And it can be used for the development of health foods and pharmaceutical products. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 20, 2023 Category: Cytology Source Type: research
Up-regulation of PKC α and δ during beating cardiomyocyte differentiation of P19CL6 cells with suppressed apoptotic cell populations
ConclusionPKC isotype α and δ can regulate the cardiomyocyte differentiation potential of P19CL6 cells. Especially, PKCα showed a more effective role in cardiomyocyte differentiation with increased Tbx5 protein expression and decreased apoptotic cell populations compared to PKCδ. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 17, 2023 Category: Cytology Source Type: research
S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
ConclusionOur study suggests that the S100A8/A9-RAGE signal pathway is the mainstream of the inflammation-immune response induced in cancer progression in CSE-related smoke-induced lung carcinogenesis in vitro and in vivo. Further studies are needed to identify the therapeutic targets of cigarette smoke-induced inflammation and immunosuppression in the tumor microenvironment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 15, 2023 Category: Cytology Source Type: research
Long non-coding RNA NONHSAT217600.1 is involved in the regulation of neodymium oxide-induced cytotoxicity in 16HBE cells
ConclusionThis study demonstrates the regulatory roles of lncRNA NONHSAT217600.1 in Nd2O3-induced cytotoxicity, providing evidence for the potential of lncRNAs in the risk/hazard assessment of rare-earth element-related toxicity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 13, 2023 Category: Cytology Source Type: research
