S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis

ConclusionOur study suggests that the S100A8/A9-RAGE signal pathway is the mainstream of the inflammation-immune response induced in cancer progression in CSE-related smoke-induced lung carcinogenesis in vitro and in vivo. Further studies are needed to identify the therapeutic targets of cigarette smoke-induced inflammation and immunosuppression in the tumor microenvironment.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research