miR-125-5p inhibits thyroid cancer growth and metastasis by suppressing the ERK/PI3K/AKT signal pathway
ConclusionIn summary, these results indicate that miR-125-5p can inhibit thyroid cancer cell growth, migration and invasion through the ERK/PI3K/AKT signaling pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 19, 2021 Category: Cytology Source Type: research
GALNT14 promotes cancer stem cell-like characteristics and metastasis of nasopharyngeal carcinoma cells through upregulating SOX4
ConclusionGALNT14 promoted the cancer stem cell-like characteristics and metastasis of nasopharyngeal carcinoma cells through upregulating SOX4, providing a potential therapeutic target for nasopharyngeal carcinoma treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 17, 2021 Category: Cytology Source Type: research
MiR-214 inhibits apoptosis in thyroid epithelial follicular cells induced by amiodarone through the FASL/MAPK pathway
ConclusionsOur results suggested that miR-214 could be a potential therapeutic target for Hashimoto's thyroiditis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 17, 2021 Category: Cytology Source Type: research
Acetaldehyde induces tau phosphorylation via activation of p38 MAPK/JNK and ROS production
ConclusionThe result indicated that acetaldehyde treatment increased tau phosphorylation in neuronal cells. Therefore, the accumulation of acetaldehyde resulted from alcohol abuse or defect of acetaldehyde detoxification may promote tau pathology in neurodegenerative diseases such as AD. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 12, 2021 Category: Cytology Source Type: research
Korean red ginseng extract exploits NF- κB to promote wound repair and protein expression in keratinocytes
ConclusionsKRG showed a direct modulatory effect on keratinocytes, and these modulatory functions may benefit skin health when KRG is used as a cosmeceutical or nutraceutical ingredient. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 8, 2021 Category: Cytology Source Type: research
Study the effect of crocin on the expression of PAX2 and WT1 genes in renal tissues and serum levels of NGAL and cystatin C in cadmium-treated rats
ConclusionCrocin reduces the expression of PAX2 and WT1 genes in renal tissue, and on the other hand, decreases the level of NGAL and cystine C proteins in the serum of rats, while cadmium increased the expression of these factors. Therefore, the results of our research indicate that crocin plays a protective role on the renal cell against the damage caused by cadmium. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 4, 2021 Category: Cytology Source Type: research
Safety aspects of natural food additives frequently used at their maximum levels in South Korea
ConclusionThe natural food additives tested did not exhibit cytotoxicity at their maximum usage levels. However, the cytotoxicity of smoke flavors was affected by manufacturing forms, suggesting the importance of manufacturing process for the safety of natural food additives. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 3, 2021 Category: Cytology Source Type: research
Use of neural 3D organoid with MEA in neurotoxicity testing: comparison to traditional in vitro cell culture and in vivo methods
This study aimed to investigate advantages of human derived neuronal cells, stem cells, and organoid models for screening drugs. This study also investigated a multi-electrode array for observing activities of neurons using organoids compared to other experimental models such as in vitro cell cultures and in vivo animal tests. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 25, 2021 Category: Cytology Source Type: research
Identifying the role of RUNX2 in bone development through network analysis in girls with central precocious puberty
ConclusionsThis study is the first to examine the association between gene expression changes in the blood and bone development, one of the major features of CPP, through an integrated genomic approach. Our study suggests that biological analyses using blood samples for various diseases may be performed for clinical diagnosis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 22, 2021 Category: Cytology Source Type: research
Regulation of mast cell activation by extracellular vesicles in cow ’s milk casein-induced allergic responses
ConclusionOur results demonstrate that CIA-derived EVs can induce a reaction similar to cow ’s milk allergic reaction via mast cell activation. These results provide an insight into the pathology of cow’s milk allergy and a potential therapeutic approach through targeting EV release and/or uptake. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 20, 2021 Category: Cytology Source Type: research
Screening of phytochemicals effective on relieving cancer cachexia in cisplatin-induced in vitro sarcopenia model
ConclusionTherefore, this study showed the protective effects of three phytochemicals in cisplatin-induced atrophy in vitro and these compounds may be promising therapeutic agents with the further investigation of in vivo potential in the cachexia mice model. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 15, 2021 Category: Cytology Source Type: research
KLF5-trancripted miR-125b-5p is involved in enhancing the radio-sensitivity of breast cancer cells by targeting BRCA1
ConclusionIn conclusion, these findings suggested that the KLF5/miR-125b-5p/BRCA1 axis may provide new information on radiation therapy for breast cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 11, 2021 Category: Cytology Source Type: research
miR-29 family inhibited the proliferation and migration of lung cancer cells by targeting SREBP-1
ConclusionThese findings demonstrate that transfection of miR-29 suppressed lung cancer proliferation via inhibiting SREBP-1 expression. The current study provides a basis for exploring the targeted agents against lung cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 11, 2021 Category: Cytology Source Type: research
E2F1-induced PROX1-AS1 contributes to cell growth by regulating miR-424-5p/CPEB2 pathway in endometrial carcinoma
ConclusionIn conclusion, this study uncovered that PROX1-AS1 induced by E2F1 promoted the cell viability in EC through increasing CPEB2 expression via targeting miR-424-5p. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 8, 2021 Category: Cytology Source Type: research
Leucine supplementation mimics the effects of caloric restriction on yeast chronological lifespan
ConclusionLeucine-induced CLS extension and a decreased in the rate of cell death observed in this study verified the function of leucine in cell death prevention and CLS extension in yeast. Interestingly, leucine-induced changes were similar to CR-induced changes. The results in this study suggest that leucine can function as a CR mimetic. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 1, 2021 Category: Cytology Source Type: research
