MicroRNA-10a-5p targets SERPINE1 to suppress cell progression and epithelial –mesenchymal transition process in clear cell renal cell carcinoma
ConclusionCollectively, our results indicated that miR-10a-5p is expected to be a potential target for ccRCC, providing a new approach for ccRCC treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 6, 2023 Category: Cytology Source Type: research
Anti-melanogenic effect of Moju through inhibition of tyrosinase activity
ConclusionsThese results provide evidence that Moju has antioxidant activity and anti-melanogenic effect that occur through regulation of the ERK pathway. Although further research is needed to elucidate the specific mechanism and functional components, the ability of Moju to inhibit melanin synthesis by altering tyrosinase activation suggest that it can be used as a functional whitening ingredient. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 6, 2023 Category: Cytology Source Type: research
Stable expression of human Nav1.5 for high-throughput cardiac safety assessment
ConclusionThe new HEK293 cell line stably expressing hNav1.5 channels produced a current that could be tested using both conventional and automated patch-clamp systems with similar results. This current would be strong enough to evaluate cardiac safety, thus allowing the use of the automated patch-clamp system for drug screening and functional kinetic studies to reveal the mechanism of drug action. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 6, 2023 Category: Cytology Source Type: research
Progesterone induces glioblastoma cell apoptosis by coactivating extrinsic and intrinsic apoptotic pathways
ConclusionThese findings suggested that both extrinsic and intrinsic apoptotic pathways contribute to glioblastoma cell apoptosis induced by high concentration of progesterone in vitro. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 5, 2023 Category: Cytology Source Type: research
Physical and biomimetic treatment methods to reduce microplastic waste accumulation
ConclusionsVarious post-treatment methods have been proposed to collect and remove MPs and NPs that have reached into aquatic ecosystems and subsequently reduce their toxicity. However, there are limitations that the effectiveness of these methods is hindered by the lack of policies governing the entire process of plastic use before the post-treatment.Purpose of ReviewWe purpose to reduce plastic waste through methods that use eco-imitation technologies.Recent FindingsThese eco-imitation methods are attracting attention as viable future plastic waste treatment options in line with the goals of sustainable development. (Sou...
Source: Molecular and Cellular Toxicology - January 1, 2023 Category: Cytology Source Type: research
Anti-inflammatory and relaxation effects of Ulmus pumilla L. on EGF-inflamed bronchial epithelial and asthmatic bronchial smooth muscle cells
ConclusionFrom these results, we suggest the possibility of UPL as a therapeutic agent for asthma given how it prevents inflammation and restrains bronchial smooth muscle contractions. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - December 22, 2022 Category: Cytology Source Type: research
Sodium hydroxide-induced Weissella kimchii ghosts (WKGs) as immunostimulant
ConclusionOur results indicate that NaOH-induced WKGs can be considered as candidates for inactivated bacterial immunostimulants. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - December 15, 2022 Category: Cytology Source Type: research
Correction: Cardiac biomarkers and detection methods for myocardial infarction
(Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - December 15, 2022 Category: Cytology Source Type: research
Identification of chromosomal type II toxin –antitoxin system from plant pathogenic Pseudomonas cichorii JBC 1
ConclusionTwo TA systems, PCH70-01,400/01410 and PCH70-16,550/16540, were identified inP. cichorii JBC 1. These TA systems show different toxin and antitoxin mRNA expression levels according to stressful growth conditions, including oxidative, acidic, and heat shocks inE. coli. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - December 3, 2022 Category: Cytology Source Type: research
Combination of naringenin and epicatechin sensitizes colon carcinoma cells to anoikis via regulation of the epithelial –mesenchymal transition (EMT)
ConclusionIn summary, our findings showed that the naringenin/epicatechin combination sensitized colon carcinoma cells to anoikis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 28, 2022 Category: Cytology Source Type: research
Nrf2 suppresses erastin-induced ferroptosis through activating system Xc(-) in ovarian cancer
ConclusionThis study revealed a novel cancer-promoting mechanism of Nrf2, mainly enhanced ferroptosis resistance in OV. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 27, 2022 Category: Cytology Source Type: research
Momordica charantia extracts obtained by ultrasound-assisted extraction inhibit the inflammatory pathways
ConclusionThese results indicate that theM. charantia extract collected using an industrial ultrasonic system is non-toxic and has an anti-inflammatory effect through regulation of the NF- κB and MAPK pathways, suggesting that it can act as a therapeutic candidate for the treatment of inflammatory diseases. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 21, 2022 Category: Cytology Source Type: research
Lipopolysaccharide alters VEGF-A secretion of mesenchymal stem cells via the integrin β3-PI3K-AKT pathway
ConclusionIn conclusion, VEGF-A secretion of MSCs has been prolongedly inhibited via the integrin β3-PI3K-AKT pathway in the LPS challenge. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 21, 2022 Category: Cytology Source Type: research
Comparison of the cytotoxicity of bisphenol A and its analogs on human placental BeWo cells
ConclusionBPs did not affect cell viability and proliferation. However, BPS altered the G0/G1 and G2/M phases of the trophoblast BeWo cells by increasing cyclin B1 expression. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 19, 2022 Category: Cytology Source Type: research
LncRNA PTPRG-AS1 maintains stem-cell-like features and promotes oxaliplatin resistance in colorectal cancer via regulating the miR-665 and STAT3 axis
ConclusionIn this study, PTPRG-AS1 maintains stemness features and promotes oxaliplatin resistance in CRC through modulating miR-665/STAT3. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 17, 2022 Category: Cytology Source Type: research
