Exosomes derived from regulatory T cells attenuates MPP+-induced inflammatory response and oxidative stress in BV-2 cells by inhibiting the TLR4/NF- κB signaling
ConclusionsCollectively, Treg-Exos attenuated MPP+-induced oxidative stress and inflammatory injury in BV-2 cells by inhibiting the TLR4/NF- κB signaling. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 21, 2022 Category: Cytology Source Type: research
Anti-tumor effect of novel amino acid Schiff base nickel (II) complexes on oral squamous cell carcinoma cells (CAL-27) in vitro
ConclusionThe results of the study showed that nickel complexes could potently inhibit the growth of CAL-27 cells, which was mediated via mitochondrial dysfunction, intracellular ROS accumulation, and ROS-mediated DNA damage. Altogether, the findings of the study would provide new leads for the designing and synthesis of novel metal drugs for OSCC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 13, 2022 Category: Cytology Source Type: research
Transmembrane protein 106C accelerates the progression of breast cancer through the activation of PI3K/AKT/mTOR signaling
ConclusionThis study indicated that TMEM106C could promote the malignant phenotypes of breast cancer cells by activating PI3K/AKT/mTOR signaling. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 10, 2022 Category: Cytology Source Type: research
Coal dust exposure induces proliferation and migration of human bronchial epithelial cells
ConclusionsThe results indicate that chronic CD exposure could induce abnormal proliferation and migration of BEAS-2B cells, lead to the transformation potential of human bronchial epithelial cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 10, 2022 Category: Cytology Source Type: research
Lipopolysaccharide induces oxidative stress and inhibits osteogenic differentiation in periodontal ligament stem cells through downregulating Nrf2
ConclusionLPS induced oxidative stress through downregulating Nrf2-mediated antioxidant pathways, and inhibited osteogenic differentiation in PDLSCs. Strategies enhancing antioxidant capability could reverse the impaired osteogenic potential caused by LPS. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 10, 2022 Category: Cytology Source Type: research
LncRNA XIST contributes to epithelial –mesenchymal transformation in posterior opacity via regulating miR-98-5p/COL5A2 axis and PI3K/Akt/FOXO1 pathway
ConclusionIn the study, we demonstrated that lncRNA XIST contributed to EMT in PCO via regulating miR-98-5p/COL5A2 and PI3K/Akt/FOXO1 pathway, which provided a new treatment strategy for PCO. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 24, 2022 Category: Cytology Source Type: research
Classification of dog skin diseases using deep learning with images captured from multispectral imaging device
ConclusionsWe developed consensus models for each skin disease for dogs by combining each best model developed with the normal and multispectral images, respectively. Since the normal images could be used to determine areas suspected of lesion of skin disease and additionally the multispectral images could help confirming skin redness of the area, the models achieved higher prediction accuracy with balanced performance between sensitivity and specificity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 24, 2022 Category: Cytology Source Type: research
Extracellular polysaccharides purified (Polycan) from Aureobasidium pullulans SM ‑2001 improves pathophysiology of dystrophin-deficient mdx mice
ConclusionThese results demonstrate that Polycan can improve and protect muscle atrophy by preventing apoptosis via pathway regulation related to myogenic transcription factors and energy metabolism in mdx mice. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 17, 2022 Category: Cytology Source Type: research
In vitro evaluation of antioxidant activity and biocompatibility of caffeic acid phenethyl ester loaded in polymeric micelles
ConclusionCAPE loaded into the micelles having a core segment similar to CAPE, exhibited better protective properties than pure drug in the in vitro model of oxidative stress in endothelial Ea.hy926 cells. The similarity between the drug and micellar core seems to be an effective approach for improvement of its antioxidant activity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 13, 2022 Category: Cytology Source Type: research
S-ketamine promotes autophagy and alleviates neuropathic pain by inhibiting PI3K/Akt/mTOR signaling pathway
ConclusionS-ketamine could induce autophagy to alleviate neuropathic pain by inhibition of the PI3K/Akt/mTOR pathway. These findings facilitate understating on the molecular mechanism underlying the protective effects of S-ketamine on neuropathic pain. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 11, 2022 Category: Cytology Source Type: research
LncRNA SNHG12/miR-494-3p/CBX3 axis in diffuse large B-cell lymphoma
ConclusionSNHG12 contributed to DLBCL development by regulating miR-494-3p/CBX3. The outcomes demonstrated that SNHG12 provided a potential train of thought for DLBCL theory of targeted therapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 11, 2022 Category: Cytology Source Type: research
Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways
ConclusionIntracellular JNK/ERK pathways were involved in chondrocyte apoptosis induced by SNP through oppositely regulated effects on cytoskeletal proteins; ERK pathway protected cytoskeletal protein from dissolution via inhibition of caspase-3 activation, while JNK pathway promoted the dissolution via activation of caspase-3 activity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - May 4, 2022 Category: Cytology Source Type: research
Correction to: High dose of bile acid enables the cellular entry and replication of hepatitis C virus in vitro
(Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 25, 2022 Category: Cytology Source Type: research
Circ_0101622 governs the miR-1179/RAB23 pathway to promote the aggressive progression of thyroid cancer
ConclusionCirc_0101622 might act as an oncogenic driver to promote the malignant progression of thyroid cancer by mediating the miR-1179/RAB23 pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 21, 2022 Category: Cytology Source Type: research
Combined treatment of ginsenoside Rg2 and piceatannol mixture reduces the apoptosis and DNA damage induced by UVB in HaCaT cells
ConclusionIt is inferred that Rg2 promotes DNA repair by regulating genes related with DDR and PIC promotes DNA repair by effectively scavenging UVB-induced ROS through high antioxidant activity. Enhanced DNA repair by RP leads to protecting skin from UVB-induced skin photoaging. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 19, 2022 Category: Cytology Source Type: research
