Oral health effect of an oral rinse containing cetylpyridinium chloride: a randomized clinical trial
ConclusionCPC-containing ORs can be recommended as an adjunct to the standard home care routine in promoting oral health.Clinical trial registrationNCT05644236. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 28, 2023 Category: Cytology Source Type: research
Knockout of METTL3 promotes neural functional recovery after spinal cord injury in mice via the USP4/YTHDF2 axis
ConclusionMETTL3-dominated m6A modification enhances YTHDF2 enrichment on USP4 mRNA and thereby reduces USP4 mRNA stability, eventually aggravating neurological impairment in SCI mice. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 27, 2023 Category: Cytology Source Type: research
ML385 suppresses the proliferation, migration, and invasion of thyroid carcinoma cells by impairing aerobic glycolysis
ConclusionsML385 inhibits the biological behavior of thyroid cancer cells by impairing aerobic glycolysis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 20, 2023 Category: Cytology Source Type: research
Scutellarein ameliorates inflammation and oxidative stress in L-arginine induced acute pancreatitis in mice through regulating the expression of VEGF
ConclusionScutellarein treatment alleviated pancreas injury of AP mice by inhibiting oxidative stress and inflammatory response via downregulating VEGF expression. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 20, 2023 Category: Cytology Source Type: research
Molecular mechanism of long non-coding RNA SNHG12 regulating bladder cancer cell activities
ConclusionsGenerally, SNHG12/miR-143-3p induces the malignant activities of BC cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 17, 2023 Category: Cytology Source Type: research
Circ_0000732 promotes breast cancer cell proliferation, metastasis and stemness by mediating COL11A1 through the regulation of miR-1253
ConclusionOur data showed that circ_0000732 might be a potential target for BC treatment, which could enhance BC malignant phenotype through miR-1253/COL11A1 axis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 14, 2023 Category: Cytology Source Type: research
Sublethal effects of acetaminophen exposure on benthic aquatic animal (Hydra magnipapillata)
ConclusionToxicity level of APAP inH. magnipapillata is relatively low, and showed non-lethal effects. However, at relatively high concentration, APAP could inhibit the regeneration of tentacles that may affect its life abilities. At relatively low concentration, APAP exposure induces various physiological effects that may affects its reproductive activity and morphological development. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 1, 2023 Category: Cytology Source Type: research
CHL1 promotes autophagy and apoptosis of multiple myeloma cells via inhibiting the Hedgehog pathway
ConclusionWe therefore thought CHL1may be a potential target for treating MM. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 29, 2023 Category: Cytology Source Type: research
Myricetin alleviates pancreatic microcirculation and inflammation in rats with severe acute pancreatitis through FOXO1 and NF- κB pathways
ConclusionMyricetin improves SAP-induced pancreatic injury through suppressing microcirculation dysfunction, overactive inflammatory response, and cell apoptosis. In addition, myricetin deregulates acetylated FOXO1 and phosphorylated nuclear factor kappa B (NF-kB), which may be the potential mechanism for SAP alleviation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 24, 2023 Category: Cytology Source Type: research
Chemically induced bacterial ghosts: a novel approach for advancing biomedical applications
ConclusionChemically induced BGs represent a novel and promising approach for vaccine development, holding the potential for advancing disease prevention and public health.Purpose of reviewIn this review, we discuss key aspects of chemically induced BGs, including their production principles, mechanisms of formation, characterization techniques, immunogenicity, and medical applications. We also discuss the challenges and direction of future research for optimizing production methods for chemically induced BGs, evaluating long-term safety, and undertaking clinical trials to assess their efficacy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 21, 2023 Category: Cytology Source Type: research
Chronic toxic effects of fragmented polyvinyl chloride on the water flea Moina macrocopa
ConclusionThese results imply that fragmentation of MPs can induce a significant physiological and biochemical effects to aquatic crustaceans by inducing strong oxidative stress and impairing antioxidant defense. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 18, 2023 Category: Cytology Source Type: research
Evaluations of carcinogens from comparison of cancer slope factors: meta-analysis and systemic literature reviews
ConclusionBased on the obtained CSF value, the gene expression analysis of each chemical and toxic gene expression analysis of the CTD, inhalation carcinogenicity priority was estimated and a DB (chemical list) was prepared according to the CSF value. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 14, 2023 Category: Cytology Source Type: research
miR-365b-3p adsorbed by HCG18 inhibits the proliferation and angiogenesis of stomach adenocarcinoma by downregulating STC1
ConclusionThis study unraveled that miR-365b-3p exerted the inhibitory impacts on cell proliferation and angiogenesis of STAD through targeting STC1 and interacting with HCG18 for the first time, which broadened our understanding of STAD etiology and contributed to the treatment of STAD. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 14, 2023 Category: Cytology Source Type: research
In silico molecular docking validation of procalcitonin-binding aptamer and sepsis diagnosis
ConclusionThrough this study, we were able to develop a technique for early disease diagnosis using aptamer-based protein detection. We also performed aptamer binding validation studies using a combination of molecular validation and in silico validation methods. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 7, 2023 Category: Cytology Source Type: research
MicroRNA-1271-5p suppresses the proliferation, invasion and migration of oral squamous cell carcinoma by inhibiting F13A1 expression
ConclusionMiR-1271-5p could suppress OSCC progression by influencing F13A1 expression to inhibit the PI3K/AKT signaling, indicating the promising potential of targeting miR-1271-5p as a novel approach for treating OSCC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 4, 2023 Category: Cytology Source Type: research
