Circ_0074027 regulates the progression of non-small cell lung cancer via miR-1304-5p/GJB2 axis
ConclusionCirc_0074027 regulates the expression of GJB2 by regulating miR-1304-5p, thereby promoting the development of NSCLC. Our study provides a novel targeted therapy for NSCLC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 19, 2022 Category: Cytology Source Type: research
Sodium aescinate alleviates bone cancer pain in rats by suppressing microglial activation via p38 MAPK/c-Fos signaling
ConclusionOur findings suggest that SA plays a promising analgesic role in the BCP rats by suppressing inflammation and microglial activation, and these effects may be associated with the suppression of p38 MAPK/c-Fos signaling. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 12, 2022 Category: Cytology Source Type: research
Knockdown of RBBP6 enhances radiosensitivity of gastric cancer cells through p53 pathway
ConclusionRBBP6 silence was considered to be a potential sensitizer for the radiotherapy of gastric cancer through activation of p53 signaling. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - April 12, 2022 Category: Cytology Source Type: research
iTRAQ-based proteomics analysis of diethylstilbestrol induced dysfunction of testicular gubernaculum development in mouse
ConclusionProteomics profiling and functional analysis reveal new clues on how DES interferes with cellular processes and disrupts the development of gubernaculum. These findings have potential applications in the treatment of genitourinary diseases such as cryptorchidism. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 28, 2022 Category: Cytology Source Type: research
High dose of bile acid enables the cellular entry and replication of hepatitis C virus in vitro
ConclusionThis study reveals that a high dose of BA, specifically tCA, can directly regulate lipid bilayer status in vitro, allowing HCV entry into immortalized hepatocytes, and non-hepatocytes in humans and mice. This is the first report on HCV permissiveness into human or rodent hepatocytes and non-hepatocytes via non-genetic humoral milieu modulation alone, establishing the platform for a robust HCV replication system in vitro. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 28, 2022 Category: Cytology Source Type: research
Association of expression of GADD family genes and apoptosis in human kidney proximal tubular (HK-2) cells exposed to nephrotoxic drugs
ConclusionOur findings support that cisplatin, amphotericin B, and geneticin mediate induction of the GADD family of genes via the p38 MAPK pathway, resulting in the induction of apoptosis in HK-2 cells. We suggest that the apoptosis-related genes GADD45A and GADD153 may be reasonable candidate biomarkers for the screening of nephrotoxicity of drugs. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 23, 2022 Category: Cytology Source Type: research
Protective effects of Dioscorea polystachya ethanol extracts against lead acetate-induced oxidative DNA damage in MRC-5 cells
ConclusionOur results demonstrate the protective effects of DEE on lead acetate-induced oxidative DNA damage, mediated through a reduction in the levels of cellular ROS and an increase in those of DDR-related proteins at early time points. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 23, 2022 Category: Cytology Source Type: research
Network-based toxicogenomic approach to explore oral benzo(a)pyrene exposure effect on respiratory system
ConclusionOur study suggested canonical pathways related to benzo(a)pyrene toxicity in the respiratory system and validated potential biomarkers in human lung cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 23, 2022 Category: Cytology Source Type: research
Hyaluronic acid suppresses the effect of di-(2-ethylhexyl) phthalate in HaCaT keratinocytes
ConclusionTherefore, our findings provide evidence that HMW-HA treatment involves the anti-inflammatory cell pathways that prevent or mitigate skin disorders caused by exposure to DEHP. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 22, 2022 Category: Cytology Source Type: research
Acute effects of 4-EA-NBOMe, 3, 4-DCMP, LY-2183240 and AB-CHFUPYCA on the excitability of rat cortical primary cultured neurons
ConclusionAcute treatment with PSs changed neural excitability as evidenced by the number of APs. Our data provide scientific evidence that acute PS exposure can affect the CNS. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 22, 2022 Category: Cytology Source Type: research
Network analysis to understand side effects of UVB on skin through transcriptomic approach
ConclusionThe analytical approach used in this study suggests that the regulation of gene expression by UVB light leads to skin diseases by changing the cellular processes of keratinocytes. This strategy can be applied to research to suggest mechanisms and biomarkers from a toxicological perspective. Although further functional studies on the modes of action for each factor are required, this study might help develop strategies for exploring UVB light-induced signaling networks through analyzing transcriptomic data. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 15, 2022 Category: Cytology Source Type: research
Correction to: Acetaldehyde induces tau phosphorylation via activation of p38 MAPK/JNK and ROS production
(Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 10, 2022 Category: Cytology Source Type: research
Normobaric hyperoxia re-sensitizes paclitaxel-resistant lung cancer cells
ConclusionIn summary, NBO increased cell death in lung cancer cells and promoted PTX re-sensitization in A549/PR cells through apoptosis and CHOP-mediated ER stress. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - March 4, 2022 Category: Cytology Source Type: research
Novel data archival system for multi-omics data of human exposure to harmful substances
ConclusionWe provide a brief account of multi-omics data repositories, the data processing method, and an analysis pipeline for the application of omics data. This data processing ability helps to comprehensively understand multi-omics data regarding harmful environmental substances. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 25, 2022 Category: Cytology Source Type: research
Hsa_circ_0070194 targets the miR-384/HDAC2 axis to enhance proliferation, cell cycle, migration and invasion of trophoblast cells
ConclusionThis study suggested that hsa_circ_0070194 facilitated trophoblast cell proliferation, cell cycle, migration and invasion by the miR-384/HDAC2 axis. Hsa_circ_0070194 might relieve PE progression in pregnancy women. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 17, 2022 Category: Cytology Source Type: research
