Circ_0003204 downregulation protected vascular smooth muscle cells from ox-LDL-induced injury by acting on miR-637/FOSL2 axis
ConclusionIn short, circ_0003204 was significantly upregulated in atherosclerotic samples, knockdown of circ_0003204 could inhibit ox-LDL-induced VSMCs injury by miR-637/FOSL2 axis, which might be an effective therapeutic target for AS. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 17, 2022 Category: Cytology Source Type: research
Evaluating the comparative MT1B, MT1F, MT1G, and MT1H expression in human pulmonary alveolar epithelial cells treated with polyhexamethylene guanidine-phosphate, chloromethylisothiazolinone/methylisothiazolinone, oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride, benzalkonium chloride, and sodium dichloroisocyanurate
ConclusionThe upregulation of MT1B, MT1F, MT1G, and MT1H in HPAEpiCs is a PHMG-p-specific response in pulmonary cells, and is not induced by CMIT/MIT, PGH, BKC, and NaDCC exposure. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 16, 2022 Category: Cytology Source Type: research
A cell model for evaluating mitochondrial damage in cardiomyocytes
ConclusionsContracting cells are more sensitive to bupivacaine toxicity and could be more accurately represent mitochondrial damage in vivo condition. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 16, 2022 Category: Cytology Source Type: research
Gene expression related to lung cancer altered by PHMG-p treatment in PBTE cells
ConclusionOur data show that PHMG-p induces genetic changes associated with SCC progression in PBTE cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 15, 2022 Category: Cytology Source Type: research
No association of prion protein gene (PRNP) polymorphisms with susceptibility to the pandemic 2009 swine flu
ConclusionsTo the best of our knowledge, this was the first evaluation of the association between PRNP polymorphisms and vulnerability to pandemic 2009 swine flu. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 12, 2022 Category: Cytology Source Type: research
The effects of dantrolene and 2-aminoethoxydiphenyl borate (2-APB) on arsenic-induced osteoporosis
ConclusionNaAsO2 can lead to osteoporosis in rats, dantrolene and 2-APB can reduce the degree of arsenic-induced osteoporosis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 7, 2022 Category: Cytology Source Type: research
The oxidative damage induced by lead sulfide nanoparticles in rat kidney
ConclusionsLead sulfide nanoparticles exposure can cause oxidative damage to rat kidney tissues. Compared with different particle sizes, lead sulfide nanoparticles group is obviously more serious than lead sulfide micron particles group. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 4, 2022 Category: Cytology Source Type: research
Shikonin alleviates testosterone-induced benign prostatic hyperplasia in rats via the Nrf2-ARE and NF- κB pathway
ConclusionOur data revealed that shikonin treatment had a beneficial effect on the inflammation response, apoptotic process, and oxidative stress of BPH via the Nrf2-ARE and NF- κB pathways. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 2, 2022 Category: Cytology Source Type: research
Identification of miRNA expression associated with Alzheimer ’s disease and neurodegeneration in rat models with obstructive sleep apnea
ConclusionOSA rat model with tongue hypertrophy showed neurodegenerative changes in brain and the epigenetic changes of mRNA/miRNA which have been known as AD-related genes. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 28, 2022 Category: Cytology Source Type: research
CTCF-mediated H3K27me3 enrichment on the LncRNA MALAT1 promoter regulates the cardiomyocytes from I/R-induced apoptosis through targeting miR-26b-5p
ConclusionsCTCF was highly expressed in H/R cardiomyocytes and I/R myocardial tissue and the silencing of CTCF-mediated H3K27me3 dissociating from the MALAT1 promoter to regulate cardiomyocytes survival and apoptosis by targeting miR-26b-5p. It provided a new therapeutic marker for myocardial I/R injury. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 27, 2022 Category: Cytology Source Type: research
The activation of Wnt signaling facilitates autophagy by modulating GSK-3 β-AMPK axis in atherosclerosis
ConclusionWnt3a activates AMPK through inhibiting GSK-3 β, thereby facilitating autophagy in AS. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 26, 2022 Category: Cytology Source Type: research
Single-cell transcriptomics to understand the cellular heterogeneity in toxicology
ConclusionThe most toxicological mechanism in organisms occurs through intramolecular combinations, and heterogeneity issues have reached a surmountable level. We hope this review provides insights to successfully conduct future studies on toxicology.Purpose of the reviewToxicogenomics is an interdisciplinary field between toxicology and genomics that was successfully applied to construct molecular profiles in a broad spectrum of toxicology. However, heterogeneity within samples makes toxicology studies challenging because the purity of target cell in the samples remains unknown until their actual utilisation. In this revi...
Source: Molecular and Cellular Toxicology - October 25, 2022 Category: Cytology Source Type: research
Diesel particulate matter aggravates cyclophosphamide-induced testicular toxicity in mice via elevating oxidative damage
ConclusionThese results suggest that DPM exposure exacerbates CP-induced testicular toxicity in mice, which might be attributable to the reduced antioxidant activity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 25, 2022 Category: Cytology Source Type: research
Identification of allergens in Acorus gramineus using protein analysis
ConclusionThis research made it possible to study allergen-causing proteins in herbal medicines. In addition, it can be used for various purposes, such as knowing and treating side effects and allergic reactions when prescribing various herbal medicines. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 24, 2022 Category: Cytology Source Type: research
In vitro application of redesigned vacuole extracted in yeast
ConclusionsYeast vacuole is being added with novel functions through artificial redesign and genetic engineering. Accordingly, it has drawn a great deal of attention in variety of fields. Therefore, yeast vacuole is expected to be applicable to many fields, and it will provide better opportunities as a new material, especially in fields that value biocompatibility.Purpose of the reviewRecently, the researchers have been revealed novel functions of vacuole in the yeastSaccharomyces cerevisiae, and their new functions are being emphasized through genetic engineering system and expression control mechanisms. Also, research is...
Source: Molecular and Cellular Toxicology - October 22, 2022 Category: Cytology Source Type: research
