Long non-coding RNA LINC01133 promotes the progression of pancreatic adenocarcinoma through miR-625
ConclusionsThe study confirmed that LINC01133 was up-regulated in PAAD, promoting the malignant process of PAAD by targeting miR-625. It may be a potential biomarker and therapeutic target of PAAD. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 29, 2021 Category: Cytology Source Type: research
Comparative toxicity of polyhexamethylene guanidine phosphate in three strains of rats
ConclusionThese results could potentially provide baseline data on the selection of experimental species for inhalation toxicity studies. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 27, 2021 Category: Cytology Source Type: research
Core fucosylation of maternal milk N-glycan prevents intestinal inflammation by regulating Treg/Th17 balance in infant gut microbiota
ConclusionThese findings indicated that core fucosylation of maternal milk N-glycan could assist the colonization of gut Lactobacillus and Bifidobacterium and regulate the Treg/Th17 balance, subsequently preventing intestinal inflammation in breast-fed newborns. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 23, 2021 Category: Cytology Source Type: research
Madecassic acid protects human periodontal ligament fibroblasts against hydrogen peroxide-induced cell damage by maintaining mitochondrial membrane potential
ConclusionsCollectively, these findings suggest that MA inhibits H2O2-induced oxidative stress and apoptosis of hPDLFs by reducing intracellular ROS production to maintain ΔΨm stability. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 20, 2021 Category: Cytology Source Type: research
Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency
ConclusionFurther studies regarding mRNA-structural elements and their optimization are needed to create new opportunities
for engineering mRNA vaccines. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 20, 2021 Category: Cytology Source Type: research
Protective effect of Acer palmatum Thunb. leaf extract on mice with steroid-induced ocular hypertension
ConclusionsTreatment with KIOM-2015E improved steroid-induced ocular hypertension. KIOM-2015E prevented retinal degeneration caused by increased ocular pressure by regulating protein levels and histological parameter expression in retina. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 20, 2021 Category: Cytology Source Type: research
Fatty acid-binding protein 5 activates cyclooxygenase-2 and promotes hypoxic injury in LO2 cells
ConclusionsFABP5 was shown to activate COX-2/PGE2 pathway and promote hypoxic injury in LO2 cells. FABP5 may be a potential target for the treatment of hypoxic liver injury. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 17, 2021 Category: Cytology Source Type: research
Platelet-derived exosomes promote the epithelial –mesenchymal transition in MCF7 cells
ConclusionIn conclusion, platelet-derived exosomes initiate EMT and promote the migration and invasiveness of MCF7 cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - September 3, 2021 Category: Cytology Source Type: research
microRNA-506-3p suppresses the proliferation of triple negative breast cancer cells via targeting SNAI2
ConclusionsThese results demonstrated the suppressive function of miR-506-3p in TNBC via targeting SNAI2, indicating the possible application of miR-506-3p in TNBC treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 25, 2021 Category: Cytology Source Type: research
Autophagy inhibition contributes to epigallocatechin-3-gallate-mediated apoptosis in papillary thyroid cancer cells
ConclusionTaken together, these results demonstrated that autophagy inhibition was beneficial to EGCG –mediated apoptosis in papillary thyroid cancer cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 25, 2021 Category: Cytology Source Type: research
USP38 protein alleviates neuroinflammation of cerebral ischemia –reperfusion injury via KDM5B expression
ConclusionOur data demonstrated that USP38 protein alleviates neuroinflammation of cerebral ischemia –reperfusion injury via KDM5B expression, as a novel therapy to counteract inflammation of CI–RI. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 23, 2021 Category: Cytology Source Type: research
Classification of advanced methods for evaluating neurotoxicity
AbstractPurpose of reviewAs fields such as neurotoxicity evaluation and neuro-related drug research are increasing in popularity, there is a demand for the expansion of neurotoxicity research. Currently, neurotoxicity is assessed by measuring changes in weight and behavior. However, measurement of such changes does not allow the detection of subtle and inconspicuous neurotoxicity. In this review, methods for advancing neurotoxicity research are divided into molecule-, cell-, circuit-, and animal model-based methods, and the results of previous studies assessing neurotoxicity are provided and discussed.Recent findingsIn com...
Source: Molecular and Cellular Toxicology - August 18, 2021 Category: Cytology Source Type: research
Hosta longipes inhibits melanogenesis by reducing expression of the melanocortin 1 receptor
ConclusionTaken together, the potential for antimelanogenesis by HLE will provide insight into the development of new skin-whitening products for photodamaged skin. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 18, 2021 Category: Cytology Source Type: research
Effect of combined therapy with camel milk-derived exosomes, tamoxifen, and hesperidin on breast cancer
ConclusionCotreatment with tamoxifen, hesperidin, and camel milk exosomes synergistically inhibited MCF7 proliferation, migration and minimized tamoxifen adverse effects. Therefore, exosomes and hesperidin could be utilized as safe adjuvants/vehicles to tamoxifen during breast cancer chemotherapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 18, 2021 Category: Cytology Source Type: research
Liver kinase B1 (LKB1) reduced inflammation and oxidative stress by regulating the AMPK/NLRP3 signaling pathway in LPS-induced lung injury
ConclusionTherefore, our results indicate that LKB1 reduced inflammation and oxidative stress by regulating the AMPK/NLRP3 signaling pathway in LPS-induced lung injury. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 17, 2021 Category: Cytology Source Type: research
