Jageum-Jung, the herbal pharmaceuticals, inhibits the hepatic fibrogenesis as mediated with TGF- β1/smad signaling
ConclusionsJGJ inhibits hepatic fibrogenesis and TGF- β1/Smad signaling. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 15, 2022 Category: Cytology Source Type: research
The antitumor effect of natural killer cells against hepatocellular carcinoma through CXCL9
ConclusionThese findings suggest that CXCL9 can directly induce NK cells to be recruited to HCC and activate NK cytotoxicity against HCC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - February 7, 2022 Category: Cytology Source Type: research
Correction to: Binding of silver nanowaste using jellyfish immune reaction extract and an assessment of aquatic toxicity
(Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 28, 2022 Category: Cytology Source Type: research
LRG1 expression reduced inflammation of sepsis-renal injury via activation of NLRP3 inflammasome by HIF-1 alpha
ConclusionsThe present study suggests that LRG1 expression reduced inflammation of sepsis-renal injury via activation of NLRP3 inflammasome by HIF-1 α, thereby may be a promising therapeutic target of sepsis-renal injury. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 26, 2022 Category: Cytology Source Type: research
High expression of ring finger protein 115 contributes to the progression of colorectal cancer via WNT/ β-catenin pathway
ConclusionRNF115 was highly expressed in human CRC tissues and cell lines and correlated with poor prognosis. RNF115 contributed to the growth of CRC cells via mediating cell cycle and colony formation, and also induced the apoptosis of CRC cells via targeting WNT/ β-catenin pathway. RNF115 could serve as a target for CRC treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 22, 2022 Category: Cytology Source Type: research
Antigrowth effects of Kaempferia parviflora extract enriched in anthocyanidins on human ovarian cancer cells through Ca2+-ROS overload and mitochondrial dysfunction
ConclusionCollectively, these results showed the anticancer effects ofKaempferia parviflora anthocyanidin extracts against the progression of ovarian cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 22, 2022 Category: Cytology Source Type: research
LGR4 protects PC12 against OGD/R-induced oxidative stress and apoptosis through activation of AKT/GSK3 β
ConclusionThe protective effect of LGR4 against OGD/R-induced oxidative stress and apoptosis in PC12 was mediated by activation of AKT/GSK3 β pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 21, 2022 Category: Cytology Source Type: research
Relationship between the levels of cord blood resistin, adiponectin, CD4 and CD8 and their influence on early neonatal outcomes
ConclusionThe level of cord blood resistin and adiponectin can measure fetal growth and development, and are closely related to neonatal early outcomes. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 21, 2022 Category: Cytology Source Type: research
Myricitrin exerts protective effect on retina in diabetic retinopathy via modulating oxidative stress expression of VEGF and apoptosis in experimental rats: a docking confirmation study
ConclusionsMCT could be a potential therapeutic molecule in treating diabetic retinopathy which could modulate glucose levels, oxidative stress and levels of VEGF in diabetic rats. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 20, 2022 Category: Cytology Source Type: research
Isofraxidin exerts anti-diabetic, antilipidemic, and antioxidant effects and protects renal tissues via inhibition of NF- ĸB in Streptozotocin-induced diabetic rats
ConclusionOur study demonstrated the substantial anti-diabetic, antilipidemic, and antioxidant effects of ISO, which protects renal tissues possibly via the inhibition of NF- ĸB in Streptozotocin-induced diabetic rats. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 20, 2022 Category: Cytology Source Type: research
Misoprostol alleviates paclitaxel-induced liver damage through its antioxidant and anti-apoptotic effects
ConclusionWhen the obtained data were evaluated, it was concluded that the combined use of PAX with MP could reduce the cytotoxic effects of PAX on normal liver tissue, allowing cancer treatment to be continued uninterrupted and effectively. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 20, 2022 Category: Cytology Source Type: research
Hydrochloric acid-treated Bacillus subtilis ghosts induce IL-1 beta, IL-6, and TNF-alpha in murine macrophage
ConclusionThese data suggest that the HCl-induced BSGs may be potentially safe and effective candidates for inactivated bacterial vaccines and/or immunostimulants. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 18, 2022 Category: Cytology Source Type: research
Polyphyllin I combined with doxorubicin shows chemosensitization effect in vivo and reduces immunotoxicity of doxorubicin
ConclusionOur study revealed that the PPI-sensitized chemotherapeutic effect, when used in safe doses, circumvents immunotoxic side effects of DOX in vivo; thus, helping future clinical research. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 13, 2022 Category: Cytology Source Type: research
USP18 alleviates neurotoxicity induced by sevoflurane via AKT and NF- κB pathways
ConclusionUSP18 was involved in the pathology of sevoflurane-induced neurotoxicity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 12, 2022 Category: Cytology Source Type: research
Sensitive-stage embryo irradiation affects embryonic neuroblasts and adult motor function
ConclusionEmbryonic NBs survived irradiation at doses as high as 40 Gy, while cells in other parts of the embryos underwent apoptosis at doses higher than 3 Gy within 2 h after treatment. Three hours after exposure to a minimum dose of 3 Gy, the number of NBs marked by Dpn and Klu decreased, and the surviving adults exhibited defects in locomotor ability. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 10, 2022 Category: Cytology Source Type: research
