Ferulic acid exhibits anti-inflammatory effects by inducing autophagy and blocking NLRP3 inflammasome activation
ConclusionIt is concluded that FA enhanced autophagy, inhibited the activation of NLRP3 inflammasome and reduced the expression and release of inflammatory factors. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 10, 2022 Category: Cytology Source Type: research
S-Adenosylmethionine enhances the inhibitory effect of gemcitabine against pancreatic cancer cells via suppression of the EGFR/AKT pathways
ConclusionBy suppressing the EGFR/AKT pathways, SAM could synergistically boost the inhibitory impact of gemcitabine on pancreatic cancer cells and might be a promising therapeutic drug for the management of pancreatic cancer. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 10, 2022 Category: Cytology Source Type: research
RNA interference-mediated knockdown of tripartite motif containing 44 suppresses cervical cancer growth in vitro and in vivo
ConclusionTaken together, TRIM44 is involved in tumorigenesis of cervical cancer and may represent a novel molecular target for cervical cancer prevention and therapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 10, 2022 Category: Cytology Source Type: research
FXYD3 promotes the proliferation, migration, and invasion of pancreatic cancer cells by regulating the cGMP-PKG signaling pathway
ConclusionOur study speculated that FXYD3 was likely to activate the cGMP-PKG signaling pathway to promote tumor proliferative activity. These findings contribute to understanding the role of FXYD3 in the development of pancreatic cancer and provide new therapeutic targets for its treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 8, 2022 Category: Cytology Source Type: research
Transcriptome dynamics in benzo[a]pyrene exposed Hydra
ConclusionWe successfully demonstrated the dynamic response ofHydra to BaP by exposure time at transcription level. The results could extend our knowledge on acute toxic effect of BaP at sublethal conditions. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 8, 2022 Category: Cytology Source Type: research
HOXA11-AS/miR-208-3p/ETS1 axis modulates osteogenic differentiation in bone marrow-derived mesenchymal stem cells
ConclusionWe therefore thought HOXA11-AS could serve as a promising target for the treatment of OP. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 6, 2022 Category: Cytology Source Type: research
LncRNA SNHG14 promoted inflammation of cerebral apoplexy by miR-124-3p/TRAF6 axis
ConclusionLncRNA SNHG14 plays a crucial role in inflammation of cerebral apoplexy by miR-124-3p/TRAF6 axis, thereby it may be a promising therapeutic target for cerebral apoplexy.Graphical abstract (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - January 5, 2022 Category: Cytology Source Type: research
Sample management: a primary critical starting point for successful omics studies
AbstractBiological samples collected from cohort studies are widely utilized in molecular genetic studies and are typically stored long term for future applications, such as omics analyses. The extent of sample availability is determined by proper sample handling, and it is of primary importance for successful omics studies. However, questions on whether samples in long-term storage are properly available for omics experiments has been raised, because the quality and availability of such samples remain unknown until their actual utilization. In that perspective, several guidelines for proper sample management have been sug...
Source: Molecular and Cellular Toxicology - January 4, 2022 Category: Cytology Source Type: research
Glycosidic flavonoids and their potential applications in cancer research: a review
AbstractPurpose of reviewEvery year, the cancer patient registry increases, and the leading cause of death in a global context. Plant-based molecules are gaining attention in cancer research due to the side effects of chemotherapy. A glycosidic derivative of flavonoid (GDF) plays a significant role in cancer proliferation mechanisms. GDF inhibits cell proliferation by elevating the expression of apoptotic proteins, altering the expression of nuclear factor-kappa B (NF- κB), and decreasing mitochondrial membrane potential (Δψm) in cancer cells.Recent findingsReported studies on the flavonoids orientin, vitexin, prunetion...
Source: Molecular and Cellular Toxicology - December 22, 2021 Category: Cytology Source Type: research
Antioxidant and apoptotic activity of cocoa bean husk extract on prostate cancer cells
ConclusionCBH, a by-product of cocoa processing, contains large amounts of phenolic compounds and exhibits high antioxidant activity and anticancer effects on prostate cancer cells. CBH has potential applications as a functional food material. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 30, 2021 Category: Cytology Source Type: research
Pratensein glycoside attenuates respiratory syncytial virus infection-induced oxidative and inflammatory injury via TGF- β signaling pathway
ConclusionsPG attenuated RSV infection-induced oxidative stress and inflammation through inhibiting the TGF- β signaling pathway. This study provides evidence for the application of traditional Chinese herbal medicine in the treatment of viral infection. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 29, 2021 Category: Cytology Source Type: research
Esculentoside A exerts anti-oxidative stress and anti-apoptotic effects in rat experimental membranous nephropathy by regulating MAPK pathway
ConclusionThe renoprotective effects of Esculentoside A on a rat model with membranous nephropathy was mediated by its anti-oxidant and anti-apoptotic effects through inactivation of MAPKs pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 26, 2021 Category: Cytology Source Type: research
Binding of silver nanowaste using jellyfish immune reaction extract and an assessment of aquatic toxicity
ConclusionJEIs captured Ag-citrate NPs and AgN-PVP and reduced their nano-toxicity. The BJEI extraction method resulted in lower toxicity for zebrafish embryogenesis, as copmared to that with AJEI. JEI has antibacterial effects; however, information on the specific targets of the antibacterial materials is scarce. JEI did not accumulate or persist since it is a reaction material from the jellyfish and degraded in aquatic environments. Therefore, BJEI can be a promising material for removing AgNPs from aquatic ecosystems. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 25, 2021 Category: Cytology Source Type: research
Knockdown of hsa_circ_0001964 inhibits hepatocellular carcinoma cell proliferation by inactivating PI3K/AKT signaling pathway
ConclusionThe results of the present study suggested that hsa_circ_0001964 may correlate with HBV infection, and it promotes HCC carcinogenesis via the PI3K/AKT signaling pathway. The findings of the present study provide important insights into the molecular mechanisms of HCC initiation, which may help to develop new treatment strategies against HCC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 23, 2021 Category: Cytology Source Type: research
Tissue-specific DNA damage response in Mouse Whole-body irradiation
ConclusionThese results suggest that each tissue has a preferable repair mechanism in response to γ-irradiation. Therefore, the understanding and application of tissue-specific DNA damage responses could improve the clinical approach of radiotherapy for treating specific cancers. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 19, 2021 Category: Cytology Source Type: research
