Intestine epithelial cell-derived extracellular vesicles alleviate inflammation induced by Clostridioides difficile TcdB through the activity of TGF- β1
ConclusionFor the first time, our study demonstrated that I-Evs originated from intestine epithelial cells can alleviate inflammation induced byC. difficile TcdB both in vitro and in vivo. Therefore, I-Evs might be potentially a novel endogenous candidate for effective treatment of CDI. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 30, 2022 Category: Cytology Source Type: research
Anticancer activity of herbal formula Jisilhaebaekgyeji-Tang against human breast cancer cells and its mechanism
ConclusionThe results suggest that the JHG extract exerts potent anticancer effects and that these effects may be due to the inhibition of ER α and the induction of intrinsic pathway-mediated apoptosis in MCF-7 cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 27, 2022 Category: Cytology Source Type: research
3-Hydroxymorphinan protects against hypoxia-induced cell death in primary astrocyte by regulating Ca2+ influx and the glutamate homeostasis
ConclusionTaken together, these results suggest that 3-HM has a potential to regulate glutamate release from the astrocytic cell death in hypoxic condition and could be used as a promising preventive or therapeutic agent for ischemic brain injury. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 27, 2022 Category: Cytology Source Type: research
Hsa_circ_0011292 regulates paclitaxel resistance partially through regulating CDCA4 expression by serving as a miR-3619-5p sponge in non-small cell lung cancer
ConclusionsCirc_0011292 facilitates PTX resistance in NSCLC partially through the miR-3619-5p/CDCA4 pathway, highlighting a new mechanism responsible for PTX resistance in NSCLC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 22, 2022 Category: Cytology Source Type: research
MiR-370-3p aggravates blood –brain barrier injury and neuron apoptosis by targeting SMURF1 to activate the TLR4/MyD88/NF-κB signaling in sepsis-associated encephalopathy
ConclusionMiR-370-3p aggravates BBB disruption and neuron apoptosis by targeting SMURF1 to activate the TLR4/MyD88/NF- κB signaling in SAE. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 22, 2022 Category: Cytology Source Type: research
Osteopontin promotes microglia activation and aggravates neuromyelitis optica via interferon-gamma/nuclear factor kappa B/interleukin-12 signaling
ConclusionOPN promotes microglia activation and facilitates the pathogenesis of NMO by activating the IFN- γ/NF-kB/IL-12 signaling pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 22, 2022 Category: Cytology Source Type: research
Analysis of the effect of Rhodopseudomonas palustris on the lead exposure rat model using 1H-NMR-based metabolomics of urine and plasma
ConclusionThe effects of removing lead ions ofR. palustris in rats with lead exposure were confirmed. This research demonstrated that1H-NMR-based metabolomics was a promising tool to identify potential biomarkers and unravel protective effect mechanisms ofR. palustris in lead poisoning rats. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 20, 2022 Category: Cytology Source Type: research
EPS8L3 suppresses apoptosis and autophagy of gastric cancer through PI3K/AKT/mTOR signaling
ConclusionEPS8L3 functioned as an oncogene in GC through suppression of cell apoptosis and autophagy via activation of PI3K/AKT/mTOR signaling. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 14, 2022 Category: Cytology Source Type: research
Transcriptional responses in Ecklonia cava to short-term exposure to polycyclic aromatic hydrocarbons
ConclusionThis study demonstrated the discovery of DEGs inE. cava that may be impacted by environmental PAHs, as well as predicted how the transcript levels would affect physiology and metabolism. Such results will contribute to a better understanding of how seaweed reacts to pollution. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 11, 2022 Category: Cytology Source Type: research
Mitochondrial dysfunction is underlying fluoroquinolone toxicity: an integrated mitochondrial toxicity assessment
ConclusionThis study exemplifies an integrated/holistic approach with a selected battery/panel of in vitro assays/endpoints serving to identify mitochondrial toxicity early on in the development of drugs, in particular, antibiotics. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 5, 2022 Category: Cytology Source Type: research
CRISPR-Cas9-generated mouse model of neurofibromatosis type 1
ConclusionOur study showed that the CRISPR-Cas9 embryo editing method is an efficient tool for creatingNF1 heterozygous (NF1+/ −) animal model. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 27, 2022 Category: Cytology Source Type: research
Omentin-1 ameliorates oxidative stress in model of diabetic ophthalmopathy via the promotion of AMPK function
ConclusionThese findings indicate that Omentin-1 Ameliorates oxidative stress in the model of diabetic ophthalmopathy via the promotion of AMPK function. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 27, 2022 Category: Cytology Source Type: research
Correction to: Network analysis to understand side effects of UVB on skin through transcriptomic approach
AbstractDue to an unfortunate oversight during the e.proofing process the article note has been given erroneously. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 27, 2022 Category: Cytology Source Type: research
Amphiregulin secreted by cartilage endplate stem cells inhibits intervertebral disk degeneration and TNF- α production via PI3K/AKT and ERK1/2 signaling pathways
ConclusionECSCs reduce NPC apoptosis, oxidative stress, production of inflammatory factors, and fibrotic response via the release of Areg. Moreover, Areg can exert these protective effects on NPCs via PI3K/AKT and ERK1/2 signaling pathways. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 21, 2022 Category: Cytology Source Type: research
FoxM1 contributes to progestin resistance and epithelial-to-mesenchymal transition in endometrial carcinoma
ConclusionThese findings indicated the role of FoxM1 in the MPA resistance of EC. Down-regulated FoxM1 expression might be a potential strategy for overcoming MPA resistance. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - June 21, 2022 Category: Cytology Source Type: research
