Impact of diesel particulate matter on the olfactory bulb of mice: insights from behavioral, histological, and molecular assessments
ConclusionOur findings suggest a plausible association between DPM-induced olfactory dysfunction and disruptions in a range of molecular pathways. This hypothesis is supported by observed alterations in gene expression and the presence of mild neuroinflammation, primarily driven by microglial activation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - December 1, 2023 Category: Cytology Source Type: research
Silibinin alleviates DNA damage, mitochondrial dysfunction, and apoptosis caused by oxidative stress in human retinal pigment epithelial cells
ConclusionThese findings imply that silibinin has potent ROS scavenging activity with the potential to protect against oxidative stress-mediated ocular diseases. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 25, 2023 Category: Cytology Source Type: research
Circ_101692 promotes the proliferation, invasion and glycolysis of colorectal cancer through the regulation of miR-449b-5p/GOLPH3 axis
ConclusionOur results showed that circ_101692 promoted CRC progression by modulating the miR-449b-5p/GOLPH3 axis, implying that circ_101692 might be a possible target for CRC treatment.Graphical abstract (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 24, 2023 Category: Cytology Source Type: research
Heme oxygenase-1 mediates the inhibitory effect of ginseng (Panax ginseng) leaf extract on differentiation in 3T3-L1 adipocytes
ConclusionsOverall, our results suggest that GLE inhibits the differentiation of 3T3-L1 preadipocytes by regulating HO-1 expression and Wnt/ β-catenin signaling. Therefore, GLE could have preventive uses as a natural product for the treatment of obesity. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 20, 2023 Category: Cytology Source Type: research
Neuregulin-1 suppresses anti-apoptotic effect of Der p 38 on neutrophils by inhibition of cytokine secretion
ConclusionNRG-1 may exhibit anti-inflammatory effects in a Der p 38-induced allergenic environment, particularly neutrophilic inflammation. The present study on NRG may open up approach opportunities for understanding of pathogenesis and treatment of asthma. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 14, 2023 Category: Cytology Source Type: research
Claudin-5 overexpression correlates with proliferation and migration in gastric cancer
ConclusionClaudin-5 overexpression expedited GC cells proliferation, migration and invasion, but repressed GC cells apoptosis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 11, 2023 Category: Cytology Source Type: research
HDAC3 deacetylates H3K27ac and H3K9ac on the TrkC promoter to exacerbate sevoflurane-induced neurotoxicity
ConclusionHDAC3 enhanced Sev-induced neurotoxicity by reducing H3K27ac and H3K9ac to repress TrkC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 9, 2023 Category: Cytology Source Type: research
Alveolar damage and development of emphysema in rats with carbon monoxide poisoning
ConclusionThis is the first study to demonstrate the long-term effects and emphysematous changes in CO-poisoned lung models. We recommend long-term monitoring following CO poisoning. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 4, 2023 Category: Cytology Source Type: research
Role of CREB1 dysregulation in calcium oxalate monohydrate crystals-induced tubular epithelial cell injury
ConclusionsCREB1 repressed MLKL expression to attenuate COM-induced RTEC injury, suggesting that CREB1 may be a therapeutic target for kidney stone disease. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - November 2, 2023 Category: Cytology Source Type: research
Carcinogenicity assessment of industrial chemicals 1,2-dichlorobenzene, 2-methoxyethanol and anisol via Bhas 42 cell transformation assay
ConclusionAnisol, 2-methoxyethanol, and 1,2-dichlorobenzene do not exert nongenotoxic carcinogenicity or methylation-related epigenetic changes. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 17, 2023 Category: Cytology Source Type: research
Fucoidan ameliorates amyloid- β 42 oligomer-induced neuronal apoptosis by activating the PI3K/Akt signaling pathway and MAPK cascades in human neuroblastoma SH-SY5Y cells
ConclusionThis study proposes fucoidan as a potential therapeutic candidate for AD treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 15, 2023 Category: Cytology Source Type: research
Scallop-derived plasmalogen attenuates amyloid beta-induced inflammation and apoptosis in SH-SY5Y cells
ConclusionOur study indicates that SPL would reduce A β-induced neurotoxicity associated with inflammation and apoptosis in human neuroblastoma cells. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 15, 2023 Category: Cytology Source Type: research
SEC61G knockdown enhances the sensitivity of gastric cancer cells to etoposide through EGFR and glycolytic-mediated pathways
ConclusionsSEC61G knockdown weakened the proliferation, EGFR phosphorylation and glycolysis of gastric cancer cells, as well as increased the sensitivity of gastric cancer to etoposide, which make SEC61G a promising therapeutic target for gastric cancer treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 14, 2023 Category: Cytology Source Type: research
LncRNA-SNHG3 promotes neuroinflammation post-intracerebral hemorrhage by regulating the miR-106b-5p/TXNIP axis
ConclusionCompetitive binding of lncRNA-SNHG3 to miR-106b-5p resulted in the upregulation of TXNIP, consequently inducing neuroinflammation and exacerbating ICH-induced damage. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 13, 2023 Category: Cytology Source Type: research
miR-20b-5p exerts protective effects against experimental autoimmune encephalomyelitis in mice by inhibiting NLRP3 transcription and NLRP3/ASC/caspase-1 axis activation
ConclusionmiR-20b-5p exerted a protective effect on EAE in mice by inhibiting NLRP3 transcription and NLRP3/ASC/caspase-1 pathway activation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - October 13, 2023 Category: Cytology Source Type: research
