SSX2IP as a novel prognosis biomarker plays an important role in the development of breast cancer
ConclusionThese data indicated that SSX2IP promotes tumor progression in BC, include cell activity, proliferation, migratory and invasive, clone formation abilities were inhibited, and the cell apoptosis increased. This work further suggest that SSX2IP could be used to be a potential therapeutic targets in BC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 31, 2022 Category: Cytology Source Type: research
Oleuropein induces apoptosis in colorectal tumor spheres via mitochondrial fission
ConclusionThese findings showed the suppressive effects of OLP against the colorectal tumor spheres and 5-FU-resistant cells. In addition, these results offer the new insights into novel therapeutic strategies for combining 5-FU and OLP in patients with chemo-resistant CRC. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 29, 2022 Category: Cytology Source Type: research
KLF9 promotes autophagy and apoptosis in T-cell acute lymphoblastic leukemia cells by inhibiting AKT/mTOR signaling pathway
ConclusionKLF9 suppressed viability and promoted autophagy as well as apoptosis in T-ALL cells by inhibiting AKT/mTOR pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 23, 2022 Category: Cytology Source Type: research
MicroRNA-5582-3p alleviates the progression of osteosarcoma via targeting FZD4
ConclusionsOur findings uncovered the novel anti-cancer potency of miR-5582-3p in OS via repressing FZD4, suggesting the possibility of miR-5582-3p as a therapeutic target of OS. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 22, 2022 Category: Cytology Source Type: research
Beta-naphthoflavone increases the differentiation of osteoblasts and suppresses adipogenesis in human adipose derived stem cells involving STAT3 pathway
ConclusionBNF treatment resulted in increased differentiation of osteoblast of hASCs by targeting STAT3 pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 22, 2022 Category: Cytology Source Type: research
LncRNA PVT1 upregulates FBN1 by sponging miR-30b-5p to aggravate pulpitis
ConclusionPVT1 expedited the improvement of pulpitis via miR-30b-5p/FBN1.Article highlightsThe expression of PVT1 was upregulated in pulpitis.Silencing PVT1 enhanced cell proliferation and cell vitality, whereas inhibited cell inflammatory reaction in HDPFs.PVT1 expedited pulpitis via miR-30b-5p.MiR-30b-5p impeded pulpitis by targeting FBN1. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 22, 2022 Category: Cytology Source Type: research
MiR-601 inhibited small cell lung cancer progression by modulating SIRT1
ConclusionOur data documented the tumor-suppressive function of miR-601 in SCLC via targeting SIRT1, suggesting miR-601 as a new potential therapeutic approach for SCLC treatment. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 18, 2022 Category: Cytology Source Type: research
Comparative RNA-seq analysis and ceRNA network of genistein-treated GT1-7 neurons
ConclusionResults from the study could provide potential targets of both mRNA and non-coding RNAs for further studies to explore the endocrine-interfering effects of genistein. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 17, 2022 Category: Cytology Source Type: research
Integrated analysis of miRNA and mRNA expression profiles in diabetic mouse kidney treated to Korean Red Ginseng
ConclusionOur data suggest that KRG may regulate miRNA and gene expression in a way that relieves diabetic nephropathy in mice. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 8, 2022 Category: Cytology Source Type: research
CircBLNK regulates tumor proliferation and apoptosis by miR-578/ING5 axis in non-small cell lung cancer
ConclusionCircBLNK functioned as a tumor suppressor in NSCLC to suppress the proliferation and cell cycle and promote cell apoptosis of NSCLC cells through miR-578/ING5 axis. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 5, 2022 Category: Cytology Source Type: research
Iridin abrogates LPS-induced inflammation in L6 skeletal muscle cells by inhibiting NF- κB and MAPK signaling pathway
ConclusionThe results showed that iridin inhibited the phosphorylation of NF- κB and MAPK proteins and inflammatory cytokines COX-2 and iNOS in LPS-induced L6 cells. Based on findings in this work, iridin possesses anti-inflammatory action on L6 cells and could be considered for an attractive candidate for anti-inflammation. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 5, 2022 Category: Cytology Source Type: research
FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated cervical cancer by inactivating the LKB1/AMPK pathway
ConclusionThis research hinted that FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated CC by inactivating the LKB1/AMPK pathway. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 4, 2022 Category: Cytology Source Type: research
Concurrent upregulation of immune checkpoint molecule genes in colorectal cancer
ConclusionColorectal cancers more commonly express multiple immune checkpoint molecules simultaneously than single molecules. This suggests that blocking multiple immune checkpoint pathways may serve as a potential strategy for immunotherapy. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 4, 2022 Category: Cytology Source Type: research
Correction to: Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways
(Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - August 3, 2022 Category: Cytology Source Type: research
NEAT1 promotes keratinocyte migration and proliferation during wound healing by regulating miR-26a-5p/LGR4 axis
ConclusionNEAT1/miR-26a-5p/LGR4 network is an important participant in TGF- β1-mediated keratinocyte proliferation and migration, which provides a novel perspective for understanding the cellular behavior and related molecular events in re-epithelialization. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 30, 2022 Category: Cytology Source Type: research
