Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways

ConclusionIntracellular JNK/ERK pathways were involved in chondrocyte apoptosis induced by SNP through oppositely regulated effects on cytoskeletal proteins; ERK pathway protected cytoskeletal protein from dissolution via inhibition of caspase-3 activation, while JNK pathway promoted the dissolution via activation of caspase-3 activity.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research