Acetaldehyde induces tau phosphorylation via activation of p38 MAPK/JNK and ROS production

ConclusionThe result indicated that acetaldehyde treatment increased tau phosphorylation in neuronal cells. Therefore, the accumulation of acetaldehyde resulted from alcohol abuse or defect of acetaldehyde detoxification may promote tau pathology in neurodegenerative diseases such as AD.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research