Synthesis, biological evaluation and mechanism studies of C-3 substituted nitrogenous heterocyclic 23-Hydroxybetulinic acid derivatives as anticancer agents
Fitoterapia. 2022 May 23:105222. doi: 10.1016/j.fitote.2022.105222. Online ahead of print.ABSTRACTA series of novel nitrogenous heterocycle substituted 23-Hydroxybetulinic acid (23-HBA) derivatives with amide linkages at the C-3 position were designed, synthesized and evaluated for their antitumor activities. The biological screening results showed that most of the derivatives exhibited more potent antiproliferative activities than 23-HBA. In particular compound II-9 exhibited the most potent activities with IC50 values ranging from 1.96 μM to 6.20 μM against five cancer cell lines (B16, HepG2, A2780, MCF-7 and A549). Th...
Source: Fitoterapia - May 26, 2022 Category: Biochemistry Authors: Haipin Zhou Huajian Zhu Yuxin Zha Jinyi Xu Tingfang Wang Shengtao Xu Source Type: research

Glucosyloxybenzyl 2-isobutylmalates and phenolic glycosides from the flowers of Bletilla striata
Fitoterapia. 2022 May 16;160:105220. doi: 10.1016/j.fitote.2022.105220. Online ahead of print.ABSTRACTFour previously undescribed compounds, including three glucosyloxybenzyl 2-isobutylmalates (1-3), one phenolic glycoside (4), along with ten known compounds were isolated from the flowers of Bletilla striata. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, and acid hydrolysis experiment. Cytotoxicity of the isolated compounds against A549, HCT-116, and SW1990 cells and protective effects of t-BHP-induced L02 cytotoxi...
Source: Fitoterapia - May 19, 2022 Category: Biochemistry Authors: Yi-Ke Fang Zhi-Mei Shang Guo-Qing Sun Mao-Sheng Zhang Gang Wang De-Lin Xu Yan Zhou Cheng-Xin Sun Shi-Ji Xiao Source Type: research

Glucosyloxybenzyl 2-isobutylmalates and phenolic glycosides from the flowers of Bletilla striata
Fitoterapia. 2022 May 16;160:105220. doi: 10.1016/j.fitote.2022.105220. Online ahead of print.ABSTRACTFour previously undescribed compounds, including three glucosyloxybenzyl 2-isobutylmalates (1-3), one phenolic glycoside (4), along with ten known compounds were isolated from the flowers of Bletilla striata. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, and acid hydrolysis experiment. Cytotoxicity of the isolated compounds against A549, HCT-116, and SW1990 cells and protective effects of t-BHP-induced L02 cytotoxi...
Source: Fitoterapia - May 19, 2022 Category: Biochemistry Authors: Yi-Ke Fang Zhi-Mei Shang Guo-Qing Sun Mao-Sheng Zhang Gang Wang De-Lin Xu Yan Zhou Cheng-Xin Sun Shi-Ji Xiao Source Type: research

Glucosyloxybenzyl 2-isobutylmalates and phenolic glycosides from the flowers of Bletilla striata
Fitoterapia. 2022 May 16;160:105220. doi: 10.1016/j.fitote.2022.105220. Online ahead of print.ABSTRACTFour previously undescribed compounds, including three glucosyloxybenzyl 2-isobutylmalates (1-3), one phenolic glycoside (4), along with ten known compounds were isolated from the flowers of Bletilla striata. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, and acid hydrolysis experiment. Cytotoxicity of the isolated compounds against A549, HCT-116, and SW1990 cells and protective effects of t-BHP-induced L02 cytotoxi...
Source: Fitoterapia - May 19, 2022 Category: Biochemistry Authors: Yi-Ke Fang Zhi-Mei Shang Guo-Qing Sun Mao-Sheng Zhang Gang Wang De-Lin Xu Yan Zhou Cheng-Xin Sun Shi-Ji Xiao Source Type: research

Glucosyloxybenzyl 2-isobutylmalates and phenolic glycosides from the flowers of Bletilla striata
Fitoterapia. 2022 May 16;160:105220. doi: 10.1016/j.fitote.2022.105220. Online ahead of print.ABSTRACTFour previously undescribed compounds, including three glucosyloxybenzyl 2-isobutylmalates (1-3), one phenolic glycoside (4), along with ten known compounds were isolated from the flowers of Bletilla striata. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, and acid hydrolysis experiment. Cytotoxicity of the isolated compounds against A549, HCT-116, and SW1990 cells and protective effects of t-BHP-induced L02 cytotoxi...
Source: Fitoterapia - May 19, 2022 Category: Biochemistry Authors: Yi-Ke Fang Zhi-Mei Shang Guo-Qing Sun Mao-Sheng Zhang Gang Wang De-Lin Xu Yan Zhou Cheng-Xin Sun Shi-Ji Xiao Source Type: research

Glucosyloxybenzyl 2-isobutylmalates and phenolic glycosides from the flowers of Bletilla striata
Fitoterapia. 2022 May 16:105220. doi: 10.1016/j.fitote.2022.105220. Online ahead of print.ABSTRACTFour previously undescribed compounds, including three glucosyloxybenzyl 2-isobutylmalates (1-3), one phenolic glycoside (4), along with ten known compounds were isolated from the flowers of Bletilla striata. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, and acid hydrolysis experiment. Cytotoxicity of the isolated compounds against A549, HCT-116, and SW1990 cells and protective effects of t-BHP-induced L02 cytotoxic we...
Source: Fitoterapia - May 19, 2022 Category: Biochemistry Authors: Yi-Ke Fang Zhi-Mei Shang Guo-Qing Sun Mao-Sheng Zhang Gang Wang De-Lin Xu Min-Jian Dong Cheng-Xin Sun Shi-Ji Xiao Source Type: research

Glucosyloxybenzyl 2-isobutylmalates and phenolic glycosides from the flowers of Bletilla striata
Fitoterapia. 2022 May 16:105220. doi: 10.1016/j.fitote.2022.105220. Online ahead of print.ABSTRACTFour previously undescribed compounds, including three glucosyloxybenzyl 2-isobutylmalates (1-3), one phenolic glycoside (4), along with ten known compounds were isolated from the flowers of Bletilla striata. The structures and absolute configurations of the undescribed compounds were elucidated on the basis of HR-ESIMS, NMR spectroscopy, optical rotation value, and acid hydrolysis experiment. Cytotoxicity of the isolated compounds against A549, HCT-116, and SW1990 cells and protective effects of t-BHP-induced L02 cytotoxic we...
Source: Fitoterapia - May 19, 2022 Category: Biochemistry Authors: Yi-Ke Fang Zhi-Mei Shang Guo-Qing Sun Mao-Sheng Zhang Gang Wang De-Lin Xu Min-Jian Dong Cheng-Xin Sun Shi-Ji Xiao Source Type: research

( ±)-Hyperpyran A: Terpenoid-based bicyclic dihydropyran enantiomers with hypoglycemic activity from Hypericum perforatum (St. John's wort)
Fitoterapia. 2022 May 15:105221. doi: 10.1016/j.fitote.2022.105221. Online ahead of print.ABSTRACT(±)-Hyperpyran A (1a/1b), a pair of new terpenoid-based bicyclic dihydropyran enantiomers, were isolated from the aerial parts of Hypericum perforatum (St. John's wort). Their structures and absolute configurations were elucidated by NMR spectroscopic analyses, ECD comparison, and X-ray crystal diffraction. Compounds 1a/1b possess hexahydrocyclopenta[c]pyran ring system and a plausible biosynthetic pathway was also proposed. In addition, compound 1a exhibited a moderate promotion of glucose uptake activity in hepatocytes.PMID...
Source: Fitoterapia - May 18, 2022 Category: Biochemistry Authors: Xuebing Zhao Yi Guo Qianqian Xu Zhengyi Shi Ming Xiang Hua Li Yanyan Wang Changxing Qi Yonghui Zhang Source Type: research

( ±)-Hyperpyran A: Terpenoid-based bicyclic dihydropyran enantiomers with hypoglycemic activity from Hypericum perforatum (St. John's wort)
Fitoterapia. 2022 May 15:105221. doi: 10.1016/j.fitote.2022.105221. Online ahead of print.ABSTRACT(±)-Hyperpyran A (1a/1b), a pair of new terpenoid-based bicyclic dihydropyran enantiomers, were isolated from the aerial parts of Hypericum perforatum (St. John's wort). Their structures and absolute configurations were elucidated by NMR spectroscopic analyses, ECD comparison, and X-ray crystal diffraction. Compounds 1a/1b possess hexahydrocyclopenta[c]pyran ring system and a plausible biosynthetic pathway was also proposed. In addition, compound 1a exhibited a moderate promotion of glucose uptake activity in hepatocytes.PMID...
Source: Fitoterapia - May 18, 2022 Category: Biochemistry Authors: Xuebing Zhao Yi Guo Qianqian Xu Zhengyi Shi Ming Xiang Hua Li Yanyan Wang Changxing Qi Yonghui Zhang Source Type: research

Synthesis and biological evaluation of scutellarein derivatives as neuroprotective agents via activating Nrf2/HO-1 pathway
Fitoterapia. 2022 May 12:105207. doi: 10.1016/j.fitote.2022.105207. Online ahead of print.ABSTRACTOxidative stress has been considered as the main factor of neurodegenerative diseases. Activation of the Nrf2/HO-1 pathway, as one of the most crucial endogenous protection systems, was regarded as an effective strategy to against oxidative injury. Here, a series of phosphate esters or phosphonates of scutellarein derivatives were designed, synthesized and evaluated on SH-SY5Y cell lines to examine neuroprotective effects against H2O2 induced damage. Among them, compound 16d exhibited more potent cytoprotective effect than the...
Source: Fitoterapia - May 15, 2022 Category: Biochemistry Authors: Tong Han Shuang Zhang Renyue Wei Guiyan Jia Bin Wang Qinghui Xu Jingwen Su Chunyu Jiang Chenghao Jin Source Type: research

Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida
Fitoterapia. 2022 May 12:105216. doi: 10.1016/j.fitote.2022.105216. Online ahead of print.ABSTRACTSeven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated ...
Source: Fitoterapia - May 15, 2022 Category: Biochemistry Authors: Ben-Song Xin Peng Zhao Shu-Yan Qin Guo-Dong Yao Xiao-Xiao Huang Shao-Jiang Song Source Type: research

Synthesis and biological evaluation of scutellarein derivatives as neuroprotective agents via activating Nrf2/HO-1 pathway
Fitoterapia. 2022 May 12:105207. doi: 10.1016/j.fitote.2022.105207. Online ahead of print.ABSTRACTOxidative stress has been considered as the main factor of neurodegenerative diseases. Activation of the Nrf2/HO-1 pathway, as one of the most crucial endogenous protection systems, was regarded as an effective strategy to against oxidative injury. Here, a series of phosphate esters or phosphonates of scutellarein derivatives were designed, synthesized and evaluated on SH-SY5Y cell lines to examine neuroprotective effects against H2O2 induced damage. Among them, compound 16d exhibited more potent cytoprotective effect than the...
Source: Fitoterapia - May 15, 2022 Category: Biochemistry Authors: Tong Han Shuang Zhang Renyue Wei Guiyan Jia Bin Wang Qinghui Xu Jingwen Su Chunyu Jiang Chenghao Jin Source Type: research

Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida
Fitoterapia. 2022 May 12:105216. doi: 10.1016/j.fitote.2022.105216. Online ahead of print.ABSTRACTSeven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated ...
Source: Fitoterapia - May 15, 2022 Category: Biochemistry Authors: Ben-Song Xin Peng Zhao Shu-Yan Qin Guo-Dong Yao Xiao-Xiao Huang Shao-Jiang Song Source Type: research

Synthesis and biological evaluation of scutellarein derivatives as neuroprotective agents via activating Nrf2/HO-1 pathway
Fitoterapia. 2022 May 12:105207. doi: 10.1016/j.fitote.2022.105207. Online ahead of print.ABSTRACTOxidative stress has been considered as the main factor of neurodegenerative diseases. Activation of the Nrf2/HO-1 pathway, as one of the most crucial endogenous protection systems, was regarded as an effective strategy to against oxidative injury. Here, a series of phosphate esters or phosphonates of scutellarein derivatives were designed, synthesized and evaluated on SH-SY5Y cell lines to examine neuroprotective effects against H2O2 induced damage. Among them, compound 16d exhibited more potent cytoprotective effect than the...
Source: Fitoterapia - May 15, 2022 Category: Biochemistry Authors: Tong Han Shuang Zhang Renyue Wei Guiyan Jia Bin Wang Qinghui Xu Jingwen Su Chunyu Jiang Chenghao Jin Source Type: research

Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida
Fitoterapia. 2022 May 12:105216. doi: 10.1016/j.fitote.2022.105216. Online ahead of print.ABSTRACTSeven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated ...
Source: Fitoterapia - May 15, 2022 Category: Biochemistry Authors: Ben-Song Xin Peng Zhao Shu-Yan Qin Guo-Dong Yao Xiao-Xiao Huang Shao-Jiang Song Source Type: research