Four sulfur-containing compounds with effect from marine-derived fungus aspergillus terreus
In this study, four previously undescribed sulfur-containing compounds asperteretals L and M, terreins A and B, together with 17 known compounds were obtained from a culture of marine fungus A. terreus supplemented with inorganic sulfur source Na2SO4. Their planar structures and absolute configurations were elucidated by NMR, HRESIMS, and ECD experiments. The in vitro cytotoxicities of compounds 1-21 against HCT-116 and Caco-2 were evaluated by SRB assay. Asperteretal M (2) exhibited activity against HCT-116 with the IC50 value at 30 μM. The antiproliferative effect of asperteretal M was confirmed by colony formation assa...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Guang-Yu Zhang Bei-Jia Liu Hui-Lin Pan Hou-Jin Li Zi-Feng Huang Taifo Mahmud Wen-Zhe Ma Wen-Jian Lan Source Type: research
Anti-inflammatory monomeric sorbicillinoids from the marine-fish- derived fungus Trichoderma sp. G13
Fitoterapia. 2024 Apr 15:105963. doi: 10.1016/j.fitote.2024.105963. Online ahead of print.ABSTRACTFour new monomeric sorbicillinoids, trichillinoids A - D (1-4), along with two known dimeric sorbicillinoids (5 and 6), and five known monomeric sorbicillinoids (7-11), were obtained from the marine-fish-derived fungus Trichoderma sp. G13. They were structurally characterized on the basis of comprehensive spectroscopic investigations (NMR, HRESIMS, and ECD). Compounds 1-4 displayed moderate anti-inflammatory activities, according to inhibiting the production of NO in RAW264.7 cells activated with IC50 values ranging from 14 to...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yuhan Zhang Yi Zhang Gang Li Kemin Dong Jialing Wang Shengjia Xiao Hongxiang Lou Xiaoping Peng Source Type: research
Four lathyrane diterpenoids from the seeds of Euphorbia lathyris
Fitoterapia. 2024 Apr 15:105965. doi: 10.1016/j.fitote.2024.105965. Online ahead of print.ABSTRACTFour new diterpenoids, including three secolathyrane diterpenoids (1-3) and one lathyrane diterpenoid (4), together with seven known diterpenoids, were obtained in the shelled seeds of Euphorbia lathyris. In particular, 1-3 possess a rare split ring structure, and currently only one compound with the same skeleton has been identified in E. lathyris. Compound 4 furnishes an unprecedented oxygen bridge structure. The structures were identified using various spectral techniques, including NMR, HR-ESI-MS, single-crystal X-ray diff...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Peng-Xu Chen Lin-Wei Li Shu Xu Guo-Dong Zhang Xu Feng Qi-Zhi Wang Fu-Qin Guan Yu Chen Source Type: research
Isoflavones isolated from the fruits of Ficus altissima and their anti-proliferative activities
In this study, we isolated and identified one new isoflavone (1), three new hydroxycoumaronochromones (2a, 2b and 3a) and 12 known compounds from the fruits of F. altissima. Their chemical structures were determined using spectroscopic analysis methods. We also tested all the isolated compounds for their anti-proliferative activities against eight human tumour cell lines (A-549, AGS, K562, K562/ADR, HepG2, HeLa, SPC-A-1 and CNE2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Our experiments showed that compound 6 exhibited obvious anti-proliferative activity against the K562 cell line...
Source: Fitoterapia - April 17, 2024 Category: Biochemistry Authors: Yiliang Liu Yajing Pu Liyuan Shen Dan Li Jingwen Xu Xiangjiu He Yihai Wang Source Type: research
Chemical constituents of Rubia tibetica Hook. f. from Tibetan medicine and cytotoxic activity evaluation
Fitoterapia. 2024 Apr 16;175:105961. doi: 10.1016/j.fitote.2024.105961. Online ahead of print.ABSTRACTTwo unprecedented quinone compounds Rubiaxylm A (1) and Rubiaxylm B (2), along with fifteen known anthraquinones (3-17) were isolated and characterized from the roots of Rubia tibetica in Tibetan medicine. Their structures were identified through comprehensive analyses of 1D/2D NMR as well as HR-ESIMS data. Furthermore, all separated compounds were evaluated for their cytotoxic activity on A549, Caco-2, MDA-MB-231 and Skov-3 cell lines. In particular, compound 2 effectively inhibited MDA-MB-231 cells with an IC50 value of ...
Source: Fitoterapia - April 16, 2024 Category: Biochemistry Authors: Min-Min Gu Qing Li Yu Zhang Hong-Wei Wu Yuan-Ling Shao Hong-Ping Han Zhi-Xin Liao Source Type: research
Chemical constituents of Rubia tibetica Hook. f. from Tibetan medicine and cytotoxic activity evaluation
Fitoterapia. 2024 Apr 14:105961. doi: 10.1016/j.fitote.2024.105961. Online ahead of print.ABSTRACTTwo unprecedented quinone compounds Rubiaxylm A (1) and Rubiaxylm B (2), along with fifteen known anthraquinones (3-17) were isolated and characterized from the roots of Rubia tibetica in Tibetan medicine. Their structures were identified through comprehensive analyses of 1D/2D NMR as well as HR-ESIMS data. Furthermore, all separated compounds were evaluated for their cytotoxic activity on A549, Caco-2, MDA-MB-231 and Skov-3 cell lines. In particular, compound 2 effectively inhibited MDA-MB-231 cells with an IC50 value of 8.15...
Source: Fitoterapia - April 16, 2024 Category: Biochemistry Authors: Min-Min Gu Qing Li Yu Zhang Hong-Wei Wu Yuan-Ling Shao Hong-Ping Han Zhi-Xin Liao Source Type: research
Five new eremophilane-type sesquiterpenes from the fresh roots of Rehmannia glutinosa
Fitoterapia. 2024 Apr 13:105960. doi: 10.1016/j.fitote.2024.105960. Online ahead of print.ABSTRACTFive undescribed eremophilane-type sesquiterpenes, remophilanetriols E-I (1-5), along with seven known compounds (6-12) were isolated from the fresh roots of Rehmannia glutinosa. Their structures were characterized by extensive spectroscopic data analysis and their absolute configurations were determined by comparing their calculated electronic circular dichroism (ECD) spectra and experimental ECD spectra. The anti-pulmonary fibrosis activities of all compounds were evaluated in vitro by MTT methods, and compounds 2, 8, 10, an...
Source: Fitoterapia - April 15, 2024 Category: Biochemistry Authors: Xiang-Da Li Yan-Gang Cao Yu-Han Zhang Ying-Jie Ren Meng-Nan Zeng Yan-Ling Liu Xu Chen Xin-Yi Ma Bing-Xian Zhao Xiao-Ke Zheng Wei-Sheng Feng Source Type: research
Lysimachia capillipes Hemsl. saponins ameliorate colorectal cancer in mice via regulating gut microbiota and restoring metabolic profiles
Fitoterapia. 2024 Apr 12:105959. doi: 10.1016/j.fitote.2024.105959. Online ahead of print.ABSTRACTLysimachia capillipes Hemsl., a traditional Chinese medicine (TCM), is commonly prescribed for its anti-inflammatory and anti-tumor properties. Pharmacological studies have demonstrated that Lysimachia capillipes Hemsl. saponins (LCS) are the primary bioactive component. However, its mechanism for treating colorectal cancer (CRC) is still unknown. Increasing evidence suggests a close relationship between CRC, intestinal flora, and host metabolism. Thus, this study aims to investigate the mechanism of LCS amelioration of CRC fr...
Source: Fitoterapia - April 14, 2024 Category: Biochemistry Authors: Wei Li Shenghong Guan Xueli Hu Huan Zhao Jinhong Cai Xiaohan Li Xiaoyong Zhang Wei Zhu Xin Pan Shouxin Li Jingkui Tian Source Type: research
Irpexols A-C, xanthone derivatives from the endophyte fungus Irpex laceratus A878
Fitoterapia. 2024 Apr 11:105952. doi: 10.1016/j.fitote.2024.105952. Online ahead of print.ABSTRACTThree new xanthone derivatives irpexols A-C (1-3) and five known xanthones including three dimeric ones were successfully isolated from Irpex laceratus A878, an endophytic fungus of the family Irpicaceae from the medicinal plant Pogostemon cablin (Blanco) Bentham (Lamiaceae). The structures of these compounds were elucidated by extensive spectroscopic analyses includingultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), and nuclear magnetic resonance (NMR). All of the three new compounds ...
Source: Fitoterapia - April 13, 2024 Category: Biochemistry Authors: Yuchan Chen Nuoyi Wang Weipeng Ma Wei Gu Zihuan Sang Haibo Tan Weimin Zhang Hongxin Liu Source Type: research
Irpexols A-C, xanthone derivatives from the endophyte fungus Irpex laceratus A878
Fitoterapia. 2024 Apr 11:105952. doi: 10.1016/j.fitote.2024.105952. Online ahead of print.ABSTRACTThree new xanthone derivatives irpexols A-C (1-3) and five known xanthones including three dimeric ones were successfully isolated from Irpex laceratus A878, an endophytic fungus of the family Irpicaceae from the medicinal plant Pogostemon cablin (Blanco) Bentham (Lamiaceae). The structures of these compounds were elucidated by extensive spectroscopic analyses includingultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), and nuclear magnetic resonance (NMR). All of the three new compounds ...
Source: Fitoterapia - April 13, 2024 Category: Biochemistry Authors: Yuchan Chen Nuoyi Wang Weipeng Ma Wei Gu Zihuan Sang Haibo Tan Weimin Zhang Hongxin Liu Source Type: research
Pararorine A, isoindolinone alkaloid from the endophytic fungus Paramyrothecium roridum and its anti-tumor activity
Fitoterapia. 2024 Apr 10;175:105931. doi: 10.1016/j.fitote.2024.105931. Online ahead of print.ABSTRACTPararorine A, a new isoindolinone alkaloid was isolated from Paramyrothecium roridum, an endophytic fungus from the medicinal plant Gynochthodes officinalis (F.C. How) Razafim. & B. Bremer. The structure of this compound was elucidated by extensive spectroscopic (UV, IR, MS, and NMR) analyses. In addition, the antitumor activity of pararorine A was evaluated against SF-268, MCF-7, HepG2, and A549 tumor cell lines. The results revealed that pararorine A exhibited potent antitumor activities with the IC50 values ranging ...
Source: Fitoterapia - April 12, 2024 Category: Biochemistry Authors: Yuchan Chen Hongxin Liu Nuoyi Wang Haibo Tan Weimin Zhang Source Type: research
Molecular networking-based mass spectral identification of Brucea javanica (L.) Merr. metabolites and their selective binding affinities for dengue virus enzymes
This study aims to simultaneously identify chemical classes and metabolites within B. javanica using molecular networking (MN), by Global Natural Product Social (GNPS), and SIRIUS in silico annotation. Liquid chromatography-mass spectrometry (LC-MS2)-based MN explores chemical diversity across four plant parts (leaves, roots, fruits, and stem bark), revealing diverse metabolites such as tryptophan-derived alkaloids, terpenoids, and octadecadenoids. Simultaneous LC-MS2 and MN analyses reveal a discriminative capacity for individual plant components, with roots accumulating tryptophan alkaloids, fruits concentrating quassino...
Source: Fitoterapia - April 11, 2024 Category: Biochemistry Authors: Nor Syaidatul Akmal Mohd Yousof Adlin Afzan Murizal Zainol Syahrul Imran Abu Bakar Mohd Ridzuan Mohd Abd Razak Nur Hana Md Jelas Nor Nadirah Abdullah Geoffrey A Cordell Nor Hadiani Ismail Source Type: research
Curcuma wenyujin rhizomes extract ameliorates lipid accumulation
In conclusion, CWP rich in sesquiterpenes reduces the accumulation of lipids in vivo and in vitro by improving lipid metabolism and activating autophagy.PMID:38604260 | DOI:10.1016/j.fitote.2024.105957 (Source: Fitoterapia)
Source: Fitoterapia - April 11, 2024 Category: Biochemistry Authors: Hong Wang Lijia Chen Ruiyu Zhang Guanying Zhang Jingwen Liu Fujiang Guo Source Type: research
Discovery and characterization of novel ATP citrate lyase inhibitors from Acanthopanax senticosus (Rupr. & amp; Maxim.) Harms
Fitoterapia. 2024 Apr 9;175:105956. doi: 10.1016/j.fitote.2024.105956. Online ahead of print.ABSTRACTATP citrate lyase (ACLY) is a key enzyme in glucolipid metabolism, and abnormally high expression of ACLY occurs in many diseases, including cancers, dyslipidemia and cardiovascular diseases. ACLY inhibitors are prospective treatments for these diseases. However, the scaffolds of ACLY inhibitors are insufficient with weak activity. The discovery of inhibitors with structural novelty and high activity continues to be a research hotpot. Acanthopanax senticosus (Rupr. & Maxim.) Harms is used for cardiovascular disease trea...
Source: Fitoterapia - April 11, 2024 Category: Biochemistry Authors: Pan Wang Xiujie Guo Tao Hou Fengbin Luo Miao Li Xiaoyu Wang Jie Zhang Jixia Wang Chaoran Wang Xinmiao Liang Source Type: research
Mirror, mirror on the wall, which phytochemicals in Clinacanthus nutans inhibits advanced glycation end products of them all?
Fitoterapia. 2024 Apr 9:105958. doi: 10.1016/j.fitote.2024.105958. Online ahead of print.ABSTRACTIn our quest to discover advanced glycation end products (AGEs) inhibitors from Clinacanthus nutans (Burm.f.) Lindau leaves, we conducted Bioactive Molecular Networking. This approach integrates LC-MS2 profiling and in vitro antiglycation data to predict bioactive compounds. We began by screening three extracts: 100% ethanol, 70% ethanol and 100% water alongside the in vitro antioxidant activity, total phenolics content (TPC) and schaftoside content. Among these extracts, 100% ethanol extract exhibited the highest total AGEs in...
Source: Fitoterapia - April 11, 2024 Category: Biochemistry Authors: Adlin Afzan June Lee Chelyn Zainah Adam Norhayati Mustafa Khalid Rathi Devi Nair Gunasegavan Mohd Fairulnizal Md Noh Mohd Isa Wasiman Source Type: research
