Lessons learned from a multi-data source research collaboration: The mirabegron post-authorization safety study program
CONCLUSIONS: This large PMR/PASS program was a long-term commitment from all parties and benefited from an effective coordinating center and extensive scientific interactions across research partners, scientific advisory board, study sponsor, and health authorities, and delivered useful learnings related to the design and organization of multi-data source NI-PASS.PMID:38680102 | DOI:10.1002/pds.5799 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Stefan de Vogel John D Seeger Alejandro Arana Andrea V Margulis Lisa J McQuay Susana Perez-Gutthann Jesper Hallas Nina Sahlertz Kristiansen Marie Linder Ingvild Odsbu Brandon Suehs Yihua Xu Claudia Uribe Kwame Appenteng Noah Jamie Robinson Source Type: research
Antifibrotic Effect of Baicalin on Arecoline Induced Human Oral Fibroblast: An In-Vitro Study
CONCLUSION: Baicalin can be used as an antifibrotic herb to treat OSMF.PMID:38679996 | DOI:10.31557/APJCP.2024.25.4.1349 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Pallavi Channe Mahesh Chavan Ramesh Bhonde Supriya M Kheur Source Type: research
Prevalence, Reach of Anti-smokeless Tobacco Messages and Quit Attempts by Product Type: A Secondary Data Analysis from the Global Adult Tobacco Survey (GATS - 2016-17)
CONCLUSION: The reach of media messages and warning labels varies by SLT type. Quit intention and attempts vary by SLT type and access to media messages and warning labels. There is a need to re-strategise the tobacco control Information, Education and Communication (IEC) to reach out with effective messaging to the most unreached.PMID:38679988 | DOI:10.31557/APJCP.2024.25.4.1277 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Shraddha Chatterjee Nilesh C Gawde Prakash C Gupta Source Type: research
Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia in a Group of Thai Patients
CONCLUSION: The subcellular mislocalization of CLLD7 and CHC1L in OED suggests that the expression of these potential tumor suppressor proteins might be dysregulated during the dysplastic process. The distinct membrane staining of CHC1L observed in OED but not in NOM is a useful characteristic that can be used to separate OED from NOM. Thus, CHC1L may be a good marker to assist in the diagnosis of OED.PMID:38679985 | DOI:10.31557/APJCP.2024.25.4.1257 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Patcharanun Wiphakphongpakorn Rachai Juengsomjit Sopee Poomsawat Ounruean Meesakul Bishwa Prakash Bhattarai Boworn Klongnoi Waranun Buajeeb Siribang-On Piboonniyom Khovidhunkit Source Type: research
Demographical and Epidemiological Contribution to Cancer Incidence in Delhi and Its Trends from 1991-2015
CONCLUSION: A significant contribution to new cancer cases was observed due to a demographical shift in both population size and structure, in addition to plausible cancer-specific risk factors. This transformation could surge a potential burden on the Delhi healthcare system. Persistent endeavours are essential to expand and enhance the existing cancer care infrastructure to meet the rising demand driven by aging and population growth. Implementing a stringent population policy can help to mitigate the impact of population growth on cancer incidence.PMID:38679980 | DOI:10.31557/APJCP.2024.25.4.1213 (Source: Asian Pacific ...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Rajeev Kumar Malhotra N Manoharan Sv Suryanarayana Deo Sushma Bhatnagar Source Type: research
< em > Fusobacterium nucleatum < /em > -induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer
CONCLUSION: F. nucleatum can promote cancer progression through its inhibitory effect on butyric acid, via the AMPK signaling pathway.PMID:38681125 | PMC:PMC11045493 | DOI:10.3748/wjg.v30.i14.2018 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-Liang Lou Xiang Li Source Type: research
Safety Profile of Upadacitinib up to 5 Years in Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis: An Integrated Analysis of Clinical Trials
CONCLUSION: Higher rates of serious infection, HZ, lymphopenia, and NMSC were observed with upadacitinib versus adalimumab in PsA; slightly elevated rates for most of these TEAEs were seen with upadacitinib in PsA versus axSpA. Upadacitinib 15 mg demonstrated a generally consistent safety profile across disease states with no new safety signals identified.TRIAL REGISTRATION: SELECT-AXIS 1: NCT03178487; SELECT-AXIS 2: NCT04169373; SELECT-PsA 1: NCT03104400; SELECT-PsA 2: NCT03104374.PMID:38683479 | DOI:10.1007/s40744-024-00671-4 (Source: Herpes)
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Gerd R Burmester Jayne Stigler Andrea Rubbert-Roth Yoshiya Tanaka Valderilio F Azevedo Derek Coombs Ivan Lagunes Ralph Lippe Peter Wung Lianne S Gensler Source Type: research
< em > Fusobacterium nucleatum < /em > -induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer
CONCLUSION: F. nucleatum can promote cancer progression through its inhibitory effect on butyric acid, via the AMPK signaling pathway.PMID:38681125 | PMC:PMC11045493 | DOI:10.3748/wjg.v30.i14.2018 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-Liang Lou Xiang Li Source Type: research
[Retracted] Reduced miR ‑202 levels enhanced oral cancer development via targeting Sp1
Exp Ther Med. 2024 Apr 15;27(6):251. doi: 10.3892/etm.2024.12539. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/etm.2019.7603.].PMID:38682115 | PMC:PMC11046176 | DOI:10.3892/etm.2024.12539 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Jia Zhao Deguang Ding Ge Zhao Source Type: research
In vitro anti-leukemic effect of Wharton's jelly derived mesenchymal stem cells
CONCLUSIONS: MSCs are known to inhibit the growth of tumors of both hematopoietic and non-hematopoietic origin in vitro. In our study, WJ-MSC treatment strongly inhibited the viability of HL-60 and K562 and induced apoptosis. Our results also provided new insights into the inhibition of tumor growth by WJ-MSCs in vitro. In the future, WJ-MSCs could be used to inhibit cancer cells in clinical applications.PMID:38683436 | DOI:10.1007/s11033-024-09512-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Mediha S üleymanoğlu Ay şe Erol Bozkurt Figen Abatay Sel İsa Aykut Özdemir Fatma Savran O ğuz D ürdane Serap Kuruca Zerrin Akta ş Zeynep Karaka ş Mustafa Oral Öncül Source Type: research
In vitro anti-leukemic effect of Wharton's jelly derived mesenchymal stem cells
CONCLUSIONS: MSCs are known to inhibit the growth of tumors of both hematopoietic and non-hematopoietic origin in vitro. In our study, WJ-MSC treatment strongly inhibited the viability of HL-60 and K562 and induced apoptosis. Our results also provided new insights into the inhibition of tumor growth by WJ-MSCs in vitro. In the future, WJ-MSCs could be used to inhibit cancer cells in clinical applications.PMID:38683436 | DOI:10.1007/s11033-024-09512-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Mediha S üleymanoğlu Ay şe Erol Bozkurt Figen Abatay Sel İsa Aykut Özdemir Fatma Savran O ğuz D ürdane Serap Kuruca Zerrin Akta ş Zeynep Karaka ş Mustafa Oral Öncül Source Type: research
Oral targeted therapy for the treatment of non-small cell lung carcinoma
CMAJ. 2024 Apr 28;196(16):E558-E561. doi: 10.1503/cmaj.231562.NO ABSTRACTPMID:38684283 | DOI:10.1503/cmaj.231562 (Source: Canadian Medical Association Journal)
Source: Canadian Medical Association Journal - April 29, 2024 Category: General Medicine Authors: William J Phillips Natasha B Leighl Normand Blais Paul Wheatley-Price Source Type: research
An Acid-Responsive Iron-Based Nanocomposite for OSCC Treatment
In this study, by loading ultra-small Prussian blue nanoparticles (USPBNPs) into mesoporous calcium-silicate nanoparticles (MCSNs), we developed an acid-responsive iron-based nanocomposite, USPBNPs@MCSNs (UPM), for the OSCC treatment. UPM demonstrated excellent dual enzyme activities, generating toxic ·OH in a mildly acidic environment, effectively killing OSCC cells and producing O2 in a neutral environment to alleviate tissue hypoxia. The results showed that UPM could effectively inhibit the proliferation, migration, and invasion of OSCC cells, as well as the growth of mice solid tumors, without obvious systemic toxicit...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: X Zhao D Leng H Wang H Jin Y Wu Z Qin D Wu X Wei Source Type: research
A Pilot Study to Determine the Effect of Individualized Enteral Nutrition Management Based on Prognostic Nutrition Index on Surgical Patients With Oral Malignancies
This study aimed to assess the effect of individualized enteral nutrition management based on the prognostic nutrition index (PNI) on surgical patients with oral malignancies. This quasi-experimental pilot study consecutively included patients diagnosed with oral malignancies who underwent radical surgery in Ningbo No. 2 Hospital between January 2020 and May 2023. The primary outcome was PNI. A total of 71 patients with oral malignancies were enrolled, and 35 patients received PNI-based individualized enteral nutrition management. The PNI group displayed significantly higher PNI than the routine enteral nutrition support g...
Source: Nutrition and Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Chunbo Ding Long Chen Hedan Gu Bin Xu Yaqin Du Source Type: research
Antifibrotic Effect of Baicalin on Arecoline Induced Human Oral Fibroblast: An In-Vitro Study
CONCLUSION: Baicalin can be used as an antifibrotic herb to treat OSMF.PMID:38679996 | DOI:10.31557/APJCP.2024.25.4.1349 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Pallavi Channe Mahesh Chavan Ramesh Bhonde Supriya M Kheur Source Type: research
