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Number of Healthy Teeth Can Predict the Response of Rectal Cancer to Chemoradiotherapy: A Retrospective Study
This study is the first to identify a correlation between the number of healthy teeth, which is an oral health indicator, and the efficacy of preoperative chemotherapy for rectal cancer.METHODS: This retrospective single-center study included 30 patients who underwent radical surgery after preoperative chemoradiotherapy (CRT) between December 2013 and June 2021. The relationship between number of teeth before CRT and the efficacy of CRT, CRT-related adverse events, postoperative complications, and long-term postoperative outcomes was examined.RESULTS: The number of healthy teeth was significantly greater in patients with d...
Source: The American Surgeon - April 18, 2024 Category: Surgery Authors: Toshihiro Nakao Mitsuo Shimada Kozo Yoshikawa Takuya Tokunaga Masaaki Nishi Hideya Kashihara Chie Takasu Yuma Wada Toshiaki Yoshimoto Source Type: research

Current knowledge of ferroptosis in the pathogenesis and prognosis of oral squamous cell carcinoma
In this study, we performed a first attempt to collect the current evidence on the proposed roles of ferroptosis in OSCC through a comprehensive review. Based on clinical data from the relevant studies within this topic, we found that ferroptosis-associated tumor microenvironment, ferroptosis-related genes (FRGs), and ferroptosis-related lncRNAs exhibited a potent prognostic value for OSCC patients. Mechanistically, experimental data revealed that the proliferation and tumorigenesis of OSCC might be associated with the inhibition of cellular ferroptosis through the activation of glutathione peroxidase 4 (GPX4) and adipocyt...
Source: Cellular Signalling - April 18, 2024 Category: Cytology Authors: Liyuan Zhou Youjun Wu Yukang Ying Yan Ding Source Type: research

Salivary carcinoma showing thymus-like differentiation: clinicopathological analysis of 7 cases
Conclusions: Salivary CASTLE is a rare tumor, it should be distinguished from lymphoepithelial carcinoma and squamous cell carcinoma. The patients often have better prognosis and CD5 protein expression has a valuable role in the differential diagnosis.PMID:38637002 | DOI:10.3760/cma.j.cn112144-20231211-00290 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - April 18, 2024 Category: Dentistry Authors: C Y Zhang T Gu S Xia Y Wang J Li Source Type: research

Lipid droplets functional protein caveolin-2 is associated with lipid metabolism-related molecule FABP5 and EMT marker E-cadherin in oral epithelial dysplasia
Conclusion In the oral epithelial carcinogenesis process, LDs begin to accumulate early in the precancerous stage. LDs may be the regulator of FABP5-associated lipid metabolism and may closely related to the process of EMT; caveolin-2 could be the main functional protein. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Chen, X.-J., Bai, Y.-T., Xie, J.-R., Zhou, G. Tags: Original research Source Type: research

The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression
Cell Death & Disease, Published online: 18 April 2024; doi:10.1038/s41419-024-06640-7The role of CXCL2-mediated crosstalk between tumor cells and macrophages in Fusobacterium nucleatum-promoted oral squamous cell carcinoma progression (Source: Cell death and disease)
Source: Cell death and disease - April 18, 2024 Category: Internal Medicine Authors: Fujiao Nie Jie Zhang Haoyang Tian Jingjing Zhao Pizhang Gong Huiru Wang Suli Wang Pishan Yang Chengzhe Yang Source Type: research

Cancers, Vol. 16, Pages 1550: Precursor Lesions, Overdiagnosis, and Oral Cancer: A Critical Review
o Despite the profession placing great emphasis on oral potentially malignant disorders (OPMDs) as a gateway for early recognition and consequently better outcomes for oral cancer, the death rates for lip and oral cavity cancer have remained stagnant for three decades. Evidence shows that only a small fraction of oral cancers are in fact preceded by OPMDs, and that most OPMDs have an annual transformation rate of less than 1%. As OPMDs encompass a very heterogeneous group of oral conditions, it could be argued that only patients with oral mucosal diseases bearing a substantial risk of malignant transformation warrant c...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Nicola Cirillo Tags: Review Source Type: research

Cancers, Vol. 16, Pages 1548: Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review
ilva Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this system...
Source: Cancers - April 18, 2024 Category: Cancer & Oncology Authors: Ricardo Bragu ês Maria Francisca Marv ão Patr ícia Correia Raquel M. Silva Tags: Systematic Review Source Type: research

Role of Imaging in Predicting the Deep Surgical Margin in Gingivobuccal Complex Cancers: A Pilot Study
AbstractCancers arising from the gingivobuccal complex are one of the most common types of cancer in the oral cavity and are associated with poor prognosis. Among the various prognostic factors, positive surgical margin is the most important one that can be controlled by the operating surgeon. The deep surgical margins for buccal mucosa cancers is normally assessed by palpating the skin for induration and skin pinchability. The present study evaluates the role of imaging in assessing the deep surgical margin and its efficacy for skin preservation in buccal mucosa/ gingivobuccal carcinomas. The patients of gingivobuccal com...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 18, 2024 Category: ENT & OMF Source Type: research

The incidence of osteoradionecrosis of the jaws in oral cavity cancer patients treated with intensity-modulated radiotherapy: A systematic review and meta-analysis
A systematic review with meta-analysis was conducted to define the incidence of osteoradionecrosis (ORN) in patients with oral cavity cancer (OCC) treated with intensity-modulated radiotherapy (IMRT), and to identify the risk factors influencing its development. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 18, 2024 Category: ENT & OMF Authors: Luis Augusto de Almeida-Silva, Juliana dos Santos Lupp, Leonardo Alvares Sobral-Silva, Luiz Augusto Rodrigues dos Santos, Thays Oliveira Marques, Danillo Babinskas Ribeiro da Silva, Taciana Marco Ferraz Caneppele, Michelle Bianchi-de-Moraes Source Type: research

How good is ChatGPT at answering patients ’ questions related to early detection of oral (mouth) cancer?
To examine the quality, reliability, readability, and usefulness of ChatGPT in promoting oral cancer early detection. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 18, 2024 Category: ENT & OMF Authors: Yazan Hassona, Dua'a Alqaisi, Alaa AL-Haddad, Eleni Georgokopolo, Dimitris Malamos, Mohammad Alrashdan, Faleh Sawair Source Type: research

Construction of flake ball-shaped Bi 2 WO 6 embedded on phenyl functionalized g-C 3 N 4 nanosheet for efficient degradation insight of colorless pollutants and its biological application
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33294-x. Online ahead of print.ABSTRACTA facile solvent-free solid-state method was adapted to synthesize the spherical-shaped Bi2WO6 engraved on phenyl-doped g-C3N4 nanosheet, i.e., Bi2WO6/Ph-gC3N4 (or BPCN) composites with varying weights of Bi2WO6. Several spectral analyses were used to characterize all the synthesized nanomaterials. The synthesized photocatalyst showed good absorption under visible light as confirmed by UV-visible DRS analysis. Morphological analyses like SEM and TEM determine the successful fabrication of binary heterocomposite. Further,...
Source: Environmental Science and Pollution Research International - April 17, 2024 Category: Environmental Health Authors: Ziyaur Rasool Mohammad Saud Athar Mohammad Muneer Source Type: research

Construction of flake ball-shaped Bi 2 WO 6 embedded on phenyl functionalized g-C 3 N 4 nanosheet for efficient degradation insight of colorless pollutants and its biological application
Environ Sci Pollut Res Int. 2024 Apr 17. doi: 10.1007/s11356-024-33294-x. Online ahead of print.ABSTRACTA facile solvent-free solid-state method was adapted to synthesize the spherical-shaped Bi2WO6 engraved on phenyl-doped g-C3N4 nanosheet, i.e., Bi2WO6/Ph-gC3N4 (or BPCN) composites with varying weights of Bi2WO6. Several spectral analyses were used to characterize all the synthesized nanomaterials. The synthesized photocatalyst showed good absorption under visible light as confirmed by UV-visible DRS analysis. Morphological analyses like SEM and TEM determine the successful fabrication of binary heterocomposite. Further,...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Ziyaur Rasool Mohammad Saud Athar Mohammad Muneer Source Type: research