Retraction Note: TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway
Mol Cell Biochem. 2024 Apr 24. doi: 10.1007/s11010-024-05015-y. Online ahead of print.NO ABSTRACTPMID:38656596 | DOI:10.1007/s11010-024-05015-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - April 24, 2024 Category: Biochemistry Authors: Yixue Gu Shasha Fan Binjie Liu Guopei Zheng Yanhui Yu Yongmei Ouyang Zhimin He Source Type: research
Transforming growth factor-beta signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis
In this study, we examined the effects of TGF-β signaling on the murine squamous cell carcinoma, SCCVII cells in vitro and in vivo. The incubation of SCCVII cells with TGF-β induced the activation of TGF-β signals and epithelial-mesenchymal transition (EMT). Notably, the motility of SCCVII cells was increased upon the activation of the TGF-β signaling. RNA sequencing revealed upregulation of genes related to EMT and angiogenesis. Consistent with these in vitro results, the inhibition of TGF-β signals in SCCVII cell-derived primary tumors resulted in suppressed angiogenesis. Furthermore, we identified six candidate fac...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Haruka Ibi Kazuki Takahashi Hiroyuki Harada Tetsuro Watabe Katarzyna A Podyma-Inoue Source Type: research
Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination
CONCLUSIONS: This study successfully demonstrated that C. butyricum and C. sporogenes can produce the two recombinant antigen proteins (NY-ESO-1 and SARS-CoV-2-related Spike_S1 antigens) through genetic manipulations, utilizing the AUU start codon. This approach overcomes challenges in cloning difficult proteins in E. coli. These findings underscore the feasibility of harnessing commensal clostridia for antigen protein secretion, emphasizing the applicability of non-canonical translation initiation across diverse species with broad implications for medical or industrial biotechnology.PMID:38659027 | DOI:10.1186/s12934-024-...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Yanchao Zhang Tom S Bailey Philip Hittmeyer Ludwig J Dubois Jan Theys Philippe Lambin Source Type: research
From the Randomized AMBORA Trial to Clinical Practice: Comparison of Medication Errors in Oral Antitumor Therapy
Clin Pharmacol Ther. 2024 Apr 24. doi: 10.1002/cpt.3266. Online ahead of print.ABSTRACTThe randomized AMBORA trial showed that medication errors are frequent in patients treated with oral antitumor therapeutics and that they can be substantially reduced by an intensified clinical pharmacological/pharmaceutical care program. While randomized controlled trials are essential to generate clinical evidence, their generalizability in real-world is not always given. The AMBORA care program was implemented in clinical routine within the AMBORA Competence and Consultation Center (AMBORA Center) at the Comprehensive Cancer Center Er...
Source: Clinical Pharmacology and Therapeutics - April 24, 2024 Category: Drugs & Pharmacology Authors: Lisa Cuba Pauline D ürr Frank D örje Martin F Fromm Katja Schlichtig Source Type: research
Letter to Editor: "The Trajectory of Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Its Influencing Factors"
Ear Nose Throat J. 2024 Apr 24:1455613241249268. doi: 10.1177/01455613241249268. Online ahead of print.NO ABSTRACTPMID:38656170 | DOI:10.1177/01455613241249268 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: Erkan Topkan Efsun Somay Ali Ayberk Besen Huseyin Mertsoylu Source Type: research
Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells
Eur J Med Chem. 2024 Apr 20;271:116416. doi: 10.1016/j.ejmech.2024.116416. Online ahead of print.ABSTRACTTargeting polo-box domain (PBD) small molecule for polo-like kinase 1 (PLK1) inhibition is a viable alternative to target kinase domain (KD), which could avoid pan-selectivity and dose-limiting toxicity of ATP-competitive inhibitors. However, their efficacy in these settings is still low and inaccessible to clinical requirement. Herein, we utilized a structure-based high-throughput virtual screen to find novel chemical scaffold capable of inhibiting PLK1 via targeting PBD and identified an initial hit molecule compound ...
Source: European Journal of Medicinal Chemistry - April 24, 2024 Category: Chemistry Authors: Pingping Li Yongkun Li Xuesong Ma Liangping Li Shulan Zeng Yan Peng Hong Liang Guohai Zhang Source Type: research
Transforming growth factor- β signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis
In this study, we examined the effects of TGF-β signaling on the murine squamous cell carcinoma, SCCVII cells in vitro and in vivo. The incubation of SCCVII cells with TGF-β induced the activation of TGF-β signals and epithelial-mesenchymal transition (EMT). Notably, the motility of SCCVII cells was increased upon the activation of the TGF-β signaling. RNA sequencing revealed upregulation of genes related to EMT and angiogenesis. Consistent with these in vitro results, the inhibition of TGF-β signals in SCCVII cell-derived primary tumors resulted in suppressed angiogenesis. Furthermore, we identified six candidate fac...
Source: Biochemical and Biophysical Research communications - April 24, 2024 Category: Biochemistry Authors: Haruka Ibi Kazuki Takahashi Hiroyuki Harada Tetsuro Watabe Katarzyna A Podyma-Inoue Source Type: research
Retraction Note: TCRP1 promotes radioresistance of oral squamous cell carcinoma cells via Akt signal pathway
Mol Cell Biochem. 2024 Apr 24. doi: 10.1007/s11010-024-05015-y. Online ahead of print.NO ABSTRACTPMID:38656596 | DOI:10.1007/s11010-024-05015-y (Source: Molecular and Cellular Biochemistry)
Source: Molecular and Cellular Biochemistry - April 24, 2024 Category: Biochemistry Authors: Yixue Gu Shasha Fan Binjie Liu Guopei Zheng Yanhui Yu Yongmei Ouyang Zhimin He Source Type: research
Letter to Editor: "The Trajectory of Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Its Influencing Factors"
Ear Nose Throat J. 2024 Apr 24:1455613241249268. doi: 10.1177/01455613241249268. Online ahead of print.NO ABSTRACTPMID:38656170 | DOI:10.1177/01455613241249268 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: Erkan Topkan Efsun Somay Ali Ayberk Besen Huseyin Mertsoylu Source Type: research
Identification of naphthalimide-derivatives as novel PBD-targeted polo-like kinase 1 inhibitors with efficacy in drug-resistant lung cancer cells
Eur J Med Chem. 2024 Apr 20;271:116416. doi: 10.1016/j.ejmech.2024.116416. Online ahead of print.ABSTRACTTargeting polo-box domain (PBD) small molecule for polo-like kinase 1 (PLK1) inhibition is a viable alternative to target kinase domain (KD), which could avoid pan-selectivity and dose-limiting toxicity of ATP-competitive inhibitors. However, their efficacy in these settings is still low and inaccessible to clinical requirement. Herein, we utilized a structure-based high-throughput virtual screen to find novel chemical scaffold capable of inhibiting PLK1 via targeting PBD and identified an initial hit molecule compound ...
Source: European Journal of Medicinal Chemistry - April 24, 2024 Category: Chemistry Authors: Pingping Li Yongkun Li Xuesong Ma Liangping Li Shulan Zeng Yan Peng Hong Liang Guohai Zhang Source Type: research
Human papillomavirus associated oropharyngeal cancer now the most common mucosal head and neck cancer in Queensland
ConclusionOPSCC is now the most common mucosal head and neck cancer diagnosed in Queensland, having surpassed oral cavity cancer. The majority are HPV-associated (p16+), presenting with early-stage disease with a favourable prognosis. (Source: Journal of Medical Imaging and Radiation Oncology)
Source: Journal of Medical Imaging and Radiation Oncology - April 24, 2024 Category: Radiology Authors: Sandro V Porceddu,
Theresa Negrello,
Neal Rawson,
Nathan Dunn,
Martin Batstone,
Michael Collins,
Sam Dowthwaite,
Brett GM Hughes,
Liz Kenny,
Rahul Ladwa,
Ben Panizza,
Danica Cossio Tags: Radiation Oncology —Original Article Source Type: research
Clinical Pathology Conference: Case 4: An exophytic gingival mass of the right anterior mandible
An 83-year-old male presented to a community oral maxillofacial surgeon with a tender, pink, pedunculated exophytic tumor measuring 2 × 1.5 cm involving the right anterior mandible adjacent to tooth #27 (Figure 1A). His medical history was significant for hypertension, congestive heart failure, atrial fibrillation, and prostate cancer treated with radiation and androgen deprivation chemotherapy. The patient had been taking a miodarone, metoprolol, digoxin, rivaroxaban, furosemide, bicalutamide, and leuprorelin injections. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 24, 2024 Category: ENT & OMF Authors: Safia Durab, Ida A. Varghese, Laith Mahmood, Nadarajah Vigneswaran Source Type: research
Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination
Clostridium spp. has demonstrated therapeutic potential in cancer treatment through intravenous or intratumoral administration. This approach has expanded to include non-pathogenic clostridia for the treatment of... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - April 24, 2024 Category: Microbiology Authors: Yanchao Zhang, Tom S. Bailey, Philip Hittmeyer, Ludwig J. Dubois, Jan Theys and Philippe Lambin Tags: Research Source Type: research
Cancers, Vol. 16, Pages 1642: Assessing the Effects of Curcumin and 450 nm Photodynamic Therapy on Oxidative Metabolism and Cell Cycle in Head and Neck Squamous Cell Carcinoma: An In Vitro Study
Andrea Amaroli
Oral cancer is the 16th most common malignant tumor worldwide. The risk of recurrence and mortality is high, and the survival rate is low over the following five years. Recent studies have shown that curcumin causes apoptosis in tumor cells by affecting FoF1-ATP synthase (ATP synthase) activity, which, in turn, hinders cell energy production, leading to a loss of cell viability. Additionally, irradiation of curcumin within cells can intensify its detrimental effects on cancer cell viability and proliferation (photodynamic therapy). We treated the OHSU-974 cell line, a model for human head and neck squam...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Silvia Ravera Claudio Pasquale Isabella Panfoli Matteo Bozzo Dimitrios Agas Silvia Bruno Michael R. Hamblin Andrea Amaroli Tags: Article Source Type: research
Sunlight: Time for a Rethink?
UVR is a skin carcinogen, yet no studies link sun exposure to increased all-cause mortality. Epidemiological studies from the United Kingdom and Sweden link sun exposure with reduced all-cause, cardiovascular, and cancer mortality. Vitamin D synthesis is dependent on UVB exposure. Individuals with higher serum levels of vitamin D are healthier in many ways, yet multiple trials of oral vitamin D supplementation show little benefit. Growing evidence shows that sunlight has health benefits through vitamin D–independent pathways, such as photomobilization of nitric oxide from cutaneous stores with reduction in cardiovascu...
Source: Journal of Investigative Dermatology - April 24, 2024 Category: Dermatology Authors: Richard B. Weller Tags: Review Source Type: research
