UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice
UV irradiation of the human skin downregulates lipid synthesis and adipokine production in subcutaneous fat. Recent evidence has suggested that UV exposure limits body weight gain in mouse models of obesity. However, the relationship between norepinephrine and UV irradiation has not been previously reported. Chronic UV exposure stimulated food intake but prevented body weight gain. Leptin, an appetite-suppressing hormone, was significantly reduced in the serum of the UV-irradiated mice. In contrast, UV irradiation induced browning of subcutaneous white adipose tissues without increasing physical activity. (Source: Journal ...
Source: Journal of Investigative Dermatology - May 22, 2024 Category: Dermatology Authors: Qing-Ling Quan, Eun Ju Kim, Sungsoo Kim, Yeon Kyung Kim, Min Hwa Chung, Yu-Dan Tian, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung Tags: Original Article Source Type: research

Editors ’ Picks
Cutibacterium acnes offers an attractive manner to deliver targeted therapeutic molecules owing to its engraftment potential, specific niche in sebaceous sites, importance to skin homeostasis, and close contact with therapeutic targets. Thus, Kn ödlseder et al (2024) engineered this bacterial species to produce and deliver the therapeutic molecule NGAL, which is a protein upregulated in patients with acne treated with the drug isotretinoin. Mechanistically, NGAL mediates sebocyte apoptosis and reduces sebum as well as C acnes count, succe ssfully ameliorating acne symptoms. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 21, 2024 Category: Dermatology Tags: Editors ’ Picks Source Type: research

Clinical Snippets
Artificial intelligence (AI) has been applied to classification of skin lesions, with the greatest successes observed with dermatologist –AI collaboration; however, the incorporation of total body photography (TBP) for 3-dimensional imaging alters the current landscape of AI skin image analysis. Toward better real-world clinical application, TBP offers opportunities for intrapatient evaluation of lesions and incorporation of patien t-level metadata, such as demographics, clinical history, skin color, history of changes, and geographical information, to enhance risk profiling. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 21, 2024 Category: Dermatology Tags: Clinical Snippets Source Type: research

From GWASs toward Mechanistic Understanding with Case Studies in Dermatogenetics
Many human skin diseases result from the complex interplay of genetic and environmental mechanisms that are largely unknown. GWASs have yielded insight into the genetic aspect of complex disease by highlighting regions of the genome or specific genetic variants associated with disease. Leveraging this information to identify causal genes and cell types will provide insight into fundamental biology, inform diagnostics, and aid drug discovery. However, the etiological mechanisms from genetic variant to disease are still unestablished in most cases. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 21, 2024 Category: Dermatology Authors: Silvia Shen, Maria K. Sobczyk, Lavinia Paternoster, Sara J. Brown Tags: Methods and Techniques for Skin Research Source Type: research

Editorial Board
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 21, 2024 Category: Dermatology Source Type: research

Subscription Information
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Source: Journal of Investigative Dermatology - May 21, 2024 Category: Dermatology Source Type: research

Table of Contents
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 21, 2024 Category: Dermatology Source Type: research

Genetic study of psoriasis highlights its close link with socio-economic status and affective symptoms
Psoriasis is an inflammatory skin disease with an estimated heritability of around 70 %. Previous genome-wide association studies (GWASs) have detected several risk loci for psoriasis. To further improve the understanding of the genetic risk factors impacting the disease, we conducted a discovery GWAS in FinnGen and a subsequent replication and meta-analysis with data from the Estonian Biobank and the UK biobank; the study sample included 925 649 individuals (22 659 cases and 902 990 controls), the largest sample for psoriasis yet. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 17, 2024 Category: Dermatology Authors: Anni Heikkil ä, Eeva Sliz, Laura Huilaja, FinnGen, Estonian Biobank Research Team, Kadri Reis, Priit Palta, Abdelrahman G. Elnahas, Anu Reigo, Tõnu Esko, Triin Laisk, Maris Teder-Laving, Kaisa Tasanen, Johannes Kettunen Tags: Original Article Source Type: research

CASZ1 Regulates Late Epidermal Differentiation
The epidermis is a constantly renewing stratified epithelium that provides crucial barrier functions against insults and dehydration. During epidermal development and tissue homeostasis, a monolayer of keratinocyte progenitors located at the base of the epidermis differentiate and give rise to a stratified epidermis. Disrupted skin barrier due to impaired epidermal differentiation characterizes common skin diseases, such as psoriasis, atopic dermatitis, and squamous cell carcinoma (Lopez-Pajares et al., 2013). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 17, 2024 Category: Dermatology Authors: Liat Oss-Ronen, Nili Tickotsky Moskovitz, Hilla Levi, Liron Levin, Idan Cohen Tags: Letters to the Editor Source Type: research

Twin prime editing mediated exon skipping/reinsertion for restored collagen VII expression in recessive dystrophic epidermolysis bullosa
Gene editing nucleases, base editors, and prime editors are potential locus specific genetic treatment strategies for recessive dystrophic epidermolysis bullosa (RDEB); however, many RDEB COL7A1 mutations are unique, making the development of personalized editing reagents challenging. 270 of the ∼320 COL7A1 EB mutations reside in exons that can be skipped, and antisense oligonucleotides (ASO) and gene editing nucleases have been used to create in-frame deletions. ASOs are transient and nucleases generate deleterious double stranded DNA breaks (DSB) and uncontrolled mixtures of allele prod ucts. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 17, 2024 Category: Dermatology Authors: Benjamin J. Steinbeck, Xin D. Gao, Amber N. McElroy, Smriti Pandey, Jordan L. Doman, Megan J. Riddle, Lily Xia, Weili Chen, Cindy R. Eide, Andre H. Lengert, Sang Won Han, Bruce R. Blazar, Hans H. Wandall, Sally Dabelsteen, David R. Liu, Jakub Tolar, Mark Tags: Original Article Source Type: research

Biomechanical activation of keloid fibroblasts promotes lysosomal remodelling and exocytosis
Keloids are a severe form of scarring for which the underlying mechanisms are poorly understood, and treatment options are limited or inconsistent. While biomechanical forces are potential drivers of keloid scarring, the direct cellular responses to mechanical cues have yet to be defined. The aim of this study was to examine the distinct responses of normal dermal fibroblasts (NDFs) and keloid-derived fibroblasts (KDFs) to changes in extracellular matrix (ECM) stiffness. When cultured on hydrogels mimicking the elasticity of normal or scarred skin, KDFs displayed greater stiffness-dependent increases in cell spreading, F-a...
Source: Journal of Investigative Dermatology - May 17, 2024 Category: Dermatology Authors: Rosie Ross, Yiyang Guo, Rebecca N. Walker, Daniele Bergamaschi, Tanya J. Shaw, John T. Connelly Tags: Original Article Source Type: research

Keratinocytes present Staphylococcus aureus enterotoxins and promote malignant and non-malignant T cell proliferation in cutaneous T cell lymphoma
Cutaneous T-cell lymphoma (CTCL) is characterized by malignant T-cells proliferating in a unique tumor microenvironment (TME) dominated by keratinocytes. Skin colonization and infection by Staphylococcus aureus (S. aureus) is a common cause of morbidity and suspected of fueling disease activity. Here we show that expression of HLA-DR, high-affinity receptors for Staphylococcal enterotoxins (SE), by keratinocytes correlates with IFN- γ expression in the TME. Importantly, IFN-γ induces HLA-DR, SE-binding, and SE-presentation by keratinocytes to malignant T-cells from Sézary syndrome (SS) patients, and malignant and non-ma...
Source: Journal of Investigative Dermatology - May 16, 2024 Category: Dermatology Authors: Ziao Zeng, Chella Krishna Vadivel, Maria Gluud, Martin R.J. Namini, Lang Yan, Sana Ahmad, Morten Bagge Hansen, Jonathan Coquet, Tomas Mustelin, Sergei B. Koralov, Charlotte Menne Bonefeld, Anders Woetmann, Carsten Geisler, Emmanuella Guenova, Maria R. Kam Tags: Original Article Source Type: research

Dermal Dive: An Overview of Cutaneous Wounding Techniques in Zebrafish
Cutaneous wounds are common injuries that affect millions of people around the world. In vulnerable populations such as the elderly and those with diabetes, defects in wound healing can lead to the development of chronic open wounds. Although mammalian models are commonly used to study cutaneous wound healing, the challenges of in  vivo imaging in mammals have hampered detailed observation of cell coordination and cell signaling during wound healing. The zebrafish is becoming increasingly popular for studying cutaneous wound healing owing to its genetic accessibility, suitability for experimental manipulation, and the abi...
Source: Journal of Investigative Dermatology - May 15, 2024 Category: Dermatology Authors: Leah J. Greenspan, Isabella Cisneros, Brant M. Weinstein Tags: Methods and Techniques for Skin Research Source Type: research

From Thin to Thick: Weight Gain in Children Feeds the Risk of Atopic Dermatitis
The pathogenesis of immune-mediated skin diseases continues to be unclear. Even though many of these diseases, such as atopic dermatitis (AD), psoriasis, and alopecia areata (AA), have a strong genetic component, this alone cannot explain the steady increase in the prevalence of these conditions that has been observed in many parts of the world over the last decades. Assuming that these changes are not due to genetic variations, which is doubtful given the brief period, the explanation underlying their increasing prevalence must be environmental. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 14, 2024 Category: Dermatology Authors: Arturo Borzutzky, Carolina Cabal ín Tags: Commentary Source Type: research

Erratum
Baricitinib Blocks Cytokine-Mediated Downregulation of PAD1 in Human Keratinocytes: A Possible Molecular Link to the Effects of JAK Inhibitors in Atopic Dermatitis. 10.1016/j.jid.2022.12.012 (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - May 14, 2024 Category: Dermatology Tags: Erratum Source Type: research