Journal of Investigative Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Strategy for the optimization of read-through therapy for junctional epidermolysis bullosa with COL17A1 nonsense mutation
The read-through therapy suppresses premature termination codons and induces read-through activity consequently restoring missing proteins. Aminoglycosides are widely studied as read-through drugs in different human genetic disorders including hereditary skin diseases. Our previous work revealed that aminoglycosides have effect on COL17A1 nonsense mutations and represent a therapeutic option to alleviate disease severity. However, the amount of restored type XVII collagen (C17) in C17 deficient junctional epidermolysis bullosa (JEB-C17) keratinocytes was less than 1% relative to normal keratinocytes and was achieved only a...
Source: Journal of Investigative Dermatology - March 21, 2024 Category: Dermatology Authors: Saliha Beyza Sayar, Cristina Has Tags: Original Article Source Type: research

Applications and Best Practices for Geospatial Analysis Research in Dermatology
Dermatologic diseases often exhibit distinct geographic patterns, underscoring the significant role of regional environmental, genetic, and sociocultural factors in driving their prevalence and manifestations. Geographic information and geospatial analysis enable researchers to investigate the spatial distribution of adverse health outcomes and their relationship with socioeconomic and environmental risk factors that are inherently geographic. Health geographers and spatial epidemiologists have developed numerous geospatial analytical tools to collect, process, visualize, and analyze geographic data. (Source: Journal of In...
Source: Journal of Investigative Dermatology - March 20, 2024 Category: Dermatology Authors: Megan M. Tran, Lauryn Orsillo, Guixing Wei, Fatima N. Mirza, Sara Yumeen, Oliver J. Wisco Tags: Methods and Techniques for Skin Research Source Type: research

Clinical Snippets
The incomplete understanding of the pathogenesis of the chronic inflammatory disease hidradenitis suppurativa (HS) contributes to a lack of effective therapies. Recently, a proof-of-concept phase 2 clinical trial showed that fostamatinib, a spleen Y kinase inhibitor, led to clinical benefit in patients with moderate-to-severe HS. Proteomics analysis of samples from the study demonstrated that inhibition with fostamatinib downregulated T helper 17 –associated cytokines IL-12B and IL-17A; B-cell–associated chemokines CCL19 and CCL20; and IFN-γ–associated proteins CX3CL1, IL-2, and CXCL10 in the serum of patients with ...
Source: Journal of Investigative Dermatology - March 20, 2024 Category: Dermatology Tags: Clinical Snippets Source Type: research

Editors ’ Picks
Immune responses at barrier surfaces are differentially managed by multiple skin-resident CD8+ T-cell subsets, including IFN- γ–producing tissue-resident memory T (TRM) 1 cells, which are associated with viral and tumor control, and IL-17–producing (TRM17) cells, which are associated with bacterial defense and wound healing. Park et al (2023) demonstrated that TRM1 and TRM17 cells employ distinct molecular networks t o establish tissue residency. TRM1 cells are programmed by the canonical T-bet–Hobit–IL-15-axis, whereas TRM17 cells are regulated by the ICOS–cMaf–IL-17 network. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 20, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research

Editorial Board
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 20, 2024 Category: Dermatology Source Type: research

Subscription Information
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Source: Journal of Investigative Dermatology - March 20, 2024 Category: Dermatology Source Type: research

Table of Contents
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 20, 2024 Category: Dermatology Source Type: research

Paradoxical Psoriasis: From Its Many Faces to Possible Shared Therapeutic Targets
Paradoxical psoriasis (PP) may be defined as the unexpected occurrence or worsening of psoriasiform skin lesions in patients undergoing treatment with biologics or small molecules (Murphy et  al, 2022). In this letter, we comment on the different settings of presentation of PP, including cases developing under anti–IL-4/IL-13 and anti–TNF-α agents, highlighting differences as well as shared pathophysiological features. An overview of available evidence is provided and put in persp ective, with possible implications for future research on druggable targets. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 19, 2024 Category: Dermatology Authors: Carlo Alberto Maronese, Antonio Costanzo, Michel Gilliet, Angelo Valerio Marzano Tags: Letters to the Editor Source Type: research

Paradoxical Psoriasis: from its many faces to possible shared therapeutic targets.
Paradoxical psoriasis (PP) may be defined as the unexpected occurrence or worsening of psoriasiform skin lesions in patients undergoing treatment with biologics or small molecules (Murphy et al., 2022). Herein, we comment on the different settings of presentation of PP, including cases developing under anti-interleukin (IL)-4/IL-13 and anti-Tumor Necrosis Factor- α agents, highlighting differences as well as shared pathophysiological features. An overview of available evidence is provided and put in perspective, with possible implications for future research on druggable targets. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 19, 2024 Category: Dermatology Authors: Carlo Alberto Maronese, Antonio Costanzo, Michel Gilliet, Angelo Valerio Marzano Tags: Letters to the Editor Source Type: research

Skin cancer risk is increased by somatic mutations detected noninvasively in healthy-appearing sun-exposed skin
Skin cancer risk is increased by exposure to ultraviolet radiation (UVR). Since UVR exposure accumulates over time and lighter skin is more susceptible to UVR, age and skin tone are risk factors for skin cancer. However, measurements of somatic mutations in healthy-appearing skin have not been used to calculate skin cancer risk. Herein, we developed a noninvasive test that quantifies somatic mutations in healthy-appearing sun-exposed skin and applied it to a 1,038-subject cohort. Somatic mutations were combined with other known skin cancer risk factors to train a model to calculate risk. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 19, 2024 Category: Dermatology Authors: Kulvinder Kaur, Rizi Ai, Allyson G. Perry, Bae Riley, Emma L. Roberts, Erica N. Montano, Jessica Han, Joanna Roacho, Brenda Garcia Lopez, Maral K. Skelsey, Maria V. Childs, James N. Childs, John Dobak, Claudia Ibarra, Burkhard Jansen, Loren E. Clarke, Ste Tags: Original Article Source Type: research

Time Is Running Out: The Circadian Clock Suggests Sex and Aging Differences in Human Epidermis
Day and night have long guided daily activities in our lives. Before time-keeping innovations such as sundials and clocks, humans maintained schedules by merely opening their eyes as the sun rose in the sky. Unbeknownst to them, their internal biological clock was maintaining regulation of their bodily functions throughout the course of the day through the trillions of cells that comprise the human body. This endogenous cellular process is referred to as one ’s circadian or biological rhythm and oscillates over an approximately 24-hour period, often portrayed as a cosine wave. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Rachel Bernstein, Shobhan Gaddameedhi Tags: Commentary Source Type: research

Advances in Skin-on-a-Chip Technologies for Dermatological Disease Modeling
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Seo Won Cho, Hamza Malick, Soo Jung Kim, Alessandro Grattoni Tags: Review Source Type: research

Emerging Role of Fibroblasts in Vitiligo: A Formerly Underestimated Rising Star
Vitiligo is a disfiguring depigmentation disorder characterized by loss of melanocytes. Although numerous studies have been conducted on the pathogenesis of vitiligo, the underlying mechanisms remain unclear. Although most studies have focused on melanocytes and keratinocytes, growing evidence suggests the involvement of dermal fibroblasts, residing deeper in the skin. This review aims to elucidate the role of fibroblasts in both the physiological regulation of skin pigmentation and their pathological contribution to depigmentation, with the goal of shedding light on the involvement of fibroblasts in vitiligo. (Source: Jou...
Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Yue Wu, Yiwen Yang, Yi Lin, Yuecen Ding, Ziqi Liu, Leihong Xiang, Mauro Picardo, Chengfeng Zhang Tags: Review Source Type: research

Endothelial Dysfunction in Psoriasis: An Integrative Review
Vascular endothelial cells (ECs), the inner layer of blood vessels, were previously considered to be a passive lining that facilitates cellular and molecular exchange. However, recent studies have revealed that ECs can respond to various stimuli and actively regulate vascular function and skin inflammation. Specific subtypes of ECs are known to have significant roles in a diverse range of physiological and pathological processes in the skin. This review suggests that EC dysfunction is both causal and consequential in the pathogenesis of psoriasis. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Qingyang Li, Bingyu Pang, Erle Dang, Gang Wang Tags: Review Source Type: research

Efficacy and Safety of Rilzabrutinib in Pemphigus: PEGASUS Phase 3 Randomized Study
Pemphigus is a rare, but life-threatening autoimmune disease requiring long-term treatment that minimizes corticosteroid (CS) exposure while providing consistent disease control. The phase 2 pemphigus study of oral, reversible, covalent Bruton tyrosine kinase (BTK) inhibitor rilzabrutinib demonstrated rapid and sustained efficacy with well-tolerated safety. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Dedee F. Murrell, Fr édéric Caux, Aikaterini Patsatsi, Owen Hagino, Lidia Rudnicka, Snejina Vassileva, Soner Uzun, Jenny Ye, Karl Yen, Puneet Arora, Steven G. Gourlay, Pascal Joly, Victoria P. Werth Tags: Original Article Source Type: research