Journal of Investigative Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers
Hair graying holds psychosocial importance and serves as an excellent model for studying human pigmentation and aging in an accessible miniorgan. Current evidence suggests that graying results from an interindividually varying mixture of cumulative oxidative and DNA damage, excessive mTORC1 activity, melanocyte senescence, and inadequate production of pigmentation-promoting factors in the hair matrix. Various regulators modulate this process, including genetic factors (DNA repair defects and IRF4 sequence variation, peripheral clock genes, P-cadherin signaling, neuromediators, HGF, KIT ligand secretion, and autophagic flux...
Source: Journal of Investigative Dermatology - December 13, 2023 Category: Dermatology Authors: Ralf Paus, Alec Sevilla, James M. Grichnik Tags: Review Source Type: research

Lack of cutaneous B cells differentiates lupus-like skin disease in MRL/lpr mice from human discoid lupus
Cutaneous lupus erythematosus (CLE) comprises all of the various presentations of lupus skin disease. All CLE subtypes exhibit a strong interferon signature and prominent T cell infiltrate (Wenzel et al., 2007). Discoid lupus (DLE) is the most common CLE subtype, characterized by erythematosus, scaly plaques with dyspigmentation and scarring, predominantly affecting the scalp and face. Histologically, these lesions exhibit epidermal atrophy, interface dermatitis, follicular plugging, and a perivascular and periadnexal lymphocytic infiltrate (Blake and Daniel, 2019). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 13, 2023 Category: Dermatology Authors: Joshuah Yon, Timothy Curran, Christopher T. Richardson Tags: Letters to the Editor Source Type: research

Genetic and Immunological Pathogenesis of Atopic Dermatitis
Type 2 immune –mediated diseases give a clear answer to the issue of nature (genetics) versus nurture (environment). Both genetics and environment play vital complementary roles in the development of atopic dermatitis (AD). As a key component of the atopic march, AD demonstrates the interactive nature of geneti c and environmental contributions to atopy. From sequence variants in the epithelial barrier gene encoding FLG to the hygiene hypothesis, AD combines a broad array of contributions into a single syndrome. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 11, 2023 Category: Dermatology Authors: Charles F. Schuler, Lam C. Tsoi, Allison C. Billi, Paul W. Harms, Stephan Weidinger, Johann E. Gudjonsson Tags: Review Source Type: research

Comparing the efficacy of updated treatment choices for prurigo nodularis: A network meta-analysis
Prurigo nodularis (PN) is a chronic dermatological condition characterized by intensely pruritic nodules or papules. (Huang et al., 2020) Conventional treatment choices often have side effects and uncertain long-term effectiveness, limiting their use and forming a lack of clear guidance for therapy. However, recent advances in understanding PN's chronic pruritus mechanisms have led to more treatment choices that show the potential to enhance skin health, reduce itchiness, and improve the life quality of PN patients. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 11, 2023 Category: Dermatology Authors: Xin-Yu Wang, Qian-Nan Jia, Meng-Yin Wu, Ming-Juan Liu, Xia Mi, Jun Li Tags: Letters to the Editor Source Type: research

Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 IFN in Cutaneous Lupus: An In-Depth Immunoprofile of Subacute and Discoid Lupus
The immunologic drivers of cutaneous lupus erythematosus (CLE) and its clinical subtypes remain poorly understood. We sought to characterize the immune landscape of discoid lupus erythematosus and subacute CLE using multiplexed immunophenotyping. We found no significant differences in immune cell percentages between discoid lupus erythematosus and subacute CLE (P> .05) with the exception of an increase in TBK1 in discoid lupus erythematosus (P (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 9, 2023 Category: Dermatology Authors: Thomas Vazquez, Jay Patel, Nilesh Kodali, DeAnna Diaz, Muhammad M. Bashir, Felix Chin, Emily Keyes, Meena Sharma, Grant Sprow, Madison Grinnell, Joshua Dan, Victoria P. Werth Tags: Original Article Source Type: research

Age at Natural Menopause, Reproductive Lifespan, and the Risk of Late-Onset Psoriasis and Psoriatic Arthritis in Women: A Prospective Cohort Study
This study aims to elucidate the association between reproductive lifespan and the risk of late-onset psoriasis and psoriatic arthritis (PsA). Utilizing the UK Biobank data, we conducted a prospective cohort study in postmenopausal women without baseline psoriatic diseases. The exposure variables included age at natural menopause (ANM) and duration from menarche to menopause, termed reproductive years. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 9, 2023 Category: Dermatology Authors: Yi Xiao, Yan Yi, Danrong Jing, Songchun Yang, Yeye Guo, Hui Xiao, Yehong Kuang, Wu Zhu, Jing Zhao, Yanping Li, Hong Liu, Jinchen Li, Xiang Chen, Minxue Shen Tags: Original Article Source Type: research

Plasmacytoid dendritic cells are not major producers of type 1 interferon in cutaneous lupus: An in depth immunoprofile of subacute and discoid lupus
The immunologic drivers of cutaneous lupus erythematosus (CLE) and its clinical subtypes remains poorly understood. We sought to characterize the immune landscape of discoid lupus erythematosus (DLE) and subacute CLE (SCLE) using multiplexed immunophenotyping. We found no significant differences in immune cell percentages between DLE and SCLE (p>0.05) with the exception of an increase in TANK binding kinase 1 (TBK1) in DLE (p (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 9, 2023 Category: Dermatology Authors: Thomas Vazquez, Jay Patel, Nilesh Kodali, DeAnna Diaz, Muhammad M. Bashir, Felix Chin, Emily Keyes, Meena Sharma, Grant Sprow, Madison Grinnell, Joshua Dan, Victoria P. Werth Tags: Original Article Source Type: research

Age at Natural Menopause, Reproductive Lifespan and the Risk of Late-onset Psoriasis and Psoriatic Arthritis in Women: A Prospective Cohort Study
While a peak incidence of psoriasis in women around 60 years of age has been observed, the link between reproductive lifespan and late-onset psoriatic diseases is underexplored. The current study aims to elucidate the association between reproductive lifespan and the risk of late-onset psoriasis and psoriatic arthritis (PsA). Utilizing the UK Biobank data, we conducted a prospective cohort study in postmenopausal women without baseline psoriatic diseases. The exposure variables included age at natural menopause (ANM) and duration from menarche to menopause, termed reproductive years (RYs). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 9, 2023 Category: Dermatology Authors: Yi Xiao, Yan Yi, Danrong Jing, Songchun Yang, Yeye Guo, Hui Xiao, Yehong Kuang, Wu Zhu, Jing Zhao, Yanping Li, Hong Liu, Jinchen Li, Xiang Chen, Minxue Shen Tags: Original Article Source Type: research

Single-Cell and Spatial Transcriptome Analysis of Dermal Fibroblast Development in Perinatal Mouse Skin: Dynamic Lineage Differentiation and Key Driver Genes
Several single-cell RNA (scRNA) studies of developing mouse skin have elucidated the molecular and cellular processes involved in skin development. However, they have primarily focused on either the fetal or early postnatal period, leaving a gap in our understanding of skin development. Here, we conducted a comprehensive time-series analysis by combining scRNA sequencing datasets collected at different stages of development (embryonic days 13.5, 14.5, and 16.5 and postnatal days 0, 2, and 4) and validated our findings through multi-panel in situ spatial transcriptomics. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 8, 2023 Category: Dermatology Authors: Hanjae Lee, So Young Kim, Nak-Jung Kwon, Seong Jin Jo, Ohsang Kwon, Jong-Il Kim Tags: Original Article Source Type: research

Integrative Keratinocyte Responses to TWEAK with IL-13 and IL-22 Reveal Pathogenic Transcriptomes Associated with Atopic Dermatitis
Atopic dermatitis (AD) is characterized by dysregulated activity of keratinocytes, and IL-13 and IL-22 are considered drivers of disease in part through stimulating these cells (Facheris et al., 2023, Kim et al., 2019, Humeau et al., 2022). Whether these cytokines act independently or with other inflammatory molecules is not clear. Previously, we reported that mice deficient in the cytokine TWEAK (tumor necrosis factor-related weak inducer of apoptosis; TNFSF12) were resistant to developing experimental AD, with its receptor Fn14 (TNFRSF12A) prominently expressed on keratinocytes (Sidler et al., 2017). (Source: Journal of ...
Source: Journal of Investigative Dermatology - December 8, 2023 Category: Dermatology Authors: Rinkesh K. Gupta, Kai Fung, Daniela Salgado Figueroa, Ferhat Ay, Michael Croft Tags: Letters to the Editor Source Type: research

Spatial distribution and functional impact of human scalp hair follicle microbiota
Human hair follicles (HFs) constitute a unique microbiota habitat that differs substantially from the skin surface. Traditional HF sampling methods fail to eliminate skin microbial contaminants or assess the HF microbiota incompletely, while microbiota functions in human HF physiology remain ill-explored. Therefore, we used laser-capture microdissection, metagenomic shotgun sequencing, and FISH to characterize the human scalp HF microbiota in defined anatomical compartments. This revealed significant compartment-, tissue lineage- and donor age-dependent variations in microbiota composition. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 7, 2023 Category: Dermatology Authors: Marta B. Lousada, Janin Edelkamp, Tim Lachnit, Markus Fehrholz, Irena Pastar, Francisco Jimenez, Hanieh Erdmann, Thomas C.G. Bosch, Ralf Paus Tags: Original Article Source Type: research

Deciphering the Pathobiological Impairment Mechanisms of the Lymphatic System during Secondary Lymphedema Progression
Lymphedema is the state or condition in which the lymphatic system cannot efficiently drain the extravasated fluid from the periphery, leading to a delayed while progressive edema formation. In fact, the term “delayed” illustrates one of the most important clinical characteristics of patients with lymphedema. Lymphedema does not appear immediately after the oncologic surgery or radiotherapy but requires months-to-years to become noticeable. This occurs when the compensatory mechanisms of the lymphati c vascular system are exhausted, leading subsequently to the development and (if left untreated) establishment of lymphe...
Source: Journal of Investigative Dermatology - December 3, 2023 Category: Dermatology Authors: Epameinondas Gousopoulos Tags: Commentary Source Type: research

Enhancer of Zeste Homolog 2 Inhibition Induces HLA Class I Re-Expression in Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with frequent metastases and poor outcomes (Dellambra et  al, 2021). MCC can be induced either by Merkel cell polyomavirus or by UV exposure, both resulting in the expression of immunogenic proteins, that is, viral antigens or neoantigens, respectively. Accordingly, immune escape mechanisms such as T-cell exhaustion through the expression of PD-1 (Afanas iev et al, 2013) and PD-L1 (Dellambra et al, 2021) in the tumor microenvironment are frequently observed in MCC tumors. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 2, 2023 Category: Dermatology Authors: Marie-Alice Durand, Aur élie Drouin, Kamel Bachiri, Laurine Durand, Patricia Berthon, Roland Houben, David Schrama, Etienne Coyaud, Mahtab Samimi, Antoine Touzé, Thibault Kervarrec Tags: Letters to the Editor Source Type: research

EZH2 inhibition induces HLA class I re-expression in Merkel Cell Carcinoma
Merkel cell carcinoma (MCC) is a rare primary cutaneous neuroendocrine carcinoma with frequent metastases and poor outcome (Dellambra et al. 2021). MCC can be induced either by Merkel cell polyomavirus or by UV exposure both resulting in the expression of immunogenic proteins, i.e., viral antigens or neoantigens, respectively. Accordingly, immune escape mechanisms such as T-cell exhaustion through the expression of PD-1 (Afanasiev et al. 2013) and PD-L1 (Dellambra et al. 2021) in the tumor microenvironment are frequently observed in MCC tumors. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 2, 2023 Category: Dermatology Authors: Marie-Alice Durand, Aur élie Drouin, Kamel Bachiri, Laurine Durand, Patricia Berthon, Roland Houben, David Schrama, Etienne Coyaud, Mahtab Samimi, Antoine Touzé, Thibault Kervarrec Tags: Letters to the Editor Source Type: research

Highly Efficient Ex  Vivo Correction of COL7A1 through Ribonucleoprotein-Based CRISPR/Cas9 and Homology-Directed Repair to Treat Recessive Dystrophic Epidermolysis Bullosa
In this study, we achieved highly efficient COL7A1 editing in primary RDEB keratinocytes and fibroblasts from 2 patients homozygous for the c.6508C>T (p.Gln2170 ∗) variant through CRISPR/Cas9-mediated homology-directed repair. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - December 1, 2023 Category: Dermatology Authors: Camille Berthault, Sonia Gaucher, Olivier Gouin, Alain Schmitt, Mei Chen, David Woodley, Matthias Titeux, Alain Hovnanian, Araksya Izmiryan Tags: Original Article Source Type: research