Desmosomal hyper-adhesion affects direct inhibition of desmoglein interactions in pemphigus

During differentiation, keratinocytes acquire a strong, hyper-adhesive state, where desmosomal cadherins interact Ca2+-independently. Previous data indicate that hyper-adhesion protects keratinocytes from pemphigus vulgaris autoantibody (PV-IgG)-induced loss of intercellular adhesion although the underlying mechanism remains to be elucidated. Thus, we here investigated the effect of hyper-adhesion on PV-IgG-induced direct inhibition of desmoglein (Dsg) 3 interactions by atomic force microscopy.Hyper-adhesion abolished loss of intercellular adhesion and corresponding morphological changes of all pathogenic antibodies used.

Source: Journal of Investigative Dermatology - April 25, 2024 Category: Dermatology Authors: Letyfee Steinert, Michael Fuchs, Anna M. Sigmund, Dario Didona, Christoph Hudemann, Christian M öbs, Michael Hertl, Takashi Hashimoto, Jens Waschke, Franziska Vielmuth Tags: Original Article Source Type: research