Journal of Investigative Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tnf signaling deficiency promotes UVB-induced melanocyte stem cell activation and migration
In recent decades, the incidence rate of melanoma has risen rapidly in the United States ( “Melanoma Skin Cancer Statistics” 2023), with ultraviolet B (UVB) exposure representing a significant risk factor (Armstrong and Kricker 2001). Understanding the cellular and molecular mechanisms of UVB-induced melanocyte stem cell (McSC) activation could uncover novel methods to prevent melanom a initiation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Luye An, Dahihm Kim, William Zhuang, Andrew C. White Tags: Letters to the Editor Source Type: research

Plantar skin exhibits altered physiology, constitutive activation of wound-associated phenotypes, and inherently delayed healing
Wound research has typically been performed without regard for where the wounds are located on the body, despite well-known heterogeneities in physical and biological properties between different skin areas. Skin covering the palms and soles is highly specialized, and plantar ulcers are one of the most challenging and costly wound types to manage. Using primarily the porcine model, we show that plantar skin is molecularly and functionally more distinct from non-plantar skin than previously recognized, with unique gene and protein expression profiles, broad alterations in cellular functions, constitutive activation of many ...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Christiane Fuchs, Katherine J. Stalnaker, Clifton L. Dalgard, Gauthaman Sukumar, Daniel Hupalo, Jonathan M. Dreyfuss, Hui Pan, Ying Wang, Linh Pham, Xunwei Wu, Ivan Jozic, R. Rox Anderson, Sunghun Cho, Jon H. Meyerle, Joshua Tam Tags: Original Article Source Type: research

Interleukin-26 potentiates type 2 skin inflammation in presence of interleukin-1 β
This study aimed to investigate the downstream effects of IL-26 on skin in the context of type 2 skin inflammation. We found that IL-26 alone exhibited limited inflammatory activity in skin. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Katharina Bier, Zuzana Senajova, Fanny Henrion, Yichen Wang, Sandro Bruno, Celine Rauld, Lisa C. H örmann, Carmen Barske, Corinne Delucis-Bronn, Sebastian Bergling, Marc Altorfer, Jasmin Hägele, Judith Knehr, Tobias Junt, Ben Roediger, Till A. Röhn, Fr Tags: Original Article Source Type: research

Computational Flow Cytometry Accurately Identifies Sezary Cells Based on Simplified Aberrancy and Clonality Features
Flow cytometric identification of circulating neoplastic cells (Sezary cells) in patients with mycosis fungoides (MF) and Sezary syndrome (SS) is essential for diagnosis, staging and prognosis. While recent advances have improved the performance of this laboratory assay, the complex immunophenotype of Sezary cells and overlap with reactive T cells demand a high level of analytic expertise. We utilized machine learning to simplify this analysis using only 2 pre-defined Sezary cell-gating plots. We studied 114 samples from 59 patients with SS/MF, and 66 samples from unique patients with inflammatory dermatoses. (Source: Jour...
Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Jansen N. Seheult, Matthew J. Weybright, Dragan Jevremovic, Min Shi, Horatiu Olteanu, Pedro Horna Tags: Original Article Source Type: research

Clinical Snippets
Monogenic etiologies are increasingly found to contribute to the population disease burden, and understanding the affected pathways can affect treatment decisions, improving healthcare efficiency. Inborn errors of immunity (IEIs) are monogenic etiologies that cause immune dysregulation and are associated with infection, autoimmunity, allergy, pathological inflammation, and cancer. Colvin et  al utilized bioinformatic analyses to identify 316 IEI genes that are associated with cutaneous manifestations. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Tags: Clinical Snippets Source Type: research

Editorial Board
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Source Type: research

Subscription Information
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Source Type: research

Table of Contents
(Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Source Type: research

Editors ’ Picks
Soft microfluidic analysis systems that adhere to the skin have been developed to capture, store, and evaluate biomarkers in eccrine sweat, which comprises the largest total volume of sweat loss. In a recent perspective, Yang et  al (2023) described the development and benefits of these systems. Activation of eccrine sweat glands through increased temperature, exercise, or pharmacological agents induces sweat production, and wearable microfluidic patches collect and analyze sweat samples in real time in a simple, cost-effe ctive, and noninvasive manner. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Tags: Editors' Picks Source Type: research

Romidepsin and Afatinib Abrogate Jak –Signal Transducer and Activator of Transcription Signaling and Elicit Synergistic Antitumor Effects in Cutaneous T-Cell Lymphoma
In this study, we demonstrate that the combination of romidepsin, a selective class I histone deacetylase inhibitor, with afatinib, an EGFR family inhibitor, induces strongly synergistic antitumor effects in cutaneous T-cell lymphoma models in  vitro and in vivo through abrogation of Jak–signal transducer and activator of transcription signaling. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Authors: Bobby B. Shih, Cindy Ma, Jose R. Cortes, Clara Reglero, Hannah Miller, S. Aidan Quinn, Robert Albero, Anouchka P. Laurent, Adam Mackey, Adolfo A. Ferrando, Larisa Geskin, Teresa Palomero Tags: Original Article Source Type: research

Romidepsin and afatinib abrogate JAK-STAT signaling and elicit synergistic antitumor effects in cutaneous T-cell lymphoma
Cutaneous T-cell lymphomas (CTCL) are mature lymphoid neoplasias resulting from the malignant transformation of skin-resident T cells. A distinctive clinical feature of CTCL is their sensitivity to treatment with histone deacetylase (HDAC) inhibitors. However, responses to HDAC inhibitor therapy are universally transient and non-curative, highlighting the need for effective and durable drug combinations. Here we demonstrate that the combination of romidepsin, a selective class I HDAC inhibitor, with afatinib, an epidermal growth factor receptor (EGFR) family inhibitor, induces strongly synergistic antitumor effects in CTCL...
Source: Journal of Investigative Dermatology - January 12, 2024 Category: Dermatology Authors: Bobby B. Shih, Cindy Ma, Jose R. Cortes, Clara Reglero, Hannah Miller, S. Aidan Quinn, Robert Albero, Anouchka P. Laurent, Adam Mackey, Adolfo A. Ferrando, Larisa Geskin, Teresa Palomero Tags: Original Article Source Type: research

Profibrotic Subsets of SPP1+ Macrophages and POSTN+ Fibroblasts Contribute to Fibrotic Scarring in Acne Keloidalis
Acne keloidalis (AK) is a primary scarring alopecia characterized by longstanding inflammation in the scalp causing keloid-like scar formation and hair loss. Histologically, AK is characterized by mixed leukocytic infiltrates in the acute stage followed by a granulomatous reaction and extensive fibrosis in the later stages. To further explore its pathogenesis, bulk RNA-sequencing, single-cell RNA-sequencing, and spatial transcriptomics were applied to occipital scalp biopsy specimens of lesional and adjacent non-lesional skin in patients with clinically active disease. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 11, 2024 Category: Dermatology Authors: Yi-Kai Hong, Daw-Yang Hwang, Chao-Chun Yang, Siao Muk Cheng, Peng-Chieh Chen, Wilson Jr Aala, Hans I ‐Chen Harn, Spencer T. Evans, Alexandros Onoufriadis, Si-Lin Liu, Yu-Chen Lin, Yi-Han Chang, Tzu-Kun Lo, Kuo-Shu Hung, Yi-Chao Lee, Ming-Jer Tang, Kurt Tags: Original Article Source Type: research

Contribution of Langerhans Cells to Early Dengue Infection
Dengue virus (DENV) is  a single-stranded positive-sense RNA flavivirus enclosed within a capsid and encircled by an envelope protein comprising envelope and premembrane/membrane structural proteins. Mosquitos transmit DENV through bites, and the skin is the primary site of infection. After a female Aedes mosquito’s bi te, the virus is injected into the outermost superficial layers of the skin, in the epidermis, and possibly deeper into the dermis. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 9, 2024 Category: Dermatology Authors: Stephan M. Caucheteux, Vincent Piguet Tags: Commentary Source Type: research

Immunobiology of IL-26
T helper 17 (Th17) cells produce a set of cytokines that include IL-17 family members, IL-21, IL-22, and IL-26. These cytokines all contribute to the classic function of Th17 cells in combatting extracellular infection and promoting inflammation in autoimmune diseases. However, of the Th17 cytokines, only IL-26 has direct antimicrobial activity against microbes and can activate a broad range of immune cells through its ability to bind DNA and trigger pattern recognition receptors. It is noteworthy that IL-26 is produced by mammalian cells, including human Th17 cells, but is absent in rodents. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 8, 2024 Category: Dermatology Authors: Michel Gilliet, Robert L. Modlin Tags: Review Source Type: research

Peripheral Mechanisms of Mechanical Itch
Mechanical itch, which is defined as an itch sensation caused by innocuous mechanical force, may warn of the potential risk in the skin. The increased mechanosensitivity in sensory neurons may cause scratch-induced itch and promote the transition from acute itch to chronic itch. Recent studies have not only expanded our knowledge about the neuronal circuits in the CNS but have also highlighted the importance of the peripheral epithelia –immune–neuronal crosstalk in the development of mechanical itch. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - January 8, 2024 Category: Dermatology Authors: Huijuan Ding, Liqin Zhou, Jiaying Zhou, Jing Feng Tags: Review Source Type: research