Clinical Snippets

Schuler et  al penned an in-depth review of atopic dermatitis (AD) to describe the intersection between the genetic features, immunopathogenesis, environmental influences, and relationship to other atopic diseases. Heritability of this disease is as high as 80%, stemming from null sequence variants in the ski n barrier protein FLG as well as other epidermis-related factors. Dysfunction of immune cells (T helper [Th]2 cells, dendritic cells, mast cells, basophils, and keratinocytes) and cytokines (IL-2, IL-4, and IL-13) has also been rigorously explored in AD.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Clinical Snippets Source Type: research