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Noninvasive Imaging Techniques for Monitoring Cellular Response to Treatment in Stable Vitiligo
Vitiligo, an immune-mediated melanocyte destruction disorder (Harris, 2018), is often treated with immunomodulators and phototherapy (Bae et  al, 2017). Surgical interventions can achieve 45%–47% success with>90% repigmentation (Ju et  al, 2021) in stable vitiligo, but responses are unpredictable (Rajaram et al, 2017). Quantifying vitiligo treatment response to grafting is challenging because of the limited sensitivity of the Vitiligo Area Scoring Index (Gan et al, 2017; Komen et al, 2015), which can only capture macroscopic changes after 6–12 months (Gao et al, 2022). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 10, 2023 Category: Dermatology Authors: Jessica Shiu, Griffin Lentsch, Christopher M. Polleys, Pezhman Mobasher, Marissa Ericson, Irene Georgakoudi, Anand K. Ganesan, Mihaela Balu Tags: Letters to the Editor Source Type: research

Non-invasive Imaging Techniques for Monitoring Cellular Response to Treatment in Stable Vitiligo
Vitiligo, an immune-mediated melanocyte destruction disorder (Harris, 2018), is often treated with immunomodulators and phototherapy (Bae et al., 2017). Surgical interventions can achieve 45-47% success with>90% repigmentation (Ju et al., 2021) in stable vitiligo but responses are unpredictable (Rajaram M, 2017). Quantifying vitiligo treatment response to grafting is challenging due to the limited sensitivity of the vitiligo area scoring index (VASI) (Gan et al., 2017) (Komen et al., 2015), which can only capture macroscopic changes after 6-12 months (Gao et al., 2022). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 10, 2023 Category: Dermatology Authors: Jessica Shiu, Griffin Lentsch, Christopher M. Polleys, Pezhman Mobasher, Marissa Ericson, Irene Georgakoudi, Anand K. Ganesan, Mihaela Balu Tags: Letters to the Editor Source Type: research

Barrier abnormalities in type 1 diabetes mellitus: the roles of inflammation and ceramide metabolism
Xerosis is a common sign of both type 1 and type 2 diabetes mellitus (DM); and DM patients and DM mouse models show a compromised epidermal permeability barrier. Barrier defects then allow the entry of foreign substances into the skin, triggering inflammation, infection and worsening skin symptoms. Characterizing how barrier abnormalities develop in DM could suggest treatments for xerosis and other skin disease traits. Since the proper ratio, as well as proper bulk amounts, of heterogeneous ceramide species are keys to forming a competent barrier, we investigated how ceramide metabolism is affected in type 1 DM (DM1) using...
Source: Journal of Investigative Dermatology - November 10, 2023 Category: Dermatology Authors: Kyong-Oh Shin, Bokyung Kim, Yerim Choi, Yoo-Jin Bae, Jae-Ho Park, Soo-Hyun Park, Jin-Taek Hwang, Eung Ho Choi, Yoshikazu Uchida, Kyungho Park Tags: Original Article Source Type: research

Human Skin T Cells Express Conserved T-Cell Receptors that Cross-React with Staphylococcal Superantigens and CD1a
Human Langerhans cells highly express CD1a antigen-presenting molecules. To understand the functions of CD1a in human skin, we used CD1a tetramers to capture T cells and determine their effector functions and TCR patterns. Skin T cells from all donors showed CD1a tetramer staining, which in three cases exceeded 10% of skin T cells. CD1a tetramer –positive T cells produced diverse cytokines, including IL-2, IL-4, IL-5, IL-9, IL-17, IL-22, and IFN-γ. Conserved TCRs often recognize nonpolymorphic antigen-presenting molecules, but no TCR motifs are known for CD1a. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 9, 2023 Category: Dermatology Authors: Elizabeth Bryan, Jessica E. Teague, Sezin Eligul, Wellington C. Arkins, D. Branch Moody, Rachael A. Clark, Ildiko Van Rhijn Tags: Original Article Source Type: research

Human skin T cells express conserved T cell receptors that cross-react with staphylococcal superantigens and CD1a
Human Langerhans cells highly express CD1a antigen presenting molecules. To understand the functions of CD1a in human skin, we used CD1a tetramers to capture T cells and determine their effector functions and T cell receptor patterns. Skin T cells from all donors showed CD1a tetramer staining, which in three cases exceeded 10% of skin T cells. CD1a tetramer+ T cells produced diverse cytokines, including interleukins 2, 4, 5, 9, 17, 22 and IFN γ. Conserved T cell receptors (TCRs) often recognize nonpolymorphic antigen presenting molecules, but no TCR motifs are known for CD1a. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 9, 2023 Category: Dermatology Authors: Elizabeth Bryan, Jessica E. Teague, Sezin Eligul, Wellington C. Arkins, D. Branch Moody, Rachael A. Clark, Ildiko Van Rhijn Tags: Original Article Source Type: research