Human Skin T Cells Express Conserved T-Cell Receptors that Cross-React with Staphylococcal Superantigens and CD1a

Human Langerhans cells highly express CD1a antigen-presenting molecules. To understand the functions of CD1a in human skin, we used CD1a tetramers to capture T cells and determine their effector functions and TCR patterns. Skin T cells from all donors showed CD1a tetramer staining, which in three cases exceeded 10% of skin T cells. CD1a tetramer –positive T cells produced diverse cytokines, including IL-2, IL-4, IL-5, IL-9, IL-17, IL-22, and IFN-γ. Conserved TCRs often recognize nonpolymorphic antigen-presenting molecules, but no TCR motifs are known for CD1a.

Source: Journal of Investigative Dermatology - November 9, 2023 Category: Dermatology Authors: Elizabeth Bryan, Jessica E. Teague, Sezin Eligul, Wellington C. Arkins, D. Branch Moody, Rachael A. Clark, Ildiko Van Rhijn Tags: Original Article Source Type: research