Journal of Investigative Dermatology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dermatologists ’ Perspectives and Usage of Large Language Models in Practice: An Exploratory Survey
The advent of artificial intelligence (AI) presents multiple avenues for the application of new technologies to medicine, including the use of computer vision to interpret clinical images and large language models (LLMs) to analyze and synthesize text-based healthcare data (Rajpurkar and Lungren, 2023). Nevertheless, healthcare systems must assess best practices in incorporating these technologies into clinical practice. Physicians must balance the analytical strengths of AI technologies with their shortcomings, such as ethical considerations surrounding AI-induced medical errors and their potential to perpetuate existing ...
Source: Journal of Investigative Dermatology - April 4, 2024 Category: Dermatology Authors: Haiwen Gui, Shawheen J. Rezaei, Daniel Schlessinger, Jason Weed, Jenna Lester, Shannon Wongvibulsin, Dom Mitchell, Justin Ko, Veronica Rotemberg, Ivy Lee, Roxana Daneshjou Tags: Letters to the Editor Source Type: research

Dermatologists ’ perspectives and usage of large language models in practice- an exploratory survey
To the Editor: The advent of artificial intelligence (AI) presents multiple avenues for the application of new technologies to medicine, including the use of computer vision to interpret clinical images and large-language models (LLMs) to analyze and synthesize text-based healthcare data (Rajpurkar and Lungren 2023). Nevertheless, healthcare systems must assess best practices in incorporating these technologies into clinical practice. Physicians must balance the analytical strengths of AI technologies with their shortcomings, such as ethical considerations surrounding AI-induced medical errors and their potential to perpet...
Source: Journal of Investigative Dermatology - April 4, 2024 Category: Dermatology Authors: Haiwen Gui, Shawheen J. Rezaei, Daniel Schlessinger, Jason Weed, Jenna Lester, Shannon Wongvibulsin, Dom Mitchell, Justin Ko, Veronica Rotemberg, Ivy Lee, Roxana Daneshjou Tags: Letters to the Editor Source Type: research

The molecular evolution of melanoma distant metastases
We examined the genomic diversity in melanoma progression in matched primary melanomas, lymph node and distant metastases from 17 patients. Fluorescence in situ hybridization (FISH) analysis revealed cancer cell fractions with monotonic copy number alterations (CNAs), including PHIP gain and PTEN loss, in the metastatic cascade. By contrast, the cancer cell fraction with CNAs for BPTF and MITF was reduced in lymph node metastases but increased in distant metastases. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 4, 2024 Category: Dermatology Authors: Vladimir Bezrookove, Sara Kianian, Lea McGeever, Robyn Jones, Chongshan Caressi, Mehdi Nosrati, Kevin B. Kim, Stanley P. Leong, James R. Miller, Pierre-Yves Desprez, Mohammed Kashani-Sabet Tags: Original Article Source Type: research

Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis
Chronic non-healing wounds negatively impact on quality of life and are a significant financial drain on health systems. The risk of infection that exacerbates co-morbidities in patients necessitates regular application of wound care. Understanding mechanisms underlying impaired wound healing are therefore a key priority to inform effective new generation treatments. Here, we demonstrate that 14-3-3-mediated suppression of signaling through ROCK is a critical mechanism that inhibits the healing of diabetic wounds. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 4, 2024 Category: Dermatology Authors: M. Zahied Johan, Natasha T. Pyne, Natasha Kolesnikoff, Valentina Poltavets, Zahra Esmaeili, Joanna M. Woodcock, Angel F. Lopez, Allison J. Cowin, Stuart M. Pitson, Michael S. Samuel Tags: Original Article Source Type: research

ASH2L mediates epidermal differentiation and hair follicle morphogenesis via H3K4me3 modification
The processes of epidermal development in mammals are regulated by complex molecular mechanisms, such as histone modifications. Histone H3 lysine K4 (H3K4) methylation mediated by COMPASS methyltransferase is associated with gene activation, but its effect on epidermal lineage development remains unclear. Therefore, we constructed a mouse model of specific ASH2L (COMPASS methyltransferase core subunit) deletion in epidermal progenitor cells and investigated its effect on the development of mouse epidermal lineage. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 4, 2024 Category: Dermatology Authors: Qirui Wang, Siyi Zeng, Yimin Liang, Renpeng Zhou, Danru Wang Tags: Original Article Source Type: research

E3 ubiquitin ligase NEDD4L negatively regulates skin tumorigenesis by inhibiting of IL-6/GP130 signaling pathway
In this study, protein expression levels of NEDD4L and GP130 were measured in tumor tissues from patients with cutaneous squamous cell carcinoma (cSCC). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 3, 2024 Category: Dermatology Authors: Huan Liu, Ning Wang, Run Yang, Jing Luan, Meng Cao, Cui Zhai, Shan Wang, Mengqian Wei, Duorong Wang, Jiayue Qiao, Yuqian Liu, Wenting She, Na Guo, Bo Liao, Xingchun Gou Tags: Original Article Source Type: research

Neutrophil-driven M2-like macrophages are critical for skin fibrosis in a systemic sclerosis model
In this study, we elucidated that CD206hiMHCIIlo M2-like macrophages constitute the predominant pathogenic immune cell population in the fibrotic skin of a bleomycin (BLM)-induced SSc mouse model. These cells emerged as pivotal contributors to the profibrotic response by orchestrating the production of TGF- β1 through a MerTK signaling-dependent manner. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 3, 2024 Category: Dermatology Authors: Pixia Gong, Yayun Ding, Wen Li, Jie Yang, Xiao Su, Ruifeng Tian, Yipeng Zhou, Tingting Wang, Junjie Jiang, Rui Liu, Jiankai Fang, Chao Feng, Changshun Shao, Yufang Shi, Peishan Li Tags: Original Article Source Type: research

Preclinical Atopic Dermatitis Skin in Infants: An Emerging Research Area
In this study, we review the structural, immunologic, and microbiome nature of the preclinical AD phenotype. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 2, 2024 Category: Dermatology Authors: Amy S. Paller, Tiffany C. Scharschmidt, Sanja Kezic, Alan D. Irvine Tags: Review Source Type: research

Dipeptidyl Peptidase-4 –Mediated Fibronectin Processing Evokes a Profibrotic Extracellular Matrix
Fibronectin serves as a platform to guide and facilitate deposition of collagen and fibrillin microfibrils. During development of fibrotic diseases, altered fibronectin deposition in the extracellular matrix (ECM) is generally an early event. After this, dysregulated organization of fibrillins and fibrillar collagens occurs. Because fibronectin is an essential orchestrator of healthy ECM, perturbation of its ECM-organizational capacity may be involved in development of fibrosis. To investigate this, we employed recessive dystrophic epidermolysis bullosa as a disease model with progressive, severe dermal fibrosis. (Source: ...
Source: Journal of Investigative Dermatology - April 1, 2024 Category: Dermatology Authors: Karina A. Zeyer, Olivier Bornert, Valentin Nelea, Xinyi Bao, Alexandre Leytens, Svetlana Sharoyan, Gerhard Sengle, Alvard Antonyan, Leena Bruckner-Tuderman, J örn Dengjel, Dieter P. Reinhardt, Alexander Nyström Tags: Original Article Source Type: research

The β-Secretase BACE1 Drives Fibroblast Activation in Systemic Sclerosis through the APP/β-Catenin/Notch Signaling Axis
BACE1 is well-known for its role in the development of Alzheimer ’s disease. Recent publications, including our own, have demonstrated a role for this enzyme in other chronic diseases. The aim of this study was to investigate the role of BACE1 in the autoimmune disease systemic sclerosis (SSc). BACE1 protein levels were elevated in the skin of patients with SSc . Inhibition of BACE1 with small-molecule inhibitors or small interfering RNA blocked SSc and fibrotic stimuli–mediated fibroblast activation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 1, 2024 Category: Dermatology Authors: Christopher W. Wasson, Enrico De Lorenzis, Eva M. Clavane, Rebecca L. Ross, Kieran A. Walker, Bego ña Caballero-Ruiz, Cristina Antinozzi, Rebecca Wells, Gemma Migneco, Jane M.Y. Brown, Samuel J. Turvey, Katie J. Simmons, Natalia A. Riobo-Del Galdo, Luigi Tags: Original Article Source Type: research

Autophagy Modulation in Endothelial Hyperglycemia-Induced Wound-Healing Impairment
Two studies have recently delved into the intricate signaling affecting the malfunctioning of endothelial cells in the wound-healing process of individuals with diabetes. They report on 2 alternative mechanisms of deregulated autophagy that occur because of high blood sugar levels (Wang et  al, 2024; Xu et al, 2023). Previous research has already shown a decrease in the formation of new blood vessels, known as neovascularization, due to dysfunction of endothelial cells caused by hyperglycemia (Funk et al, 2012). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 1, 2024 Category: Dermatology Authors: Daniele Bergamaschi Tags: Commentary Source Type: research

Dipeptidyl peptidase-4-mediated fibronectin processing evokes a pro-fibrotic extracellular matrix
Fibronectin serves as a platform to guide and facilitate deposition of collagen and fibrillin microfibrils. During development of fibrotic diseases, altered fibronectin deposition in the extracellular matrix (ECM) is generally an early event. Following this, dysregulated organization of fibrillins and fibrillar collagens occurs. Because fibronectin is an essential orchestrator of healthy ECM, perturbation of its ECM-organizational capacity may be involved in development of fibrosis. To investigate this, we employed recessive dystrophic epidermolysis bullosa (RDEB) as a disease model with progressive, severe dermal fibrosis...
Source: Journal of Investigative Dermatology - April 1, 2024 Category: Dermatology Authors: Karina A. Zeyer, Olivier Bornert, Valentin Nelea, Xinyi Bao, Alexandre Leytens, Svetlana Sharoyan, Gerhard Sengle, Alvard Antonyan, Leena Bruckner-Tuderman, J örn Dengjel, Dieter P. Reinhardt, Alexander Nyström Tags: Original Article Source Type: research

Chemo-senolytic therapeutic potential against angiosarcoma
Angiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, a taxane (genotoxic drug), although it has a limited effect owing to chemoresistance to prolonged treatment. Here, we examine an alternative angiosarcoma treatment approach that combines chemotherapeutic and senolytic agents. We find that the chemotherapeutic drugs cisplatin and paclitaxel efficiently induce senescence in angiosarcoma cells. Subsequent treatment with the senolytic agent ABT-263 eliminates senescent cells by activating the apoptotic pathway. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 1, 2024 Category: Dermatology Authors: Xuebing Wang, Claire Yik-Lok Chung, Ai Yoshioka, Shinya Hashimoto, Haruki Jimbo, Hideki Tanizawa, Shinya Ohta, Takeshi Fukumoto, Ken-ichi Noma Tags: Original Article Source Type: research

The Beta secretase BACE1 drives fibroblasts activation in Systemic Sclerosis through the APP/ β-catenin/Notch signalling axis
The beta-amyloid precursor protein cleaving enzyme 1 (BACE1) is well known for its role in the development of Alzheimer ’s disease. Recent publications, including our own, have demonstrated a role for this enzyme in other chronic diseases. The aim of this study was to investigate the role of BACE1 in the autoimmune disease systemic sclerosis (SSc). BACE1 protein levels were elevated in SSc patient skin. Inhibition of BACE1 with small molecule inhibitors or siRNA blocked SSc and fibrotic stimuli mediated fibroblast activation. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 1, 2024 Category: Dermatology Authors: Christopher W. Wasson, Enrico De Lorenzis, Eva M. Clavane, Rebecca L. Ross, Kieran A. Walker, Bego ña Caballero-Ruiz, Cristina Antinozzi, Rebecca Wells, Gemma Migneco, Jane M.Y. Brown, Samuel J. Turvey, Katie J. Simmons, Natalia A. Riobo-Del Galdo, Luigi Tags: Original Article Source Type: research

The Switch/Sucrose Nonfermentable Subunit ARID1A Mediates Neutrophil-Associated Skin Inflammatory Responses
ARID1A is part of the switch/sucrose nonfermentable chromatin remodeling complex that plays important roles in development and disease by altering chromatin structure through adenosine triphosphate hydrolysis (Pulice and Kadoch, 2016). ARID1A binds to AT-rich DNA sequences through its A –T rich interaction domain and is expressed in most cell types. ARID1A is one of the most heavily mutated switch/sucrose nonfermentable complex member, and loss-of-function mutations have been linked to various cancers, including endometrial, bladder, gastric, and hepatocellular carcinoma; cholang iocarcinoma; melanoma; and colorectal, lu...
Source: Journal of Investigative Dermatology - March 28, 2024 Category: Dermatology Authors: Uyanga Batzorig, Yifang Chen, Ye Liu, Celia Fern ández-Méndez, Samiksha Mahapatra, Sung Ha Lim, Seung-Phil Hong, George L. Sen Tags: Letters to the Editor Source Type: research