The molecular evolution of melanoma distant metastases

We examined the genomic diversity in melanoma progression in matched primary melanomas, lymph node and distant metastases from 17 patients. Fluorescence in situ hybridization (FISH) analysis revealed cancer cell fractions with monotonic copy number alterations (CNAs), including PHIP gain and PTEN loss, in the metastatic cascade. By contrast, the cancer cell fraction with CNAs for BPTF and MITF was reduced in lymph node metastases but increased in distant metastases.

https://www.jidonline.org/article/S0022-202X(24)00271-9/fulltext?rss=yes

Source: Journal of Investigative Dermatology - April 4, 2024 Category: Dermatology Authors: Vladimir Bezrookove, Sara Kianian, Lea McGeever, Robyn Jones, Chongshan Caressi, Mehdi Nosrati, Kevin B. Kim, Stanley P. Leong, James R. Miller, Pierre-Yves Desprez, Mohammed Kashani-Sabet Tags: Original Article Source Type: research