Dipeptidyl peptidase-4-mediated fibronectin processing evokes a pro-fibrotic extracellular matrix

Fibronectin serves as a platform to guide and facilitate deposition of collagen and fibrillin microfibrils. During development of fibrotic diseases, altered fibronectin deposition in the extracellular matrix (ECM) is generally an early event. Following this, dysregulated organization of fibrillins and fibrillar collagens occurs. Because fibronectin is an essential orchestrator of healthy ECM, perturbation of its ECM-organizational capacity may be involved in development of fibrosis. To investigate this, we employed recessive dystrophic epidermolysis bullosa (RDEB) as a disease model with progressive, severe dermal fibrosis.

Source: Journal of Investigative Dermatology - April 1, 2024 Category: Dermatology Authors: Karina A. Zeyer, Olivier Bornert, Valentin Nelea, Xinyi Bao, Alexandre Leytens, Svetlana Sharoyan, Gerhard Sengle, Alvard Antonyan, Leena Bruckner-Tuderman, J örn Dengjel, Dieter P. Reinhardt, Alexander Nyström Tags: Original Article Source Type: research